Enabling organizational change – leadership, commitment to change and the mediating role of change readiness

There has been little empirical analysis on the complex relationship between leadership, change readiness and commitment to change in the context of Asian countries. In this paper, we propose a research model to analyze the interrelationship between leadership, change readiness and commitment to change using the partial least square technique. Results of the study suggest that leadership positively and significantly affect change readiness but not commitment to change. Consequently, change readiness is found to significantly affect commitment to change. In other words, change readiness is found to mediate the relationship between transformational leadership and commitment to change. This may suggest that the influence of leadership is a sequential process affecting change readiness, and in turn, the commitment to change as opposed to the conventional belief that it affects both change readiness and commitment to change simultaneously. The implication of the study is further discussed

Stokes' Drift of linear Defects

A linear defect, viz. an elastic string, diffusing on a planar substrate traversed by a travelling wave experiences a drag known as Stokes' drift. In the limit of an infinitely long string, such a mechanism is shown to be characterized by a sharp threshold that depends on the wave parameters, the string damping constant and the substrate temperature. Moreover, the onset of the Stokes' drift is signaled by an excess diffusion of the string center of mass, while the dispersion of the drifting string around its center of mass may grow anomalous.Comment: 14 pages, no figures, to be published in Phys.Rev.

Maternal exposure to di(2-ethylhexyl)phthalate (DEHP) promotes the transgenerational inheritance of adult-onset reproductive dysfunctions through the female germline in mice

Endocrine disruptors (EDS) are compounds known to promote transgenerational inheritance of adult-onset disease in subsequent generations after maternal exposure during fetal gonadal development. This study was designed to establish whether gestational and lactational exposure to the plasticizer di(2-ethylhexyl)phthalate (DEHP) at environmental doses promotes transgenerational effects on reproductive health in female offspring, as adults, over three generations in the mouse. Gestating F0 mouse dams were exposed to 0, 0.05, 5 mg/kg/day DEHP in the diet from gestational day 0.5 until the end of lactation. The incidence of adult-onset disease in reproductive function was recorded in F1, F2 and F3 female offspring. In adult Fl females, DEHP exposure induced reproductive adverse effects with: i) altered ovarian follicular dynamics with reduced primordial follicular reserve and a larger growing pre-antral follicle population, suggesting accelerated follicular recruitment; ii) reduced oocyte quality and embryonic developmental competence; iii) dysregulation of the expression profile of a panel of selected ovarian and pre-implantation embryonic genes. F2 and F3 female offspring displayed the same altered reproductive morphological phenotype and gene expression profiles as Fl, thus showing transgenerational transmission of reproductive adverse effects along the female lineage. These findings indicate that in mice exposure to DEHP at doses relevant to human exposure during gonadal sex determination significantly perturbs the reproductive indices of female adult offspring and subsequent generations. Evidence of transgenerational transmission has important implications for the reproductive health and fertility of animals and humans, significantly increasing the potential biohazards of this toxicant

Diagnostic potential of simplified methods for measuring glomerular filtration rate to detect chronic kidney disease in dogs

Background: Glomerular filtration rate (GFR) is the most sensitive indicator of initial renal function decline during chronic kidney disease (CKD), but conventional protocols for measuring GFR are labor-intensive and stressful for the dog. Objectives: To assess the diagnostic potential for detecting CKD with simplified GFR protocols based on iohexol plasma clearance. Animals: Seventeen CKD positive and 23 CKD negative dogs of different breeds and sex. Methods: Prospective nonrandomised study. Plasma iohexol was measured 5, 15, 60, 90, 180 min after injection. GFR was calculated using five samples (GFR5) or simplified protocols based on one, two, or three samples. GFR5 and simplified GFR were compared by Bland-Altmann and concordance correlation coefficient (CCC) analysis, and diagnostic accuracy for CKD by receiver operating characteristic curves. A grey zone for each protocol was bounded by the fourth quartile of the CKD positive population (lower cut-off) and the first quartile of the CKD negative population (upper cut-off). Results: All simplified protocols gave reliable GFR measurements, comparable to reference GFR5 (CCC > 0.92). Simplified protocols which included the 180-min sampling granted the best GFR measure (CCC: 0.98), with strong diagnostic potential for CKD (area under the receiver operating characteristic curve \ub1 SE: 0.98 \ub1 0.01). A double cut-off including a zone of CKD uncertainty guaranteed reliable diagnosis outside the grey area, and identified borderline dogs inside it. Conclusions: The simplified GFR protocols offer an accurate, hands-on tool for CKD diagnosis in dogs. The grey zone might help decision-making in the management of early kidney dysfunction

Exposure to di(2-ethyl-hexyl) phthalate (DEHP) in utero and during lactation causes long-term pituitary-gonadal axis disruption in male and female mouse offspring

The present study examined the effects in mice of exposure to di(2-ethyl-hexyl) phthalate (DEHP) throughout pregnancy and lactation on the development and function of the pituitary-gonadal axis in male and female offspring once they have attained adulthood. Groups of two to three dams were exposed with the diet from gestational d 0.5 until the end of lactation, at 0, 0.05, 5, and 500 mg DEHP/kg \ub7 d. The experiment was repeated three times (total: seven to 10 dams per treatment). The 500-mg dose caused complete pregnancy failure, whereas exposure to doses of 0.05 and 5 mg did not affect pregnancy and litter size. In total, about 30 male and 30 female offspring per group were analyzed. Offspring of the DEHP-treated groups, compared with controls, at sexual maturity showed: 1) lower body weight (decrease 20-25%, P < 0.001); 2) altered gonad weight (testes were 3c13% lighter and ovaries 3c40% heavier; P < 0.001); 3) poor germ cell quality (semen was 3c50% less concentrated and 20% less viable, and 3c10% fewer oocytes reached MII stage, P < 0.001); 4) significant lower expression of steroidogenesis and gonadotropin-receptor genes in the gonads; and 5) up-regulated gonadotropin subunit gene expression in the pituitary. In conclusion, our findings suggest that, in maternally exposed male and female mice, DEHP acts on multiple pathways involved in maintaining steroid homeostasis. Specifically, in utero and lactational DEHP exposure may alter estrogen synthesis in both sexes. This, in turn, induces dysregulation of pituitary-gonadal feedback and alters the reproductive performance of exposed animals

Effects of polychlorinated biphenyls in Cd-1 mice : reproductive toxicity and intergenerational transmission

Several studies indicate that in-utero and peri-natal exposure to polychlorinated biphenyls (PCBs) induces adverse reproductive effects but it remains unclear whether such effects may be transmitted to subsequent generations. We therefore investigated the association between maternal exposure to PCBs and reproductive health in male and female offspring over three generations.Mouse dams were fed 0, 1, 10, 100 \u3bcg/kg/day of a PCB mixture (101+118) during pregnancy and lactation. PCB levels were measured in the tissues of both dams and offspring.PCB concentrations at all doses investigated were greater in the offspring than in the dams (P 640.0001) confirming that the progeny were exposed as a result of maternal exposure. In F1 offspring, exposure to PCBs resulted in reductions in: i) testis weight (P 640.05) and seminiferous tubule diameter (P 640.05); ii) sperm viability (P 640.0001) and developmental capacity (P 640.05); iii) ovary weight (P 640.05); iv) oocyte developmental capacity (P 640.05), and in v) increased follicular atresia (P 640.0001).In females, adverse effects were observed only in the F1 animals. In contrast, male offspring exhibited reduced sperm viability and altered seminiferous tubule distribution up to the third generation, showing intergenerational transmission.In summary, our data indicate that exposure to PCBs at the time of gonadal sex determination perturbed, significantly, the reproductive physiology of male and female offspring in adulthood. Furthermore, male reproductive deficiencies may be observed in at least two further generations. These findings have significant implications for reproductive health and fertility of animals and humans

Driven diffusion in a periodically compartmentalized tube: homogeneity versus intermittency of particle motion

We study the effect of a driving force F on drift and diffusion of a point Brownian particle in a tube formed by identical ylindrical compartments, which create periodic entropy barriers for the particle motion along the tube axis. The particle transport exhibits striking features: the effective mobility monotonically decreases with increasing F, and the effective diffusivity diverges as F → ∞, which indicates that the entropic effects in diffusive transport are enhanced by the driving force. Our consideration is based on two different scenarios of the particle motion at small and large F, homogeneous and intermittent, respectively. The scenarios are deduced from the careful analysis of statistics of the particle transition times between neighboring openings. From this qualitative picture, the limiting small-F and large-F behaviors of the effective mobility and diffusivity are derived analytically. Brownian dynamics simulations are used to find these quantities at intermediate values of the driving force for various compartment lengths and opening radii. This work shows that the driving force may lead to qualitatively different anomalous transport features, depending on the geometry design

Energy fluctuations in a biharmonically driven nonlinear system

We study the fluctuations of work done and dissipated heat of a Brownian particle in a symmetric double well system. The system is driven by two periodic input signals that rock the potential simultaneously. Confinement in one preferred well can be achieved by modulating the relative phase between the drives. We show that in the presence of pumping the stochastic resonance signal is enhanced when analyzed in terms of the average work done on the system per cycle. This is in contrast to the case when pumping is achieved by applying an external static bias, which degrades resonance. We analyze the nature of work and heat fluctuations and show that the steady state fluctuation theorem holds in this system.Comment: 13 pages, 14 figures, revised manuscrip

Width of the Δ\Delta resonance in nuclei

In this work we evaluate the imaginary part of the isobar $\Delta$ self-energy $\Sigma_{\Delta}$ from the two-body absorption process $\Delta+N\rightarrow 2N$. This contribution is calculated using a recently developed non-relativistic scheme, which allows for an evaluation of the self-energy with a basis of single-particle states appropriate for both bound hole states and for particle states in the continuum. In order to test the medium dependence of the self-energy, we calculate the two-body absorption term $\Sigma_{\Delta}^{A2}$ for several finite nuclei with $N=Z$, i.e.\ $^{16}$O, $^{40}$Ca and $^{100}$Sn. The resulting self-energy, which is energy dependent and non-local, is compared with a simple parameterization derived from nuclear matter.Comment: 5 pages 3 figures can be obtained from the authors, TU-93-160