2,232 research outputs found
The Clustering of Financial Services in London*
This paper reports a one-year study which investigated the clustering of financial services activity in London. A questionnaire asking about the advantages and disadvantages of a London location was sent to a stratified sample of 1,500 firms and institutions. In addition, thirty-nine on-site interviews with firms, professional institutions, government bodies and other related agencies were conducted. The study finds that banking, including investment banking, forms the cluster’s hub with most other companies depending on relationships with this sub-sector. Generally, the cluster confers many advantages to its incumbents including enhanced reputation, the ability to tap into large, specialized labor pool and customer proximity. The localized nature of relationships between skilled labor, customers and suppliers is a critical factor which helps firms achieve innovative solutions, develop new markets and attain more efficient ways to deliver services and products. Particularly important are the personal relationships which are enhanced by the on-going face-to-face contact that is possible in a compact geographical space. Many of the cluster’s advantages are dynamic in that they become stronger as agglomeration increases. The study also finds important disadvantages in the cluster which threaten its future growth and prosperity. These include the poor quality and reliability of transport, particularly the state of the London Underground and links to airports, increasing levels of regulation and government policy that is not co-ordinated with the whole of the cluster in mind. Key words: Industrial clustering, agglomeration, financial services.
Lagrangian Framework for Systems Composed of High-Loss and Lossless Components
Using a Lagrangian mechanics approach, we construct a framework to study the
dissipative properties of systems composed of two components one of which is
highly lossy and the other is lossless. We have shown in our previous work that
for such a composite system the modes split into two distinct classes,
high-loss and low-loss, according to their dissipative behavior. A principal
result of this paper is that for any such dissipative Lagrangian system, with
losses accounted by a Rayleigh dissipative function, a rather universal
phenomenon occurs, namely, selective overdamping: The high-loss modes are all
overdamped, i.e., non-oscillatory, as are an equal number of low-loss modes,
but the rest of the low-loss modes remain oscillatory each with an extremely
high quality factor that actually increases as the loss of the lossy component
increases. We prove this result using a new time dynamical characterization of
overdamping in terms of a virial theorem for dissipative systems and the
breaking of an equipartition of energy.Comment: 53 pages, 1 figure; Revision of our original manuscript to
incorporate suggestions from refere
Biodiversité et territoire viticole : étude des interactions entre viticulture et biodiversité dans le cadre d’une initiative locale à l’échelle de l’AOC Saumur-Champigny
Comparing London and Frankfurt as world cities: a relational study of contemporary urban change
The report examines changing relations between London and Frankfurt with
the introduction of a single European currency and the decision to
locate the European Central Bank in Frankfurt. Based on interviews with
key personnel in global financial and business service firms and
institutions in both cities, the findings support a network model of
inter-city relations, which, the authors contend, is more appropriate
than the simplistic competition model that dominates public discussion
B(E1) Strengths from Coulomb Excitation of 11Be
The (E1;) strength for Be has been extracted from
intermediate energy Coulomb excitation measurements, over a range of beam
energies using a new reaction model, the extended continuum discretized coupled
channels (XCDCC) method. In addition, a measurement of the excitation cross
section for Be+Pb at 38.6 MeV/nucleon is reported. The (E1)
strength of 0.105(12) efm derived from this measurement is consistent
with those made previously at 60 and 64 MeV/nucleon, i n contrast to an
anomalously low result obtained at 43 MeV/nucleon. By coupling a
multi-configuration description of the projectile structure with realistic
reaction theory, the XCDCC model provides for the first time a fully quantum
mechanical description of Coulomb excitation. The XCDCC calculations reveal
that the excitation process involves significant contributions from nuclear,
continuum, and higher-order effects. An analysis of the present and two earlier
intermediate energy measurements yields a combined B(E1) strength of 0.105(7)
efm. This value is in good agreement with the value deduced
independently from the lifetime of the state in Be, and has a
comparable p recision.Comment: 5 pages, 2 figures, accepted for publication in Phys. Lett.
Toward a complete theory for predicting inclusive deuteron breakup away from stability
We present an account of the current status of the theoretical treatment of
inclusive reactions in the breakup-fusion formalism, pointing to some
applications and making the connection with current experimental capabilities.
Three independent implementations of the reaction formalism have been recently
developed, making use of different numerical strategies. The codes also
originally relied on two different but equivalent representations, namely the
prior (Udagawa-Tamura, UT) and the post (Ichimura-Austern-Vincent, IAV)
representations.
The different implementations have been benchmarked, and then applied to the
Ca isotopic chain. The neutron-Ca propagator is described in the Dispersive
Optical Model (DOM) framework, and the interplay between elastic breakup (EB)
and non-elastic breakup (NEB) is studied for three Ca isotopes at two different
bombarding energies. The accuracy of the description of different reaction
observables is assessed by comparing with experimental data of on
Ca. We discuss the predictions of the model for the extreme case of
an isotope (Ca) currently unavailable experimentally, though possibly
available in future facilities (nominally within production reach at FRIB). We
explore the use of reactions as surrogates for processes,
by using the formalism to describe the compound nucleus formation in a
reaction as a function of excitation energy, spin, and parity.
The subsequent decay is then computed within a Hauser-Feshbach formalism.
Comparisons between the and induced gamma decay
spectra are discussed to inform efforts to infer neutron captures from
reactions. Finally, we identify areas of opportunity for future
developments, and discuss a possible path toward a predictive reaction theory
Two superluminous supernovae from the early universe discovered by the Supernova Legacy Survey
We present spectra and lightcurves of SNLS 06D4eu and SNLS 07D2bv, two
hydrogen-free superluminous supernovae discovered by the Supernova Legacy
Survey. At z = 1.588, SNLS 06D4eu is the highest redshift superluminous SN with
a spectrum, at M_U = -22.7 is one of the most luminous SNe ever observed, and
gives a rare glimpse into the restframe ultraviolet where these supernovae put
out their peak energy. SNLS 07D2bv does not have a host galaxy redshift, but
based on the supernova spectrum, we estimate it to be at z ~ 1.5. Both
supernovae have similar observer-frame griz lightcurves, which map to restframe
lightcurves in the U-band and UV, rising in ~ 20 restframe days or longer, and
declining over a similar timescale. The lightcurves peak in the shortest
wavelengths first, consistent with an expanding blackbody starting near 15,000
K and steadily declining in temperature. We compare the spectra to theoretical
models, and identify lines of C II, C III, Fe III, and Mg II in the spectrum of
SNLS 06D4eu and SCP 06F6, and find that they are consistent with an expanding
explosion of only a few solar masses of carbon, oxygen, and other trace metals.
Thus the progenitors appear to be related to those suspected for SNe Ic. A high
kinetic energy, 10^52 ergs, is also favored. Normal mechanisms of powering
core- collapse or thermonuclear supernovae do not seem to work for these
supernovae. We consider models powered by 56Ni decay and interaction with
circumstellar material, but find that the creation and spin-down of a magnetar
with a period of 2ms, magnetic field of 2 x 10^14 Gauss, and a 3 solar mass
progenitor provides the best fit to the data.Comment: ApJ, accepted, 43 pages, 15 figure
Efficacy and Safety of Daridorexant in Older and Younger Adults with Insomnia Disorder: A Secondary Analysis of a Randomised Placebo-Controlled Trial.
BACKGROUND AND OBJECTIVE
The dual orexin receptor antagonist daridorexant, studied in two phase III trials, dose-dependently improved objective and subjective sleep variables and daytime functioning in adults with insomnia. Because treatment of insomnia in older adults is challenging and has limited options, the purpose of the current analysis was to further analyse the phase III trial studying the higher doses of daridorexant, those that showed efficacy (daridorexant 50 mg, daridorexant 25 mg and placebo, nightly for 3 months), and compare the safety and efficacy of daridorexant in patients aged ≥ 65 ('older adults') to those aged < 65 years ('younger adults').
METHODS
Analyses by age (≥ 65 years, n = 364; < 65 years, n = 566) were performed on data from the randomised, double-blind, placebo-controlled Trial 1 in adult patients with insomnia (NCT03545191). Efficacy endpoints included a change from baseline at month 1 and month 3 in polysomnography-measured wake after sleep onset (WASO) and latency to persistent sleep (LPS), self-reported total sleep time (sTST) and daytime functioning assessed using the validated Insomnia Daytime Symptoms and Impacts Questionnaire (IDSIQ). Safety endpoints included adverse events and the Visual Analog Scale for morning sleepiness.
RESULTS
At baseline, mean [standard deviation] WASO was numerically greater (110 [39] vs 92 [38] min) in older than younger adults, while LPS was comparable (~ 65 min). Mean baseline IDSIQ total and all domain scores were numerically lower (i.e. better) in older adults. Daridorexant caused similar reductions in WASO and LPS, and similar increases in sTST, from baseline, in both age groups; improvements were numerically greater with daridorexant 50 mg than 25 mg. At month 3, daridorexant 50 mg, compared with placebo, decreased WASO by a least-squares mean of 19.6 (95% confidence interval 9.7, 29.5) in older patients versus 17.4 min (10.7, 24.0) in younger patients and decreased LPS by a least-squares mean of 14.9 (7.5, 22.3) in older patients versus 9.7 min (3.7, 15.7) in younger patients. Daridorexant 50 mg increased sTST from baseline to month 3 by a least-squares mean of 59.9 (49.6, 70.3) in older patients versus 57.1 min (48.9, 65.3) in younger patients. Daridorexant 50 mg progressively improved IDSIQ total and domain scores from week 1 onwards similarly in both groups; daridorexant 25 mg improved IDSIQ scores, but only in younger adults. In both age groups, in comparison with placebo, the overall incidence of adverse events was comparable, and there were fewer falls on daridorexant. Daridorexant improved Visual Analog Scale morning sleepiness in both groups; daridorexant 50 mg increased the mean (standard deviation) Visual Analog Scale morning sleepiness score by 15.9 (20.7) in older adults and by 14.9 (18.7) in younger adults from baseline to month 3. In older adults, there was one case of sleep paralysis, and no cases of narcolepsy, cataplexy, or complex sleep behaviour.
CONCLUSIONS
In older patients with insomnia, as in younger patients, the efficacy of daridorexant is maximal on night-time and daytime variables at the higher dose of 50 mg. Older patients particularly require this dose to improve daytime functioning. Older patients are not at an increased risk of adverse events or residual effects the next morning after night-time administration of daridorexant, even at 50 mg. The dose of daridorexant does not need to be decreased for older patients.
CLINICAL TRIAL REGISTRATION
ClinicalTrials.gov (NCT03545191) [first posted: 4 June, 4 2018], https://clinicaltrials.gov/ct2/show/NCT03545191
Exome and transcriptome sequencing of Aedes aegypti identifies a locus that confers resistance to Brugia malayi and alters the immune response.
Many mosquito species are naturally polymorphic for their abilities to transmit parasites, a feature which is of great interest for controlling vector-borne disease. Aedes aegypti, the primary vector of dengue and yellow fever and a laboratory model for studying lymphatic filariasis, is genetically variable for its capacity to harbor the filarial nematode Brugia malayi. The genome of Ae. aegypti is large and repetitive, making genome resequencing difficult and expensive. We designed exome captures to target protein-coding regions of the genome, and used association mapping in a wild Kenyan population to identify a single, dominant, sex-linked locus underlying resistance. This falls in a region of the genome where a resistance locus was previously mapped in a line established in 1936, suggesting that this polymorphism has been maintained in the wild for the at least 80 years. We then crossed resistant and susceptible mosquitoes to place both alleles of the gene into a common genetic background, and used RNA-seq to measure the effect of this locus on gene expression. We found evidence for Toll, IMD, and JAK-STAT pathway activity in response to early stages of B. malayi infection when the parasites are beginning to die in the resistant genotype. We also found that resistant mosquitoes express anti-microbial peptides at the time of parasite-killing, and that this expression is suppressed in susceptible mosquitoes. Together, we have found that a single resistance locus leads to a higher immune response in resistant mosquitoes, and we identify genes in this region that may be responsible for this trait.This work was funded by a Cambridge-
KAUST Academic Excellence Alliance (AEA2) project
grant to AP and CVA was supported by a Cambridge
Overseas Trust Studentship. JA was supported by a
Darwin Trust of Edinburgh. WJP was supported by a
Medical Research Council. FMJ was supported by Royal Society Research. EASIH is supported by
Cambridge NIHR-BRC. The Wellcome Trust Centre
for Human Genetics is funded by Wellcome Trust
grant reference 090532/Z/09/Z and MRC hub grant
G0900747 91070. The funders had no role in the
study design, data collection and analysis, decision to
publish, or preparation of the manuscript.his is the final version of the article. It first appeared from PLOS via http://dx.doi.org/10.1371/journal.ppat.100476
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