Eficácia do tratamento preventivo da dor na histerectomia laparoscópica com diclofenaco, tramadol, metamizol e dexametasona

The intensity and duration of pain are influenced by different factors of the subjects undergoing a surgical intervention. In order to evaluate the effectiveness of preventive analgesia with diclofenac, tramadol, metamizole, and dexamethasone in postoperative pain in patients operated on for laparoscopic surgery, a prospective, quasi-experimental, controlled, double-blind study was performed in patients who underwent surgery for hysterectomy due to Laparoscopic video surgery, at the Carlos Manuel de Céspedes University Hospital in Bayamo in the period from August 2017 to August 2019. The patients were divided into two groups: group I (Experimental or study), consisting of 37 patients who received preventive analgesia with diclofenac 75 mg diluted EV before anesthetic induction, tramadol 100 mg EV is administered intraoperatively, metamizole sodium 1200 mg IM with dexamethasone 4 mg and group II (Control) are administered at the end of surgery, 37 patients in whom diclofenac 75 mg EV is administered before anesthetic induction ca and metamizole 1200 mg before concluding IM surgery. The analog visual scale was applied to assess pain intensity. The postoperative pain appears at 2 hours in the control group and at 4 hours in the study group, 10 patients had pain in the study group, 27 in the control group with this preventive treatment scheme. The intensity of pain was null in 86.4% in the study group, 8.1% in the control, statistically significant results. La intensidad y duración del dolor están influenciadas por diferentes factores de los sujetos sometidos a una intervención quirúrgica. Con el objetivo de evaluar la efectividad de la analgesia preventiva con diclofenaco, tramadol, metamizol y dexametasona en el dolor postoperatorio en pacientes operado para cirugía laparoscópica, se realizó un estudio prospectivo, cuasi experimental, controlado, doble ciego en pacientes intervenidas quirúrgicamente de Histerectomía por cirugía video laparoscópica, en el Hospital Universitario Carlos Manuel de Céspedes de Bayamo en el período comprendido desde agosto de 2017 hasta agosto de 2019. Los pacientes fueron distribuidos en dos grupos: el grupo I (Experimental o estudio), formado por 37 pacientes que recibieron analgesia preventiva con diclofenaco 75 mg  diluido EV antes de la inducción anestésica, transoperatorio se administra tramadol 100 mg EV , al terminar intervención quirúrgica se administra metamizol sódico 1200 mg  IM con dexametasona 4 mg y el grupo II (Control), 37 pacientes en los que se  administra diclofenaco 75 mg  EV antes de la inducción anestésica y metamizol  1200 mg antes de concluir intervención quirúrgica  IM. Se aplicó la escala visual análoga para evaluar la intensidad de dolor. El dolor en el pos operatorio aparece a las 2 horas en el grupo control y a las 4 horas en grupo estudio, 10 pacientes tuvieron dolor en el grupo estudio, 27 en grupo control con este esquema de tratamiento preventivo.  La intensidad de dolor fue nula en el 86,4 % en el grupo estudio, 8,1 % en el control, resultados estadísticamente significativos.A intensidade e a duração da dor são influenciadas por diferentes fatores dos sujeitos submetidos a uma intervenção cirúrgica. Para avaliar a eficácia da analgesia preventiva com diclofenaco, tramadol, metamizol e dexametasona na dor pós-operatória em pacientes operados para cirurgia laparoscópica, foi realizado um estudo prospectivo, quase experimental, controlado e duplo-cego em pacientes submetidos à cirurgia para histerectomia devido a A cirurgia videolaparoscópica, realizada no Hospital Universitário Carlos Manuel de Céspedes, em Bayamo, no período de agosto de 2017 a agosto de 2019, foi dividida em dois grupos: grupo I (experimental ou estudo), composto por 37 pacientes que receberam analgesia preventiva com diclofenaco 75 mg EV diluído antes da indução anestésica, tramadol 100 mg EV é administrado no intraoperatório, metamizol sódico 1200 mg IM com dexametasona 4 mg e grupo II (Controle) são administrados no final da cirurgia, 37 pacientes nos quais diclofenaco 75 mg EV é administrado antes da indução anestésica ca e metamizol 1200 mg antes de concluir a cirurgia IM. A escala visual analógica foi aplicada para avaliar a intensidade da dor. A dor pós-operatória aparece às 2 horas no grupo controle e às 4 horas no grupo de estudo, 10 pacientes apresentaram dor no grupo de estudo, 27 no grupo controle com esse esquema de tratamento preventivo. A intensidade da dor foi nula em 86,4% no grupo de estudo, 8,1% no controle, resultados estatisticamente significantes

Aeromycological studies in the crops of the main cereals: A systematic review

Aeromycological studies on cereal crops allow to determine the temporal variation of plant pathogens affecting the crop and to determine the appropriate time to apply fungicides. However, this topic has not been systematically reviewed. The aim of this work was to systematically analyze all aeromycological studies carried out on corn, wheat, rice, oats, barley, rye, sorghum, and millet. A systematic search was carried out in Scopus from the start of the database until 1 August 2022. Inclusion criteria were that they were aeromycological studies on wheat or rice or corn or oats or sorghum or rye or barley or millet and studies published in peer-reviewed journals indexed in Journal Citation Reports and written in English or Spanish. Forty-three studies (21 in wheat, 15 in rice, 5 in corn, 1 in sorghum, and 2 in barley) that met all eligibility criteria were included (one of the studies in corn was also conducted in wheat). No aeromycological studies were found in oats, rye, and millet. It was noted that most aeromycological research has been conducted on wheat crops and predominantly in countries in the Americas. Also, fungal propagules are mainly collected by non-viable methods, using various types of collectors. Generally, the studies were aimed at identifying a specific pathogen and not at the diversity of pathogens that can be found. The relationship of the fungi identified with meteorological parameters was variable in the different studies. This systematic review helps to summarize aeromycological studies that have been conducted on wheat, rice, corn, sorghum, and barley crops. It also suggests where future studies in this area should be directed, based on the limitations encountered

In vitro health promoting properties of antioxidant dietary fiber extracted from spent coffee (Coffee arabica L.) grounds

Antioxidant dietary fiber extracted from spent coffee grounds (FSCG) was evaluated as a potential functional food ingredient when incorporated in a food model (biscuits), and digested in vitro under simulated human gastrointestinal conditions. FSCG added to biscuits increased its total dietary fiber, antioxidant capacity after in vitro digestion, bioaccessibility of phenolic compounds (gallic acid and catechin) and amino acids. Furthermore, advanced glycation end products (AGEs), involved in chronic diseases, decreased up to 6-folds in the biscuits containing FSCG when compared with the traditional biscuit. The digestible fraction of biscuits containing the highest amount of FSCG (5 g) displayed the higher inhibiting α-glucosidase activity, correlating with the bioaccessibility of ascorbic acid and catechin. Our study seems to indicate that anti-diabetic compounds may be released in the small intestine during FSCG digestion, where biscuits containing FSCG may be able to beneficially regulate sugar metabolism thereby helping in producing foods friendly for diabetes.This study was supported by the National Council of Science and Technology (CONACYT) Project No. 242282 and the AGL2014-57239-R, MINECO, Madrid, Spain project.Peer reviewe

Tópicos de marketing

Lograr un equilibrio entre acciones humanas, armonía con la naturaleza, y satisfacer las necesidades del mercado actual sin poner en riesgo aquellos recursos que pudieran precisar las futuras generaciones, es lo importante de impulsar la aplicación del marketing sostenible en las organizaciones. Esto se logra a través de la elaboración de un plan de marketing sostenible que permitirá promover un consumo responsable a través de información clara y oportuna sobre los beneficios personales y sociales que genera la adquisición de productos sostenibles; implantar el reciclado a través de la logística de reversa, procedimiento que origina poca o nula generación de desechos, proporcionar empleos seguros, apoyar al medio ambiente y con responsabilidad social, son algunos beneficios que aporta. El presente capítulo tiene como objetivo proporcionar los principales aspectos que abordan el marketing sostenible, mostrar la importancia de la realización de este marketing para las empresas, así como aportar los pasos para desarrollar un plan de marketing sostenible

À qui profite les réseaux de transport ?

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Effects of copy number variations on brain structure and risk for psychiatric illness: Large-scale studies from the ENIGMA Working Groups on CNVs

The Enhancing Neuroimaging Genetics through Meta-Analysis copy number variant (ENIGMA-CNV) and 22q11.2 Deletion Syndrome Working Groups (22q-ENIGMA WGs) were created to gain insight into the involvement of genetic factors in human brain development and related cognitive, psychiatric and behavioral manifestations. To that end, the ENIGMA-CNV WG has collated CNV and magnetic resonance imaging (MRI) data from ~49,000 individuals across 38 global research sites, yielding one of the largest studies to date on the effects of CNVs on brain structures in the general population. The 22q-ENIGMA WG includes 12 international research centers that assessed over 533 individuals with a confirmed 22q11.2 deletion syndrome, 40 with 22q11.2 duplications, and 333 typically developing controls, creating the largest-ever 22q11.2 CNV neuroimaging data set. In this review, we outline the ENIGMA infrastructure and procedures for multi-site analysis of CNVs and MRI data. So far, ENIGMA has identified effects of the 22q11.2, 16p11.2 distal, 15q11.2, and 1q21.1 distal CNVs on subcortical and cortical brain structures. Each CNV is associated with differences in cognitive, neurodevelopmental and neuropsychiatric traits, with characteristic patterns of brain structural abnormalities. Evidence of gene-dosage effects on distinct brain regions also emerged, providing further insight into genotype-phenotype relationships. Taken together, these results offer a more comprehensive picture of molecular mechanisms involved in typical and atypical brain development. This ‘genotype-first’ approach also contributes to our understanding of the etiopathogenesis of brain disorders. Finally, we outline future directions to better understand effects of CNVs on brain structure and behavior