Measurements of π±\pi^\pm, K±^\pm, p and pˉ\bar{\textrm{p}} spectra in proton-proton interactions at 20, 31, 40, 80 and 158 GeV/c with the NA61/SHINE spectrometer at the CERN SPS

Measurements of inclusive spectra and mean multiplicities of $\pi^\pm$, K$^\pm$, p and $\bar{\textrm{p}}$ produced in inelastic p+p interactions at incident projectile momenta of 20, 31, 40, 80 and 158 GeV/c ($\sqrt{s} =$ 6.3, 7.7, 8.8, 12.3 and 17.3 GeV, respectively) were performed at the CERN Super Proton Synchrotron using the large acceptance NA61/SHINE hadron spectrometer. Spectra are presented as function of rapidity and transverse momentum and are compared to predictions of current models. The measurements serve as the baseline in the NA61/SHINE study of the properties of the onset of deconfinement and search for the critical point of strongly interacting matter

Measurements of π±\pi^\pm, K±K^\pm, KS0K^0_S, Λ\Lambda and proton production in proton-carbon interactions at 31 GeV/cc with the NA61/SHINE spectrometer at the CERN SPS

Measurements of hadron production in p+C interactions at 31 GeV/c are performed using the NA61/ SHINE spectrometer at the CERN SPS. The analysis is based on the full set of data collected in 2009 using a graphite target with a thickness of 4% of a nuclear interaction length. Inelastic and production cross sections as well as spectra of $\pi^\pm$, $K^\pm$, p, $K^0_S$ and $\Lambda$ are measured with high precision. These measurements are essential for improved calculations of the initial neutrino fluxes in the T2K long-baseline neutrino oscillation experiment in Japan. A comparison of the NA61/SHINE measurements with predictions of several hadroproduction models is presented.Comment: v1 corresponds to the preprint CERN-PH-EP-2015-278; v2 matches the final published versio

Multiplicity and transverse momentum fluctuations in inelastic proton-proton interactions at the CERN Super Proton Synchrotron

Measurements of multiplicity and transverse momentum fluctuations of charged particles were performed in inelastic p+p interactions at 20, 31, 40, 80 and 158 GeV/c beam momentum. Results for the scaled variance of the multiplicity distribution and for three strongly intensive measures of multiplicity and transverse momentum fluctuations \$\Delta[P_{T},N]\$, \$\Sigma[P_{T},N]\$ and \$\Phi_{p_T}\$ are presented. For the first time the results on fluctuations are fully corrected for experimental biases. The results on multiplicity and transverse momentum fluctuations significantly deviate from expectations for the independent particle production. They also depend on charges of selected hadrons. The string-resonance Monte Carlo models EPOS and UrQMD do not describe the data. The scaled variance of multiplicity fluctuations is significantly higher in inelastic p+p interactions than in central Pb+Pb collisions measured by NA49 at the same energy per nucleon. This is in qualitative disagreement with the predictions of the Wounded Nucleon Model. Within the statistical framework the enhanced multiplicity fluctuations in inelastic p+p interactions can be interpreted as due to event-by-event fluctuations of the fireball energy and/or volume.Comment: 18 pages, 12 figure

Оценка биоэквивалентности двух таблетированных форм лизиноприла на здоровых добровольцах

Under cross, single, open, randomized trial with 1 week washout period, with two sequences of 18 volunteers studied bioequivalence coated tablets, two manufacturers of lisinopril (20 mg dose). The concentration of lisinopril in the plasma samples was determined using HPLC with fluorimetric detection within 72 hours for the investigated preparations the following pharmacokinetic parameters were calculated:AUC0-∞, Cmax, tmax, Cmax/AUC. 90% confidence interval relations AUC0-∞ compared drugs totaled 0.8520 — 1.2102 for Cmax — 0,9288 — 1,1451. In addition to the 90% confidence intervals, analysis of variance revealed no statistically significant differences between the studied drugs. Concluded bioequivalence compared drugs lisinopril.В рамках перекрёстного, однократного, открытого, рандомизированного исследования с периодом отмывки 1 неделя, с двумя последовательностями на 18 добровольцах изучена биоэквивалентность таблеток, покрытых оболочкой, лизиноприла двух производителей (доза 20 мг). Концентрацию лизиноприла в образцах плазмы крови определяли методом ВЭЖХ с флуориметрическим детектированием в течение 72 ч. Для исследуемых препаратов рассчитаны следующие фармакокинетические параметры: AUC0-∞, Cmax, tmax, Cmax/AUC. 90% доверительный интервал отношений AUC0-» сравниваемых препаратов составил 0,8520 — 1,2102 и для Cmax — 0,9288 — 1,1451. В дополнение к 90% доверительным интервалам, дисперсионный анализ не выявил статистически значимых различий между изучаемыми препаратами. Сделан вывод о биоэквивалентности сравниваемых препаратов лизиноприла

Исследование сравнительной фармакокинетики и биоэквивалентности препаратов Кардиоприл таблетки, 20 мг (АО «Химфарм», Республика Казахстан) и Моноприл® таблетки, 20 мг («Бристол-Майерс Сквибб С.Р.Л.», Италия)

In a single-dose, two-treatment, two-period, two-sequence crossover study with a 1-week washout period was carry out the bioequivalence study of two tablet coated formulation of fosinopril that given to 18 volunteers in equal doses (20 mg). Drug blood plasma concentrations were determined by validated LC-MS method for 48 hours. There were calculated the followed parameters: AUC 0-t ,Cmax, tmax , Cmax /AUC. 90% confidence interval for log-transformed AUC 0-tvalues was 0,9393 - 1,1473 and one for log-transformed Cmax was 0,8861 - 1,066, respectively. It was made the conclusion about bioequivalence of compared fosinopril formulations.В рамках перекрёстного, однократного, открытого, рандомизированного исследования с однонедельным периодом отмывки, с двумя последовательностями была изучена биоэквивалентность двух таблетированных форм фозиноприла на 18 добровольцах (дозировка 20 мг). Образцы плазмы крови анализировали валидированным методом ВЭЖХ-МС/МС в течение 48 часов. Для анализируемых препаратов рассчитаны следующие фармакокинетические параметры: AUC0-t, Cmax, tmax, Cmax/AUC. 90% доверительный интервал для логарифмически преобразованных значений AUC0-t составил 0,9393 - 1,1473 и для Cmax - 0,8861 - 1,066. По результатам исследования был сделан вывод о биоэквивалентности сравниваемых препаратов фозиноприла

Анизотропия механических свойств и механизмы упрочнения в кристаллах твердых растворов ZrO2—Y2O3

Abstract. The anisotropy of the mechanical properties of single crystal ZrO2 — 2.8 mol.% Y2O3 solid solutions has been studied. The crystals have been grown by skull melting technique. The microhardness and fracture toughness have been tested for different crystallographic planes by indentation with different indenter diagonal orientations. The study shows that the microhardness of the material depends on the crystallographic orientation but slightly whereas the fracture toughness varies for different planes. The maximum fracture toughness has been observed in the crystal specimen cut laterally to the <100> orientation. We have studied the anisotropy of the microhardness in the material for different indenter diagonal orientations. The maximum fracture toughness has been obtained for the {100} plane and the <100> indenter diagonal orientation. The phase composition inside and outside the indents on the {100}, {110} and {111} surfaces for 20, 3 and 1 N loads has been studied in local areas using Raman spectroscopy. The degree of the tetragonal−monoclinic transition has been evaluated for different crystallographic planes and different indenter diagonal orientations. The tetragonal−monoclinic transition proves to be anisotropic, and this affects the transformation hardening mechanism. The maximum amount of the monoclinic phase is present in the vicinity of the indent in the {100} plane for the <100> indenter diagonal orientation. The highest fraction toughness has also been observed in the {100} plane for the <100> indenter diagonal orientation. Probably, the abovementioned indenter diagonal orientation provides for the maximum stress concentration along the coherent conjugation planes between the tetragonal and the monoclinic phases during the tetragonal−monoclinic transition, i.e. (100)t||(100)m and [001]t||[010]m.Исследована анизотропия механических характеристик кристаллов твердых растворов ZrO2 — 2,8 % (мол.) Y2O3. Кристаллы выращены методом направленной кристаллизации расплава с использованием прямого высокочастотного нагрева. Методом индентирования проведены измерения микротвердости и трещиностойкости на разных кристаллографических гранях и при разной ориентации диагоналей индентора. Установлено, что микротвердость слабо зависит от кристаллографической ориентации, в то время как значения трещиностойкости для разных плоскостей отличаются. Максимальные значения трещиностойкости отмечены на образце, вырезанном из кристалла перпендикулярно к направлению <100>. Исследована анизотропия микротвердости в зависимости от ориентации диагоналей индентора. Максимальное значение трещиностойкости получено на плоскости {100} при ориентации диагоналей индентора в направлении <100>. Методом локальной спектроскопии комбинационного рассеяния света исследован фазовый состав внутри и вокруг отпечатков индентора на плоскостях {100}, {110} и {111} при нагрузках 20, 3 и 1 Н. Выполнена оценка степени интенсивности тетрагонально− моноклинного перехода на разных кристаллографических плоскостях и при разной ориентации диагоналей индентора. Показано, что наблюдается анизотропия тетрагонально−моноклинного перехода, влияющего на трансформационный механизм упрочнения. Максимальное количество моноклинной фазы обнаружено в области отпечатка индентора на плоскости {100}, при ориентации диагоналей индентора в направлении <100>. Также максимальное значение трещиностойкости реализуется на плоскости {100} при такой же ориентации диагоналей индентора. Возможно, что при данной ориентации диагоналей индентора максимальные действующие напряжения получаются вдоль когерентных плоскостей сопряжения тетрагональной и моноклинной фазы: при тетрагонально−моноклинном переходе — (100)t || (100)m и [001]t || [010]m

KS_{S}0^{0} meson production in inelastic p+p interactions at 158 GeV/c beam momentum measured by NA61/SHINE at the CERN SPS

The production of K$_{S}$$^{0}$ mesons in inelastic p+p collisions at beam momentum 158 GeV / ($\sqrt{SNN}$=17.3 GeV ) was measured with the NA61/SHINE spectrometer at the CERN Super Proton Synchrotron. Double-differential distributions were obtained in transverse momentum and rapidity. The mean multiplicity of K$_{S}$$^{0}$ was determined to be 0.162±0.001(.)±0.011(.). The results on K$_{S}$$^{0}$ production are compared with model predictions (EPOS 1.99, SMASH 2.0, PHSD and UrQMD 3.4 models) as well as with published world data

Measurements of π±\pi ^\pm , K±K^\pm , p and pˉ\bar{p} spectra in 7^7Be+9^9Be collisions at beam momenta from 19A to 150A GeV ⁣/ ⁣c{\mathrm{Ge} \mathrm{V}}\!/\!c with the NA61/SHINE spectrometer at the CERN SPS

The NA61/SHINE experiment at the CERN Super Proton Synchrotron (SPS) studies the onset of deconfinement in hadron matter by a scan of particle production in collisions of nuclei with various sizes at a set of energies covering the SPS energy range. This paper presents results on inclusive double-differential spectra, transverse momentum and rapidity distributions and mean multiplicities of π ± π± , K ± K± , p and p ¯ p¯ produced in the 20% most central 7 7 Be+ 9 9 Be collisions at beam momenta of 19A, 30A, 40A, 75A and 150A GeV/c GeV/c . The energy dependence of the K ± K± /π ± π± ratios as well as of inverse slope parameters of the K ± K± transverse mass distributions are close to those found in inelastic p+p reactions. The new results are compared to the world data on p+p and Pb+Pb collisions as well as to predictions of the Epos, Urqmd, Ampt, Phsd and Smash models

Measurements of π−\pi ^- production in 7^7Be + 9^9Be collisions at beam momenta from 19A to 150A GeV ⁣/ ⁣cA\,\text{ GeV }\!/\!c in the NA61/SHINE experiment at the CERN SPS

The NA61/SHINE experiment at the CERN Super Proton Synchrotron (SPS) studies the onset of deconfinement in hadron matter by a scan of particle production in collisions of nuclei with various sizes at a set of energies covering the SPS energy range. This paper presents results on inclusive double-differential spectra, transverse momentum and rapidity distributions and mean multiplicities of $\pi ^\pm$, $K^\pm$, p and $\bar{p}$ produced in the 20% most central$^7$Be+$^9$Be collisions at beam momenta of 19A, 30A, 40A, 75A and 150A ${\mathrm{Ge} \mathrm{V}}\!/\!c$. The energy dependence of the $K^\pm$/$\pi ^\pm$ ratios as well as of inverse slope parameters of the $K^\pm$ transverse mass distributions are close to those found in inelastic p+p reactions. The new results are compared to the world data on p+p and Pb+Pb collisions as well as to predictions of the Epos, Urqmd, Ampt, Phsd and Smash models