Intermolecular force calculations based on the EXP-6 pair potential

Imperial Users onl

Improving our fitnesse: From concrete executions to partial specification

Fitnesse and FIT [5] allow systems tests to be written by non-programmers using a Wiki or HTML style of input. However, there is little support for syntactic and semantic checks as the tests are being designed. This paper describes a support tool for designing table-based test cases that gives deep semantic analysis about a set of test cases. It uses a variety of strategies such as pairwise analysis, boundary value analysis and test case subsumption to suggest missing test cases and to generalise concrete tests into more abstract tests. The goal is to interactively improve the quality of test suites during the test design phase

A multinational, multi-institutional study of assessment of programming skills of first-year CS students

In computer science, an expected outcome of a student's education is programming skill. This working group investigated the programming competency students have as they complete their first one or two courses in computer science. In order to explore options for assessing students, the working group developed a trial assessment of whether students can program. The underlying goal of this work was to initiate dialog in the Computer Science community on how to develop these types of assessments. Several universities participated in our trial assessment and the disappointing results suggest that many students do not know how to program at the conclusion of their introductory courses. For a combined sample of 216 students from four universities, the average score was 22.89 out of 110 points on the general evaluation criteria developed for this study. From this trial assessment we developed a framework of expectations for first-year courses and suggestions for further work to develop more comprehensive assessments

Evolving web-based test automation into agile business specifications

Usually, test automation scripts for a web application directly mirror the actions that the tester carries out in the browser, but they tend to be verbose and repetitive, making them expensive to maintain and ineffective in an agile setting. Our research has focussed on providing tool-support for business-level, example-based specifications that are mapped to the browser level for automatic verification. We provide refactoring support for the evolution of existing browser-level tests into business-level specifications. As resulting business rule tables may be incomplete, redundant or contradictory, our tool provides feedback on coverage

Hypoxia Inhibits Osteogenesis in Human Mesenchymal Stem Cells through Direct Regulation of RUNX2 by TWIST

Bone loss induced by hypoxia is associated with various pathophysiological conditions, however, little is known about the effects of hypoxia and related signaling pathways on osteoblast differentiation and bone formation. Because bone marrow-derived mesenchymal stem cells (MSCs) survive under hypoxic conditions and readily differentiate into osteoblasts by standard induction protocols, they are a good in vitro model to study the effects of hypoxia on osteoblast differentiation.Using human MSCs, we discovered TWIST, a downstream target of HIF-1α, was induced under hypoxia and acted as a transcription repressor of RUNX2 through binding to the E-box located on the promoter of type 1 RUNX2. Suppression of type 1 RUNX2 by TWIST under hypoxia further inhibited the expression of BMP2, type 2 RUNX2 and downstream targets of RUNX2 in MSCs.Our findings point to the important role of hypoxia-mediated signalling in osteogenic differentiation in MSCs through direct regulation of RUNX2 by TWIST, and provide a method for modifying MSC osteogenesis upon application of these cells in fracture healing and bone reconstruction

Marketing as a means to transformative social conflict resolution: lessons from transitioning war economies and the Colombian coffee marketing system

Social conflicts are ubiquitous to the human condition and occur throughout markets, marketing processes, and marketing systems.When unchecked or unmitigated, social conflict can have devastating consequences for consumers, marketers, and societies, especially when conflict escalates to war. In this article, the authors offer a systemic analysis of the Colombian war economy, with its conflicted shadow and coping markets, to show how a growing network of fair-trade coffee actors has played a key role in transitioning the country’s war economy into a peace economy. They particularly draw attention to the sources of conflict in this market and highlight four transition mechanisms — i.e., empowerment, communication, community building and regulation — through which marketers can contribute to peacemaking and thus produce mutually beneficial outcomes for consumers and society. The article concludes with a discussion of implications for marketing theory, practice, and public policy

Reviewing the family unit as a stakeholder in talent development: Is it undervalued?

As elite youth sport becomes more organized and professionalized, the role of the family is increasingly acknowledged as significant to the development of young talent. High profile examples across a range of professional sports, both positive and negative, have drawn attention towards this important stakeholder. Accordingly, in this review we first examine the key issues in relation to family involvement in Talent Development, with relation to what is perceived as good and bad practice on behalf of the family. We next consider the key theoretical underpinning, Family Systems Theory, and how it may be integrated within elite youth sport. Finally, we conclude with a summary of where the current literature leaves us, and where we can progress from here. We suggest two possible inputs that could benefit the effectiveness of family involvement, with a focus on the family holistically, and a second on the role different family members can play