Kerr effect as a tool for the investigation of dynamic heterogeneities

We propose a dynamic Kerr effect experiment for the distinction between dynamic heterogeneous and homogeneous relaxation in glassy systems. The possibility of this distinction is due to the inherent nonlinearity of the Kerr effect signal. We model the slow reorientational molecular motion in supercooled liquids in terms of non-inertial rotational diffusion. The Kerr effect response, consisting of two terms, is calculated for heterogeneous and for homogeneous variants of the stochastic model. It turns out that the experiment is able to distinguish between the two scenarios. We furthermore show that exchange between relatively 'slow' and 'fast' environments does not affect the possibility of frequency-selective modifications. It is demonstrated how information about changes in the width of the relaxation time distribution can be obtained from experimental results.Comment: 23 pages incl. 6 figures accepted for publication in The Journal of Chemical Physic

Field-induced transition of the magnetic ground state from A-type antiferromagnetic to ferromagnetic order in CsCo2Se2

We report on the magnetic properties of CsCo$_2$Se$_2$ with ThCr$_2$Si$_2$ structure, which we have characterized through a series of magnetization and neutron diffraction measurements. We find that CsCo$_2$Se2$_2$ undergoes a phase transition to an antiferromagnetically ordered state with a N\'eel temperature of $T_{\rm N} \approx$ 66 K. The nearest neighbour interactions are ferromagnetic as observed by the positive Curie-Weiss temperature of $\Theta \approx$ 51.0 K. We find that the magnetic structure of CsCo$_2$Se$_2$ consists of ferromagnetic sheets, which are stacked antiferromagnetically along the tetragonal \textit{c}-axis, generally referred to as A-type antiferromagnetic order. The observed magnitude of the ordered magnetic moment at $T$ = 1.5 K is found to be only 0.20(1)$\mu_{\rm Bohr}$/Co. Already in comparably small magnetic fields of $\mu_0 H_{MM}$(5K) $\approx$ 0.3 T, we observe a metamagnetic transition that can be attributed to spin-rearrangements of CsCo$_2$Se$_2$, with the moments fully ferromagnetically saturated in a magnetic field of $\mu_0 H_{\rm FM}$(5K) $\approx$ 6.4 T. We discuss the entire experimentally deduced magnetic phase diagram for CsCo$_2$Se$_2$ with respect to its unconventionally weak magnetic coupling. Our study characterizes CsCo$_2$Se$_2$, which is chemically and electronically posed closely to the $A_xFe_{2-y}Se_2$ superconductors, as a host of versatile magnetic interactions

Analysis of products from the oxidation of technical lignins by oxygen and H3PMo12O40 in water and aqueous methanol by size-exclusion chromatography

One kraft lignin and two lignosulfonates were oxidized in aqueous acidic solutions containing a polyoxometalate (POM). The degradations were carried out in H2O or MeOH/H2O mixtures in the presence of oxygen. The treatment with aqueous H3PMo12O40 led to the dissolution of the studied lignins in the acidic medium (pH 1-2) and to the formation of up to 6.5 wt% vanillin and 6.2 wt% methyl vanillate based on the weight of dry lignin. The lignin oxidation products were analyzed by size-exclusion chromatography (SEC). For this purpose, a SEC method was developed, which allows the analysis of kraft lignin, lignosulfonates, and reaction products thereof without the need to remove the homogeneous catalyst. This method allows the direct observation of depolymerization and repolymerization reactions and hence the provision of a tool for studying the underlying chemistry. It has been demonstrated that the depolymerization of kraft lignin in water is accompanied by counterproductive condensation reactions. These repolymerization reactions were effectively prevented by addition of methanol, which couples competitively with lignin intermediate

Dental Education and Care for Underserved Patients: An Analysis of Students’ Intentions and Alumni Behavior

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153676/1/jddj002203372006704tb04094x.pd

Semi-Synthetic Mithramycin Derivatives with Anti-Cancer Activity

Mithramycin derivatives and their pharmaceutically acceptable salts are disclosed. The mithramycin derivatives can be used in the treatment of Ewing sarcoma or other cancer or neuro-disease associated with an aberrant erythroblast transformation- specific transcription factor

Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer

Ovarian cancer is a highly deadly malignancy in which recurrence is considered incurable. Resistance to platinum-based chemotherapy bodes a particularly abysmal prognosis, underscoring the need for novel therapeutic agents and strategies. The use of mithramycin, an antineoplastic antibiotic, has been previously limited by its narrow therapeutic window. Recent advances in semisynthetic methods have led to mithramycin analogs with improved pharmacological profiles. Mithramycin inhibits the activity of the transcription factor Sp1, which is closely linked with ovarian tumorigenesis and platinum-resistance. This article summarizes recent clinical developments related to mithramycin and postulates a role for the use of mithramycin, or its analog, in the treatment of platinum-resistant ovarian cancer

XMM-Newton observations of the eastern jet of SS433

The radio supernova remnant W50 hosts at its center the peculiar galactic X-ray binary SS 433. It shows a central spherical structure with two `ears' which are supposed to be formed by the interaction of the precessing jets of SS 433 with the supernova shell. In two pointings in September/October 2004 for 30 ks each the eastern jet of SS 433 was observed with XMM-Newton to study the outermost parts of the `ear' and the X-ray bright emission region about 35 arcmin from SS 433. The spectra consist of two components: a non-thermal power law with photon index \Gamma ~ 2.17+/-0.02 and a thermal component at a typical temperature of kT ~ 0.3 keV. The X-ray emission seems to fill the whole interior region of the radio remnant W50. The jet terminates in the eastern `ear' in a ring-like terminal shock which indicates a flow with a kind of hollow-cone morphology. The spatial coincidence of X-ray and radio emission suggests physical conditions similar to those found at the outer shocks of ordinary supernova remnants. The bright emission region closer to SS 433 radiates non-thermally in a spatially well confined geometry at higher X-ray energies. At soft X-rays the shape of the region gets blurred, centered on the hard lenticular emission. The shape of this region and the bend in the jet propagation direction might be caused by the interaction of a re-collimated jet with the outer, non homogeneous interstellar matter distribution. The physical conditions leading to the re-collimation of the jet and the peculiar emission morphology are far from being understood and require deeper observations as well as a detailed modeling of the interaction of a jet with its surroundings.Comment: 10 pages, 8 figures, to appear in A&