Prakara Yogas as an Immunomodulator during Infancy - A Critical Evaluation

Infancy is a crucial phase where the child comes across many mild to life threatening infections. The immunodeficiency of this period is compensated to some extend by the vertically transmitted antibodies from mother, exclusive breast feeding and through proper vaccination. But the protection offered by the maternal antibodies is transient and wanes off within 1 year. Concept of exclusive breastfeeding cannot be met in all circumstances especially in working mothers. Vaccinations provide protection against specific infections. In the present setting of pandemic, where the difficulties faced in tackling the spread of infections are witnessed, vaccinations become chaotic due to the unpredictable mutations of microbes. At this juncture arises the need for a well-built generalized immunity that will protect against a number of infections irrespective of the causative organism. Prakara Yogas are various immunomodulatory formulations elaborated in the textbook Arogyaraksha Kalpadruma that are scheduled to be administered during childhood in order to prevent diseases. The drug combinations in Prakara Yogas counteract the expected Dosha Vaishamya at specific ages, stabilize Agni and enhances immunity thereby preventing the onset of diseases. For protecting our future generations, usage of these formulations should be promoted for boosting their innate immunity, rather than attaining disease specific immunity against diseases through vaccination. This paper elaborates Prakara Yogas advised during infancy and also an attempt is made to critically analyse the formulations in aiding immunomodulation

CRITICAL REVIEW OF MEDHYA RASAYANA DRUGS MENTIONED IN AYURVEDA - TRADITIONAL INDIAN MEDICINE

Ayurvedic system of medicine has mentioned several medicinal preparations under the category 'Medhya'. By virtue of inducing mental upliftment as major influence several medicinal plants mentioned as 'Rasayana drugs' in Ayurveda are primarily claimed as 'Medhya'. Further there is a special class of Rasayana drugs called 'Medhya Rasayana' which is supposed to be having specific influence on brain functions. Cognitive deficits like memory disorders are found in high prevalence among the aged. In Ayurvedic literature, impairment of memory is mentioned as Smriti bhramsha which occurs due to vitiation of Rajo and Tamo doshas. It has been noted that cognitive functions are thoroughly affected due to stress and other related psychological disorders. It is clearly emphasized that Medha (intellect) and Buddhi (wisdom) deteriorate in these conditions. People's lifestyle also has an additional influence on the intellectual capacity. Several Medhya Rasayana drugs mentioned in Ayurveda have multi-dimensional actions having influence on memory. They not only enhance the intellectual capacity but also rejuvenate the whole system and their pathways.&nbsp

Clinical Evaluation of Pleurotus florida (White Oyster Mushroom) – Chatraka in the management of Vitamin D deficiency

Oyster mushroom (Pleurotus florida) commonly called in India as 'dhingri' develops spontaneously on dead and rotting wooden logs or sporadically on dying trunks of deciduous or coniferous trees in temperate and tropical woodlands. On exposure to sunlight or UV lamp, oyster mushrooms produce concentrations of Vitamin D that are nutritionally significant. Though long periods of storage and different types of cooking tend to decrease the vitamin D level of UV-exposed oyster mushrooms, the vitamin D level in all probability expected to remain at 10ug/100g fresh weight, which is greater than the amount in the majority of foods containing vitamin D and comparable to the recommended daily intake of vitamin D at the global level. Eligible candidates (n=50) were screened by computerized randomization method to receive Pflorida soup during the 03-month study. The efficacy parameters were evaluated through the blood investigation Vit D 25 (OH)

Spectral, structural and energetic study of acephate, glyphosate, monocrotophos and phorate: an experimental and computational approach

In the current study, experimental (UV–visible, Fourier transform infrared [FTIR], 1H-NMR and scanning electron microscope) and computational (UV–visible, FTIR, 1H-NMR, HOMO–LUMO, steric and geometric parameters) analyses of acephate, glyphosate, monocrotophos and phorate were performed for the first time. Computational studies were performed at the HF/6–311G(d,p) level of theory. It was found that experimental values of UV–visible, FTIR, 1H-NMR and geometric data were in very good agreement with the computational ones. The current study may assist future studies, like spectral analysis, pesticide(s) detection, surface behaviour and decomposition analysis of top selling titled pesticides of world market