Self-reported impact of the COVID-19 pandemic and lockdown on young patients with tic disorders: findings from a case\u2013control study

Background: Little is known about the perceived impact of the COVID-19 pandemic and subsequent lockdown measures on young patients with tic disorders. Previous studies focused on clinician and parent ratings of tic severity, whereas the only international self-report data are available for adult populations. We present the first findings from a case\u2013control study on children and adolescents with tics during lockdown in Italy. Methods: We surveyed 49 patients aged 6\u201318 years and 245 matched controls with a newly developed questionnaire covering socio-demographic and clinical data, as well as lockdown-related changes to daily life activities. Results: About half (53.2%) of the Italian school-age patients who took part in our survey experienced changes in tic severity during lockdown. Perceived increases in tic severity (29.8%) were reported more often than decreases (23.4%). Analogous trends were reported for perceived restlessness and, more significantly, irritability, whereas changes in pain symptoms were less common and were similar in both directions. The presence of tics was associated with increased difficulties with remote learning (p = 0.01), but decreased feelings of missing out on social interactions with schoolmates (p = 0.03). Conclusions: Self-reported data on the impact of COVID-19 lockdown in school-age patients with tic disorders indicate perceived changes in tic severity, as well as restlessness and irritability, in about half of the cases. These findings could guide both clinicians and teachers in the implementation of targeted adjustments in the delivery of care and educational strategies, respectively

Investigating the effects of COVID-19 lockdown on Italian children and adolescents with and without neurodevelopmental disorders: a cross-sectional study

We conducted a cross-sectional study to compare the impact of social distancing and lifestyle changes that occurred during Corona Virus Disease 2019 (COVID-19) lockdown on children and adolescents with and without Neurodevelopmental Disorders (NDDs). An online questionnaire was administered in order to investigate the effects of NDD condition, socio-demographic status, familiar/home environment and COVID-19 exposure on their lives during a two months period of social isolation. We used logistic regression, focusing on five endpoints (remote learning, lifestyle, stress/anxiety, sociality, scolding) to define the extent of these effects. Most questions were paired up to parents and children, to verify the occurrence of agreement. 8305 questionnaires were analyzed, 1362 of which completed by NDDs and 6943 by controls. Results showed that the presence of a NDD, compared to controls, had a significant impact on: Remote Learning (i.e. subjects with NDDs experienced more difficulties in attending online classes and studying), Sociality (i.e. subjects with NDDs missed their schoolmates less), Scolding (i.e. subjects with NDDs were scolded more often) and Anxiety (i.e. subjects with NDDs were perceived by their parents as more anxious). Substantial agreement between parents and children arose from questions concerning Remote learning, Lifestyle and Scolding. The current study actually points out that having a NDD gives account for a stronger influence on school performance and on behavioral and psychological aspects, during a two months lockdown. Such results may provide useful information to governments and school authorities on how carrying through supportive strategies for youth affected by NDDs

Supernova 1987A did not test the neutrino mass hierarchy

We dispel the misconception that data from SN 1987A favor the normal neutrino mass hierarchy over the inverted hierarchy for \sin^2 \theta_{13} \gsim 10^{-4}. We find comparable fits for the two hierarchies. No bound can be placed on the mixing angle $\theta_{13}$ even at the 1$\sigma$ level.Comment: 15 pages, 9 figure

Probing the neutrino mass hierarchy and the 13-mixing with supernovae

We consider in details the effects of the 13-mixing (sin^2 theta_{13}) and of the type of mass hierarchy/ordering (sign[ Delta m^2_{13}]) on neutrino signals from the gravitational collapses of stars. The observables (characteristics of the energy spectra of nu_e and antinu_e events) sensitive to sin^2 theta_{13} and sign[Delta m^2_{13}] have been calculated. They include the ratio of average energies of the spectra, r_E = /, the ratio of widths of the energy distributions, r_Gamma, the ratios of total numbers of nu_e and antinu_e events at low energies, S, and in the high energy tails, R_{tail}. We construct and analyze scatter plots which show the predictions for the observables for different intervals of sin^2 theta_{13} and signs of Delta m^2_{13}, taking into account uncertainties in the original neutrino spectra, the star density profile, etc.. Regions in the space of observables r_E, r_Gamma, S, R_{tail} exist in which certain mass hierarchy and intervals of sin^2 theta_{13} can be identified or discriminated. We elaborate on the method of the high energy tails in the spectra of events. The conditions are formulated for which sin^2 theta_{13} can be (i) measured, (ii) restricted from below, (iii) restricted from above. We comment on the possibility to determine sin^2 theta_{13} using the time dependence of the signals due to the propagation of the shock wave through the resonance layers of the star. We show that the appearance of the delayed Earth matter effect in one of the channels (nu_e or antinu_e) in combination with the undelayed effect in the other channel will allow to identify the shock wave appeareance and determine the mass hierarchy.Comment: LaTeX, 56 pages, 12 figures; a few clarifications added; typos corrected. Version to appear in JCA

High motor variability in DYT1 dystonia is associated with impaired visuomotor adaptation.

For the healthy motor control system, an essential regulatory role is maintaining the equilibrium between keeping unwanted motor variability in check whilst allowing informative elements of motor variability. Kinematic studies in children with generalised dystonia (due to mixed aetiologies) show that movements are characterised by increased motor variability. In this study, the mechanisms by which high motor variability may influence movement generation in dystonia were investigated. Reaching movements in the symptomatic arm of 10 patients with DYT1 dystonia and 12 age-matched controls were captured using a robotic manipulandum and features of motor variability were extracted. Given that task-relevant variability and sensorimotor adaptation are related in health, markers of variability were then examined for any co-variance with performance indicators during an error-based learning visuomotor adaptation task. First, we confirmed that motor variability on a trial-by-trial basis was selectively increased in the homogenous and prototypical dystonic disorder DYT1 dystonia. Second, high baseline variability predicted poor performance in the subsequent visuomotor adaptation task offering insight into the rules which appear to govern dystonic motor control. The potential mechanisms behind increased motor variability and its corresponding implications for the rehabilitation of patients with DYT1 dystonia are highlighted

Cosmological and Astrophysical Neutrino Mass Measurements

Cosmological and astrophysical measurements provide powerful constraints on neutrino masses complementary to those from accelerators and reactors. Here we provide a guide to these different probes, for each explaining its physical basis, underlying assumptions, current and future reach.Comment: 11 page

Hiding relativistic degrees of freedom in the early universe

We quantify the extent to which extra relativistic energy density can be concealed by a neutrino asymmetry without conflicting with the baryon asymmetry measured by the Wilkinson Microwave Anisotropy Probe (WMAP). In the presence of a large electron neutrino asymmetry, slightly more than seven effective neutrinos are allowed by Big Bang Nucleosynthesis (BBN) and WMAP at 2\sigma. The same electron neutrino degeneracy that reconciles the BBN prediction for the primordial helium abundance with the observationally inferred value also reconciles the LSND neutrino with BBN by suppressing its thermalization prior to BBN.Comment: 5 pages, 5 figure

Supernova neutrino oscillations: A simple analytical approach

Analyses of observable supernova neutrino oscillation effects require the calculation of the electron (anti)neutrino survival probability P_ee along a given supernova matter density profile. We propose a simple analytical prescription for P_ee, based on a double-exponential form for the crossing probability and on the concept of maximum violation of adiabaticity. In the case of two-flavor transitions, the prescription is shown to reproduce accurately, in the whole neutrino oscillation parameter space, the results of exact numerical calculations for generic (realistic or power-law) profiles. The analytical approach is then generalized to cover three-flavor transitions with (direct or inverse) mass spectrum hierarchy, and to incorporate Earth matter effects. Compact analytical expressions, explicitly showing the symmetry properties of P_ee, are provided for practical calculations.Comment: 22 pages (RevTeX) + 5 figures (PostScript

Superluminal neutrinos in long baseline experiments and SN1987a

Precise tests of Lorentz invariance in neutrinos can be performed using long baseline experiments such as MINOS and OPERA or neutrinos from astrophysical sources. The MINOS collaboration reported a measurement of the muonic neutrino velocities that hints to super-luminal propagation, very recently confirmed at 6 sigma by OPERA. We consider a general parametrisation which goes beyond the usual linear or quadratic violation considered in quantum-gravitational models. We also propose a toy model showing why Lorentz violation can be specific to the neutrino sector and give rise to a generic energy behaviour E^alpha, where alpha is not necessarily an integer number. Supernova bounds and the preferred MINOS and OPERA regions show a tension, due to the absence of shape distortion in the neutrino bunch in the far detector of MINOS. The energy independence of the effect has also been pointed out by the OPERA results.Comment: 22 pages, 7 figures; comment on Cherenkov emission added, version matching JHEP published pape

The MSW effect and Matter Effects in Neutrino Oscillations

The MSW (Mikheyev-Smirnov-Wolfenstein) effect is the adiabatic or partially adiabatic neutrino flavor conversion in medium with varying density. The main notions related to the effect, its dynamics and physical picture are reviewed. The large mixing MSW effect is realized inside the Sun providing the solution of the solar neutrino problem. The small mixing MSW effect driven by the 1-3 mixing can be realized for the supernova (SN) neutrinos. Inside the collapsing stars new elements of the MSW dynamics may show up: the non-oscillatory transition, non-adiabatic conversion, time dependent adiabaticity violation induced by shock waves. Effects of the resonance enhancement and the parametric enhancement of oscillations can be realized for the atmospheric and accelerator neutrinos in the Earth. Precise results for neutrino oscillations in the low density medium with arbitrary density profile are presented and the attenuation effect is described. The area of applications is the solar and SN neutrinos inside the Earth, and the results are crucial for the neutrino oscillation tomography.Comment: 18 pages, latex, 6 figures, talk given at the Nobel Symposium 129, ``Neutrino Physics'', Haga Slott, August 19 - 24, 200