Aspectos farmacológicos de las anfetaminas

El amplio grupo de sustancias que componen los derivados de la estructura fenilisopropilamina se encuentra en unestado de continua renovación debido al auge del consumo y tráfico ilícito de drogas como el éxtasis (MDMA), MDA,STP, DOI, etc... El estudio de su mecanismo de acción implica la participación de neurotransmisores como Dopamina,Serotonina y Catecolaminas, con un complejo comportamiento que da lugar a una difícil interpretación de losmúltiples efectos aparecidos durante su consumo. Así mismo, los derivados anfetamínicos que se conservan en elarsenal terapéutico con fines anorexígenos, presentan todas las propiedades estimulantes de la molécula inicial, conel mismo riesgo implícito que cualquiera de las de tráfico ilegal

Relaciones históricas entre olmos y vides

In Spanish, the expression «You cannot ask an elm for pears» denotes something that is impossible. Although its origin is unknown, it can be dated back to the 1st century BC, when appeared the Latin maxim Pirum, non ulmum accedas, si cupias pira (You should go to a pear-tree for pears, not to an elm), a sentence from which we believe the Spanish saying comes. The objective of this paper is to show how the historical relationship of elms and vines can be related to these expressions, because elms did not give pears but, figuratively, did give grapes. The cultivation of vines was soon included among the domestic plants at the beginning of the Neolithic Age. During the Assyrian Empire (7th century BC), vines are represented growing up around pine-like trees. The first documentary evidence of the marriage between elms and vines is found in the Ancient Greece: a wine called Pteleaikós oinos is mentioned, which refers to the region where it was produced, Ptelea (Elm). During the Roman Ages, the cultivation of vines married to elms became more important as it is reflected in the treatises in agriculture. This technique was so common that it appears recurrently as a topic in Poetry and Drama. The classical books were copied during the Middle Ages, and only the Arabian agronomists in the Iberian Peninsula gave new evidence of the relationship between vines and elms in the 12th century. Some four hundred years later the use of elms as props for vines was rare in Spain and, although not to elms, the marriage of vines to trees lasted in the South of Spain until the 19th century. In Italy, elms and vines were even planted together in the 20th century, before the Dutch Elm Disease began to kill the plantations of trees and farmers were forced to replace them with poles.En castellano, la expresión «No se le puede pedir peras al olmo» indica algo imposible. A pesar de que su origen es desconocido, puede situarse en el siglo I A.C., cuando aparece la máxima latina Pirum, non ulmum accedas, si cupias pira (Al peral acude, no al olmo, si quieres peras), de la cual creemos que procede la expresión española. En este trabajo se pretende mostrar que la relación histórica de los olmos y las vides puede estar relacionada con estas expresiones en la medida en que los olmos no daban peras mas, en sentido figurado, daban uvas. La vid fue una de las primeras plantas cultivadas ya desde el comienzo del Neolítico. En el Imperio Asirio (s. VII A.C.), las vides aparecen representadas creciendo alrededor de árboles que se asemejan a pinos. La primera evidencia documental del maridaje de olmos y vides la encontramos en la Grecia Clásica, donde se menciona un vino llamado Pteleaikós oinos que hace referencia a la región dónde se producía, Ptelea (Olmo). Durante la época Romana el cultivo de las vides maridadas a los olmos adquiere mayor importancia, como se refleja en los tratados de agricultura. La práctica fue tan común que aparece de modo recurrente como tópico en la literatura. Los textos clásicos son copiados durante la Edad Media, y sólo los agrónomos árabes de la península Ibérica proporcionan nuevas evidencias de la relación entre vides y olmos ya en el siglo XII. Cuatro siglos después la utilización de olmos como tutores de las vides era rara en España, pero el maridaje de las vides con árboles, aunque no olmos, duró en el Sur de España hasta el siglo XIX. Sin embargo en Italia olmos y vides se plantaban juntos incluso en el siglo XX, antes de que la grafiosis comenzara a matar las plantaciones de árboles y los agricultores se vieran obligados a sustituirlos por postes

Academic literacy and student diversity: evaluating a curriculum-integrated inclusive practice intervention in the United Kingdom

The sustainability of universities is based, among other aspects, on their ability to adapt to changes and the needs of students, an increasingly diverse population. In this sense, Academic literacy provision at universities tends to be centralized and to offer language support for general academic literacy purposes rather than language development that responds in a more nuanced way to the particular literacy needs of students’ disciplines. Yet, in recent years, several studies have supported the integration of academic literacy into subject teaching outlining the principles of an inclusive model of academic literacy instruction. This paper draws on a theoretical framework developed by Wingate to evaluate a curriculum-integrated inclusive practice intervention in the United Kingdom with students from a first-year credit-bearing module at Middlesex University Business School. The study used a mixed methods approach that includes a literature review, secondary data, feedback questionnaire and a focus group to evaluate our teaching method and reflect on the collaboration of the team members to develop this inclusive pedagogical approach. The findings suggest that, on the whole, this intervention was perceived by both the module teaching team and students as positive, welcoming and often crucial for supporting undergraduate students into the disciplinary discourse of their subject of study. Yet, recommendations were made with respect to developing better guidelines for subject lecturers on how to deliver the integrated academic literacy as well as the importance of the participation of students, student learning assistants and graduate teaching assistants in the design of the intervention. This study contributes to the literature on inclusive practice intervention and pedagogical approaches to integrating academic literacy into subject teaching for a diverse student population, contributing to the social sustainability of the universities

Identification of an inducible nitric oxide synthase in diaphragm mitochondria from septic miceIts relation with mitochondrial dysfunction and prevention by melatonin

Producción CientíficaSepsis provokes an induction of inducible nitric oxide synthase (iNOS) and melatonin down-regulates its expression and activity. Looking for an inducible mtNOS isoform, we induced sepsis by cecal ligation and puncture in both normal and iNOS knockout mice and studied the changes in mtNOS activity. We also studied the effects of mtNOS induction in mitochondrial function, and the role of melatonin against induced mtNOS and mitochondrial dysfunction. The activity of mtNOS and nitrite levels significantly increased after sepsis in iNOS+/+ mice. These animals showed a significant inhibition of the respiratory chain activity and an increase in mitochondrial oxidative stress, reflected in the disulfide/glutathione ratio, glutathione redox cycling enzymes activity and lipid peroxidation levels. Interestingly, mtNOS activity remained unchanged in iNOS-/- septic mice, and mitochondria of these animals were unaffected by sepsis. Melatonin administration to iNOS+/+ mice counteracted mtNOS induction and respiratory chain failure, restoring the redox status. The results support the existence of an inducible mtNOS that is likely coded by the same gene as iNOS. The results also suggest that sepsis-induced mtNOS is responsible for the increase of mitochondrial impairment due to oxidative stress in sepsis, perhaps due to the high production of NO. Melatonin treatment prevents mitochondrial failure at the same extend as the lack of iNOS gene

Sheep husbandry in the early Neolithic of the Pyrenees: new data on feeding and reproduction in the cave of Chaves

Sheep predominate the Early Neolithic faunal assemblages in the Iberian Peninsula. Their exploitation for meat and milk production made them key to the economy of these early farming societies. Management of sheep breeding season and feeding in the context of the local environment were decisive in obtaining these livestock products. This work focuses on these aspects through stable isotope and dental microwear analyses on sheep teeth from the cave of Chaves (Huesca, Spain). The results show the existence of “out of season” (autumn/early winter) sheep births in the Early Neolithic, contrasting significantly with spring lambing prevailing in Neolithic husbandries elsewhere in Europe and confirming the antiquity of a western Mediterranean characteristic in this regard. Furthermore, little changes in sheep diet throughout the year have been documented, as far as could be evidenced from stable carbon isotope ratios and dental microwear. Only two individuals showed higher variability in diet on a seasonal scale with possible contribution of C4 plants, possibly from grazing in the valley steppes at lower altitudes. Overall the results suggest good adaptation of sheep to the Pyrenean mid-altitude environment and strong zootechnical knowledge of the earliest shepherds in this area

Dendro-anthracological tools applied to Scots type pine forests exploitation as fuel during the Mesolithic-Neolithic transition in the southern central pre-Pyrenees (Spain)

This work focuses on the reconstruction of fuelwood procurement during the Mesolithic-Neolithic transition in the southern central Pre-Pyrenees (Spain). The study combines wood charcoal identification with the application of dendro-anthracological approaches in the archaeological sequence of Esplugón (9.4–6.8 kyr cal BP) (Sabiñanigo, Huesca). Scots type pine (Pinus sylvestris tp.) reaches in this record around 90% of exploited firewood in line with its abundance in the inner Iberia mountainous areas during the onset of the Holocene. The classification of pine wood fragments in anthraco-groups is based on the combination of different dendro-anthracological tools: i) pith location tool and wood diameter estimation based on the trigonomethric method tool (ADmodel), ii) the study of growth rate based on the annual tree-ring width measurements, and iii) a modern dendrological dataset. There are hardly any differences observed in firewood procurement between the last hunter-gatherers and the first farmers in the long sequences from rock-shelters with recurrent human occupations. First results from this site point to the exploitation of whole trees but a high use of small pine branches probably from the gathering of branch shedding

Understanding illnesses through a film festival: an observational study

Audio-visual materials play a fundamental role in the context of education, care and clinical treatment, as they seem to have a high impact on public awareness. This study aims to describe what messages are perceived by the society at an International Festival of Short Films and Art on Diseases that may help to understand difficult topics, such as illness, dying and suffering. Through an observational, descriptive, cross-sectional study, using full participant observation and an open, self-administered questionnaire, 32 short films were analysed during a healthcare art festival. Categories were developed using inductive content analysis. The message perceived by the participants, after the viewing of the shorts and reflection of the debates among the attendees, were considered in four categories: i) creative and positive education is possible; ii) awareness of preconception and practical duties; iii) meaning of life changes the experience of illness; iv) family and caregivers also experienced suffering. The short films are considered as an excellent tool to generate social dialogue and debate. Public events can be understood as an opportunity to ac- quire, in an emotional and critical manner, other competencies for public awareness. Together, they are capable of communicating difficult messages through a fast, positive, and creative way

Community impacts of anthropogenic disturbance: natural enemies exploit multiple routes in pursuit of invading herbivore hosts.

This is the final version of the article. Available from the publisher via the DOI in this record.BACKGROUND: Biological invasions provide a window on the process of community assembly. In particular, tracking natural enemy recruitment to invading hosts can reveal the relative roles of co-evolution (including local adaptation) and ecological sorting. We use molecular data to examine colonisation of northern Europe by the parasitoid Megastigmus stigmatizans following invasions of its herbivorous oak gallwasp hosts from the Balkans. Local host adaptation predicts that invading gallwasp populations will have been tracked primarily by sympatric Balkan populations of M. stigmatizans (Host Pursuit Hypothesis). Alternatively, ecological sorting allows parasitoid recruitment from geographically distinct populations with no recent experience of the invading hosts (Host Shift Hypothesis). Finally, we test for long-term persistence of parasitoids introduced via human trade of their hosts' galls (Introduction Hypothesis). RESULTS: Polymorphism diagnostic of different southern refugial regions was present in both mitochondrial and nuclear microsatellite markers, allowing us to identify the origins of northern European invaded range M. stigmatizans populations. As with their hosts, some invaded range populations showed genetic variation diagnostic of Balkan sources, supporting the Host Pursuit Hypothesis. In contrast, other invading populations had an Iberian origin, unlike their hosts in northern Europe, supporting the Host Shift Hypothesis. Finally, both British and Italian M. stigmatizans populations show signatures compatible with the Introduction Hypothesis from eastern Mediterranean sources. CONCLUSIONS: These data reveal the continental scale of multi-trophic impacts of anthropogenic disturbance and highlight the fact that herbivores and their natural enemies may face very different constraints on range expansion. The ability of natural enemies to exploit ecologically-similar hosts with which they have had no historical association supports a major role for ecological sorting processes in the recent assembly of these communities. The multitude of origins of invading natural enemy populations in this study emphasises the diversity of mechanisms requiring consideration when predicting consequences of other biological invasions or biological control introductions.Funding was provided by NERC grant NE/B504406/1 to GNS and KS and NE/E014453/1 to GNS and JAN

Determination and analysis of in situ spectral aerosol optical properties by a multi-instrumental approach

Continuous in situ measurements of aerosol optical properties were conducted from 29 June to 29 July 2012 in Granada (Spain) with a seven-wavelength Aethalometer, a Multi-Angle Absorption Photometer, and a three-wavelength integrating nephelometer. The aim of this work is to describe a methodology to obtain the absorption coefficients (babs) for the different Aethalometer wavelengths. In this way, data have been compensated using algorithms which best estimate the compensation factors needed. Two empirical factors are used to infer the absorption coefficients from the Aethalometer measurements: C – the parameter describing the enhancement of absorption by particles in the filter matrix due to multiple scattering of light in the filter matrix – and f, the parameter compensating for non-linear loading effects in the filter matrix. Spectral dependence of f found in this study is not very strong. Values for the campaign lie in the range from 1.15 at 370 nm to 1.11 at 950 nm. Wavelength dependence in C proves to be more important, and also more difficult to calculate. The values obtained span from 3.42 at 370 nm to 4.59 at 950 nm. Furthermore, the temporal evolution of the Ångström exponent of absorption (αabs) and the single-scattering albedo (ω0) is presented. On average αabs is around 1.1 ± 0.3, and ω0 is 0.78 ± 0.08 and 0.74 ± 0.09 at 370 and 950 nm, respectively. These are typical values for sites with a predominance of absorbing particles, and the urban measurement site in this study is such. The babs average values are of 16 ± 10 Mm−1 (at 370 nm) and 5 ± 3 Mm−1 (at 950 nm), respectively. Finally, differences between workdays and Sundays have been further analysed, obtaining higher babs and lower ω0 during the workdays than on Sundays as a consequence of the diesel traffic influence.This work was financed jointly by the Spanish Ministry of Economy and Competitiveness and the European Regional Development Fund through projects CGL2011-24290, CGL2010-18782, CSD2007-00067, and CGL2012-33294; by the Valencia Autonomous Government through project PROMETEO/2010/064; the Andalusia Regional Government through projects P08-RNM-3568 and P10-RNM-6299; and by the Slovenian Ministry of Economic Development and Technology JR-KROP grant 3211-11-000519. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement no. 262254 (ACTRIS). The collaboration of S. Segura in this work was possible thanks to fellowship BES-2010-031626