Optimization immunepharmacotherapy of pyoinflammatory diseases

The results of clinical investigation of several pyoinflammatory diseases are presented. Objectives: On clinical data of various models of pyoinflammatory diseases - deep pyodermia (UCP), chronic salpingooforitis (OHSO), chronic pyelonephritis (CPN), authors found a significant mechanism of influence the pathogenesis on the manifestation of immunopathology, efficacy and mechanisms of pharmacological immunocorrection actio

Innovation and investment safety as the condition for neo-industrial development

The paper suggests considering neo-industrial development that is represented as alternative to post-industrialism from the perspective of provision of innovation and investment safety of the country. Authors make an effort to determine economic and institutional backgrounds and criteria of safety of innovation and investment activities. Specification of categorical framework used in researched sphere was conducted; in particular, it was suggested to consider innovation and investment safety the key part of national economic safety. On the basis of regression analysis the appraisal of relation between the size of internal expenditures for research and development and living standards in the country was held - it has demonstrated rather weak relation between researched variables during a short period of time. In addition, the work formulates the key problems in the sphere of innovation and investment safety in Russia and suggests proposals on their solution.peer-reviewe

Immune-metabolic genesis of pathological processes

This article deals with metabolic-immune processes at rest and under stress conditions, which, in turn, results in the development of immune-dependent and immune-associated disorders. The authors also analyzed metabolic effects of immunomodulators. Based on the analysis of the literature and own clinical and experimental data, the authors identified the ability of metabolic factors to regulate immunological processe

Pharmacological body-wide and immunotropic effects of galavit in the treatment of patients with purulent-inflammatory diseases of various origins and allergization

The aim of the study was to specify pharmacological (body-wide) and specific (immunotropic) effects of the immunomodulator galavit additionally prescribed in the context of basic treatment for patients with deep pyoderma, chronic pyelonephritis, adnexitis, purulent infection of soft tissues, complicated by atopic dermatiti

ПОЛУЧЕНИЕ СВЕЖЕЙ ПРОДУКЦИИ ОВОЩНЫХ КОРНЕПЛОДОВ СЕМЕЙСТВА КАПУСТНЫЕ В ОТКРЫТОМ ГРУНТЕ ПРИ РАЗНЫХ СРОКАХ ВЫРАЩИВАНИЯ

The data of spring-summer sowing time of vegetable root crops of the family Brassicaceae in the open filed are presented. Five varieties and three hybrids of daikon, seven varieties of radish, and four varieties of turnip were tested. Based on the results, the minimal and maximal root weight for each time of sowing were determined; average fresh weight of vegetable roots for three years of investigation was accounted.В статье представлены данные весенне-летних сроков посева овощных корнеплодов семейства Капустные в открытом грунте. Было исследовано пять сортов и три гибрида дайкона, семь сортов редьки и четыре сорта репы. По результатам проведенных исследований определена наименьшая и наибольшая масса корнеплодов по каждым срокам посева, подсчитана средняя масса продукции за три года исследований

ВЫРАЩИВАНИЕ ОВОЩНЫХ КОРНЕПЛОДОВ СЕМЕЙСТВА КАПУСТНЫЕ В ЗАЩИЩЕННОМ ГРУНТЕ

The results of winter and spring sowing times of vegetable root crops of Brassicaceae family in protected area are presented. Five varieties and three hybrids of daikon, seven varieties of radish, and five varieties of turnip were studied. The minimal and maximal weight of roots for each sowing time was revealed. The average weight of products over three years of research was calculated.В статье приведены результаты зимне-весенних сроков посева овощных корнеплодов семейства Капустные в защищенном грунте. Было исследовано пять сортов и три гибрида дайкона, семь сортов редьки и пять сортов репы. По результатам проведенных исследований установлена наименьшая и наибольшая масса корнеплодов по каждым срокам посева, подсчитана средняя масса продукции за три года исследований

Immune reactions as induction factors and correction of the pathology

On clinical models of infectious, somatic, malignant, and other diseases, the ability of immune responses to induce pathological processes due to competition, “pathogenicity”, hypersensitivity, and insufficiency has been shown. We are talking about the competitiveness of antibacterial and antiviral immunity, when the deployment of cellular and humoral immune responses weaken both defense mechanisms, competition of allergy and immune deficiency, which aggravates and modifies it, and antiviral immunity often induces a number of pathological conditions of the body. This is due to the inability of antiviral antibodies to completely inactivate the antireceptor structures of virions, interact with them without changing their function, and even stimulate a viral infection, induce autoimmune reactions. The protective system of interferons, which often cause side reactions, is also faulty. In  the  body, immunopathological reactions develop, manifested by immediate and delayed hypersensitivity, which have alternative properties – protective and damaging and autoimmune reactions, mainly with a negative effect. The mechanisms of the processes are discussed in detail in the review. The “inferiority” of immune reactions, respectively, cellular, humoral, phagocytic links, incomplete consistency of anticancer immunity, virus-induced immunodeficiencies are comprehensively covered. Such “alternativeness” of the considered immune reactions, at the same time, turns out to be a necessary condition for eliminating the emerging disorders of the organism’s reactivity. These include specificity and non-specificity, stimulation and suppression, variability and integration of immune responses. At the same time, immunoregulatory reactions are individual and interrelated, develop regionally and systemically and provide degradation of exogenous and endogenous objects and immune activation. All these aspects are discussed in detail in the review

Emulsion sheet doublets as interface trackers for the OPERA experiment

New methods for efficient and unambiguous interconnection between electronic counters and target units based on nuclear photographic emulsion films have been developed. The application to the OPERA experiment, that aims at detecting oscillations between mu neutrino and tau neutrino in the CNGS neutrino beam, is reported in this paper. In order to reduce background due to latent tracks collected before installation in the detector, on-site large-scale treatments of the emulsions ("refreshing") have been applied. Changeable Sheet (CSd) packages, each made of a doublet of emulsion films, have been designed, assembled and coupled to the OPERA target units ("ECC bricks"). A device has been built to print X-ray spots for accurate interconnection both within the CSd and between the CSd and the related ECC brick. Sample emulsion films have been extensively scanned with state-of-the-art automated optical microscopes. Efficient track-matching and powerful background rejection have been achieved in tests with electronically tagged penetrating muons. Further improvement of in-doublet film alignment was obtained by matching the pattern of low-energy electron tracks. The commissioning of the overall OPERA alignment procedure is in progress.Comment: 19 pages, 19 figure