Modulatory effects of magnetic vestibular stimulation on resting-state networks can be explained by subject-specific orientation of inner-ear anatomy in the MR static magnetic field

Strong static magnetic fields, as used in magnetic resonance imaging (MRI), stimulate the vestibular inner ear leading to a state of imbalance within the vestibular system that causes nystagmus. This magnetic vestibular stimulation (MVS) also modulates fluctuations of resting-state functional MRI (RS-fMRI) networks. MVS can be explained by a Lorentz force model, indicating that MVS is the result of the interaction of the static magnetic field strength and direction (called \textquotedblB0 magnetic field\textquotedbl in MRI) with the inner ear's continuous endolymphatic ionic current. However, the high variability between subjects receiving MVS (measured as nystagmus slow-phase velocity and RS-fMRI amplitude modulations) despite matching head position, remains to be explained. Furthermore, within the imaging community, an \textquotedbleasy-to-acquire-and-use\textquotedbl proxy accounting for modulatory MVS effects in RS-fMRI fluctuations is needed. The present study uses MRI data of 60 healthy volunteers to examine the relationship between RS-fMRI fluctuations and the individual orientation of inner-ear anatomy within the static magnetic field of the MRI. The individual inner-ear anatomy and orientation were assessed via high-resolution anatomical CISS images and related to fluctuations of RS-fMRI networks previously associated with MVS. More specifically, we used a subject-specific proxy for MVS (pMVS) that corresponds to the orientation of the individual inner-ear anatomy within the static magnetic field direction (also called \textquotedblz-direction\textquotedbl in MR imaging). We found that pMVS explained a considerable fraction of the total variance in RS-fMRI fluctuations (for instance, from 11% in the right cerebellum up to 36% in the cerebellar vermis). In addition to pMVS, we examined the angle of Reid's plane, as determined from anatomical imaging as an alternative and found that this angle (with the same sinus transformation as for pMVS) explained considerably less variance, e.g., from 2 to 16%. In our opinion, an excess variability due to MVS should generally be addressed in fMRI research analogous to nuisance regression for movement, pulsation, and respiration effects. We suggest using the pMVS parameter to deal with modulations of RS-fMRI fluctuations due to MVS. MVS-induced variance can easily be accounted by using high-resolution anatomical imaging of the inner ear and including the proposed pMVS parameter in fMRI group-level analysis

ASK/PSK-correspondence and the r-map

We formulate a correspondence between affine and projective special K\"ahler manifolds of the same dimension. As an application, we show that, under this correspondence, the affine special K\"ahler manifolds in the image of the rigid r-map are mapped to one-parameter deformations of projective special K\"ahler manifolds in the image of the supergravity r-map. The above one-parameter deformations are interpreted as perturbative $\alpha'$-corrections in heterotic and type-II string compactifications with $N=2$ supersymmetry. Also affine special K\"ahler manifolds with quadratic prepotential are mapped to one-parameter families of projective special K\"ahler manifolds with quadratic prepotential. We show that the completeness of the deformed supergravity r-map metric depends solely on the (well-understood) completeness of the undeformed metric and the sign of the deformation parameter

Acoustic radiation controls friction: Evidence from a spring-block experiment

Brittle failures of materials and earthquakes generate acoustic/seismic waves which lead to radiation damping feedbacks that should be introduced in the dynamical equations of crack motion. We present direct experimental evidence of the importance of this feedback on the acoustic noise spectrum of well-controlled spring-block sliding experiments performed on a variety of smooth surfaces. The full noise spectrum is quantitatively explained by a simple noisy harmonic oscillator equation with a radiation damping force proportional to the derivative of the acceleration, added to a standard viscous term.Comment: 4 pages including 3 figures. Replaced with version accepted in PR

Slider-Block Friction Model for Landslides: Application to Vaiont and La Clapiere Landslides

Accelerating displacements preceding some catastrophic landslides have been found empirically to follow a time-to-failure power law, corresponding to a finite-time singularity of the velocity $v \sim 1/(t_c-t)$ [{\it Voight}, 1988]. Here, we provide a physical basis for this phenomenological law based on a slider-block model using a state and velocity dependent friction law established in the laboratory and used to model earthquake friction. This physical model accounts for and generalizes Voight's observation: depending on the ratio $B/A$ of two parameters of the rate and state friction law and on the initial frictional state of the sliding surfaces characterized by a reduced parameter $x_i$, four possible regimes are found. Two regimes can account for an acceleration of the displacement. We use the slider-block friction model to analyze quantitatively the displacement and velocity data preceding two landslides, Vaiont and La Clapi\`ere. The Vaiont landslide was the catastrophic culmination of an accelerated slope velocity. La Clapi\`ere landslide was characterized by a peak of slope acceleration that followed decades of ongoing accelerating displacements, succeeded by a restabilizing phase. Our inversion of the slider-block model on these data sets shows good fits and suggest to classify the Vaiont (respectively La Clapi\`ere) landslide as belonging to the velocity weakening unstable (respectively strengthening stable) sliding regime.Comment: shortened by focusing of the frictional model, Latex document with AGU style file of 14 pages + 11 figures (1 jpeg photo of figure 6 given separately) + 1 tabl

Atmospheric rivers in CMIP5 climate ensembles downscaled with a high-resolution regional climate model

Atmospheric rivers (ARs) are important drivers of hazardous precipitation levels and are often associated with intense floods. So far, the response of ARs to climate change in Europe has been investigated using global climate models within the CMIP5 framework. However, the spatial resolution of those models (1–3∘) is too coarse for an adequate assessment of local to regional precipitation patterns. Using a regional climate model with 0.22∘ resolution, we downscaled an ensemble consisting of 1 ERA-Interim (ERAI) reanalysis data hindcast simulation, 9 global historical, and 24 climate scenario simulations following greenhouse gas emission scenarios RCP2.6, RCP4.5, and RCP8.5. The performance of the climate model to simulate AR frequencies and AR-induced precipitation was tested against ERAI. Overall, we find a good agreement between the downscaled CMIP5 historical simulations and ERAI. However, the downscaled simulations better represented small-scale spatial characteristics. This was most evident over the terrain of the Iberian Peninsula, where the AR-induced precipitation pattern clearly reflected prominent east–west topographical elements, resulting in zonal bands of high and low AR impact. Over central Europe, the models simulated a smaller propagation distance of ARs toward eastern Europe than obtained using the ERAI data. Our models showed that ARs in a future warmer climate will be more frequent and more intense, especially in the higher-emission scenarios (RCP4.5, RCP8.5). However, assuming low emissions (RCP2.6), the related changes can be mostly mitigated. According to the high-emission scenario RCP8.5, AR-induced precipitation will increase by 20 %–40 % in western central Europe, whereas mean precipitation rates increase by a maximum of only 12 %. Over the Iberian Peninsula, AR-induced precipitation will slightly decrease (∼6 %) but the decrease in the mean rate will be larger (∼15 %). These changes will lead to an overall increased fractional contribution of ARs to heavy precipitation, with the greatest impact over the Iberian Peninsula (15 %–30 %) and western France (∼15 %). Likewise, the fractional share of yearly maximum precipitation attributable to ARs will increase over the Iberian Peninsula, the UK, and western France. Over Norway, average AR precipitation rates will decline by −5 % to −30 %, most likely due to dynamic changes, with ARs originating from latitudes > 60∘ N decreasing by up to 20 % and those originating south of 45∘ N increasing. This suggests that ARs over Norway will follow longer routes over the continent, such that additional moisture uptake will be impeded. By contrast, ARs from >60∘ N will take up moisture from the North Atlantic before making landfall over Norway. The found changes in the local AR pathway are probably driven by larger-scale circulation changes such as a change in dominating weather regimes and/or changes in the winter storm track over the North Atlantic

Boundary lubrication with a glassy interface

Recently introduced constitutive equations for the rheology of dense, disordered materials are investigated in the context of stick-slip experiments in boundary lubrication. The model is based on a generalization of the shear transformation zone (STZ) theory, in which plastic deformation is represented by a population of mesoscopic regions which may undergo non affine deformations in response to stress. The generalization we study phenomenologically incorporates the effects of aging and glassy relaxation. Under experimental conditions associated with typical transitions from stick-slip to steady sliding and stop start tests, these effects can be dominant, although the full STZ description is necessary to account for more complex, chaotic transitions

Ancient gene duplications have shaped developmental stage-specific expression in Pristionchus pacificus

BACKGROUND: The development of multicellular organisms is accompanied by gene expression changes in differentiating cells. Profiling stage-specific expression during development may reveal important insights into gene sets that contributed to the morphological diversity across the animal kingdom. RESULTS: We sequenced RNA-seq libraries throughout a developmental timecourse of the nematode Pristionchus pacificus. The transcriptomes reflect early larval stages, adult worms including late larvae, and growth-arrested dauer larvae and allowed the identification of developmentally regulated gene clusters. Our data reveals similar trends as previous transcriptome profiling of dauer worms and represents the first expression data for early larvae in P. pacificus. Gene expression clusters characterizing early larval stages show most significant enrichments of chaperones, while collagens are most significantly enriched in transcriptomes of late larvae and adult worms. By combining expression data with phylogenetic analysis, we found that developmentally regulated genes are found in paralogous clusters that have arisen through lineage-specific duplications after the split from the Caenorhabditis elegans branch. CONCLUSIONS: We propose that gene duplications of developmentally regulated genes represent a plausible evolutionary mechanism to increase the dosage of stage-specific expression. Consequently, this may contribute to the substantial divergence in expression profiles that has been observed across larger evolutionary time scales

Beyond binary parcellation of the vestibular cortex - A dataset

The data-set presented in this data article is supplementary to the original publication, doi:10.1016/j.neuroimage.2018.05.018 (Kirsch et al., 2018). Named article describes handedness-dependent organizational patterns of functional subunits within the human vestibular cortical network that were revealed by functional magnetic resonance imaging (fMRI) connectivity parcellation. 60 healthy volunteers (30 left-handed and 30 right-handed) were examined on a 3T MR scanner using resting state fMRI. The multisensory (non-binary) nature of the human (vestibular) cortex was addressed by using masked binary and non-binary variations of independent component analysis (ICA). The data have been made publicly available via github (https://github.com/RainerBoegle/BeyondBinar yParcellationData). (C) 2019 The Authors. Published by Elsevier Inc

Towards Landslide Predictions: Two Case Studies

In a previous work [Helmstetter, 2003], we have proposed a simple physical model to explain the accelerating displacements preceding some catastrophic landslides, based on a slider-block model with a state and velocity dependent friction law. This model predicts two regimes of sliding, stable and unstable leading to a critical finite-time singularity. This model was calibrated quantitatively to the displacement and velocity data preceding two landslides, Vaiont (Italian Alps) and La Clapi\`ere (French Alps), showing that the former (resp. later) landslide is in the unstable (resp. stable) sliding regime. Here, we test the predictive skills of the state-and-velocity-dependent model on these two landslides, using a variety of techniques. For the Vaiont landslide, our model provides good predictions of the critical time of failure up to 20 days before the collapse. Tests are also presented on the predictability of the time of the change of regime for la Clapi\`ere landslide.Comment: 30 pages with 12 eps figure