Color pattern recognition with circular component whitening

Polychromatic object recognition based on circular whitening preprocessing of red-green-blue components and multichannel matched filtering is described. Computer simulations and experimental results are provided to facilitate recognizing a color target among objects of similar shape but with different color contents. Experimental results are obtained with an optical correlator with two spatial light modulators, one to introduce the scene and the second one to introduce the filter

The Physics of K0−Kˉ0K^0 -\bar K^0 Mixing: B^K\widehat{B}_K and ΔMLS\Delta M_{LS} in the Chiral Quark Model

We compute the $\widehat B_K$ parameter and the mass difference $\Delta M_{LS}$ of the $K^0-\bar K^0$ system by means of the chiral quark model. The chiral coefficients of the relevant $\Delta S=2$ and $\Delta S=1$ chiral lagrangians are computed via quark-loop integration. We include the relevant effects of one-loop corrections in chiral perturbation theory. The final result is very sensitive to non-factorizable corrections of $O(\alpha_S N)$ coming from gluon condensation. The size of the gluon condensate is determined by fitting the experimental value of the amplitude $K^+ \to \pi^+\pi^0$. By varying all the relevant parameters we obtain $\widehat{B}_K= 0.87 \pm 0.33\ .$ We evaluate within the model the long-distance contributions to $\Delta M_{LS}$ induced by the double insertion of the $\Delta S = 1$ chiral lagrangian and study the interplay between short- and long-distance amplitudes. By varying all parameters we obtain $\Delta M_{LS}^{th}/\Delta M_{LS}^{exp} = 0.76 ^{+0.64}_{-0.34} .$ Finally, we investigate the phenomenological constraints on the Kobayashi-Maskawa parameter Im $\lambda _t$ entering the determination of $\epsilon'/\epsilon$.Comment: 31 pages, Latex file including 7 eps figures. Revised version to appear in Nucl. Phys.

The finding and researching algorithm for potentially oscillating enzymatic systems

Many processes in living organisms are subject to periodic oscillations at different hierarchical levels of their organization: from molecular-genetic to population and ecological. Oscillatory processes are responsible for cell cycles in both prokaryotes and eukaryotes, for circadian rhythms, for synchronous coupling of respiration with cardiac contractions, etc. Fluctuations in the numbers of organisms in natural populations can be caused by the populations’ own properties, their age structure, and ecological relationships with other species. Along with experimental approaches, mathematical and computer modeling is widely used to study oscillating biological systems. This paper presents classical mathematical models that describe oscillatory behavior in biological systems. Methods for the search for oscillatory molecular-genetic systems are presented by the example of their special case – oscillatory enzymatic systems. Factors influencing the cyclic dynamics in living systems, typical not only of the molecular-genetic level, but of higher levels of organization as well, are considered. Application of different ways to describe gene networks for modeling oscillatory molecular-genetic systems is considered, where the most important factor for the emergence of cyclic behavior is the presence of feedback. Techniques for finding potentially oscillatory enzymatic systems are presented. Using the method described in the article, we present and analyze, in a step-by-step manner, first the structural models (graphs) of gene networks and then the reconstruction of the mathematical models and computational experiments with them. Structural models are ideally suited for the tasks of an automatic search for potential oscillating contours (linked subgraphs), whose structure can correspond to the mathematical model of the molecular-genetic system that demonstrates oscillatory behavior in dynamics. At the same time, it is the numerical study of mathematical models for the selected contours that makes it possible to confirm the presence of stable limit cycles in them. As an example of application of the technology, a network of 300 metabolic reactions of the bacterium Escherichia coli was analyzed using mathematical and computer modeling tools. In particular, oscillatory behavior was shown for a loop whose reactions are part of the tryptophan biosynthesis pathway

Vanishing Minors in the Neutrino Mass Matrix from Abelian Gauge Symmetries

Augmenting the Standard Model by three right-handed neutrinos allows for an anomaly-free gauge group extension G_max = U(1)_(B-L) x U(1)_(L_e-L_mu) x U(1)_(L_mu-L_tau). While simple U(1) subgroups of G_max have already been discussed in the context of approximate flavor symmetries, we show how two-zero textures in the right-handed neutrino Majorana mass matrix can be enforced by the flavor symmetry, which is spontaneously broken very economically by singlet scalars. These zeros lead to two vanishing minors in the low-energy neutrino mass matrix after the seesaw mechanism. This study may provide a new testing ground for a zero-texture approach: the different classes of two-zero textures with almost identical neutrino oscillation phenomenology can in principle be distinguished by their different Z' interactions at colliders.Comment: 12 pages; Extended and clarified discussion; comments on finetuning in the textures; matches published versio

Information technology creation of basic educational programs for realization the Federal Government Educational Standards

В работе выполнено проектирование и разработка реляционной базы данных, которая содержит совокупность описаний объектов и их связей, характеризующих процесс создания и модернизации ООП на базе ФГОС. Создано программное обеспечение автоматизированной информационной системы, которое реализует функционал автоматизированного формирования и проверки на соответствие требованиям ФГОС учебных планов специальностей и направлений подготовки с учетом профилей подготовки и специализаций.We will design and develop a relational database, which contains a collection of descriptions of objects and their relationships that characterize the process of creating and upgrading basic education programs on the basis of the federal state educational standards. The software automated information system, which implements the functionality of automated generation and verification for compliance with standards, curriculum specialties and areas of training, taking into account profiles and specializations

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis

Incorporation of locally produced signaling molecules into cell-derived vesicles may serve as an endogenous mediator delivery system. We recently reported that levels alpha-2-macroglobulin (A2MG)-containing microparticles are elevated in plasma from patients with sepsis. Herein, we investigated the immunomodulatory actions of A2MG containing microparticles during sepsis. Administration of A2MG-enriched (A2MG-E)-microparticles to mice with microbial sepsis protected against hypothermia, reduced bacterial titers, elevated immunoresolvent lipid mediator levels in inflammatory exudates and reduced systemic inflammation. A2MG-E microparticles also enhanced survival in murine sepsis, an action lost in mice transfected with siRNA for LRP1, a putative A2MG receptor. In vitro, A2MG was functionally transferred onto endothelial cell plasma membranes from microparticles, augmenting neutrophil–endothelial adhesion. A2MG also modulated human leukocyte responses: enhanced bacterial phagocytosis, reactive oxygen species production, cathelicidin release, prevented endotoxin induced CXCR2 downregulation and preserved neutrophil chemotaxis in the presence of LPS. A significant association was also found between elevated plasma levels of A2MG-containing microparticles and survival in human sepsis patients. Taken together, these results identify A2MG enrichment in microparticles as an important host protective mechanism in sepsis

Microparticle alpha-2-macroglobulin enhances pro-resolving responses and promotes survival in sepsis

These studies were supported by The Wellcome Trust (program 086867/Z/08) and the William Harvey Research Foundation to MP, the United Kingdom Intensive Care Society to CJH and the National Institutes of Health GM Grant P01GM095967 (awarded to Charles N. Serhan). LVN is supported by an Arthritis Research UK Career Development Fellowship (19909). EPSRC Seed Funding Cross disciplinary Grant (QMUL) awarded to GBS and MP. This work forms part of the research themes contributing to the translational research portfolio of Barts and The London NIHR Cardiovascular BRU

Impact of socio-demographic structure of the deaf people communities in prevalence of hereditary hearing loss

Hearing loss caused by environmental or genetic factors concerns more than 10 % of the world population. It leads to disability and considerably reduces the life quality of deaf people. On average, 1 in 1,000 newborns are born deaf, and 50-60 % of cases are due to genetic causes. Nonsyndromic hereditary deafness is a monogenic disease with uniquely high genetic heterogeneity. The prevalence of some forms of genetic deafness varies in different populations and could be determined, as for many other genetic diseases, by the ethnic composition of a population, isolation, founder and «bottleneck» effects, the proportion of consanguineous marriages, and probable heterozygote advantage. It is assumed that high prevalence of hearing loss due to mutations in the GJB2 (Cx26) gene was also influenced by some social factors: a long-standing tradition of assortative marriages between deaf people, combined with growth of their social adaptation and genetic fitness. The start for these events was the breakdown of the deep social isolation of deaf people, which occurred about 300 years ago in Europe, and later in the US, when special schools for the deaf with learning sign language as a common tool for communication were established (linguistic homogamy). Computer simulations and comparative retrospective study showed that over the past 200 years these social processes can have doubled the frequency of deafness in the US caused by the GJB2 gene mutations. Information about the sociodemographic structure of deaf communities in the past is extremely limited by an almost complete lack of relevant archival data. Nevertheless, studies of sociodemographic and medical-genetic characteristics of deaf people’s contemporary communities are important for predicting the prevalence of inherited forms of deafness, as well as for understanding the impact of social factors on the evolutionary processes occurring in human populations

The ΔS=1\Delta S = 1 Weak Chiral Lagrangian as the Effective Theory of the Chiral Quark Model

We use the chiral quark model to estimate the coefficients of the weak chiral lagrangian as obtained from the bosonization of the ten relevant operators of the $\Delta S = 1$ effective quark lagrangian. All contributions of order $N_c^2$ as well as $N_c$ and $\alpha_s N_c$ are included. The chiral coefficients are given in terms of $f_{\pi}$, the quark and gluon condensates and the scale-dependent NLO Wilson coefficients of the corresponding operators. In addition, they depend on the constituent quark mass $M$, a parameter characteristic of the model. The $\gamma_5$-scheme dependence of the chiral coefficients, computed via dimensional regularization, and the Fierz transformation properties of the operator basis are discussed in detail. We apply our result to the evaluation of the hadronic matrix elements for the decay $K^0 \rightarrow 2 \pi$, consistently including the renormalization induced by the meson loops. The effect of this renormalization is sizable and introduces a long-distance scale dependence that matches in the physical amplitudes the short-distance scale dependence of the Wilson coefficients.Comment: Revised version to appear in Nucl. Phys. B 48 pages, uuencoded LATEX file including 4 eps figure