930 research outputs found
Discrete lines and ant algorithms
This is a report on work in progress. The focus is on the design of an
algorithm used to construct discrete lines. It is intended that this is the
first step in applying models of complex adaptive systems to more complex geometric constructs. We construct discrete lines using agents (virtual ants) The agents are given very few rules, and otherwise move freely. With this design we allow a particular line to emerge from the movement of the agents rather than model the line first and then display it
Comparison of the solophenyl-red polarization method and the immunohistochemical analysis for collagen type III
In the present study, we have compared the staining pattern of the Solophenyl-Red 3 BL-method for the visualization of collagen type III with the immunohistochemical staining in serial sections from 7 skin wounds (wound age 3 days up to 4 weeks) to elucidate the specifity of the histochemical staining method. Large amounts of collagen type III were clearly detectable in the investigated wounds using the immunohistochemical technique. In the sections stained with Solophenyl-Red, however, only 3 out of 7 skin lesions showed a significant positive red staining at the wound margin or in the granulation tissue, while the adjacent normal connective tissue revealed a typical intensive staining. Using polarization microscopy no characteristic bright green fibrils, as reported for collagen type 111, could be seen in the wound areas without positive Solophenyl-Red staining. Since the localization of collagen type III detected by immunohistochemistry and the presumed distribution of this collagen type by the Solophenyl-Red method was not identical, the histochemical polarization method has to be regarded as non-specific for visualization of this collagen type
Seagrass ecosystem contributions to people's quality of life in the Pacific Island Countries and Territories
Seagrass ecosystems provide critical contributions (goods and perceived benefits or detriments) for the livelihoods
and wellbeing of Pacific Islander peoples. Through in-depth examination of the contributions provided by
seagrass ecosystems across the Pacific Island Countries and Territories (PICTs), we find a greater quantity in the
Near Oceania (New Guinea, the Bismarck Archipelago and the Solomon Islands) and western Micronesian (Palau
and Northern Marianas) regions; indicating a stronger coupling between human society and seagrass ecosystems.
We also find many non-material contributions historically have been overlooked and under-appreciated by
decision-makers. Closer cultural connections likely motivate guardianship of seagrass ecosystems by Pacific
communities to mitigate local anthropogenic pressures. Regional comparisons also shed light on general and
specific aspects of the importance of seagrass ecosystems to Pacific Islanders, which are critical for forming
evidence-based policy and management to ensure the long-term resilience of seagrass ecosystems and the contributions
they provide
Seagrass ecosystems of the Pacific Island countries and territories: a global bright spot
Seagrass ecosystems exist throughout Pacific Island Countries and Territories (PICTs). Despite this area covering nearly 8% of the global ocean, information on seagrass distribution, biogeography, and status remains largely absent from the scientific literature. We confirm 16 seagrass species occur across 17 of the 22 PICTs with the highest number in Melanesia, followed by Micronesia and Polynesia respectively. The greatest diversity of seagrass occurs in Papua New Guinea (13 species), and attenuates eastward across the Pacific to two species in French Polynesia. We conservatively estimate seagrass extent to be 1446.2 km2, with the greatest extent (84%) in Melanesia. We find seagrass condition in 65% of PICTs increasing or displaying no discernible trend since records began. Marine conservation across the region overwhelmingly focuses on coral reefs, with seagrass ecosystems marginalised in conservation legislation and policy. Traditional knowledge is playing a greater role in managing local seagrass resources and these approaches are having greater success than contemporary conservation approaches. In a world where the future of seagrass ecosystems is looking progressively dire, the Pacific Islands appears as a global bright spot, where pressures remain relatively low and seagrass more resilient
Psychological preparation and postoperative outcomes for adults undergoing surgery under general anaesthesia
Acknowledgements We wish to dedicate this work to the memory of Christian Osmer, a dedicated, caring doctor who was committed to achieving the best care for his patients and their relatives. He saw his contribution to this project as a way of advancing best care for surgical patients. We are very grateful for his valuable input to this work and the pleasure we had in working with him. We are grateful to Karen Hovhanisyan (former Trials Search Co-ordinator, Cochrane Anaesthesia, Critical and Emergency Care Group (ACE)) for carrying out the electronic database searches and to Jane Cracknell (Managing Editor, ACE) for her support throughout the review process. We would also like to thank W Alastair Chambers and Manjeet Shehmar for clinical advice relating to judgements about general anaesthesia usage, and Yvonne Cooper and Louise Pike who retrieved documents and screened papers as research assistants in earlier stages of the review. We are grateful to the following colleagues who helped us with foreign language papers - either by screening papers or by providing translation: Stefano Carrubba, Chuan Gao, Chen Ji, Kate Rhie, Reza Roudsari and Alena Vasianovich. We would like to thank Andy Smith (content editor), Nathan Pace (statistical editor), Michael Donnelly, Allan Cyna and Michael Wang (peer reviewers), and Shunjie Chua (consumer referee) for their help and editorial advice during the preparation of this systematic review. We would also like to thank Andrew Smith (content editor), Nathan Pace (statistical editor), Michael Wang and Allan Cyna (peer reviewers), and Lynda Lane (Cochrane Consumer Network representative) for their help and editorial advice during the preparation of the protocol (Powell 2010). Sources of support Internal sources Manchester Centre for Health Psychology, University of Manchester, UK. An award of ÂŁ2000 was received to support research assistant costs. External sources British Academy, UK. We received a small research grant of ÂŁ7480 to support research assistant costs.Peer reviewedPublisher PD
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The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and haemostasis
Objective: Heat shock protein 47 (HSP47) is an intracellular chaperone protein that is vital for collagen biosynthesis in collagen secreting cells. This protein has also been shown to be present on the surface of platelets. Given the importance of collagen and its interactions with platelets in triggering haemostasis and thrombosis, in this study we sought to characterise the role of HSP47 on these cells.
Approach and Results: The deletion of HSP47 in mouse platelets or its inhibition in human platelets reduced their function in response to collagen and the GPVI agonist (CRP-XL), but responses to thrombin were unaltered. In the absence of functional HSP47, the interaction of collagen with platelets was reduced, and this was associated with reduced GPVI-collagen binding, signalling and platelet activation. Thrombus formation on collagen, under arterial flow conditions was also decreased following the inhibition or deletion of HSP47, in the presence or absence of the eptifibatide, consistent with a role for HSP47 in enhancing platelet adhesion to collagen. Platelet adhesion under flow to von Willebrand Factor was unaltered following HSP47 inhibition. Laser-induced thrombosis in cremaster muscle arterioles was reduced and bleeding time was prolonged in HSP47 deficient mice or following inhibition of HSP47.
Conclusions: Our study demonstrates the presence of HSP47 on the platelet surface where it interacts with collagen, stabilises platelet adhesion and increases collagen mediated signalling and therefore thrombus formation and haemostasis
Lorenz-like systems and classical dynamical equations with memory forcing: a new point of view for singling out the origin of chaos
A novel view for the emergence of chaos in Lorenz-like systems is presented.
For such purpose, the Lorenz problem is reformulated in a classical mechanical
form and it turns out to be equivalent to the problem of a damped and forced
one dimensional motion of a particle in a two-well potential, with a forcing
term depending on the ``memory'' of the particle past motion. The dynamics of
the original Lorenz system in the new particle phase space can then be
rewritten in terms of an one-dimensional first-exit-time problem. The emergence
of chaos turns out to be due to the discontinuous solutions of the
transcendental equation ruling the time for the particle to cross the
intermediate potential wall. The whole problem is tackled analytically deriving
a piecewise linearized Lorenz-like system which preserves all the essential
properties of the original model.Comment: 48 pages, 25 figure
Proyecto de investigaciĂłn para la creaciĂłn de una fototeca digital y un Sistema de InformaciĂłn para Archivos FotogrĂĄficos (SIAF)
DescripciĂłn extensa de un proyecto de investigaciĂłn interdisciplinaria que abarcarĂĄ\ud
las ciencias sociales, la construcciĂłn de fuentes y la informĂĄtica. Dicha investigaciĂłn generarĂĄ\ud
diversos productos, entre ellos, una Fototeca Digital en lĂnea y un Sistema de InformaciĂłn\ud
para Archivos FotogrĂĄficos (SIAF); estos productos responderĂĄn a problemĂĄticas detectadas\ud
en el trabajo con las imĂĄgenes como fuentes de investigaciĂłn en MĂ©xico
Hobsonâs choice? Constraints on accessing spaces of creative production
Successful creative production is often documented to occur in urban areas that are more likely to be diverse, a source of human capital and the site of dense interactions. These accounts chart how, historically, creative industries have clustered in areas where space was once cheap in the city centre fringe and inner city areas, often leading to the development of a creative milieu, and thereby stimulating further creative production. Historical accounts of the development of creative areas demonstrate the crucial role of accessible low-cost business premises. This article reports on the findings of a case study that investigated the location decisions of firms in selected creative industry sectors in Greater Manchester. The study found that, while creative activity remains highly concentrated in the city centre, creative space there is being squeezed and some creative production is decentralizing in order to access cheaper premises. The article argues that the location choices of creative industry firms are being constrained by the extensive city centre regeneration, with the most vulnerable firms, notably the smallest and youngest, facing a Hobsonâs choice of being able to access low-cost premises only in the periphery. This disrupts the delicate balance needed to sustain production and begs the broader question as to how the creative economy fits into the existing urban fabric, alongside the competing demands placed on space within a transforming industrial conurbation
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