1,462 research outputs found
Polyunsaturated fatty acid-derived lipid mediators and T cell function
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open-
access article distributed under the terms of the
Creative Commons Attribution License
(CC BY)
. The use, distribution or reproduction in other forums is permitted, provided
the original author(s) or licensor are credited and that the original publication in this
journal is cited, in accordance with accepted academic practice. No use, distribution or
reproduction is permitted which does not comply with these terms
Polyunsaturated fatty acid-derived lipid mediators and T cell function
Copyright © 2014 Nicolaou, Mauro, Urquhart and Marelli-Berg . This is an open-
access article distributed under the terms of the
Creative Commons Attribution License
(CC BY)
. The use, distribution or reproduction in other forums is permitted, provided
the original author(s) or licensor are credited and that the original publication in this
journal is cited, in accordance with accepted academic practice. No use, distribution or
reproduction is permitted which does not comply with these terms
The implementation and use of Ada on distributed systems with reliability requirements
The issues involved in the use of the programming language Ada on distributed systems are discussed. The effects of Ada programs on hardware failures such as loss of a processor are emphasized. It is shown that many Ada language elements are not well suited to this environment. Processor failure can easily lead to difficulties on those processors which remain. As an example, the calling task in a rendezvous may be suspended forever if the processor executing the serving task fails. A mechanism for detecting failure is proposed and changes to the Ada run time support system are suggested which avoid most of the difficulties. Ada program structures are defined which allow programs to reconfigure and continue to provide service following processor failure
Carbamazepine on a carbamazepine monolayer forms unique 1D supramolecular assemblies
High-resolution STM imaging of the structures formed by carbamazepine molecules adsorbed onto a pseudo-ordered carbamazepine monolayer on Au(111) shows the formation of previously unreported 1-dimensional supramolecular assemblies
ATLASGAL - environments of 6.7 GHz methanol masers
Using the 870 micron APEX Telescope large area survey of the Galaxy, we have identified 577 submillimetre continuum sources with masers from the methanol multibeam survey in the region 280deg lt ell lt 20deg; |b| lt 1deg.5 94 per cent of methanol masers in the region are associated with submillimetre dust emission. We estimate masses for tilde450 maser-associated sources and find that methanol masers are preferentially associated with massive clumps. These clumps are centrally condensed, with envelope structures that appear to be scale-free, the mean maser position being offset from the peak column density by 0 plusmn 4 arcsec. Assuming a Kroupa initial mass function and a star formation efficiency of tilde30 per cent, we find that over two-thirds of the clumps are likely to form clusters with masses gt20 M. Furthermore, almost all clumps satisfy the empirical mass-size criterion for massive star formation. Bolometric luminosities taken from the literature for tilde100 clumps range between tilde100 and 10 L. This confirms the link between methanol masers and massive young stars for 90 per cent of our sample. The Galactic distribution of sources suggests that the star formation efficiency is significantly reduced in the Galactic Centre region, compared to the rest of the survey area, where it is broadly constant, and shows a significant drop in the massive star formation rate density in the outer Galaxy. We find no enhancement in source counts towards the southern Scutum-Centaurus arm tangent at ell tilde 315deg, which suggests that this arm is not actively forming stars.Peer reviewe
hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
hSSB1 is a recently discovered single-stranded DNA binding protein that is essential for efficient repair of DNA double-strand breaks (DSBs) by the homologous recombination pathway. hSSB1 is required for the efficient recruitment of the MRN complex to sites of DSBs and for the efficient initiation of ATM dependent signalling. Here we explore the interplay between hSSB1 and MRN. We demonstrate that hSSB1 binds directly to NBS1, a component of the MRN complex, in a DNA damage independent manner. Consistent with the direct interaction, we observe that hSSB1 greatly stimulates the endo-nuclease activity of the MRN complex, a process that requires the C-terminal tail of hSSB1. Interestingly, analysis of two point mutations in NBS1, associated with Nijmegen breakage syndrome, revealed weaker binding to hSSB1, suggesting a possible disease mechanism.Publisher PDFPeer reviewe
Characterisation of the Mopra Radio Telescope at 16--50 GHz
We present the results of a programme of scanning and mapping observations of
astronomical masers and Jupiter designed to characterise the performance of the
Mopra Radio Telescope at frequencies between 16-50 GHz using the 12-mm and 7-mm
receivers. We use these observations to determine the telescope beam size, beam
shape and overall telescope beam efficiency as a function of frequency. We find
that the beam size is well fit by / over the frequency range with a
correlation coefficient of ~90%. We determine the telescope main beam
efficiencies are between ~48-64% for the 12-mm receiver and reasonably flat at
~50% for the 7-mm receiver. Beam maps of strong HO (22 GHz) and SiO masers
(43 GHz) provide a means to examine the radial beam pattern of the telescope.
At both frequencies the radial beam pattern reveals the presence of three
components, a central `core', which is well fit by a Gaussian and constitutes
the telescopes main beam, and inner and outer error beams. At both frequencies
the inner and outer error beams extend out to approximately 2 and 3.4 times the
full-width half maximum of the main beam respectively. Sources with angular
sizes a factor of two or more larger than the telescope main beam will couple
to the main and error beams, and therefore the power contributed by the error
beams needs to be considered. From measurements of the radial beam power
pattern we estimate the amount of power contained in the inner and outer error
beams is of order one-fifth at 22 GHz rising slightly to one-third at 43 GHz.Comment: Accepted for publication in PAS
PEGylated silk nanoparticles for anticancer drug delivery
Silk has a robust clinical track record and is emerging as a promising biopolymer for drug delivery, including its use as nanomedicine. However, silk-based nanomedicines still require further refinements for full exploitation of their potential; the application of "stealth" design principals is especially necessary to support their evolution. The aim of this study was to develop and examine the potential of PEGylated silk nanoparticles as an anticancer drug delivery system. We first generated B. mori derived silk nanoparticles by driving β-sheet assembly (size 104 ± 1.7 nm, zeta potential -56 ± 5.6 mV) using nanoprecipitation. We then surface grafted polyethylene glycol (PEG) to the fabricated silk nanoparticles and verified the aqueous stability and morphology of the resulting PEGylated silk nanoparticles. We assessed the drug loading and release behavior of these nanoparticles using clinically established and emerging anticancer drugs. Overall, PEGylated silk nanoparticles showed high encapsulation efficiency (>93%) and a pH-dependent release over 14 days. Finally, we demonstrated significant cytotoxicity of drug loaded silk nanoparticles applied as single and combination nanomedicines to human breast cancer cells. In conclusion, these results, taken together with prior silk nanoparticle data, support a viable future for silk-based nanomedicines
Sedigism: Structure, Excitation, And Dynamics Of The Inner Galactic Interstellar Medium
The origin and life-cycle of molecular clouds are still poorly constrained, despite their importance for understanding the evolution of the interstellar medium. Many large-scale surveys of the Galactic plane have been conducted recently, allowing for rapid progress in this field. Nevertheless, a sub-arcminute resolution global view of the large-scale distribution of molecular gas, from the diffuse medium to dense clouds and clumps, and of their relationshipto the spiral structure, is still missing
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