4,141 research outputs found
Preclinical Evaluation of Antitumor Efficacy of a New Radiopharmaceutical Based on Thermoresponsive Carrier and Samarium-153
This work is devoted to studying the in vivo antitumor efficacy of the new injection radiopharmaceutical based on thermoresponsive polymer and ÎČâ-emitting radionuclide samarium-153 (153Sm-KARP-CheM). The study of in vivo antitumor efficacy was performed using mice F1 and C57Bl/6 with transplanted subcutaneously sarcoma S37 and melanoma B16, respectively. The animals received single intratumoral bolus injections of 37 MBq (1 mCi), or 18.5 MBq (0.5 mCi) of 153Sm-KARP-CheM, or saline in a volume 0.1 ml. The efficacy of antitumortreatment was evaluated using tumor growth inhibition index (TGI, %) and increase of average life span (ILS, %). The most meaningful therapeutic efficacy after intratumoral injection of 153Sm-KARPCheM was observed in melanoma-bearing mice C57Bl/6. The highest values of TGI for melanoma B16 were 79.5% and 79.6% after treatment with 18.5 MBq or 37 MBq, respectively. An increase of average life span by 17.1% was found in group of melanoma-bearing mice treated with 37 MBq of 153Sm-KARP-CheM only. Tumor growth inhibition of sarcoma S37 was slightly lower as compared with melanoma B16: 62.5% and 59.0% in 37 MBq and 18.5 MBq groups, respectively. 153Sm-KARP-CheM didnât increase average life span of treated animals. In conclusion, 153Sm-KARP-CheM seems to be effective radiopharmaceutical for local tumor radiotherapy.
Keywords: thermoresponsive polymer, samarium-153, radionuclide therapy of cancer, sarcoma S37, melanoma B16, antitumor efficacy
The OSACA Database and a Kinematic Analysis of Stars in the Solar Neighborhood
We transformed radial velocities compiled from more than 1400 published
sources, including the Geneva--Copenhagen survey of the solar neighborhood
(CORAVEL-CfA), into a uniform system based on the radial velocities of 854
standard stars in our list. This enabled us to calculate the average weighted
radial velocities for more than 25~000 HIPPARCOS stars located in the local
Galactic spiral arm (Orion arm) with a median error of +-1 km/s. We use these
radial velocities together with the stars' coordinates, parallaxes, and proper
motions to determine their Galactic coordinates and space velocities. These
quantities, along with other parameters of the stars, are available from the
continuously updated Orion Spiral Arm CAtalogue (OSACA) and the associated
database. We perform a kinematic analysis of the stars by applying an
Ogorodnikov-Milne model to the OSACA data. The kinematics of the nearest single
and multiple main-sequence stars differ substantially. We used distant
(r\approx 0.2 kpc) stars of mixed spectral composition to estimate the angular
velocity of the Galactic rotation -25.7+-1.2 km/s/kpc, and the vertex
deviation,l=13+-2 degrees, and detect a negative K effect. This negative K
effect is most conspicuous in the motion of A0-A5 giants, and is equal to
K=-13.1+-2.0 km/s/kpc.Comment: 16 pages, 8 figure
Topology of event distribution as a generalized definition of phase transitions in finite systems
We propose a definition of phase transitions in finite systems based on
topology anomalies of the event distribution in the space of observations. This
generalizes all the definitions based on the curvature anomalies of
thermodynamical potentials and provides a natural definition of order
parameters. The proposed definition is directly operational from the
experimental point of view. It allows to study phase transitions in Gibbs
equilibria as well as in other ensembles such as the Tsallis ensemble.Comment: 4 pages, 3 figure
Lyman-alpha Absorption from Heliosheath Neutrals
We assess what information HST observations of stellar Ly-alpha lines can
provide on the heliosheath, the region of the heliosphere between the
termination shock and heliopause. To search for evidence of heliosheath
absorption, we conduct a systematic inspection of stellar Ly-alpha lines
reconstructed after correcting for ISM absorption (and
heliospheric/astrospheric absorption, if present). Most of the stellar lines
are well centered on the stellar radial velocity, as expected, but the three
lines of sight with the most downwind orientations relative to the ISM flow
(Chi1 Ori, HD 28205, and HD 28568) have significantly blueshifted Ly-alpha
lines. Since it is in downwind directions where heliosheath absorption should
be strongest, the blueshifts are almost certainly caused by previously
undetected heliosheath absorption. We make an initial comparison between the
heliosheath absorption and the predictions of a pair of heliospheric models. A
model with a complex multi-component treatment of plasma within the heliosphere
predicts less absorption than a model with a simple single-fluid treatment,
which leads to better agreement with the data. Finally, we find that
nonplanetary energetic neutral atom (ENA) fluxes measured by the ASPERA-3
instrument on board Mars Express, which have been interpreted as being from the
heliosheath, are probably too high to be consistent with the relative lack of
heliosheath absorption seen by HST. This would argue for a local interplanetary
source for these ENAs instead of a heliosheath source.Comment: 27 pages, 7 figures, AASTEX v5.0, accepted by Ap
A Quasi-Model-Independent Search for New Physics at Large Transverse Momentum
We apply a quasi-model-independent strategy ("Sleuth") to search for new high
p_T physics in approximately 100 pb^-1 of ppbar collisions at sqrt(s) = 1.8 TeV
collected by the DZero experiment during 1992-1996 at the Fermilab Tevatron.
Over thirty-two e mu X, W+jets-like, Z+jets-like, and 3(lepton/photon)X
exclusive final states are systematically analyzed for hints of physics beyond
the standard model. Simultaneous sensitivity to a variety of models predicting
new phenomena at the electroweak scale is demonstrated by testing the method on
a particular signature in each set of final states. No evidence of new high p_T
physics is observed in the course of this search, and we find that 89% of an
ensemble of hypothetical similar experimental runs would have produced a final
state with a candidate signal more interesting than the most interesting
observed in these data.Comment: 28 pages, 17 figures. Submitted to Physical Review
Search for R-parity Violating Supersymmetry in Dimuon and Four-Jets Channel
We present results of a search for R-parity-violating decay of the neutralino
chi_1^0, taken to be the Lightest Supersymmetric Particle. It is assumed that
this decay proceeds through one of the lepton-number violating couplings
lambda-prime_2jk (j=1,2; k=1,2,3). This search is based on 77.5 pb-1 of data,
collected by the D0 experiment at the Fermilab Tevatron in ppbar collisions at
a center of mass energy of 1.8 TeV in 1992-1995.Comment: 10 pages, 3 figure
The Palomar Testbed Interferometer Calibrator Catalog
The Palomar Testbed Interferometer (PTI) archive of observations between 1998
and 2005 is examined for objects appropriate for calibration of optical
long-baseline interferometer observations - stars that are predictably
point-like and single. Approximately 1,400 nights of data on 1,800 objects were
examined for this investigation. We compare those observations to an
intensively studied object that is a suitable calibrator, HD217014, and
statistically compare each candidate calibrator to that object by computing
both a Mahalanobis distance and a Principal Component Analysis. Our hypothesis
is that the frequency distribution of visibility data associated with
calibrator stars differs from non-calibrator stars such as binary stars.
Spectroscopic binaries resolved by PTI, objects known to be unsuitable for
calibrator use, are similarly tested to establish detection limits of this
approach. From this investigation, we find more than 350 observed stars
suitable for use as calibrators (with an additional being
rejected), corresponding to sky coverage for PTI. This approach
is noteworthy in that it rigorously establishes calibration sources through a
traceable, empirical methodology, leveraging the predictions of spectral energy
distribution modeling but also verifying it with the rich body of PTI's on-sky
observations.Comment: 100 pages, 7 figures, 7 tables; to appear in the May 2008ApJS, v176n
Direct Search for Charged Higgs Bosons in Decays of Top Quarks
We present a search for charged Higgs bosons in decays of pair-produced top
quarks in pbar p collisions at sqrt(s) = 1.8 TeV using 62.2 pb^-1 of data
recorded by the D0 detector at the Fermilab Tevatron collider. No evidence is
found for signal, and we exclude at 95% confidence most regions of the (M
higgs, tan beta) parameter space where the decay t->H b has a branching
fraction greater than 0.36 and B(H -> tau nu) is large.Comment: 11 pages, 4 figures, submitted to Phys. Rev. Let
Search for New Physics Using Quaero: A General Interface to D0 Event Data
We describe Quaero, a method that i) enables the automatic optimization of
searches for physics beyond the standard model, and ii) provides a mechanism
for making high energy collider data generally available. We apply Quaero to
searches for standard model WW, ZZ, and ttbar production, and to searches for
these objects produced through a new heavy resonance. Through this interface,
we make three data sets collected by the D0 experiment at sqrt(s)=1.8 TeV
publicly available.Comment: 7 pages, submitted to Physical Review Letter
Improved W boson mass measurement with the D0 detector
We have measured the W boson mass using the D0 detector and a data sample of
82 pb^-1 from the Tevatron collider. This measurement used W -> e nu decays,
where the electron is close to a boundary of a central electromagnetic
calorimeter module. Such 'edge' electrons have not been used in any previous D0
analysis, and represent a 14% increase in the W boson sample size. For these
electrons, new response and resolution parameters are determined, and revised
backgrounds and underlying event energy flow measurements are made. When the
current measurement is combined with previous D0 W boson mass measurements, we
obtain M_W = 80.483 +/- 0.084 GeV. The 8% improvement from the previous D0
measurement is primarily due to the improved determination of the response
parameters for non-edge electrons using the sample of Z bosons with non-edge
and edge electrons.Comment: submitted to Phys. Rev. D; 20 pages, 18 figures, 9 table
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