1,131 research outputs found
GRB 170817A-GW170817-AT 2017gfo and the observations of NS-NS, NS-WD and WD-WD mergers
The LIGO-Virgo Collaboration has announced the detection of GW170817 and has
associated it with GRB 170817A. These signals have been followed after 11 hours
by the optical and infrared emission of AT 2017gfo. The origin of this complex
phenomenon has been attributed to a neutron star-neutron star (NS-NS) merger.
In order to probe this association we confront our current understanding of the
gravitational waves and associated electromagnetic radiation with four observed
GRBs originating in binaries composed of different combinations NSs and white
dwarfs (WDs). We consider 1) GRB 090510 the prototype of NS-NS merger leading
to a black hole (BH); 2) GRB 130603B the prototype of a NS-NS merger leading to
massive NS (MNS) with an associated kilonova; 3) GRB 060614 the prototype of a
NS-WD merger leading to a MNS with an associated kilonova candidate; 4) GRB
170817A the prototype of a WD-WD merger leading to massive WD with an
associated AT 2017gfo-like emission. None of these systems support the above
mentioned association. The clear association between GRB 170817A and AT 2017gfo
has led to introduce a new model based on on a new subfamily of GRBs
originating from WD-WD mergers. We show how this novel model is in agreement
with the exceptional observations in the optical, infrared, X- and gamma-rays
of GRB 170817A-AT 2017gfo.Comment: version accepted for publication in JCAP. Missing references adde
Sequence learning in Associative Neuronal-Astrocytic Network
The neuronal paradigm of studying the brain has left us with limitations in
both our understanding of how neurons process information to achieve biological
intelligence and how such knowledge may be translated into artificial
intelligence and its most brain-derived branch, neuromorphic computing.
Overturning our fundamental assumptions of how the brain works, the recent
exploration of astrocytes is revealing that these long-neglected brain cells
dynamically regulate learning by interacting with neuronal activity at the
synaptic level. Following recent experimental evidence, we designed an
associative, Hopfield-type, neuronal-astrocytic network and analyzed the
dynamics of the interaction between neurons and astrocytes. We show that
astrocytes were sufficient to trigger transitions between learned memories in
the neuronal component of the network. Further, we mathematically derived the
timing of the transitions that was governed by the dynamics of the
calcium-dependent slow-currents in the astrocytic processes. Overall, we
provide a brain-morphic mechanism for sequence learning that is inspired by,
and aligns with, recent experimental findings. To evaluate our model, we
emulated astrocytic atrophy and showed that memory recall becomes significantly
impaired after a critical point of affected astrocytes was reached. This
brain-inspired and brain-validated approach supports our ongoing efforts to
incorporate non-neuronal computing elements in neuromorphic information
processing.Comment: 8 pages, 5 figure
A worldwide molecular phylogeny and classification of the leafy spurges, Euphorbia subgenus Esula (Euphorbiaceae)
The leafy spurges, Euphorbia subg. Esula, make up one of four main lineages in Euphorbia. The subgenus comprises about 480 species, most of which are annual or perennial herbs, but with a small number of dendroid shrubs and nearly leafless, pencilâ stemmed succulents as well. The subgenus constitutes the primary northern temperate radiation in Euphorbia. While the subgenus is most diverse from central Asia to the Mediterranean region, members of the group also occur in Africa, in the Indoâ Pacific region, and in the New World. We have assembled the largest worldwide sampling of the group to date (273 spp.), representing most of the taxonomic and geographic breadth of the subgenus. We performed phylogenetic analyses of sequence data from the nuclear ribosomal ITS and plastid ndhF regions. Our individual and combined analyses produced wellâ resolved phylogenies that confirm many of the previously recognized clades and also establish a number of novel groupings and placements of previously enigmatic species. Euphorbia subg. Esula has a clear Eurasian center of diversity, and we provide evidence for four independent arrivals to the New World and three separate colonizations of tropical and southern Africa. One of the latter groups further extends to Madagascar and New Zealand, and to more isolated islands such as Réunion and Samoa. Our results confirm that the dendroid shrub and stemâ succulent growth forms are derived conditions in E. subg. Esula. Stemâ succulents arose twice in the subgenus and dendroid shrubs three times. Based on the molecular phylogeny, we propose a new classification for E. subg. Esula that recognizes 21 sections (four of them newly described and two elevated from subsectional rank), and we place over 95% of the accepted species in the subgenus into this new classification.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146962/1/tax6221.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146962/2/tax6221-sup-004-pdf.pd
Experimental study of the sensitivity of a porous silicon ring resonator sensor using continuous in-flow measurements
A highly sensitive photonic sensor based on a porous silicon ring resonator was developed and experimentally characterized. The photonic sensing structure was fabricated by exploiting a porous silicon double layer, where the top layer of a low porosity was used to form photonic elements by e-beam lithography and the bottom layer of a high porosity was used to confine light in the vertical direction. The sensing performance of the ring resonator sensor based on porous silicon was compared for the different resonances within the analyzed wavelength range both for transverse-electric and transverse-magnetic polarizations. We determined that a sensitivity up to 439 nm/RIU for low refractive index changes can be achieved depending on the optical field distribution given by each resonance/polarization
Association of Iron Status and Intake During Pregnancy with Neuropsychological Outcomes in Children Aged 7 Years: The Prospective Birth Cohort Infancia y Medio Ambiente (INMA) Study
The Fermi Bubble as a Source of Cosmic Rays in the Energy Range > 10E15 eV
The {\it Fermi} Large Area Telescope has recently discovered two giant
gamma-ray bubbles which extend north and south of the Galactic center with
diameters and heights of the order of kpc. We suggest that the
periodic star capture processes by the Galactic supermassive black hole Sgr
A, with a capture rate of
yr and an energy release of erg per capture, can
result in hot plasma injecting into the Galactic halo at a wind velocity of
cm s. The periodic injection of hot plasma can produce a
series of shocks. Energetic protons in the bubble are re-accelerated when they
interact with these shocks. We show that for energy larger than
eV, the acceleration process can be better described by the stochastic
second-order Fermi acceleration.
We propose that hadronic cosmic rays (CRs) within the ``knee'' of the
observed CR spectrum are produced by Galactic supernova remnants distributed in
the Galactic disk. Re-acceleration of these particles in the Fermi Bubble
produces CRs beyond the knee. With a mean CR diffusion coefficient in this
energy range in the bubble cm s, we can
reproduce the spectral index of the spectrum beyond the knee and within. The
conversion efficiency from shock energy of the bubble into CR energy is about
10\%. This model provides a natural explanation of the observed CR flux,
spectral indices, and matching of spectra at the knee.Comment: 43 pages, 8 figues, to be published in the Astrophysical Journal;
version 2, 45 pages, 8 figures, added references and corrected typo
The RINGO2 and DIPOL optical polarization catalogue of blazars
We present ∼2000 polarimetric and ∼3000 photometric observations of 15 γ-ray bright blazars over a period of 936 days (2008-10-11 to 2012-10-26) using data from the Tuorla blazar monitoring program (KVA DIPOL) and Liverpool Telescope (LT) RINGO2 polarimeters (supplemented with data from SkyCamZ (LT) and Fermi-LAT γ-ray data). In 11 out of 15 sources we identify a total of 19 electric vector position angle (EVPA) rotations and 95 flaring episodes. We group the sources into subclasses based on their broad-band spectral characteristics and compare their observed optical and γ-ray properties. We find that (1) the optical magnitude and γ-ray flux are positively correlated, (2) EVPA rotations can occur in any blazar subclass, four sources show rotations that go in one direction and immediately rotate back, (3) we see no difference in the γ-ray flaring rates in the sample; flares can occur during and outside of rotations with no preference for this behaviour, (4) the average degree of polarization (DoP), optical magnitude and γ-ray flux are lower during an EVPA rotation compared with during non-rotation and the distribution of the DoP during EVPA rotations is not drawn from the same parent sample as the distribution outside rotations, (5) the number of observed flaring events and optical polarization rotations are correlated, however we find no strong evidence for a temporal association between individual flares and rotations and (6) the maximum observed DoP increases from ∼10 per cent to ∼30 per cent to ∼40 per cent for subclasses with synchrotron peaks at high, intermediate and low frequencies, respectively
Tissue print of prostate biopsy: a novel tool in the diagnostic procedure of prostate cancer
<p>Abstract</p> <p>Background</p> <p>Nowadays, the histological examination of prostate core needle biopsies is still regarded as the gold standard in the diagnosis of prostate cancer (PCa). We investigated if the tissue print of core needle biopsy (biopsy print) could be used as adjunctive molecular investigative procedures in conjunction with routine histological examination of biopsy to improve PCa diagnosis.</p> <p>Methods</p> <p>The direct contact of PCa core biopsy to nitrocellulose membrane resulted in the release of a cellular micropeel that was used for downstream analytical procedures.</p> <p>Results</p> <p>By zymogram print-phoresis we demonstrated that matrix metalloproteases MMP-2 and MMP-9 could be visualized in biopsy prints and that the gelatinolytic activity was positively correlated with immunohistochemistry analysis of the same markers in matched bioptic specimens. Moreover, we compared the ability to detect the PCa-associated hypermethylation of GSTP1 promoter in DNA extracted from biopsy prints with those of the corresponding core needle biopsies. Biopsy prints demonstrated the same specificity of biopsies in detecting PCa (50%) while the sensitivity and the positive predictive value were lower than biopsies (56% vs 78% and 63% vs 70%, respectively).</p> <p>Conclusions</p> <p>Biopsy print, combining a molecular point of view to the routinely hystopathological analysis of prostate biopsies, should be a useful tool to improve the diagnosis of PCa.</p
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