The linearization method and new classes of exact solutions in cosmology

We develop a method for constructing exact cosmological solutions of the Einstein equations based on representing them as a second-order linear differential equation. In particular, the method allows using an arbitrary known solution to construct a more general solution parameterized by a set of 3\textit{N} constants, where \textit{N} is an arbitrary natural number. The large number of free parameters may prove useful for constructing a theoretical model that agrees satisfactorily with the results of astronomical observations. Cosmological solutions on the Randall-Sundrum brane have similar properties. We show that three-parameter solutions in the general case already exhibit inflationary regimes. In contrast to previously studied two-parameter solutions, these three-parameter solutions can describe an exit from inflation without a fine tuning of the parameters and also several consecutive inflationary regimes.Comment: 7 page

Deciphering the Finger Prints of Brain Cancer Glioblastoma Multiforme from Four Different Patients by Using Near Infrared Raman Spectroscopy

To explore the effectiveness of Raman spectra to diagnose brain cancer glioblastoma multiforme (GBM), we investigated the Raman spectra of single cell from four different GBM cell lines developed from four different patients and analyzed the spectra. The Raman spectra of brain cancer (GBM) cells were similar in all these cell lines. The results indicate that Raman spectra can offer the experimental basis for the cancer diagnosis and treatment

EFFICACY OF PLANT EXTRACT ON PERFORMANCE AND MORPHOLOGICAL AND HISTOCHEMICAL PATTERNS OF DIGESTIVE TRACT WALL IN CHICKENS

On-axis deep tow side scan sonar data are used together with off-axis bathymetric data to investigate the temporal variations of the accretion processes at the ultra-slow spreading Southwest Indian Ridge. Differences in the length and height of the axial volcanic ridges and various degrees of deformation of these volcanic constructions are observed in side scan sonar images of the ridge segments. We interpret these differences as stages in an evolutionary life cycle of axial volcanic ridge development, including periods of volcanic construction and periods of tectonic dismemberment. Using off-axis bathymetric data, we identify numerous abyssal hills with a homogeneous size for each segment. These abyssal hills all display an asymmetric shape, with a steep faulted scarp facing toward the axis and a gentle dipping volcanic slope facing away. We suggest that these hills are remnants of old split axial volcanic ridges that have been transported onto the flanks and that they result from successive periods of magmatic construction and tectonic dismemberment, i.e., a magmato-tectonic cycle. We observe that large abyssal hills are in ridge sections of thicker crust, whereas smaller abyssal hills are in ridge sections of thinner crust. This suggests that the magma supply controls the size of abyssal hills. The abyssal hills in ridge sections of thinner crust are regularly spaced, indicating that the magmato-tectonic cycle is a pseudoperiodic process that lasts ~0.4 m.y., about 4 to 6 times shorter than in ridge sections of thicker crust. We suggest that the regularity of the abyssal hills pattern is related to the persistence of a nearly constant magma supply beneath long-lived segments. By contrast, when magma supply strongly decreases and becomes highly discontinuous, regular abyssal hills patterns are no longer observed

The ancestry of eastern paraguay: A typical south american profile with a unique pattern of admixture

Immigrants from diverse origins have arrived in Paraguay and produced important demographic changes in a territory initially inhabited by indigenous Guarani. Few studies have been performed to estimate the proportion of Native ancestry that is still preserved in Paraguay and the role of females and males in admixture processes. Therefore, 548 individuals from eastern Paraguay were genotyped for three marker sets: mtDNA, Y-SNPs and autosomal AIM-InDels. A genetic homogeneity was found between departments for each set of markers, supported by the demographic data collected, which showed that only 43% of the individuals have the same birthplace as their parents. The results show a sex-biased intermarriage, with higher maternal than paternal Native American ancestry. Within the native mtDNA lineages in Paraguay (87.2% of the total), most haplogroups have a broad distribution across the subcontinent, and only few are concentrated around the Paraná River basin. The frequency distribution of the European paternal lineages in Paraguay (92.2% of the total) showed a major contribution from the Iberian region. In addition to the remaining legacy of the colonial period, the joint analysis of the different types of markers included in this study revealed the impact of post-war migrations on the current genetic background of Paraguay.Funding: F.S. and L.G. were supported by Fundação de Amparo à Pesquisa do Rio de Janeiro–FAPERJ, Brazil (process E-26/202.275/2019 and CNE-2018). L.G. was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico–CNPq, Brazil (ref. 306342/2019-7). V.G. is supported by FCT under the program contract provided in Decree-Law no.57/2016 of August 29

Asymmetric generation of oceanic crust at the ultra-slow spreading Southwest Indian Ridge, 64ºE

We describe topographic, gravity, magnetic, and sonar data from a Southwest Indian Ridge spreading segment near 64E, 28S. We interpret these to reveal crustal structure, spreading history, and volcanic and tectonic processes over the last 12 Myr. We confirm that the crust is some 2 km thicker north of the ridge axis, though it varies along and across axis on scales of 10 km and 4 Myr. The plate separation rate remained approximately constant at 13 ± 1 km Myr1, but half-spreading rates were up to 40% asymmetric, varying between faster-to-the-north and faster-to-the-south on a 4 Myr timescale. Topography shows a dominant E–W lineation normal to the N–S spreading direction. This is superficially similar to faulted abyssal hill terrain of the Mid-Atlantic Ridge (MAR), but inferred fault scarps are 3–4 times more widely spaced and have greater offsets. Conjugate pairs of massifs on either plate are interpreted as volcanic constructions similar to the large volcano currently filling the median valley at the segment center. They have temporal spacings of 4 Myr and are thought to reflect episodic melt focusing along an otherwise melt-poor ridge. Additionally, there are places, mainly on the southern plate, where lineated topography is replaced by a much blockier topography and embryonic ocean core complexes similar to those recently reported on the MAR near 13N. There is generally more extrusive volcanism on the northern plate and more tectonism on the southern one. Extrusive volcanism has propagated westward from the segment center since 2 Ma. The FUJI Dome core complex and adjacent seafloor to its east and west appear to be part of a single coherent block, capped by extrusive rock near the segment center, exposing gabbro via a detachment fault over the Dome and probably exposing deeper crust or upper mantle farther west near the segment end. Magnetic anomalies are continuous along this block. We suggest that at its eastern boundary the detachment is simply welded onto magmatically emplaced crust to the east in a similar way to young crust being welded to the old plate at ridge-transform intersections

Geometry-controlled kinetics

It has long been appreciated that transport properties can control reaction kinetics. This effect can be characterized by the time it takes a diffusing molecule to reach a target -- the first-passage time (FPT). Although essential to quantify the kinetics of reactions on all time scales, determining the FPT distribution was deemed so far intractable. Here, we calculate analytically this FPT distribution and show that transport processes as various as regular diffusion, anomalous diffusion, diffusion in disordered media and in fractals fall into the same universality classes. Beyond this theoretical aspect, this result changes the views on standard reaction kinetics. More precisely, we argue that geometry can become a key parameter so far ignored in this context, and introduce the concept of "geometry-controlled kinetics". These findings could help understand the crucial role of spatial organization of genes in transcription kinetics, and more generally the impact of geometry on diffusion-limited reactions.Comment: Submitted versio

Southeast Asian diversity: first insights into the complex mtDNA structure of Laos

<p>Abstract</p> <p>Background</p> <p>Vast migrations and subsequent assimilation processes have shaped the genetic composition of Southeast Asia, an area of close contact between several major ethnic groups. To better characterize the genetic variation of this region, we analyzed the entire mtDNA control region of 214 unrelated donors from Laos according to highest forensic quality standards. To detail the phylogeny, we inspected selected SNPs from the mtDNA coding region. For <it>a posteriori </it>data quality control, quasi-median network constructions and autosomal STR typing were performed. In order to describe the mtDNA setup of Laos more thoroughly, the data were subjected to population genetic comparisons with 16 East Asian groups.</p> <p>Results</p> <p>The Laos sample exhibited ample mtDNA diversity, reflecting the huge number of ethnic groups listed. We found several new, so far undescribed mtDNA lineages in this dataset and surrounding populations. The Laos population was characteristic in terms of haplotype composition and genetic structure, however, genetic comparisons with other Southeast Asian populations revealed limited, but significant genetic differentiation. Notable differences in the maternal relationship to the major indigenous Southeast Asian ethnolinguistic groups were detected.</p> <p>Conclusions</p> <p>In this study, we portray the great mtDNA variety of Laos for the first time. Our findings will contribute to clarify the migration history of the region. They encourage setting up regional and subpopulation databases, especially for forensic applications. The Laotian sequences will be incorporated into the collaborative EMPOP mtDNA database <url>http://www.empop.org</url> upon publication and will be available as the first mtDNA reference data for this country.</p

MAPlex: A massively parallel sequencing ancestry analysis multiplex for Asia-Pacific populations

© 2019 The Authors Current forensic ancestry-informative panels are limited in their ability to differentiate populations in the Asia-Pacific region. MAPlex (Multiplex for the Asia-Pacific), a massively parallel sequencing (MPS) assay, was developed to improve differentiation of East Asian, South Asian and Near Oceanian populations found in the extensive cross-continental Asian region that shows complex patterns of admixture at its margins. This study reports the development of MAPlex; the selection of SNPs in combination with microhaplotype markers; assay design considerations for reducing the lengths of microhaplotypes while preserving their ancestry-informativeness; adoption of new population-informative multiple-allele SNPs; compilation of South Asian-informative SNPs suitable for forensic AIMs panels; and the compilation of extensive reference and test population genotypes from online whole-genome-sequence data for MAPlex markers. STRUCTURE genetic clustering software was used to gauge the ability of MAPlex to differentiate a broad set of populations from South and East Asia, the West Pacific regions of Near Oceania, as well as the other globally distributed population groups. Preliminary assessment of MAPlex indicates enhanced South Asian differentiation with increased divergence between West Eurasian, South Asian and East Asian populations, compared to previous forensic SNP panels of comparable scale. In addition, MAPlex shows efficient differentiation of Middle Eastern individuals from Europeans. MAPlex is the first forensic AIM assay to combine binary and multiple-allele SNPs with microhaplotypes, adding the potential to detect and analyze mixed source forensic DNA