959 research outputs found
Experiments on rehabilitation of radioactive metallic waste (RMW) of reactor stainless steels of Siberian chemical plant
Stainless steel pipes, used to cool a reactor plant, have a high cost, and aftertaking a reactor out of service they must be buried together with other radioactivewaste. Therefore, the relevant problem is the rinse of pipes from contamination,followed by returning to operation
Spatial Analysis of Metal-PLGA Hybrid Microstructures Using 3D SERS Imaging
The incorporation of gold nanoparticles in biodegradable polymeric nanostructures with controlled shape and size is of interest toward different applications in nanomedicine. Properties of the polymer such as drug loading and antibody functionalization can be combined with the plasmonic properties of gold nanoparticles, to yield advanced hybrid materials. This study presents a new way to synthesize multicompartmental microgels, fibers, or cylinders, with embedded anisotropic gold nanoparticles. Gold nanoparticles dispersed in an organic solvent can be embedded within the poly(lacticâcoâglycolic acid) (PLGA) matrix of polymeric microstructures, when prepared via electrohydrodynamic coâjetting. Prior functionalization of the plasmonic nanoparticles with Raman active molecules allows for imaging of the nanocomposites by surfaceâenhanced Raman scattering (SERS) microscopy, thereby revealing nanoparticle distribution and photostability. These exceptionally stable hybrid materials, when used in combination with 3D SERS microscopy, offer new opportunities for bioimaging, in particular when longâterm monitoring is required
Facile one-pot synthesis of amoxicillin-coated gold nanoparticles and their antimicrobial activity
Nanomaterials have been the object of intense study due to promising applications in a number of different disciplines. In particular, medicine and biology have seen the potential of these novel materials with their nanoscale properties for use in diverse areas such as imaging, sensing and drug vectorisation. Gold nanoparticles (GNPs) are considered a very useful platform to create a valid and efficient drug delivery/carrier system due to their facile and well-studied synthesis, easy surface functionalization and biocompatibility. In the present study, stable antibiotic conjugated GNPs were synthesised by a one-step reaction using a poorly water soluble antibiotic, amoxicillin. Amoxicillin, a member of the penicillin family, reduces the chloroauric acid to form nanoparticles and at the same time coats them to afford the functionalised nanomaterial. A range of techniques including UV-vis spectroscopy, dynamic light scattering (DLS), transmission electron microscopy (TEM) and thermogravimetric analysis (TGA) were used to ascertain the gold/drug molar ratio and the optimum temperature for synthesis of uniform monodisperse particles in the ca. 30-40 nm size range. Amoxicillin-conjugated gold showed an enhancement of antibacterial activity against Escherichia coli compared to the antibiotic alone
Health Workers' Performance in the Implementation of Patient Centred Tuberculosis Treatment (PCT) Strategy Under Programmatic Conditions in Tanzania: A Cross Sectional Study.
Patient Centred Tuberculosis Treatment (PCT) is a promising treatment delivery strategy for Mycobacterium tuberculosis (TB). It aims to improve adherence to treatment by giving patients the choice of having drug intake supervised at the health facility by a medical professional or at home by a supporter of their choice. A cross-sectional survey was undertaken in three districts of Tanzania during October 2007, one year after PCT was rolled out nationally. Semi-structured questionnaires were used to assess whether key elements of the PCT approach were being implemented, to evaluate supporters' knowledge, to capture opinions on factors contributing to treatment completion, and to assess how treatment completion was measured. Transcripts from open-ended responses were analysed using framework analysis. Interviews were conducted with 127 TB patients, 107 treatment supporters and 70 health workers. In total, 25.2% of TB patients were not given a choice about the place of treatment by health workers, and only 13.7% of those given a choice reported that they were given adequate time to make their decision. Only 24.3% of treatment supporters confirmed that they were instructed how to complete patients' treatment cards. Proper health education was the factor most frequently reported by health workers as favouring successful completion of TB treatment (45.7%). The majority of health workers (68.6%) said they checked returned blister packs to verify whether patients had taken their treatment, but only 20.0% checked patients' treatment cards. The provision of choice of treatment location, information on treatment, and guidance for treatment supporters need to be improved. There is a requirement for regular re-training of health workers with effective supportive supervision if successful implementation of the PCT approach is to be sustained
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Natural ventilation reduces high TB transmission risk in traditional homes in rural KwaZulu-Natal, South Africa
Background: Transmission of drug susceptible and drug resistant TB occurs in health care facilities, and community and households settings, particularly in highly prevalent TB and HIV areas. There is a paucity of data regarding factors that may affect TB transmission risk in household settings. We evaluated air exchange and the impact of natural ventilation on estimated TB transmission risk in traditional Zulu homes in rural South Africa. Methods: We utilized a carbon dioxide decay technique to measure ventilation in air changes per hour (ACH). We evaluated predominant home types to determine factors affecting ACH and used the Wells-Riley equation to estimate TB transmission risk. Results: Two hundred eighteen ventilation measurements were taken in 24 traditional homes. All had low ventilation at baseline when windows were closed (mean ACH = 3, SD = 3.0), with estimated TB transmission risk of 55.4% over a ten hour period of exposure to an infectious TB patient. There was significant improvement with opening windows and door, reaching a mean ACH of 20 (SD = 13.1, p < 0.0001) resulting in significant decrease in estimated TB transmission risk to 9.6% (p < 0.0001). Multivariate analysis identified factors predicting ACH, including ventilation conditions (windows/doors open) and window to volume ratio. Expanding ventilation increased the odds of achieving â„12 ACH by 60-fold. Conclusions: There is high estimated risk of TB transmission in traditional homes of infectious TB patients in rural South Africa. Improving natural ventilation may decrease household TB transmission risk and, combined with other strategies, may enhance TB control efforts
SUSY Stops at a Bump
We discuss collider signatures of the "natural supersymmetry" scenario with
baryon-number violating R-parity violation. We argue that this is one of the
few remaining viable incarnations of weak scale supersymmetry consistent with
full electroweak naturalness. We show that this intriguing and challenging
scenario contains distinctive LHC signals, resonances of hard jets in
conjunction with relatively soft leptons and missing energy, which are easily
overlooked by existing LHC searches. We propose novel strategies for
distinguishing these signals above background, and estimate their potential
reach at the 8 TeV LHC. We show that other multi-lepton signals of this
scenario can be seen by currently existing searches with increased statistics,
but these opportunities are more spectrum-dependent.Comment: 23 pages, 7 figures, 3 tables. V2: spectrum discussion corrected,
most of the changes are in Sec. 2. Benchmarks, analysis and conclusions
unchanged. References adde
Top quark forward-backward asymmetry in R-parity violating supersymmetry
The interaction of bottom squark-mediated top quark pair production,
occurring in the R-parity violating minimal supersymmetric standard model
(MSSM), is proposed as an explanation of the anomalously large
forward-backward asymmetry (FBA) observed at the Tevatron. We find that this
model can give a good fit to top quark data, both the inclusive and invariant
mass-dependent asymmetries, while remaining consistent (at the 2-
level) with the total and differential production cross-sections. The scenario
is challenged by strong constraints from atomic parity violation (APV), but we
point out an extra diagram for the effective down quark-Z vertex, involving the
same coupling constant as required for the FBA, which tends to weaken the APV
constraint, and which can nullify it for reasonable values of the top squark
masses and mixing angle. Large contributions to flavor-changing neutral
currents can be avoided if only the third generation of sparticles is light.Comment: 24 pages, 7 figures. v3: included LHC top production cross section
data; model still consistent at 2 sigma leve
Constraining compressed supersymmetry using leptonic signatures
We study the impact of the multi-lepton searches at the LHC on supersymmetric
models with compressed mass spectra. For such models the acceptances of the
usual search strategies are significantly reduced due to requirement of large
effective mass and missing E_T. On the other hand, lepton searches do have much
lower thresholds for missing E_T and p_T of the final state objects. Therefore,
if a model with a compressed mass spectrum allows for multi-lepton final
states, one could derive constraints using multi-lepton searches. For a class
of simplified models we study the exclusion limits using ATLAS multi-lepton
search analyses for the final states containing 2-4 electrons or muons with a
total integrated luminosity of 1-2/fb at \sqrt{s}=7 TeV. We also modify those
analyses by imposing additional cuts, so that their sensitivity to compressed
supersymmetric models increase. Using the original and modified analyses, we
show that the exclusion limits can be competitive with jet plus missing E_T
searches, providing exclusion limits up to gluino masses of 1 TeV. We also
analyse the efficiencies for several classes of events coming from different
intermediate state particles. This allows us to assess exclusion limits in
similar class of models with different cross sections and branching ratios
without requiring a Monte Carlo simulation.Comment: 18 pages, 5 figure
BLUF Domain Function Does Not Require a Metastable Radical Intermediate State
BLUF
(blue light using flavin) domain proteins are an important
family of blue light-sensing proteins which control a wide variety
of functions in cells. The primary light-activated step in the BLUF
domain is not yet established. A number of experimental and theoretical
studies points to a role for photoinduced electron transfer (PET)
between a highly conserved tyrosine and the flavin chromophore to
form a radical intermediate state. Here we investigate the role of
PET in three different BLUF proteins, using ultrafast broadband transient
infrared spectroscopy. We characterize and identify infrared active
marker modes for excited and ground state species and use them to
record photochemical dynamics in the proteins. We also generate mutants
which unambiguously show PET and, through isotope labeling of the
protein and the chromophore, are able to assign modes characteristic
of both flavin and protein radical states. We find that these radical
intermediates are not observed in two of the three BLUF domains studied,
casting doubt on the importance of the formation of a population of
radical intermediates in the BLUF photocycle. Further, unnatural amino
acid mutagenesis is used to replace the conserved tyrosine with fluorotyrosines,
thus modifying the driving force for the proposed electron transfer
reaction; the rate changes observed are also not consistent with a
PET mechanism. Thus, while intermediates of PET reactions can be observed
in BLUF proteins they are not correlated with photoactivity, suggesting
that radical intermediates are not central to their operation. Alternative
nonradical pathways including a ketoâenol tautomerization induced
by electronic excitation of the flavin ring are considered
Hitting sbottom in natural SUSY
We compare the experimental prospects of direct stop and sbottom pair
production searches at the LHC. Such searches for stops are of great interest
as they directly probe for states that are motivated by the SUSY solution to
the hierarchy problem of the Higgs mass parameter - leading to a "Natural" SUSY
spectrum. Noting that sbottom searches are less experimentally challenging and
scale up in reach directly with the improvement on b-tagging algorithms, we
discuss the interplay of small TeV scale custodial symmetry violation with
sbottom direct pair production searches as a path to obtaining strong sub-TeV
constraints on stops in a natural SUSY scenario. We argue that if a weak scale
natural SUSY spectrum does not exist within the reach of LHC, then hopes for
such a spectrum for large regions of parameter space should sbottom out.
Conversely, the same arguments make clear that a discovery of such a spectrum
is likely to proceed in a sbottom up manner.Comment: 18 pages, 8 figures,v2 refs added, JHEP versio
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