Riders on the storm : workplace solidarity among gig economy couriers in Italy and the UK

In light of the individualisation, dispersal and pervasive monitoring that characterise work in the ‘gig economy’, the development of solidarity among gig workers could be expected to be unlikely. However, numerous recent episodes of gig workers’ mobilisation require reconsideration of these assumptions. This article contributes to the debate about potentials and obstacles for solidarity in the changing world of work by showing the processes through which workplace solidarity among gig workers developed in two cases of mobilisation of food delivery platform couriers in the UK and Italy. Through the framework of labour process theory, the article identifies the sources of antagonism in the app-mediated model of work organisation and the factors that facilitated and hindered the consolidation of active solidarity and the emergence of collective action among gig workers. The article emphasises the centrality of workers’ agential practices in overcoming constraints to solidarity and collective action, and the diversity of forms through which solidarity can be expressed in hostile work contexts

Redox regulation in disease and ageing

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Riders on the Storm: Workplace Solidarity among Gig Economy Couriers in Italy and the UK

In light of the individualisation, dispersal and pervasive monitoring that characterise work in the ‘gig economy’, the development of solidarity among gig workers could be expected to be unlikely. However, numerous recent episodes of gig workers’ mobilisation require reconsideration of these assumptions. This article contributes to the debate about potentials and obstacles for solidarity in the changing world of work by showing the processes through which workplace solidarity among gig workers developed in two cases of mobilisation of food delivery platform couriers in the UK and Italy. Through the framework of labour process theory, the article identifies the sources of antagonism in the app-mediated model of work organisation and the factors that facilitated and hindered the consolidation of active solidarity and the emergence of collective action among gig workers. The article emphasises the centrality of workers’ agential practices in overcoming constraints to solidarity and collective action, and the diversity of forms through which solidarity can be expressed in hostile work contexts

With or Without U(nions)? Understanding the Diversity of Gig Workers’ Organizing Practices in Italy and the UK

Since 2016, mobilizations of gig workers across European countries have become increasingly common within location-based services, such as food delivery. Despite remarkable similarities in workers’ mobilization dynamics, their organizational forms have varied considerably, ranging from self-organization, to work councils, to unionization through rank-and-file or longstanding unions. To start making sense of this diversity in organizing practices, we compare two cases of mobilization in the food delivery sector: in Italy, where workers have initially opted for self-organization, and in the UK, where they have organized through rank-and-file unions. Drawing on interview and observational data gathered between 2016 and 2018, we find that the diversity of organizational forms across the two cases derives from the interaction between agential and contextual factors, namely: the capabilities of rank-and-file unions and the political tradition of militant organizing of the environment within which gig workers are embedded. These findings contribute to the emerging debate on labour relations in the gig economy by showing the central role that factors external to the labour process and to the institutional context play in shaping the structuring of labour antagonism in a still lowly institutionalized sector characterized by transnationally homogenous challenges.Introduction Understanding variation in precarious workers' organizing practices: Insights from the extant literature Understanding the varity of organizing practices in the gig economy Case selection, methodology and data Introducing the cases: Riders' mobilizations in the UK and Italy Exploring differences in organizing forms Discussion and conclusions Acknowledgements Reference

The relationship regulator: a buyer-supplier collaborative performance measurement system

Purpose The purpose of this paper is to propose an innovative buyer-supplier performance measurement system (PMS) (called relationship regulator – RelReg), aimed at stimulating collaboration on mutual performance. The RelReg is described all throughout the phases of its lifecycle: first, design features and visual representation of the new measurement framework are reported; second, guidelines on how to implement, use and review the system are provided, highlighting the role of the buyer and the supplier at each step. Design/methodology/approach A theory building and testing approach is applied. The RelReg developed features primarily ground on previous scientific contributions matched with empirical evidence collected through case studies, workshops and focus groups. The resulting conceptual model is then validated through a dyadic buyer-supplier case study. Findings Two conceptual frameworks are provided: the RelReg dashboard – a multidimensional PMS; and the RelReg lifecycle – set of activities to be performed by both the buyer and the supplier all along the adoption process. Moreover, empirical insights on relevant issues to be considered when adopting the RelReg are reported. Originality/value The RelReg represents an innovative and smart tool, allowing buyer-supplier dyads to collaborate on relationship performance. </jats:sec

The (endo)cannabinoid signaling in female reproduction: What are the latest advances?

Cannabis extracts like marijuana have the highest consumption rate worldwide. Yet, their societal acceptance as recreational and therapeutic drugs could represent a serious hazard to female human reproduction, because cannabis ingredients [termed (phyto)cannabinoids] can perturb an endogenous system of lipid signals known as endocannabinoids. Accumulated evidence on animal models and humans has demonstrated a crucial role of these endogenous signals on different aspects of female reproduction, where they act through an ensamble of proteins that synthesize, transport, degrade and traffic them. Several reports have recently evidenced the potential role of endocannabinoids as biomarkers of female infertility for disease treatment and prevention, as well as their possible epigenetic effects on pregnancy. The purpose of this review is to provide an update of data collected in the last decade on the effects of cannabinoids and endocannabinoids on female reproductive events, from development and maturation of follicles and oocytes, to fertilization, oviductal transport, implantation and labor. In this context, a particular attention has ben devoted to the ovary and the production of fertilizable oocytes, because recent studies have addressed this hot topic with conflicting results among species

KOMPETENSI PROFESIONAL GURU BK DALAM IMPLEMENTASI ASSESMEN BK (SUATU PENELITIAN PADA GURU BK DI SMA FAVORIT KOTA BANDA ACEH)

Banda Ace

Anti-inflammatory effects of fatty acid amide hydrolase inhibition in monocytes/macrophages from alzheimer’s disease patients

Growing evidence shows that the immune system is critically involved in Alzheimer’s disease (AD) pathogenesis and progression. The modulation and targeting of peripheral immune mechanisms are thus promising therapeutic or preventive strategies for AD. Given the critical involvement of the endocannabinoid (eCB) system in modulating immune functions, we investigated the potential role of the main elements of such a system, namely type-1 and type-2 cannabinoid receptors (CB1 and CB2), and fatty acid amide hydrolase (FAAH), in distinct immune cell populations of the peripheral blood of AD patients. We found that, compared to healthy controls, CB1 and CB2 expression was significantly lower in the B-lymphocytes of AD patients. Moreover, we found that CB2 was significantly lower and FAAH was significantly higher in monocytes of the same subjects. In contrast, T-lymphocytes and NK cells did not show any variation in any of these proteins. Of note, monocytic CB2 and FAAH levels significantly correlated with clinical scores. Furthermore, the pharmacological inactivation of FAAH in monocytes and monocyte-derived macrophages obtained from AD patients was able to modulate their immune responses, by reducing production of pro-inflammatory cytokines such as TNF-α, IL-6 and IL-12, and enhancing that of the anti-inflammatory cytokine IL-10. Furthermore, FAAH blockade skewed AD monocyte-derived macrophages towards a more anti-inflammatory and pro-resolving phenotype. Collectively, our findings highlight a central role of FAAH in regulating AD monocytes/macrophages that could be of value in developing novel monocyte-centered therapeutic approaches aimed at promoting a neuroprotective environment

Proresolving lipid mediators resolvin D1, resolvin D2, and maresin 1 are critical in modulating T cell responses.

Resolution of inflammation is a finely regulated process mediated by specialized proresolving lipid mediators (SPMs), including docosahexaenoic acid (DHA)-derived resolvins and maresins. The immunomodulatory role of SPMs in adaptive immune cells is of interest. We report that D-series resolvins (resolvin D1 and resolvin D2) and maresin 1 modulate adaptive immune responses in human peripheral blood lymphocytes. These lipid mediators reduce cytokine production by activated CD8(+) T cells and CD4(+) T helper 1 (TH1) and TH17 cells but do not modulate T cell inhibitory receptors or abrogate their capacity to proliferate. Moreover, these SPMs prevented naïve CD4(+) T cell differentiation into TH1 and TH17 by down-regulating their signature transcription factors, T-bet and Rorc, in a mechanism mediated by the GPR32 and ALX/FPR2 receptors; they concomitantly enhanced de novo generation and function of Foxp3(+) regulatory T (Treg) cells via the GPR32 receptor. These results were also supported in vivo in a mouse deficient for DHA synthesis (Elovl2(-/-)) that showed an increase in TH1/TH17 cells and a decrease in Treg cells compared to wild-type mice. Additionally, either DHA supplementation in Elovl2(-/-) mice or in vivo administration of resolvin D1 significantly reduced cytokine production upon specific stimulation of T cells. These findings demonstrate actions of specific SPMs on adaptive immunity and provide a new avenue for SPM-based approaches to modulate chronic inflammation.This work was supported by Fondazione Italiana Sclerosi Multipla (FISM) to V.C. (grant 2015/R/8) and in part by National Institutes of Health (P01095467 and GM38765) to C.N.S, by Ministero dell’Istruzione, dell’Università e della Ricerca (PRIN grant 2010–2011) to M.M., and by Ministero della Salute (RF-2011- 02346771) and FISM (grant 2013/R/2) to L.B