A neuronal network model of interictal and recurrent ictal activity

We propose a neuronal network model which undergoes a saddle-node bifurcation on an invariant circle as the mechanism of the transition from the interictal to the ictal (seizure) state. In the vicinity of this transition, the model captures important dynamical features of both interictal and ictal states. We study the nature of interictal spikes and early warnings of the transition predicted by this model. We further demonstrate that recurrent seizures emerge due to the interaction between two networks.Comment: 9 pages, 7 figure

Where does the black population of South Africa stand on the nutrition transition?

OBJECTIVE: To review data on selected risk factors related to the emergence of noncommunicable diseases (NCDs) in the black population of South Africa. METHODS: Data from existing literature on South African blacks were reviewed with an emphasis placed on changes in diet and the emergence of obesity and related NCDs. DESIGN: Review and analysis of secondary data over time relating to diet, physical activity and obesity and relevant to nutrition-related NCDs. SETTINGS: Urban, peri-urban and rural areas of South Africa. National prevalence data are also included. SUBJECTS: Black adults over the age of 15 years were examined. RESULTS: Shifts in dietary intake, to a less prudent pattern, are occurring with apparent increasing momentum, particularly among blacks, who constitute three-quarters of the population. Data have shown that among urban blacks, fat intakes have increased from 16.4% to 26.2% of total energy (a relative increase of 59.7%), while carbohydrate intakes have decreased from 69.3% to 61.7% of total energy (a relative decrease of 10.9%) in the past 50 years. Shifts towards the Western diet are apparent among rural African dwellers as well. The South African Demographic and Health Survey conducted in 1998 revealed that 31.8% of African women (over the age of 15 years) were obese (body mass index (BMI) > or = 30kg m(-2)) and that a further 26.7% were overweight (BMI > or = 25 to <30 kg m(-2)). The obesity prevalence among men of the same age was 6.0%, with 19.4% being overweight. The national prevalence of hypertension in blacks was 24.4%, using the cut-off point of 140/90 mmHg. There are limited data on the population's physical activity patterns. However, the effects of the HIV/AIDS epidemic will become increasingly important. CONCLUSIONS: The increasing emergence of NCDs in black South Africans, compounded by the HIV/AIDS pandemic, presents a complex picture for health workers and policy makers. Increasing emphasis needs to be placed on healthy lifestyles

Academic and quantitative literacy in higher education: Relationship with cognate school-leaving subjects

Academic and quantitative literacies (AQL) are essential to success in higher education. These literacies are largely not explicitly taught, but acquired indirectly, mostly through practices in various school subjects. The National Benchmark Tests (NBT) Project assesses students’ AQL competencies to assist in identifying students who need support, with placement into appropriate programmes and with curriculum development. We analyse the performance on the NBT AQL test of students who took the school-leaving examinations in Mathematics, Mathematical Literacy, English Home Language and English First Additional Language. We use the subject choice as a representation of the level of a candidate’s quantitative competence and language proficiency respectively, and investigate the relative contributions made by these subject choices to a student’s AQL. Students who paired Mathematics with English as Home Language subject had the statistically significant highest mean AQL score and those who took both English First Additional Language and Mathematical Literacy had the lowest. Language competence has a stronger effect than mathematical competence on AQL. Students who took the subject combination Mathematics and English Home Language at school are better prepared for the academic demands of higher education than their counterparts who took the alternate subjects. Treating these subjects as equivalent to English Home Language and Mathematics for admissions purposes ignores the differences in preparedness of these students

Gestão de resíduos sólidos na Continental: melhoria de práticas e de processos

A Cubesat mission with a deployable solar sail of 5 meter by 5 meter in a sun-synchronous low earth orbit is analyzed to demonstrate solar sailing using active attitude stabilization of the sail panel. The sail panel is kept parallel to the orbital plane to minimize aerodynamic drag and optimize the orbit inclination change caused by the solar pressure force normal to the sail surface. A practical control system is proposed, using a combination of small 2-dimensional translation of the sail panel and 3-axis magnetic torquing which is proved to have sufficient control authority over the gravity gradient and aerodynamic disturbance torques. Miniaturized CMOS cameras are used as sun and nadir vector attitude sensors and a robust Kalman filter is used to accurately estimate the inertially referenced body rates from only the sun vector measurements. It is shown through realistic simulation tests that the proposed control system, although inactive during eclipse, will be able to stabilize the sail panel to within ±2° in all attitude angles during the sunlit part of the orbit, when solar sailing is possible. © 2010 Elsevier Masson SAS. All rights reserved.Articl

Thermomechanical testing and modelling of railway wheel steel

Studies of thermal effects of tread braking on railway wheels show that the wheel temperatures may reach above 600 \ub0C, at which the mechanical properties of the wheel steel are significantly impaired. Computational models that simulate the thermomechanical behaviour of the wheels are commonly based on results from laboratory tests which do not reflect actual in-service scenarios. Anisothermal testing and modelling are omitted due to the difficulties in designing relevant experiments and implementation of the results. In this paper, a preexisting numerical material model is extended in order to implement fully anisothermal behaviour. This is done by performing several thermomechanical experiments mimicking real-world service and worst-case scenarios ranging from room temperature up to 650 \ub0C. The results from the laboratory testing are then used in combination with data from traditional isothermal tests to optimise the numerical material model by calibrating its material parameters. As part of this process it was found necessary to include a time- and temperature-dependent, non-recoverable (irreversible) mechanism for material softening and microstructural changes which occur above 400 \ub0C. Finite element simulations with the material model using the new parameters and the softening law show markedly improved adherence to anisothermal and strain-controlled experimental results compared to the preexisting model(s). The results demonstrate that anisothermal testing is a requirement for models that are intended to simulate material behaviour for thermomechanical loads and thermally induced microstructural changes

An Attitude Control System and Commissioning Results of the SNAP-1 Nanosatellite

SNAP-1 is a low-cost nanosatellite build by Surrey Satellite Technology Ltd. (SSTL), it is amongst other objectives a technology demonstrator for 3-axis stabilisation and orbit control for a future constellation of small satellites during formation flying. The satellite uses a single miniature Ymomentum wheel, 3-axis magnetorquer rods and a single butane gas thruster to ensure a nominal nadirpointing attitude with full pitch control and in-track delta-V manoeuvrability. The magnetorquer rods do momentum maintenance and nutation damping of the Y-wheel. The primary attitude sensor used, is a miniature 3-axis fluxgate magnetometer. Precise orbital knowledge will be obtained using a small single antenna GPS receiver supported by an on-board orbit estimator. This paper describes the various attitude control modes required to support: 1) a narrow and three wide angle CMOS cameras during pointing and tracking of targets, 2) the propulsion thruster during orbit manoeuvres, 3) the initial attitude acquisition phase and 4) a safe mode backup controller. The specific attitude controllers and estimators used during these modes are explained. Simulation and in-orbit commissioning results will be presented to evaluate the performance and design objectives

Isotopic Production Cross Sections in Proton-Nucleus Collisions at 200 MeV

Intermediate mass fragments (IMF) from the interaction of $^{27}$Al, $^{59}$Co and $^{197}$Au with 200 MeV protons were measured in an angular range from 20 degree to 120 degree in the laboratory system. The fragments, ranging from isotopes of helium up to isotopes of carbon, were isotopically resolved. Double differential cross sections, energy differential cross sections and total cross sections were extracted.Comment: accepted by Phys. Rev.

Development and validation of a short questionnaire to assess sodium intake

OBJECTIVES: To develop and validate a short food-frequency questionnaire to assess habitual dietary salt intake in South Africans and to allow classification of individuals according to intakes above or below the maximum recommended intake of 6 g salt day-1. DESIGN: Cross-sectional validation study in 324 conveniently sampled men and women. METHODS: Repeated 24-hour urinary Na values and 24-hour dietary recalls were obtained on three occasions. Food items consumed by >5% of the sample and which contributed > or =50 mg Na serving-1 were included in the questionnaire in 42 categories. A scoring system was devised, based on Na content of one index food per category and frequency of consumption. RESULTS: Positive correlations were found between Na content of 35 of the 42 food categories in the questionnaire and total Na intake, calculated from 24-hour recall data. Total Na content of the questionnaire was associated with Na estimations from 24-hour recall data (r = 0.750; P or =2400 mg day-1 equated to a reference cut-off score of 48 and corresponded to mean (standard deviation) urinary Na values of 145 (68) and 176 (99) mmol day-1, respectively (P or =100 and <100 mmol day-1 was 12.4% and 93.9%, respectively. CONCLUSION: A 42-item food-frequency questionnaire has been shown to have content-, construct- and criterion-related validity, as well as internal consistency, with regard to categorising individuals according to their habitual salt intake; however, the devised scoring system needs to show improved sensitivity

Postnatal β2 adrenergic treatment improves insulin sensitivity in lambs with IUGR but not persistent defects in pancreatic islets or skeletal muscle

Placental insufficiency causes intrauterine growth restriction (IUGR) and disturbances in glucose homeostasis with associated β adrenergic receptor (ADRβ) desensitization. Our objectives were to measure insulin-sensitive glucose metabolism in neonatal lambs with IUGR and to determine whether daily treatment with ADRβ2 agonist and ADRβ1/β3 antagonists for 1 month normalizes their glucose metabolism. Growth, glucose-stimulated insulin secretion (GSIS) and glucose utilization rates (GURs) were measured in control lambs, IUGR lambs and IUGR lambs treated with adrenergic receptor modifiers: clenbuterol atenolol and SR59230A (IUGR-AR). In IUGR lambs, islet insulin content and GSIS were less than in controls; however, insulin sensitivity and whole-bodyGUR were not different from controls.Of importance, ADRβ2 stimulation with β1/β3 inhibition increases both insulin sensitivity and whole-body glucose utilization in IUGR lambs. In IUGR and IUGR-AR lambs, hindlimb GURs were greater but fractional glucose oxidation rates and ex vivo skeletal muscle glucose oxidation rates were lower than controls. Glucose transporter 4 (GLUT4) was lower in IUGR and IUGR-AR skeletal muscle than in controls but GLUT1 was greater in IUGR-AR. ADRβ2, insulin receptor, glycogen content and citrate synthase activity were similar among groups. In IUGR and IUGR-AR lambs heart rates were greater, which was independent of cardiac ADRβ1 activation. We conclude that targeted ADRβ2 stimulation improved whole-body insulin sensitivity but minimally affected defects in GSIS and skeletal muscle glucose oxidation. We show that risk factors for developing diabetes are independent of postnatal catch-up growth in IUGR lambs as early as 1 month of age and are inherent to the islets and myocytes

No evidence of an 11.16 MeV 2+ state in 12C

An experiment using the 11B(3He,d)12C reaction was performed at iThemba LABS at an incident energy of 44 MeV and analyzed with a high energy-resolution magnetic spectrometer, to re-investigate states in 12C published in 1971. The original investigation reported the existence of an 11.16 MeV state in 12C that displays a 2+ nature. In the present experiment data were acquired at laboratory angles of 25-, 30- and 35- degrees, to be as close to the c.m. angles of the original measurements where the clearest signature of such a state was observed. These new low background measurements revealed no evidence of the previously reported state at 11.16 MeV in 12C