Improved correction for the tissue fraction effect in lung PET/CT imaging

Recently, there has been an increased interest in imaging different pulmonary disorders using PET techniques. Previous work has shown, for static PET/CT, that air content in the lung influences reconstructed image values and that it is vital to correct for this 'tissue fraction effect' (TFE). In this paper, we extend this work to include the blood component and also investigate the TFE in dynamic imaging. CT imaging and PET kinetic modelling are used to determine fractional air and blood voxel volumes in six patients with idiopathic pulmonary fibrosis. These values are used to illustrate best and worst case scenarios when interpreting images without correcting for the TFE. In addition, the fractional volumes were used to determine correction factors for the SUV and the kinetic parameters. These were then applied to the patient images. The kinetic parameters K1 and Ki along with the static parameter SUV were all found to be affected by the TFE with both air and blood providing a significant contribution to the errors. Without corrections, errors range from 34-80% in the best case and 29-96% in the worst case. In the patient data, without correcting for the TFE, regions of high density (fibrosis) appeared to have a higher uptake than lower density (normal appearing tissue), however this was reversed after air and blood correction. The proposed correction methods are vital for quantitative and relative accuracy. Without these corrections, images may be misinterpreted

Density variation during respiration affects PET quantitation in the lung

PET quantitation depends on the accuracy of the CT-derived attenuation correction map. In the lung, respiration leads to both positional and density mismatches, causing PET quantitation errors at lung borders but also within the whole lung. The aim of this work is to determine the extent of the associated errors on the measured time activity curves (TACs) and the corresponding kinetic parameter estimates. 5 patients with idiopathic pulmonary fibrosis underwent dynamic 18 F-FDG PET and cine-CT imaging as part of an ongoing study. The cine-CT was amplitude gated using PCA techniques to produce end expiration (EXP), end inspiration (INS) and mid-breathing cycle (MID) gates representative of a short clinical CT acquisition. The ungated PET data were reconstructed with each CT gate and the TACs and kinetic parameters compared. Patient representative XCAT simulations with varying lung density, both with and without motion, were also produced to represent the above study allowing comparison of true to measured results. In all cases, the obtained PET TACs differed with each CT gate. For ROIs internal to the lung, the effect was dominated by changes in density, as opposed to motion. The errors in the TACs varied with time, providing evidence that errors due to attenuation mismatch depend on activity distribution. In the simulations, some kinetic parameters were over- and under-estimated by a factor of 2 in the INS and EXP gates respectively. For the patients, the maximum variation in kinetic parameters was 20%. Our results show that whole lung density changes during the respiratory cycle have a significant impact on PET quantitation. This is especially true of the kinetic parameter estimates as the extent of the error is dependent on tracer distribution which varies with time. It is therefore vital to use matched PET/CT for attenuation correction

Four-point correlator constraints on electromagnetic chiral parameters and resonance effective Lagrangians

We pursue the analysis of a set of generalized DGMLY sum rules for the electromagnetic chiral parameters at order $e^2p^2$ and discuss implications for effective Lagrangians with resonances. We exploit a formalism in which charge spurions are introduced and treated as sources. We show that no inconsistency arises from anomalies up to quadratic order in the spurions. We focus on the sum rules associated with QCD 4-point correlators which were not analyzed in detail before. Convergence properties of the sum rules are deduced from a general analysis of the form of the counterterms in the presence of electromagnetic spurions. Following the approach in which vector and axial-vector resonances are described with antisymmetric tensor fields and have a chiral order, we show that the convergence constraints are violated at chiral order four and can be satisfied by introducing a set of terms of order six. The relevant couplings get completely and uniquely determined from a set of generalized Weinberg sum-rule relations. An update on the corrections to Dashen's low-energy theorem is given.Comment: 42 pages, 1 figure. v2: references adde

Observation of ZZ production in ppbar collisions at sqrt(s) = 1.96 TeV

We present an observation for ZZ -> l+l-l'+l'- (l, l' = e or mu) production in ppbar collisions at a center-of-mass energy of sqrt(s) = 1.96 TeV. Using 1.7 fb-1 of data collected by the D0 experiment at the Fermilab Tevatron Collider, we observe three candidate events with an expected background of 0.14 +0.03 -0.02 events. The significance of this observation is 5.3 standard deviations. The combination of D0 results in this channel, as well as in ZZ -> l+l-nunubar, yields a significance of 5.7 standard deviations and a combined cross section of sigma(ZZ) = 1.60 +/- 0.63 (stat.) +0.16 -0.17 (syst.) pb.Comment: 7 pages, 1 figure, 2 tables Modified slightly following review proces

A search for the standard model Higgs boson in the missing energy and acoplanar b-jet topology at sqrt(s) = 1.96 TeV

We report a search for the standard model Higgs boson in the missing energy and acoplanar b-jet topology, using an integrated luminosity of 0.93 inverse femtobarn recorded by the D0 detector at the Fermilab Tevatron Collider. The analysis includes signal contributions from pp->ZH->nu nu b b, as well as from WH production in which the charged lepton from the W boson decay is undetected. Neural networks are used to separate signal from background. In the absence of a signal, we set limits on the cross section of pp->VH times the branching ratio of H->bb at the 95% C.L. of 2.6 - 2.3 pb, for Higgs boson masses in the range 105 - 135 GeV, where V=W,Z. The corresponding expected limits range from 2.8 pb - 2.0 pb.Comment: Submitted to Phys. Rev. Letter

Measurement of the electron charge asymmetry in ppbar->W+X->enu+X events at sqrt{s}=1.96 TeV

We present a measurement of the electron charge asymmetry in ppbar->W+X->enu+X events at a center of mass energy of 1.96 TeV using 0.75 fb-1 of data collected with the D0 detector at the Fermilab Tevatron Collider. The asymmetry is measured as a function of the electron transverse momentum and pseudorapidity in the interval (-3.2, 3.2) and is compared with expectations from next-to-leading order calculations in perturbative quantum chromodynamics. These measurements will allow more accurate determinations of the proton parton distribution functions.Comment: 7 pages, 3 figures, Fermilab-Pub-08/249-E, submitted to Phys. Rev. Let

Precise measurement of the top quark mass from lepton+jets events at D0

We measure the mass of the top quark using top quark pair candidate events in the lepton+jets channel from data corresponding to 1 fb-1 of integrated luminosity collected by the D0 experiment at the Fermilab Tevatron collider. We use a likelihood technique that reduces the jet energy scale uncertainty by combining an in-situ jet energy calibration with the independent constraint on the jet energy scale (JES) from the calibration derived using photon+jets and dijet samples. We find the mass of the top quark to be 171.5+-1.8(stat.+JES)+-1.1(syst.) GeV.Comment: submitted to Phys. Rev. Letter

Search for charged massive long-lived particles with the D0 detector

We search for charged massive long-lived particles using 1.1 fb$^{-1}$ of data collected by the D0 detector at the Fermilab Tevatron $p\bar{p}$ Collider. Time-of-flight information is used to search for pair produced long-lived tau sleptons, gaugino-like charginos, and higgsino-like charginos. We find no evidence of a signal and set 95% C.L. cross section upper limits for staus, which vary from 0.31pb to 0.04pb for stau masses between 60 GeV and 300 GeV. We also set lower mass limits of 206 GeV (171 GeV) for pair produced charged gauginos (higgsinos).Comment: To be submitted to Phys. Rev. Letters, V2: updated the figures and references, V3: final version submitted to PRL and changes in title and abstracts from "stable" to "long-lived

Search for resonant diphoton production with the D0 detector

We present a search for a narrow resonance in the inclusive diphoton final state using 2.7 fb-1 of data collected with the D0 detector at the Fermilab Tevatron ppbar Collider. We observe good agreement between the data and the background prediction, and set the first 95% C.L. upper limits on the production cross section times the branching ratio for decay into a pair of photons for resonance masses between 100 and 150 GeV. This search is also interpreted in the context of several models of electroweak symmetry breaking with a Higgs boson decaying into two photons.Comment: 7 pages, 3 figures