150 research outputs found
The behavior of single-shaft combined cycle gas turbine units at frequency drop in the connected grid
In the last 15 years many companies have developed single-shaft combined cycle gas turbine (CCGT) units having one generator, which is coupled to common single shaft of gas turbine (GT) and steam turbine (ST) via a special elaborated synchro-self-shifting (SSS) clutch. This clutch connects automatically the drive of the ST at one end of the generator to complement the drive of the GT at the other end of the generator. Such a technical solution, in comparison to previous ones, allows economizing on one generator circuit breaker (GCB) as well as the use of a two-winding transformer instead of a three-winding transformer. This scheme of single-shaft CCGT units is taking place in many countries, but cases of tripping of such units by surge protection of GT have been observed in any power plants (PP). All such trippings were accompanied by frequency drop in the high voltage (HV) grid, to which these units were connected, although these drops were within the permissible limits for the CCGT units. This paper reports the results of investigating one of these cases of tripping, discusses the possible cause of these incidents and elaborates on some measures to prevent such trippings in the future
Planetary Science Goals for the Spitzer Warm Era
The overarching goal of planetary astronomy is to deduce how the present collection of objects found in our Solar System were formed from the original material present in the proto-solar nebula. As over two hundred exo-planetary systems are now known, and multitudes more are expected, the Solar System represents the closest and best system which we can study, and the only one in which we can clearly resolve individual bodies other than planets. In this White Paper we demonstrate how to use Spitzer Space Telescope InfraRed Array Camera Channels 1 and 2 (3.6 and 4.5 µm) imaging photometry with large dedicated surveys to advance our knowledge of Solar System formation and evolution. There are a number of vital, key projects to be pursued using dedicated large programs that have not been pursued during the five years of Spitzer cold operations. We present a number of the largest and most important projects here; more will certainly be proposed once the warm era has begun, including important observations of newly discovered objects
Pea3 Transcription Factors and Wnt1-Induced Mouse Mammary Neoplasia
The role of the PEA3 subfamily of Ets transcription factors in breast neoplasia is controversial. Although overexpression of PEA3 (E1AF/ETV4), and of the related factors ERM (ETV5) and ER81 (ETV1), have been observed in human and mouse breast tumors, PEA3 factors have also been ascribed a tumor suppressor function. Here, we utilized the MMTV/Wnt1 mouse strain to further interrogate the role of PEA3 transcription factors in mammary tumorigenesis based on our previous observation that Pea3 is highly expressed in MMTV/Wnt1 mammary tumors. Pea3 expression in mouse mammary tissues was visualized using a Pea3NLSlacZ reporter strain. In normal mammary glands, Pea3 expression is predominantly confined to myoepithelial cells. Wnt1 transgene expression induced marked amplification of this cell compartment in nontumorous mammary glands, accompanied by an apparent increase in Pea3 expression. The pattern of Pea3 expression in MMTV/Wnt1 mammary glands recapitulated the cellular profile of activated β-catenin/TCF signaling, which was visualized using both β-catenin immunohistochemistry and the β-catenin/TCF-responsive reporter Axin2NLSlacZ. To test the requirement for PEA3 factors in Wnt1-induced tumorigenesis, we employed a mammary-targeted dominant negative PEA3 transgene, ΔNPEA3En. Expression of ΔNPEA3En delayed early-onset tumor formation in MMTV/Wnt1 virgin females (P = 0.03), suggesting a requirement for PEA3 factor function for Wnt1-driven tumor formation. Consistent with this observation, expression of the ΔNPEA3En transgene was profoundly reduced in mammary tumors compared to nontumorous mammary glands from bigenic MMTV/Wnt1, MMTV/ΔNPEA3En mice (P = 0.01). Our data provide the first description of Wnt1-mediated expansion of the Pea3-expressing myoepithelial compartment in nontumorous mammary glands. Consistent with this observation, mammary myoepithelium was selectively responsive to Wnt1. Together these data suggest the MMTV/Wnt1 strain as a potential model of basal breast cancer. Furthermore, this study provides evidence for a protumorigenic role of PEA3 factors in breast neoplasia, and supports targeting the PEA3 transcription factor family in breast cancer
Energy Engineering and Consulting: New Challenges and Reality
This article presents the results of studies that the authors conducted proceeding from a hypothesis that an increase of crises phenomena in the global economy, uncertainty, and higher risk along with the growing use of digital smart technology apply radically new requirements on knowledge-intensive services in the energy sector. The sector of management consulting and engineering services, which constitute the backbone of knowledge-intensive services, is faced with a new role of providing a mix of services addressing the tasks of devising anticipatory actions amid uncertainty and crisis based on forecasting. Analysis of changes in business models and the content of services indicate their strong capacity for smart logistics of complex projects, knowledge transfer in cooperation with universities and innovation institutions, managing the development of flexible technological and product solutions, and competency development in network teams. This article offers a detailed elaboration of an up-todate conceptual framework of engineering and management consulting; provides an overview of global trends; and presents a case study of collaboration problems that emerge in cross-disciplinary teams working on smart grid projects and projects of energy supply in cities based on smart grid technology. A model of proactive management and anticipatory personnel training in energy companies is proposed. This article describes the skillset needed for implementing a concept of integrated knowledge-intensive services for technological modernization and digitalization of the energy sector.The work was supported by Act 211 of the Government of the Russian Federation, contract
No. 02.A03.21.0006
The HST Key Project on the Extragalactic Distance Scale. XV. A Cepheid Distance to the Fornax Cluster and Its Implications
Using the Hubble Space Telescope (HST) 37 long-period Cepheid variables have
been discovered in the Fornax Cluster spiral galaxy NGC 1365. The resulting V
and I period-luminosity relations yield a true distance modulus of 31.35 +/-
0.07 mag, which corresponds to a distance of 18.6 +/- 0.6 Mpc. This measurement
provides several routes for estimating the Hubble Constant. (1) Assuming this
distance for the Fornax Cluster as a whole yields a local Hubble Constant of 70
+/-18_{random} [+/-7]_{systematic} km/s/Mpc. (2) Nine Cepheid-based distances
to groups of galaxies out to and including the Fornax and Virgo clusters yield
Ho = 73 (+/-16)_r [+/-7]_s km/s/Mpc. (3) Recalibrating the I-band Tully-Fisher
relation using NGC 1365 and six nearby spiral galaxies, and applying it to 15
galaxy clusters out to 100 Mpc gives Ho = 76 (+/-3)_r [+/-8]_s km/s/Mpc. (4)
Using a broad-based set of differential cluster distance moduli ranging from
Fornax to Abell 2147 gives Ho = 72 (+/-)_r [+/-6]_s km/s/Mpc. And finally, (5)
Assuming the NGC 1365 distance for the two additional Type Ia supernovae in
Fornax and adding them to the SnIa calibration (correcting for light curve
shape) gives Ho = 67 (+/-6)_r [+/-7]_s km/s/Mpc out to a distance in excess of
500 Mpc. All five of these Ho determinations agree to within their statistical
errors. The resulting estimate of the Hubble Constant combining all these
determinations is Ho = 72 (+/-5)_r [+/-12]_s km/s/Mpc.Comment: Accepted for publication in the Astrophysical Journal, Apr. 10 issue
28 pages, 3 tables, 12 figures (Correct figures and abstract
On the Nature of Star Formation at Large Galactic Radii
We have compared far-ultraviolet (FUV), near-ultraviolet (NUV), and Halpha
measurements for star forming regions in 21 galaxies, in order to characterise
the properties of their discs at radii beyond the main optical radius (R25). In
our representative sample of extended and non-extended UV discs we find that
half of the extended UV discs also exhibit extended Halpha emission. We find
that extended UV discs fall into two categories, those with a sharp truncation
in the Halpha disc close to the optical edge (R25), and those with extended
emission in Halpha as well as in the ultraviolet. Although most galaxies with
strong Halpha truncations near R25 show a significant corresponding falloff in
UV emission (factor 10--100), the transition tends to be much smoother than in
Halpha, and significant UV emission often extends well beyond this radius,
confirming earlier results by Thilker et al. (2007) and others. After
correcting for dust attenuation the median fraction of total FUV emission from
regions outside of R25 is 1.7%, but it can be as high as 35% in the most
extreme cases. The corresponding fractions of Halpha emission are approximately
half as large on average. This difference reflects both a slightly lower ratio
of Halpha to UV emission in the HII regions in the outer discs, as well as a
lower fraction of star clusters showing HII regions. Most HII regions in the
extended disc have fluxes consistent with small numbers of ionising O-type
stars, and this poor sampling of the upper initial mass function in small
clusters can probably account for the differences in the emission properties,
consistent with earlier conclusions by Zaritsky & Christlein (2007), without
needing to invoke a significant change in the stellar IMF itself. Consistent
Ha/FUV ratios and brightest HII region to total Halpha fluxes in the inner and
extended discs across our whole galaxy sample demonstrate no evidence for a
change in the cluster luminosity function or the IMF in the low gas density
outer disc.Comment: Accepted for publication in MNRAS. 21 Pages, 13 Figures, 2 Table
Deficiency and Also Transgenic Overexpression of Timp-3 Both Lead to Compromised Bone Mass and Architecture In Vivo
Tissue inhibitor of metalloproteinases-3 (TIMP-3) regulates extracellular matrix via its inhibition of matrix metalloproteinases and membrane-bound sheddases. Timp-3 is expressed at multiple sites of extensive tissue remodelling. This extends to bone where its role, however, remains largely unresolved. In this study, we have used Micro-CT to assess bone mass and architecture, histological and histochemical evaluation to characterise the skeletal phenotype of Timp-3 KO mice and have complemented this by also examining similar indices in mice harbouring a Timp-3 transgene driven via a Col-2a-driven promoter to specifically target overexpression to chondrocytes. Our data show that Timp-3 deficiency compromises tibial bone mass and structure in both cortical and trabecular compartments, with corresponding increases in osteoclasts. Transgenic overexpression also generates defects in tibial structure predominantly in the cortical bone along the entire shaft without significant increases in osteoclasts. These alterations in cortical mass significantly compromise predicted tibial load-bearing resistance to torsion in both genotypes. Neither Timp-3 KO nor transgenic mouse growth plates are significantly affected. The impact of Timp-3 deficiency and of transgenic overexpression extends to produce modification in craniofacial bones of both endochondral and intramembranous origins. These data indicate that the levels of Timp-3 are crucial in the attainment of functionally-appropriate bone mass and architecture and that this arises from chondrogenic and osteogenic lineages
Horizontal Branch Stars: The Interplay between Observations and Theory, and Insights into the Formation of the Galaxy
We review HB stars in a broad astrophysical context, including both variable
and non-variable stars. A reassessment of the Oosterhoff dichotomy is
presented, which provides unprecedented detail regarding its origin and
systematics. We show that the Oosterhoff dichotomy and the distribution of
globular clusters (GCs) in the HB morphology-metallicity plane both exclude,
with high statistical significance, the possibility that the Galactic halo may
have formed from the accretion of dwarf galaxies resembling present-day Milky
Way satellites such as Fornax, Sagittarius, and the LMC. A rediscussion of the
second-parameter problem is presented. A technique is proposed to estimate the
HB types of extragalactic GCs on the basis of integrated far-UV photometry. The
relationship between the absolute V magnitude of the HB at the RR Lyrae level
and metallicity, as obtained on the basis of trigonometric parallax
measurements for the star RR Lyrae, is also revisited, giving a distance
modulus to the LMC of (m-M)_0 = 18.44+/-0.11. RR Lyrae period change rates are
studied. Finally, the conductive opacities used in evolutionary calculations of
low-mass stars are investigated. [ABRIDGED]Comment: 56 pages, 22 figures. Invited review, to appear in Astrophysics and
Space Scienc
Extensive optical and near-infrared observations of the nearby, narrow-lined type Ic SN 2007gr: days 5 to 415
We present photometric and spectroscopic observations at optical and
near-infrared wavelengths of the nearby type Ic SN 2007gr. These represent the
most extensive data-set to date of any supernova of this sub-type, with
frequent coverage from shortly after discovery to more than one year
post-explosion. We deduce a rise time to B-band maximum of 11.5 \pm 2.7 days.
We find a peak B-band magnitude of M_B=-16.8, and light curves which are
remarkably similar to the so-called 'hypernova' SN 2002ap. In contrast, the
spectra of SNe 2007gr and 2002ap show marked differences, not least in their
respective expansion velocities. We attribute these differences primarily to
the density profiles of their progenitor stars at the time of explosion i.e. a
more compact star for SN 2007gr compared to SN 2002ap. From the
quasi-bolometric light curve of SN 2007gr, we estimate that 0.076 0.010
Msun of 56Ni was produced in the explosion. Our near-infrared (IR) spectra
clearly show the onset and disappearance of the first overtone of carbon
monoxide (CO) between ~70 to 175 days relative to B-band maximum. The detection
of the CO molecule implies that ionised He was not microscopically mixed within
the carbon/oxygen layers. From the optical spectra, near-IR light curves, and
colour evolution, we find no evidence for dust condensation in the ejecta out
to about 400 days. Given the combination of unprecedented temporal coverage,
and high signal-to-noise data, we suggest that SN 2007gr could be used as a
template object for supernovae of this sub-class.Comment: A&A accepted; 26 pages & 16 figure
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