7 research outputs found
Muscular and tendon degeneration after achilles rupture: new insights into future repair strategies
Achilles tendon rupture is a frequent injury with an increasing incidence. After clinical surgical repair, aimed at suturing the tendon stumps back into their original position, the repaired Achilles tendon is often plastically deformed and mechanically less strong than the pre-injured tissue, with muscle fatty degeneration contributing to function loss. Despite clinical outcomes, pre-clinical research has mainly focused on tendon structural repair, with a lack of knowledge regarding injury progression from tendon to muscle and its consequences on muscle degenerative/regenerative processes and function. Here, we characterize the morphological changes in the tendon, the myotendinous junction and muscle belly in a mouse model of Achilles tendon complete rupture, finding cellular and fatty infiltration, fibrotic tissue accumulation, muscle stem cell decline and collagen fiber disorganization. We use novel imaging technologies to accurately relate structural alterations in tendon fibers to pathological changes, which further explain the loss of muscle mechanical function after tendon rupture. The treatment of tendon injuries remains a challenge for orthopedics. Thus, the main goal of this study is to bridge the gap between clinicians'' knowledge and research to address the underlying pathophysiology of ruptured Achilles tendon and its consequences in the gastrocnemius. Such studies are necessary if current practices in regenerative medicine for Achilles tendon ruptures are to be improved
The Cell Tracking Challenge: 10 years of objective benchmarking
The Cell Tracking Challenge is an ongoing benchmarking initiative that
has become a reference in cell segmentation and tracking algorithm
development. Here, we present a signifcant number of improvements
introduced in the challenge since our 2017 report. These include the
creation of a new segmentation-only benchmark, the enrichment of
the dataset repository with new datasets that increase its diversity and
complexity, and the creation of a silver standard reference corpus based
on the most competitive results, which will be of particular interest for
data-hungry deep learning-based strategies. Furthermore, we present
the up-to-date cell segmentation and tracking leaderboards, an in-depth
analysis of the relationship between the performance of the state-of-the-art
methods and the properties of the datasets and annotations, and two
novel, insightful studies about the generalizability and the reusability
of top-performing methods. These studies provide critical practical
conclusions for both developers and users of traditional and machine
learning-based cell segmentation and tracking algorithms.Web of Science2071020101
Comunicación intraprofesional durante el cambio de turno a pie de cama. Percepciones del paciente
Introduction. More than 65% of the sentinel errors that take place in hospitals are related to communication issues. Among the safety
measures promoted by OMS in order to reduce errors, there is the development of strategies that improve communication at shift
change, such as including patients and relatives as an active part of the process. Nowadays, bedside communication at shift change
(BCSC) is considered to be the Gold Standard for the transfer of responsibility, and it has been described that it improves the safety
of the process and increases patient’s satisfaction. The aim of this research study is to explore patients‘ perceptions regarding BCSC.
Methodology. Descriptive study carried out at the special hospitalization area of a tertiary care university hospital. Patients‘
perception was evaluated through a questionnaire developed after a literature review.
Results. Three main issues arise from the analysis of the open-ended questions of the questionnaire: Patient’s Feelings and
Robustness and Limitations of the process
Discussion and conclusions. Patients perceive BCSC as being positive. They also report that conducting the process at the bedside
may increase their safety, since it improves patient-centered care and the quality of the information transmitted and facilitates
communication. However, the use of professional jargon may hinder the participation in the process.Introducción. Más de un 65% de los errores centinela que ocurren en los hospitales, están relacionados con problemas de
comunicación. Entre las medidas de seguridad que promueve la OMS para reducir errores, se encuentra el desarrollo de estrategias
que mejoren la comunicación en el cambio de turno, como el incluir a pacientes y familiares como parte activa del proceso. Hoy en día,
la comunicación en el cambio de turno a pie de cama (CCTPC) se considera el Gold Standar para la transferencia de responsabilidad y
se ha descrito que mejora la seguridad del proceso y aumenta la satisfacción del paciente. El objetivo de este estudio de investigación
es explorar la percepción de los pacientes en relación a la CCTPC.
Metodología. Estudio descriptivo llevado a cabo en el área de hospitalización especial de un hospital universitario de nivel terciario.
Se evaluó la percepción de los pacientes a través de un cuestionario elaborado tras una revisión de la literatura.
Resultados. Del análisis de las preguntas abiertas del cuestionario surgen 3 temas principales: Sentimientos del paciente, Fortalezas
y Limitaciones del proceso.
Discusión y conclusiones. Los pacientes perciben que la CCTPC es positiva, además refieren que llevar a cabo el proceso a pie de
cama puede aumentar su seguridad, ya que se mejora la atención centrada en el paciente, la calidad de la información transmitida y se
facilita la comunicación. Sin embargo, el uso de jerga profesional puede dificultar la participación en el proceso
On the Fertilizer Three Element Treatments of Rice Crops Sampled for Leaf Analysis by Field
Rice crops field experiment grown on fertilizer three element treatments was carried out in 1952-54. at Fukigami, Takigun, Hyogo Pref. The effect of N element was most remarkable from 1st year in total yield, and that of P was not significant until 3rd year. K effect was not significant in 1st year, but gradually became significant since 2nd year. Details of growth and yield results are shown in the tables