The Sunrise Mission

The first science flight of the balloon-borne \Sunrise telescope took place in June 2009 from ESRANGE (near Kiruna/Sweden) to Somerset Island in northern Canada. We describe the scientific aims and mission concept of the project and give an overview and a description of the various hardware components: the 1-m main telescope with its postfocus science instruments (the UV filter imager SuFI and the imaging vector magnetograph IMaX) and support instruments (image stabilizing and light distribution system ISLiD and correlating wavefront sensor CWS), the optomechanical support structure and the instrument mounting concept, the gondola structure and the power, pointing, and telemetry systems, and the general electronics architecture. We also explain the optimization of the structural and thermal design of the complete payload. The preparations for the science flight are described, including AIV and ground calibration of the instruments. The course of events during the science flight is outlined, up to the recovery activities. Finally, the in-flight performance of the instrumentation is briefly summarized.Comment: 35 pages, 17 figure

Potential Relevance of α1-Adrenergic Receptor Autoantibodies in Refractory Hypertension

-AAB might have a mechanistic role and could represent a therapeutic target. in cardiomyocytes and induce mesentery artery segment contraction.-AAB in hypertensive patients, and the notion of immunity as a possible cause of hypertension

Establishment of a 3D In Vitro Model to Accelerate the Development of Human Therapies against Corneal Diabetes

The authors thank Dr. John M Asara, Min Yuan, and Susanne Breitkopf for their technical help with metabolomics experiments, Dr. Ben Fowler for his technical help with TEM experiments and also Tina B McKay for many thoughtful discussions and scientific insights during the study.Purpose To establish an in vitro model that would mirror the in vivo corneal stromal environment in diabetes (DM) patients. Methods Human corneal fibroblasts from Healthy (HCFs), Type 1DM (T1DM) and Type 2DM (T2DM) donors were isolated and cultured for 4 weeks with Vitamin C stimulation in order to allow for extracellular matrix (ECM) secretion and assembly. Results Our data indicated altered cellular morphology, increased cellular migration, increased ECM assembly, and severe mitochondrial damage in both T1DM and T2DMs when compared to HCFs. Furthermore, we found significant downregulation of Collagen I and Collagen V expression in both T1DM and T2DMs. Furthermore, a significant up regulation of fibrotic markers was seen, including α-smooth muscle actin in T2DM and Collagen III in both T1DM and T2DMs. Metabolic analysis suggested impaired Glycolysis and Tricarboxylic acid cycle (TCA) pathway. Conclusion DM has significant effects on physiological and clinical aspects of the human cornea. The benefits in developing and fully characterizing our 3D in vitro model are enormous and might provide clues for the development of novel therapeutics.Yeshttp://www.plosone.org/static/editorial#pee

Validation of O((1)S) wind measurements on WINDII: the WIND imaging interferometer on VARS

Article first published online: 21 SEP 2012This paper describes the current state of the validation of wind measurements by the wind imaging interferometer (WINDII) in the O(1S) emission. Most data refer to the 90-to-110-km region. Measurements from orbit are compared with winds derived from ground-based observations using optical interferometers, MF radars and the European Incoherent-Scatter radar (EISCAT) during overpasses of the WINDII fields of view. Although the data from individual passes do not always agree well, the averages indicate good agreement for the zero reference between the winds measured on the ground and those obtained from orbit. A comparison with winds measured by the high resolution Doppler imager (HRDI) instrument on UARS has also been made, with excellent results. With one exception the WINDII zero wind reference agrees with all external measurement methods to within 10 m s−1 at the present time. The exception is the MF radar winds, which show large station-to-station differences. The subject of WINDII comparisons with MF radar winds requires further study. The thermospheric O(1S) emission region is less amenable to validation, but comparisons with EISCAT radar data give excellent agreement at 170 km. A zero wind calibration has been obtained for the O(1D) emission by comparing its averaged phase with that for O(1S) on several days when alternating 1D/1S measurements were made. Several other aspects of the WINDII performance have been studied using data from on-orbit measurements. These concern the instrument's phase stability, its pointing, its responsivity, the phase distribution in the fields of view, and the behavior of two of the interference filters. In some cases, small adjustments have been made to the characterization database used to analyze the atmospheric data. In general, the WINDII characteristics have remained very stable during the mission to date. A discussion of measurement errors is included in the paper. Further study of the instrument performance may bring improvement, but the utimate limitation for wind validation appears to be atmospheric variability and this needs to be better understood