Modificación superficial de nanotubos de carbono mediante un plasma de CO2

En el presente trabajo se estudió la funcionalización de nanotubos de carbono de pared múltiple (NTCPM) con un plasma de CO2, donde se determinó el efecto del tiempo de tratamiento por plasma sobre las propiedades de los NTCPM. Para determinar el cambio en la hibridación de los NTCPM se utilizó espectroscopia Raman y espectroscopia de infrarrojo para identificar los grupos funcionales. Adicionalmente se determinó el ángulo de contacto y se hicieron dispersiones en agua para corroborar el cambio de polaridad de los NTCPM. Se encontró que a medida que se incrementa el tiempo de exposición al plasma de CO2, se observan dos incrementos, uno en la banda de infrarrojo de 1070 cm-1 asociada al grupo C-O y otro en la relación de intensidades D/G del espectro Raman asociado a la hibridación sp3, los cuales corroboran el injerto de oxígeno en la superficie de los NTCPM

Using smart cards for authenticating in public services: A comparative study

The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-19713-5_37Smart cards are well-known tamper-resistant devices, and as such they represent an excellent platform for implementing strong authentication. Many services requesting high levels of security rely on smart cards, which provide a convenient security token due to their portability. This contribution analyses two Spanish smart card deployments intended to be used for accessing eGoverment services, comparing their respective contents and capabilities.This work has been partially supported by Comunidad de Madrid (Spain) under the project S2013/ICE-3095-CM (CIBERDINE)

Fijacion de nitrogeno por algas cianoficeas en los arrozales de la Albufera de Valencia

Se realizan recuentos ,aislamiento, identificación y determinación de la actividad Nitrogenasa de algas azules en muestras de suelo y agua, durante dos ciclos de cultivo del arroz . Los recuentos se realizan por la técnica del 'Plate Count', utilizando el medio de Chu y los resultados muestran grandes fluctuaciones en las muestras de agua, manteniéndose más altos y uniformes en las muestras de suelo. Después del aislamiento e identificación, llegamos a obtener colonias algales correspondientes en su mayor parte a los géneros Anabaena y Nostoc, las cuales se someten posteriormente a ensayos de reducción del acetileno, para determinar su actividad fijadora de nitrógeno. La especie identificada como N. humifusum, es en nuestras condiciones, la que posee mayor actividad fijadora, además de ser la más común en los dos campos de arroz ensayados

N,N′-Bis(4-amino­benz­yl)oxalamide

In the title compound, C16H18N4O2, the two carbonyl groups are in an anti­periplanar conformation with an O=C—C=O torsion angle of 173.86 (17)°. In the crystal, a pair of inter­molecular N—H⋯O hydrogen bonds, forming an R 2 2(10) ring motif, connect the mol­ecules into an inversion dimer. The dimers are further linked by N—H⋯N and C—H⋯π inter­actions, forming a zigzag chain along the b axis

Selective Inhibition of Vascular Endothelial Growth Factor–mediated Angiogenesis by Cyclosporin A: Roles of the Nuclear Factor of Activated T Cells and Cyclooxygenase 2

Cyclosporin A (CsA) is an immunosuppressive drug that inhibits the activity of transcription factors of the nuclear factor of activated T cells (NFAT) family, interfering with the induction of cytokines and other inducible genes required for the immune response. Here we show that CsA inhibits migration of primary endothelial cells and angiogenesis induced by vascular endothelial growth factor (VEGF); this effect appears to be mediated through the inhibition of cyclooxygenase (Cox)-2, the transcription of which is activated by VEGF in primary endothelial cells. Consistent with this, we show that the induction of Cox-2 gene expression by VEGF requires NFAT activation. Most important, the CsA-mediated inhibition of angiogenesis both in vitro and in vivo was comparable to the Cox-2 inhibitor NS-398, and reversed by prostaglandin E2. Furthermore, the in vivo corneal angiogenesis induced by VEGF, but not by basic fibroblast growth factor, was selectively inhibited in mice treated with CsA systemically. These findings involve NFAT in the regulation of Cox-2 in endothelial cells, point to a role for this transcription factor in angiogenesis, and may provide a novel mechanism underlying the beneficial effects of CsA in angiogenesis-related diseases such as rheumatoid arthritis and psoriasis.This work was supported by grant PM99-0116 from Ministerio de Educación y Cultura (MEC-DGES) of Spain (to J.M. Redondo) and grants FEDER 1FD97-0514-CO2-01 and FEDER FD97-0275 from MEC-DGES and the European Community to J.M. Redondo and M. Fresno, respectively. G.L. Hernández was supported by grants from Consejo Superior de Investigaciones Científicas y Tecnológicas (CONICET) of Argentina and Comunidad Autónoma de Madrid grant 8.3/0024/2000, and M. Fresno by grant PM97-0130, O. Volpert by American Heart Association grant AHA SDG 0030023N, and S. Martínez-Martínez by grant 8.3/19/1998 from the Comunidad Autónoma de Madrid. The Centro de Biología Molecular "Severo Ochoa" is supported by a grant from the Fundación Ramón ArecesPeer reviewe

Selective Inhibition of Vascular Endothelial Growth Factor–Mediated Angiogenesis by Cyclosporin a: Roles of the Nuclear Factor of Activated T Cells and Cyclooxygenase 2

Cyclosporin A (CsA) is an immunosuppressive drug that inhibits the activity of transcription factors of the nuclear factor of activated T cells (NFAT) family, interfering with the induction of cytokines and other inducible genes required for the immune response. Here we show that CsA inhibits migration of primary endothelial cells and angiogenesis induced by vascular endothelial growth factor (VEGF); this effect appears to be mediated through the inhibition of cyclooxygenase (Cox)-2, the transcription of which is activated by VEGF in primary endothelial cells. Consistent with this, we show that the induction of Cox-2 gene expression by VEGF requires NFAT activation. Most important, the CsA-mediated inhibition of angiogenesis both in vitro and in vivo was comparable to the Cox-2 inhibitor NS-398, and reversed by prostaglandin E2. Furthermore, the in vivo corneal angiogenesis induced by VEGF, but not by basic fibroblast growth factor, was selectively inhibited in mice treated with CsA systemically. These findings involve NFAT in the regulation of Cox-2 in endothelial cells, point to a role for this transcription factor in angiogenesis, and may provide a novel mechanism underlying the beneficial effects of CsA in angiogenesis-related diseases such as rheumatoid arthritis and psoriasis