Spin Gap and Resonance at the Nesting Wavevector in Superconducting FeSe0.4Te0.6

Neutron scattering is used to probe magnetic excitations in FeSe_{0.4}Te_{0.6} (T_c=14 K). Low energy spin fluctuations are found with a characteristic wave vector $(0.5,0.5,L)$ that corresponds to Fermi surface nesting and differs from Q_m=(\delta,0,0.5) for magnetic ordering in Fe_{1+y}Te. A spin resonance with \hbar\Omega_0=6.5 meV \approx 5.3 k_BT_c and \hbar\Gamma=1.25 meV develops in the superconducting state from a normal state continuum. We show that the resonance is consistent with a bound state associated with s+/- superconductivity and imperfect quasi-2D Fermi surface nesting.Comment: 4 pages, 4 figures, Submitted to Phys. Rev. Let

Clinical relevance of biomarkers of oxidative stress

SIGNIFICANCE Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino acids. Recent Advances: An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance. CRITICAL ISSUES The literature is very heterogeneous. It is often difficult to draw general conclusions on the significance of oxidative stress biomarkers, as only in a limited proportion of diseases have a range of different biomarkers been used, and different biomarkers have been used to study different diseases. In addition, biomarkers are often measured using nonspecific methods, while specific methodologies are often too sophisticated or laborious for routine clinical use. FUTURE DIRECTIONS Several markers of oxidative stress still represent a viable biomarker opportunity for clinical use. However, positive findings with currently used biomarkers still need to be validated in larger sample sizes and compared with current clinical standards to establish them as clinical diagnostics. It is important to realize that oxidative stress is a nuanced phenomenon that is difficult to characterize, and one biomarker is not necessarily better than others. The vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker. Antioxid. Redox Signal. 00, 000-000

Growth and characterization of A_{1-x}K_xFe_2As_2 (A = Ba, Sr) single crystals with x=0 - 0.4

Single crystals of A$_{1-x}$K$_x$Fe$_2$As$_2$ (A=Ba, Sr) with high quality have been grown successfully by FeAs self-flux method. The samples have sizes up to 4 mm with flat and shiny surfaces. The X-ray diffraction patterns suggest that they have high crystalline quality and c-axis orientation. The non-superconducting crystals show a spin-density-wave (SDW) instability at about 173 K and 135 K for Sr-based and Ba-based compound, respectively. After doping K as the hole dopant into the BaFe$_2$As$_2$ system, the SDW transition is smeared, and superconducting samples with the compound of Ba$_{1-x}$K$_x$Fe$_2$As$_2$ (0 $< x \leqslant$ 0.4) are obtained. The superconductors characterized by AC susceptibility and resistivity measurements exhibit very sharp superconducting transition at about 36 K, 32 K, 27 K and 23 K for x= 0.40,0.28,0.25 and 0.23, respectively.Comment: 9 pages, 6 figures, 1 table. This paper together with new data are modified into a new pape

Escherichia coli O157:H7 Productor de toxina Shiga aisladas de muestras de agua relacionadas a Establecimientos pecuarios de engorde a corral

Recientemente han ocurrido brotes debido vegetales contaminados por Escherichia coli productor de toxina Shiga (stec). Estos productos frescos se contaminan a través del contacto directo de heces bovinas (abono), o indirectamente a través de irrigación con agua contaminada. Este estudio tuvo como objetivo establecer la prevalencia de stec O157:H7 en muestras de agua relacionadas a establecimientos pecuarios de engorde a corral (epec) de la provincia de Entre Ríos, Argentina, y su eventual relación con cepas vinculadas a enfermedad transmitida por alimentos. Usando como indicadores microbiológicos, coliformes, Escherichia coli, y anaerobios sufito-reductores, se estudió la eficiencia en el saneamiento de los efluentes de un epec que contaba con un sistema de lagunas sanitarias. Entre abril/2009 y julio/2011 se estudiaron 320 muestras de agua vinculadas a efluentes de 11 epec. Las cepas fueron caracterizadas feno-genotípicamente y subtipificadas por macrorrestricción y electroforesis de campo pulsado. Algunos de los perfiles identificados están incluidos en la base de datos nacional, correspondiendo a cepas obtenidas de casos de Síndrome Urémico Hemolítico, diarrea, muestras alimenticias y de origen animal. Los epec deben implementar estrategias de control con objeto de limitar el ingreso de stec en el medioambiente acuático. En el sistema de lagunas sanitarias estudiado se constató una franca disminución de los indicares utilizados pero insuficiente para eliminar su aporte al ambiente. La optimización de su funcionamiento es función de su mantenimiento, en especial la frecuente remoción de barros de las primeras piletas

In vivo functional neurochemistry of human cortical cholinergic function during visuospatial attention

Cortical acetylcholine is involved in key cognitive processes such as visuospatial attention. Dysfunction in the cholinergic system has been described in a number of neuropsychiatric disorders. Levels of brain acetylcholine can be pharmacologically manipulated, but it is not possible to directly measure it in vivo in humans. However, key parts of its biochemical cascade in neural tissue, such as choline, can be measured using magnetic resonance spectroscopy (MRS). There is evidence that levels of choline may be an indirect but proportional measure of acetylcholine availability in brain tissue. In this study, we measured relative choline levels in the parietal cortex using functional (event-related) MRS (fMRS) during performance of a visuospatial attention task, with a modelling approach verified using simulated data. We describe a task-driven interaction effect on choline concentration, specifically driven by contralateral attention shifts. Our results suggest that choline MRS has the potential to serve as a proxy of brain acetylcholine function in humans