Conception and evaluation of a 3D musculoskeletal finite element foot model.

International audienceThis paper introduces a new patient-specific musculoskeletal and Finite Element (FE) model of the foot aimed to be used in the context of deep pressure ulcer prevention, orthopedic and motion analysis. This model is evaluated in both static and dynamic frameworks

Influence of the calcaneus shape on the risk of posterior heel ulcer using 3D patient-specific biomechanical modeling.

International audienceMost posterior heel ulcers are the consequence of inactivity and prolonged time lying down on the back. They appear when pressures applied on the heel create high internal strains and the soft tissues are compressed by the calcaneus. It is therefore important to monitor those strains to prevent heel pressure ulcers. Using a biomechanical lower leg model, we propose to estimate the influence of the patient-specific calcaneus shape on the strains within the foot and to determine if the risk of pressure ulceration is related to the variability of this shape. The biomechanical model is discretized using a 3D Finite Element mesh representing the soft tissues, separated into four domains implementing Neo Hookean materials with different elasticities: skin, fat, Achilles' tendon, and muscles. Bones are modelled as rigid bodies attached to the tissues. Simulations show that the shape of the calcaneus has an influence on the formation of pressure ulcers with a mean variation of the maximum strain over 6.0 percentage points over 18 distinct morphologies. Furthermore, the models confirm the influence of the cushion on which the leg is resting: a softer cushion leading to lower strains, it has less chances of creating a pressure ulcer. The methodology used for patient-specific strain estimation could be used for the prevention of heel ulcer when coupled with a pressure sensor

Body numerical phantoms for estimating soft tissue pains or injuries when interacting with shoes, seats and mattresses

International audienc

The HARPS search for southern extra-solar planets XXXV. Planetary systems and stellar activity of the M dwarfs GJ 3293, GJ 3341, and GJ 3543

Context. Planetary companions of a fixed mass induce larger amplitude reflex motions around lower-mass stars, which helps make M dwarfs excellent targets for extra-solar planet searches. State of the art velocimeters with $\sim$1m/s stability can detect very low-mass planets out to the habitable zone of these stars. Low-mass, small, planets are abundant around M dwarfs, and most known potentially habitable planets orbit one of these cool stars. Aims. Our M-dwarf radial velocity monitoring with HARPS on the ESO 3.6m telescope at La Silla observatory makes a major contribution to this sample. Methods. We present here dense radial velocity (RV) time series for three M dwarfs observed over $\sim5$ years: GJ 3293 (0.42M$_\odot$), GJ 3341 (0.47M$_\odot$), and GJ 3543 (0.45M$_\odot$). We extract those RVs through minimum $\chi^2$ matching of each spectrum against a high S/N ratio stack of all observed spectra for the same star. We then vet potential orbital signals against several stellar activity indicators, to disentangle the Keplerian variations induced by planets from the spurious signals which result from rotational modulation of stellar surface inhomogeneities and from activity cycles. Results. Two Neptune-mass planets - $msin(i)=1.4\pm0.1$ and $1.3\pm0.1M_{nept}$ - orbit GJ 3293 with periods $P=30.60\pm0.02$ d and $P=123.98\pm0.38$ d, possibly together with a super-Earth - $msin(i)\sim7.9\pm1.4M_\oplus$ - with period $P=48.14\pm0.12\;d$. A super-Earth - $msin(i)\sim6.1M_\oplus$ - orbits GJ 3341 with $P=14.207\pm0.007\;d$. The RV variations of GJ 3543, on the other hand, reflect its stellar activity rather than planetary signals.Comment: Accepted for publication in A&A, 19 pages, 12 figures, 7 table

Potential novel drug carriers for inner ear treatment: hyperbranched polylysine and lipid nanocapsules

AIM: Treatment of sensorineural hearing loss could be advanced using novel drug carriers such as hyperbranched polylysine (HBPL) or lipid nanocapsules (LNCs). This study examined HBPL and LNCs for their cellular uptake and possible toxicity in vitro and in vivo as the first step in developing novel nanosized multifunctional carriers. METHOD: Having incubated HBPL and LNCs with fibroblasts, nanoparticle uptake and cell viability were determined by confocal laser scanning microscopy, fluorescence measurements and neutral red staining. In vivo, electrophysiology, confocal laser scanning microscopy and cytocochleograms were performed for nanoparticle detection and also toxicity studies after intracochlear application. RESULTS: Both nanoparticles were detectable in the fibroblasts\u27 cytoplasm without causing cytotoxic effects. After in vivo application they were visualized in cochlear cells, which did not lead to a change in hearing threshold or loss of hair cells. Biocompatibility and traceability were demonstrated for HBPL and LNCs. Thus, they comply with the basic requirements for drug carriers for potential application in the inner ear

Data reduction methods for single-mode optical interferometry - Application to the VLTI two-telescopes beam combiner VINCI

The interferometric data processing methods that we describe in this paper use a number of innovative techniques. In particular, the implementation of the wavelet transform allows us to obtain a good immunity of the fringe processing to false detections and large amplitude perturbations by the atmospheric piston effect, through a careful, automated selection of the interferograms. To demonstrate the data reduction procedure, we describe the processing and calibration of a sample of stellar data from the VINCI beam combiner. Starting from the raw data, we derive the angular diameter of the dwarf star Alpha Cen A. Although these methods have been developed specifically for VINCI, they are easily applicable to other single-mode beam combiners, and to spectrally dispersed fringes.Comment: Accepted for publication in Astronomy & Astrophysics, 17 pages, 19 figure