Математическая модель прогноза скорости фиброза печени у больных с хроническим гепатитом С на основе комбинаций геномных маркеров

Aim of study. To evaluate clinical significance of different combinations of gene polymorphisms IL-1b, IL-6, IL-10, TNF, HFE, TGF-b, ATR1, NOS3894, CYBA, AGT, MTHFR, FII, FV, FVII, FXIII, ITGA2, ITGB3, FBG, PAI and their prognostic value for prediction of liver fibrosis progression rate in patients with chronic hepatitis C (CHC).Subjects and methods: 118 patients with CHC were divided into «fast» and «slow» (fibrosis rate progression ≥0,13 and 0,13 fibrosis units/yr; n =64 and n =54) fibrosis groups. Gene polymorphisms were determined. Statistical analysis was performed using Statistica 10.Results. A allele (p =0,012) and genotype AA (p =0,024) of AGT G-6T gene, as well as T allele (p =0,013) and MT+TT genotypes (p =0,005) of AGT 235 M/T gene were significantly more common in «fast fibrosers» than in «slow fibrosers». Patients with genotype TT of CYBA 242 C/T had a higher fibrosis progression rate than patients with CC+CT genotype (p =0,02). Our analysis showed a protective effect of TT genotype of ITGA2 807 C/T on fibrosis progression rate (p =0,03). There was a trend (p 0,15) to higher fibrosis progression rate in patients with mutant alleles and genotypes of TGFb +915 G/C, FXIII 103 G/T, PAI -675 5G/4G genes. Other gene polymorphisms were not associated with enhanced liver fibrosis. To build a mathematical model for prediction of liver fibrosis progression rate we performed coding with scores for genotypes and virus genotype. Total score correlated with the fibrosis progression rate (R =0,39, p =0,000).Conclusion: Determination of genetic profile of the patient and virus genotype allows to predict the course of CHC. Обоснование. В настоящее время большое внимание уделяется поиску генетических факторов, объясняющих течение хронического гепатита С (ХГС).Цель исследования: оценить прогностическую значимость носительства комбинаций аллельных вариантов генов IL 1b, IL 6, IL 10, TNF α, HFE, TGF b, ATR1, NOS3, CYBA, AGT, MTHFR, FII, FV, FVII, FXIII, ITGA2, ITGB3, FBG, PAI на прогрессирование фиброза печени при ХГС.Материалы и методы: 118 пациентов с ХГС разделены на группы с быстрым и медленным (скорость фиброза ≥0,13 и 0,13 ед. фиброза/год; n =64 и n =54, соответственно) фиброзом. Выполнено определение полиморфизма. Статистическую обработку результатов проводили с использованием пакетов программ Statistica 10.Результаты. У больных с быстрым фиброзом в сравнении с группой с медленным чаще встречались аллель А (р =0,012) и мутантный генотип АА (р =0,024) гена AGT G-6T, также в данной группе чаще выявляли аллель Т (р =0,013) и генотип МТ+ТТ гена AGT 235 M/T (р =0,005). Больные с генотипом ТТ гена CYBA 242 C/T имели более высокую скорость фиброза по сравнению с больными с генотипом СС+СТ (р =0,02). В ходе анализа выявлено протективное влияние гомозиготы ТТ гена ITGA2 807 C/T на темпы фиброза (р =0,03). Наблюдались тенденции к различию по встречаемости аллелей и генотипов полиморфных маркеров TGFb +915 G/С, FXIII 103 G/T, PAI -675 5G/4G между двумя группами. Для остальных генов достоверных отличий не обнаружено. В дальнейшем построена математическая модель, учитывающая протективное и профиброгенное влияние генов, в также влияние генотипа вируса. Выявлена корреляция между суммой баллов в этой модели и темпом прогрессирования фиброза в печени (R =0,39, p =0,000).Заключение: предложенная математическая модель может прогнозировать течение болезни

On Asymptotic Expansion in the Random Allocation of Particles by Sets

We consider a scheme of equiprobable allocation of particles into cells by sets. The Edgeworth type asymptotic expansion in the local central limit theorem for a number of empty cells left after allocation of all sets of particles is derived.Comment: 15 page

Crystal Field and Dzyaloshinsky-Moriya Interaction in orbitally ordered La_{0.95}Sr_{0.05}MnO_3: An ESR Study

We present a comprehensive analysis of Dzyaloshinsky-Moriya interaction and crystal-field parameters using the angular dependence of the paramagnetic resonance shift and linewidth in single crystals of La_{0.95}Sr_{0.05}MnO_3 within the orthorhombic Jahn-Teller distorted phase. The Dzyaloshinsky-Moriya interaction (~ 1K) results from the tilting of the MnO_6 octahedra against each other. The crystal-field parameters D and E are found to be of comparable magnitude (~ 1K) with D ~= -E. This indicates a strong mixing of the |3z^2-r^2> and |x^2-y^2> states for the real orbital configuration.Comment: 12 pages, 6 figure

Search for the decay K+ to pi+ gamma gamma in the pi+ momentum region P>213 MeV/c

We have searched for the K+ to pi+ gamma gamma decay in the kinematic region with pi+ momentum close to the end point. No events were observed, and the 90% confidence-level upper limit on the partial branching ratio was obtained, B(K+ to pi+ gamma gamma, P>213 MeV/c) < 8.3 x 10-9 under the assumption of chiral perturbation theory including next-to-leading order ``unitarity'' corrections. The same data were used to determine an upper limit on the K+ to pi+ gamma branching ratio of 2.3 x 10-9 at the 90% confidence level.Comment: 15 pages, 3 figures; no change in the results, accepted for publication in Physics Letters

Total Cross Section Measurements With π- , Σ- And Protons On Nuclei And Nucleons Around 600 Gev/c

Total cross sections for Σ- and π- on beryllium, carbon, polyethylene and copper as well as total cross sections for protons on beryllium and carbon have been measured in a broad momentum range around 600GeV/c . These measurements were performed with a transmission technique in the SELEX hyperon-beam experiment at Fermilab. We report on results obtained for hadron-nucleus cross sections and on results for σtot(Σ-N) and σtot(π-N) , which were deduced from nuclear cross sections. © 2000 Elsevier Science B.V.57901/02/15277312Langland, J.L., (1995) Ph.D. Thesis, , University of IowaKleinfelder, S.A., (1988) IEEE Trans. Nucl. Sci., 35 (1)Dersch, U., (1998) Ph.D. Thesis, HeidelbergBiagi, S.F., (1981) Nucl. Phys. B, 186, pp. 1-21Bellettini, G., (1966) Nucl. Phys., 79, pp. 609-624Schiz, A.M., (1980) Phys. Rev. D, 21, pp. 3010-3022Murthy, P.V.R., (1975) Nucl. Phys. B, 92, pp. 269-308Caso, C., (1998) Eur. Phys. J. C, 3. , http://pdg.lbl.gov/1998/contents_plots.html, and data on total cross sections from computer readable filesSchiz, A.M., (1979) Ph.D. Thesis, , Yale University(1973) Landolt Börnstein Tables, 7. , Springer editionEngler, J., (1970) Phys. Lett. B, 32, pp. 716-719Babaev, A., (1974) Phys. Lett. B, 51, pp. 501-504Glauber, R.J., (1959) Boulder Lectures, pp. 315-413Franco, V., (1972) Phys. Rev. C, 6, pp. 748-757Karmanov, V.A., Kondratyuk, L.A., (1973) JETP Lett., 18, pp. 266-268Burq, J.P., (1983) Nucl. Phys. B, 217, pp. 285-335Gross, D., (1978) Phys. Rev. Lett., 41, pp. 217-220Beznogikh, G.G., (1972) Phys. Lett. B, 39, pp. 411-413Vorobyov, A.A., (1972) Phys. Lett. B, 41, pp. 639-641Foley, K.J., (1967) Phys. Rev. Lett., 19, pp. 857-859Fajardo, L.A., (1981) Phys. Rev. D, 24, pp. 46-65Jenni, P., (1977) Nucl. Phys. B, 129, pp. 232-252Breedon, R.E., (1989) Phys. Rev. Lett. B, 216, pp. 459-465Amos, N., (1983) Phys. Rev. Lett. B, 128, pp. 343-348Amaldi, U., (1977) Phys. Rev. Lett. B, 66, pp. 390-394Amos, N., (1985) Nucl. Phys. B, 262, pp. 689-714Akopin, V.D., (1977) Sov. J. Nucl. Phys., 25, pp. 51-55Amirkhanov, I.V., (1973) Sov. J. Nucl. Phys., 17, pp. 636-637Foley, K.J., (1969) Phys. Rev., 181, pp. 1775-1793Apokin, V.D., (1976) Nucl. Phys. B, 106, pp. 413-429Burq, J.P., (1982) Phys. Lett. B, 109, pp. 124-127Dakhno, L.G., (1983) Sov. J. Nucl. Phys., 37, pp. 590-598Kazarinov, M., (1976) Sov. Phys. JETP, 43, pp. 598-606De Jager, C.W., (1974) At. Data Nucl. Data Tables, 14, pp. 479-508Donnachie, A., Landshoff, P.V., (1992) Phys. Lett. B, 296, pp. 227-232Lipkin, H., (1975) Phys. Rev. D, 11, pp. 1827-1831Barnett, R.M., (1996) Phys. Rev. D, 54, pp. 191-192Carroll, A.S., (1979) Phys. Lett. B, 80, pp. 423-427Badier, J., (1972) Phys. Lett. B, 41, pp. 387-39

Total Cross Section Measurements with pi-, Sigma- and Protons on Nuclei and Nucleons around 600 GeV/c

Total cross sections for Sigma- and pi- on beryllium, carbon, polyethylene and copper as well as total cross sections for protons on beryllium and carbon have been measured in a broad momentum range around 600GeV/c. These measurements were performed with a transmission technique adapted to the SELEX hyperon-beam experiment at Fermilab. We report on results obtained for hadron-nucleus cross sections and on results for sigma_tot(Sigma- N) and sigma_tot(pi- N), which were deduced from nuclear cross sections.Comment: 42 pages, submitted to Nucl.Phys.