Effect of viral storm in patients admitted to intensive care units with severe COVID-19 in Spain: a multicentre, prospective, cohort study

Background: The contribution of the virus to the pathogenesis of severe COVID-19 is still unclear. We aimed to evaluate associations between viral RNA load in plasma and host response, complications, and deaths in critically ill patients with COVID-19. Methods: We did a prospective cohort study across 23 hospitals in Spain. We included patients aged 18 years or older with laboratory-confirmed SARS-CoV-2 infection who were admitted to an intensive care unit between March 16, 2020, and Feb 27, 2021. RNA of the SARS-CoV-2 nucleocapsid region 1 (N1) was quantified in plasma samples collected from patients in the first 48 h following admission, using digital PCR. Patients were grouped on the basis of N1 quantity: VIR-N1-Zero ([removed]2747 N1 copies per mL). The primary outcome was all-cause death within 90 days after admission. We evaluated odds ratios (ORs) for the primary outcome between groups using a logistic regression analysis. Findings: 1068 patients met the inclusion criteria, of whom 117 had insufficient plasma samples and 115 had key information missing. 836 patients were included in the analysis, of whom 403 (48%) were in the VIR-N1-Low group, 283 (34%) were in the VIR-N1-Storm group, and 150 (18%) were in the VIR-N1-Zero group. Overall, patients in the VIR-N1-Storm group had the most severe disease: 266 (94%) of 283 patients received invasive mechanical ventilation (IMV), 116 (41%) developed acute kidney injury, 180 (65%) had secondary infections, and 148 (52%) died within 90 days. Patients in the VIR-N1-Zero group had the least severe disease: 81 (54%) of 150 received IMV, 34 (23%) developed acute kidney injury, 47 (32%) had secondary infections, and 26 (17%) died within 90 days (OR for death 0·30, 95% CI 0·16–0·55; p<0·0001, compared with the VIR-N1-Storm group). 106 (26%) of 403 patients in the VIR-N1-Low group died within 90 days (OR for death 0·39, 95% CI 0·26–0·57; p[removed]11 página

Policy Analysis to Support Informal Workers in Greater Lawndale

A policy analysis was conducted to identify policies that could support informal workers in the Greater Lawndale neighborhood of Chicago. With the guidance of our community partners, Equity and Transformation and Street Vendors Association of Chicago, we decided to concentrate on policies that could make it easier to establish and operate home-based businesses in Greater Lawndale. We aimed to understand the home-based business (HBB) ordinance, its likely impact and continued restrictions. A template to conduct a policy analysis is provided for replicability in academic-community spaces

Understanding the (In)effectiveness of Organizational Diversity, Equity and Inclusion (DEI) Efforts

Organizations spend annually billons of dollars on DEI-efforts. These efforts, however, are not always effective. Showcasing cutting-edge research, this symposium seeks to answer a critical question for management scholars: Why do many of these costly and often well-intentioned DEI-efforts fail to deliver and what can organizations do about it? The presentations seek to answer this question by illuminating key factors and mechanisms with regards to the (in)effectiveness of DEI-efforts. The presentations are followed by an integrative moderated discussion with a focus on what future research is needed and how the insights from the presentations can be used to better shape DEI-efforts