Редкие виды спонтанных разрывов печени на фоне беременности

This literature review is devoted to the problem of spontaneous liver ruptures in pregnant women. Its goal was to raise awareness among physicians as one of the methods to improve the early diagnosis of the disease, as well as to consider the role of the hepatological surgeon in the surgical treatment of rare obstetric diseases. The main links of the pathogenesis of liver ruptures were considered, the problem of high maternal and perinatal mortality was disclosed. Based on the literature data, the most optimal obstetric and surgical treatment and diagnostic tactics for managing pregnant women with spontaneous liver ruptures were determined.Настоящий литературный обзор посвящен проблеме спонтанных разрывов печени у беременных. Его целью стало повышение информированности врачей как одного из методов улучшения ранней диагностики болезни, а также рассмотрения роли хирурга-гепатолога в рамках хирургического лечения редкого акушерского осложнения. Были рассмотрены основные звенья патогенеза разрывов печени, раскрыта проблема высокой материнской и перинатальной смертности. На основании данных литературы была определена наиболее оптимальная акушерская и хирургическая лечебно-диагностическая тактика ведения беременных со спонтанными разрывами печени

Cytogenomic Profile of Uterine Leiomyoma: In Vivo vs. In Vitro Comparison

We performed a comparative cytogenomic analysis of cultured and uncultured uterine leiomyoma (UL) samples. The experimental approach included karyotyping, aCGH, verification of the detected chromosomal abnormalities by metaphase and interphase FISH, MED12 mutation analysis and telomere measurement by Q-FISH. An abnormal karyotype was detected in 12 out of 32 cultured UL samples. In five karyotypically abnormal ULs, MED12 mutations were found. The chromosomal abnormalities in ULs were present mostly by complex rearrangements, including chromothripsis. In both karyotypically normal and abnormal ULs, telomeres were ~40% shorter than in the corresponding myometrium, being possibly prerequisite to chromosomal rearrangements. The uncultured samples of six karyotypically abnormal ULs were checked for the detected chromosomal abnormalities through interphase FISH with individually designed DNA probe sets. All chromosomal abnormalities detected in cultured ULs were found in corresponding uncultured samples. In all tumors, clonal spectra were present by the karyotypically abnormal cell clone/clones which coexisted with karyotypically normal ones, suggesting that chromosomal abnormalities acted as drivers, rather than triggers, of the neoplastic process. In vitro propagation did not cause any changes in the spectrum of the cell clones, but altered their ratio compared to uncultured sample. The alterations were unique for every UL. Compared to its uncultured counterpart, the frequency of chromosomally abnormal cells in the cultured sample was higher in some ULs and lower in others. To summarize, ULs are characterized by both inter- and intratumor genetic heterogeneity. Regardless of its MED12 status, a tumor may be comprised of clones with and without chromosomal abnormalities. In contrast to the clonal spectrum, which is unique and constant for each UL, the clonal frequency demonstrates up or down shifts under in vitro conditions, most probably determined by the unequal ability of cells with different genetic aberrations to exist outside the body

The place of millet in food globalization during Late Prehistory as evidenced by new bioarchaeological data from the Caucasus

Two millets, Panicum miliaceum and Setaria italica, were domesticated in northern China, around 6000 BC. Although its oldest evidence is in Asia, possible independent domestication of these species in the Caucasus has often been proposed. To verify this hypothesis, a multiproxy research program (Orimil) was designed to detect the first evidence of millet in this region. It included a critical review of the occurrence of archaeological millet in the Caucasus, up to Antiquity; isotopic analyses of human and animal bones and charred grains; and radiocarbon dating of millet grains from archaeological contexts dated from the Early Bronze Age (3500–2500 BC) to the 1st Century BC. The results show that these two cereals were cultivated during the Middle Bronze Age (MBA), around 2000–1800 BC, especially Setaria italica which is the most ancient millet found in Georgia. Isotopic analyses also show a significant enrichment in 13C in human and animal tissues, indicating an increasing C4 plants consumption at the same period. More broadly, our results assert that millet was not present in the Caucasus in the Neolithic period. Its arrival in the region, based on existing data in Eurasia, was from the south, without excluding a possible local domestication of Setaria italica

Urogenital endogenous bacterial infection and systemic enzymotherapy

The article deals with terminology and modern views relating to vaginal dysbiosis and urogenital endogenous infection. Endogenous and exogenous trigger factors leading to disturbance of the vaginal microbiocenosis are characterized. Mechanisms of development of some obstetrical pathology in this infectious process are considered. Diagnostic and therapeutic approaches to correct dysbisosis with determination of the place of the system enzymotherapy in a complex therapy of this pathology are provided

Topographic instability of flow in a rotating fluid

Here are presented the results of experimental and theoretical studies on a stability of zonal geostrophic flows in the rotating layer of the shallow water. In the experiments, a special apparatus by Abastumani Astrophysical Observatory Georgian Academy of Science was used. This apparatus represents a paraboloid of rotation, which can be set in a regulable rotation around the vertical axis. Maximal diameter of the paraboloid is 1.2 m, radius of curvature in the pole is 0.698 m. In the paraboloid, water spreads on walls as a layer uniform on height under the period of rotation 1.677 s. Against a background of the rotating fluid, the zonal flows are formed by the source-sink system. It consists of two concentric circular perforations on the paraboloid bottom (width is 0.3 cm, radiuses are 8.4 and 57.3 cm, respectively); water can be pumped through them with various velocities and in all directions. It has been established that under constant vertical depth of the rotating fluid the zonal flows are stable. There are given the measurements of the radial profiles for the water level and velocity in the stationary regime. It has been found that zonal flows may lose stability under the presence of the radial gradient of full depth formed by a change of angular velocity of paraboloid rotation. An instability origin results in the loss of flow axial symmetry and in the appearance of self-excited oscillations in the zonal flow. At the given angular velocity of rotation, instability is observed only in the definite range of intensities of the source-sink system. The theoretical estimations are performed in the framework of the equations of the shallow water theory, including the terms describing the bottom friction. It has been shown that the instability of zonal flows found experimentally has a topographical nature and is related with non-monotone dependence of the potential vorticity on radius