High-order Discontinuous Galerkin Solutions of Internal Low-mach Number Turbulent Flows☆

Abstract In this work we apply the high-order Discontinuous Galerkin (DG) finite element method to internal low-Mach number turbulent flows. The method here presented is designed to improve the performance of the solution in the incompressible limit using an implicit scheme for the temporal integration of the compressible Reynolds Averaged Navier Stokes (RANS) equations. The per- formance of the scheme is demonstrated by solving a well-known test-case consisting of an abrupt axisymmetric expansion using various degrees of polynomial approximation. Computations with k–ω model are performed to assess the modelling capabilities, with high-order accurate DG discretizations of the RANS equations, in presence of non-equilibrium flow conditions

Bonn Potential and Shell-Model Calculations for 206,205,204Pb

The structure of the nuclei 206,205,204Pb is studied interms of shell model employing a realistic effective interaction derived from the Bonn A nucleon-nucleon potential. The energy spectra, binding energies and electromagnetic properties are calculated and compared with experiment. A very good overall agreement is obtained. This evidences the reliability of our realistic effective interaction and encourages use of modern realistic potentials in shell-model calculations for heavy-mass nuclei.Comment: 4 pages, 4 figures, submitted to Physical Review

Consequences of the historical demography on the global population structure of two highly migratory cosmopolitan marine fishes: the yellowfin tuna (Thunnus albacares) and the skipjack tuna (Katsuwonus pelamis)

BACKGROUND: Yellowfin and skipjack tuna are globally distributed in the world's tropical and sub-tropical oceans. Since little, if any, migration of these fishes occurs between the Atlantic and Indo-Pacific Oceans, one might expect to see genetic differences between sub-populations in these ocean basins. However, yellowfin and skipjack tuna have extremely large population sizes. Thus, the rate of genetic drift should be slower than that observed for other tunas. RESULTS: Low levels of genetic differentiation were observed between Atlantic and Pacific samples of yellowfin tuna. In contrast, no genetic differentiation was observed between Atlantic and Pacific samples of skipjack tuna. CONCLUSION: Much lower levels of genetic differentiation were found among sub-populations of yellowfin tuna compared to those observed for other large tunas, probably due to the large population size of yellowfin tuna. Since skipjack tuna appear to have even larger population sizes, it is not surprising that no genetic differentiation was detected between Atlantic and Pacific samples of these fish

Thermal water delivery in the nose: experimental results describing droplet deposition through computational fluid dynamics

Thermal water therapies have a role in treating various inflammatory disorders dating back to ancient Greece. Several studies have demonstrated beneficial effects of thermal water inhalations for upper respiratory disorders, such as improvement of mucociliary function and reduction of inflammatory cell infiltration. This experimental study describes the numerical investigation and clinical implications of thermal water droplet deposition in the nasal cavity of a single patient. To our knowledge, the numerical flow simulations described are the first investigations specifically designed for thermal water applications. To simulate nasal airflow, a patient-specific 3D computer model was created from a CT scan. The numerical approach is based on the Large Eddy Simulation (LES) technique and builds entirely upon open-source software. Deposition on mucosa was studied for two droplet sizes (5 and 10 µm diameter), corresponding to common thermal therapy applications (aerosol and vapour inhalation). The simulations consider steady inspiration at two different (low and moderate) breathing intensities. The results of this preliminary study show specific deposition patterns that favour droplet deposition in the middle meatus region to the inferior meatus, with particle size- and breathing intensity-related effects. These global data on particle deposition differ from findings related to the single-phase nasal airflow, which is more evenly distributed between the middle and inferior meatus. The potential clinical consequences of deposition data are discussed. The study furthermore provides evidence for the effectiveness of thermal aerosol and vapour inhalation therapies in reaching important areas of nasal mucosa with considerable clinical significance

HPV sensitizes OPSCC cells to cisplatin-induced apoptosis by inhibiting autophagy through E7-mediated degradation of AMBRA1

Oropharyngeal squamous cell carcinoma (OPSCC) is an increasing world health problem with a more favorable prognosis for patients with human papillomavirus (HPV)-positive tumors compared to those with HPV-negative OPSCC. How HPV confers a less aggressive phenotype, however, remains undefined. We demonstrated that HPV-positive OPSCC cells display reduced macroautophagy/autophagy activity, mediated by the ability of HPV-E7 to interact with AMBRA1, to compete with its binding to BECN1 and to trigger its calpain-dependent degradation. Moreover, we have shown that AMBRA1 downregulation and pharmacological inhibition of autophagy sensitized HPV-negative OPSCC cells to the cytotoxic effects of cisplatin. Importantly, semi-quantitative immunohistochemical analysis in primary OPSCCs confirmed that AMBRA1 expression is reduced in HPV-positive compared to HPV-negative tumors. Collectively, these data identify AMBRA1 as a key target of HPV to impair autophagy and propose the targeting of autophagy as a viable therapeutic strategy to improve treatment response of HPV-negative OPSCC. Abbreviations: AMBRA1: autophagy and beclin 1 regulator 1; CDDP: cisplatin (CDDP); FFPE: formalin-fixed paraffin-embedded (FFPE); HNC: head and neck cancers (HNC); HPV: human papillomavirus (HPV); hrHPV: high risk human papillomavirus (hrHPV); OCSCC: oral cavity squamous carcinomas (OCSSC); OPSCC: oropharyngeal squamous cell carcinoma (OPSCC); OS: overall survival (OS); qPCR: quantitative polymerase chain reaction; RB1: RB transcriptional corepressor 1; ROC: receiver operating characteristic curve (ROC)

miR-181c associates with tumor relapse of high grade osteosarcoma

High-grade osteosarcoma (OS) is characterized by low incidence, high aggressiveness and moderate 5-years survival rate after aggressive poly-chemotherapy and surgery. Here we used miRNA profiling as a tool to possibly predict and monitor OS's development and therapeutic outcome. First, we evaluated the altered expression of selected miRNAs from a case of Giant Cell Tumor (GCT) apparently evolved into an OS. We found that most of modulated miRs were associated with pathways of bone resorption and osteogenesis. miRNA expression also revealed that GCT and OS were distinct tumors. Second, we validated the observed miRNA profile in two independent casuistries of ten GCT (not evolved into malignant tumors) and sixteen OS patients. Interestingly, we found that miR-181c and other three miRNAs identified in the first step of the study were also consistently de-regulated in all OS patients. Ectopic expression of miR-181c reduced cell viability and enhanced chemotherapeutic-induced cell death of U2OS and SAOS2 cells. These findings indicate that: i) miRNAs aberrantly modulated in GCT could be predictive of its development into OS and ii) miRNAs expression could be useful to monitor the OS therapeutic outcome

Identification and shell model calculation of high spin states in 137,138Cs nuclei

High spin states of $^{137,138}\mathrm{Cs}$ have been studied by measuring \ensuremath{\gamma}\text{\ensuremath{-}}\ensuremath{\gamma}\text{\ensuremath{-}}\ensuremath{\gamma} coincidences from the spontaneous fission of $^{252}\mathrm{Cf}$ with the LBNL Gammasphere detector array. The high spin level scheme of the $N=83$ neutron-rich Cs ($Z=55$) isotope, $^{138}\mathrm{Cs}$, built on the {6}^{\ensuremath{-}} isomeric state, has been established for the first time up to a 4626 keV level, assigned (${16}^{+}$). The level scheme of $^{137}\mathrm{Cs}$ has been expanded up to a 5495 keV level, assigned (31/{2}^{\ensuremath{-}}). Spins, parities, and configurations are assigned based on the agreement between experimental level energies and shell model calculations and level systematics. Similarities are observed in the $N=82$ isotones, $^{137}\mathrm{Cs}$ and $^{135}\mathrm{I}$, up to $17/{2}^{+}$ as well as in the $N=83$ isotones, $^{138}\mathrm{Cs}$ and $^{136}\mathrm{I}$, up to {12}^{\ensuremath{-}}. The shell model calculations indicate the important role played by interactions between the excitation of the valence protons outside the $Z=50$ major shell and the ${f}_{7/2}$ valence neutron outside the $N=82$ major shell

Particle-hole excited states in 133 Te

Excited states in neutron-rich ${}^{133}\mathrm{Te}$ have been identified with the Gamma sphere array by measuring three- and higher-fold prompt coincidence events following spontaneous fission of ${}^{252}\mathrm{Cf}.$ Four types of particle-hole bands built on the known 334.3 keV isomer in ${}^{133}\mathrm{Te}$ are identified. The yrast and near yrast particle-hole states observed up to 6.2 MeV in ${}^{133}\mathrm{Te}$ have characteristics quite similar to those in ${}^{134}\mathrm{Te}.$ These states are interpreted as a result of coupling a neutron \ensuremath{\nu}{h}_{11/2} hole to the ${}^{134}\mathrm{Te}$ core. The group of states observed above 5.214 MeV is the result of a neutron particle-hole excitation of the double magic core nucleus ${}^{132}\mathrm{Sn},$ and is a candidate for a tilted rotor band. Shell-model calculations considering ${}^{132}\mathrm{Sn}$ as a closed core have been performed and have provided guidance to the interpretation of the levels below 4.3 MeV. Very good agreement between theory and experiment is obtained for these states

Signatures of three-nucleon interactions in few-nucleon systems

Recent experimental results in three-body systems have unambiguously shown that calculations based only on nucleon-nucleon forces fail to accurately describe many experimental observables and one needs to include effects which are beyond the realm of the two-body potentials. This conclusion owes its significance to the fact that experiments and calculations can both be performed with a high accuracy. In this review, both theoretical and experimental achievements of the past decade will be underlined. Selected results will be presented. The discussion on the effects of the three-nucleon forces is, however, limited to the hadronic sector. It will be shown that despite the major successes in describing these seemingly simple systems, there are still clear discrepancies between data and the state-of-the-art calculations.Comment: accepted for publication in Rep. Prog. Phy