On-chip integrated nanowire device platform with controllable nanogap for manipulation, capturing, and electrical characterization of nanoparticles

Cataloged from PDF version of article.We propose and demonstrate nanowire (NW) device platforms on-chip integrated using electric-field-assisted self-assembly. This platform integrates from nanoprobes to microprobes, and conveniently allows for on-chip manipulation, capturing, and electrical characterization of nanoparticles (NPs). Synthesizing segmented (Au–Ag–Au) NWs and aligning them across predefined microelectrode arrays under ac electric field, we controllably form nanogaps between the self-aligned end (Au) segments by selectively removing the middle (Ag) segments. We precisely control and tune the size of this middle section for nanogap formation in the synthesis process. Using electric field across nanogaps between these nanoprobes, we capture NPs to electrically address and probe them at the nanoscale. This approach holds great promise for the construction of single NP devices with electrical nanoprobe contacts

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Metamaterial based telemetric strain sensing in different materials

Cataloged from PDF version of article.We present telemetric sensing of surface strains on different industrial materials using split-ring-resonator based metamaterials. For wireless strain sensing, we utilize metamaterial array architectures for high sensitivity and low nonlinearity-errors in strain sensing. In this work, telemetric strain measurements in three test materials of cast polyamide, derlin and polyamide are performed by observing operating frequency shift under mechanical deformation and these data are compared with commercially-available wired strain gauges. We demonstrate that hard material (cast polyamide) showed low slope in frequency shift vs. applied load (corresponding to high Young's modulus), while soft material (polyamide) exhibited high slope (low Young's modulus). (C) 2010 Optical Society of America

Design and Realization of a Fully On-Chip High-Q Resonator at 15 GHz on Silicon

Cataloged from PDF version of article.We develop and demonstrate an on-chip resonator working at 15 GHz with a high quality factor (Q-factor) of 93.81 while only requiring a small chip size of 195 mu m x 195 mu m on Si by using our new design methodology. In our design, unlike previous approaches, we avoid the need for any external capacitance for tuning; instead, we utilize the film capacitance as the capacitor of the LC tank circuit and realize a fully on-chip resonator that shows a strong transmission dip of > 30 dB on resonance as required for telemetric-sensing applications. We present the design, theory, methodology, microfabrication, experimental characterization, and theoretical analysis of these resonators. We also demonstrate that the experimental results are in excellent agreement with the theoretical (both analytical and numerical) results. Based on our proof-of-concept demonstration, such high-Q on-chip resonators hold great promise for use in transmissive telemetric sensors

Use of evidence to support healthy public policy: a policy effectiveness-feasibility loop

Public policy plays a key role in improving population health and in the control of diseases, including non-communicable diseases. However, an evidence-based approach to formulating healthy public policy has been difficult to implement, partly on account of barriers that hinder integrated work between researchers and policy-makers. This paper describes a “policy effectiveness–feasibility loop” (PEFL) that brings together epidemiological modelling, local situation analysis and option appraisal to foster collaboration between researchers and policy-makers. Epidemiological modelling explores the determinants of trends in disease and the potential health benefits of modifying them. Situation analysis investigates the current conceptualization of policy, the level of policy awareness and commitment among key stakeholders, and what actually happens in practice, thereby helping to identify policy gaps. Option appraisal integrates epidemiological modelling and situation analysis to investigate the feasibility, costs and likely health benefits of various policy options. The authors illustrate how PEFL was used in a project to inform public policy for the prevention of cardiovascular diseases and diabetes in four parts of the eastern Mediterranean. They conclude that PEFL may offer a useful framework for researchers and policy-makers to successfully work together to generate evidence-based policy, and they encourage further evaluation of this approach

Microfluidic production of perfluorocarbon-alginate core-shell microparticles for ultrasound therapeutic applications

The fabrication of micrometer-sized core−shell particles for ultrasound-triggered delivery offers a variety of applications in medical research. In this work, we report the design and development of a glass capillary microfluidic system containing three concentric glass capillary tubes for the development of core−shell particles. The setup enables the preparation of perfluorocarbon-alginate core−shell microspheres in a single process, avoiding the requirement for further extensive purification steps. Core−shell microspheres in the range of 110−130 μm are prepared and are demonstrated to be stable up to 21 days upon immersion in calcium chloride solution or water. The mechanical stability of the particles is tested by injecting them through a 23 gauge needle into a polyacrylamide gel to mimic the tissue matrix. The integrity of the particles is maintained after the injection process and is disrupted after ultrasound exposure for 15 min. The results suggest that the perfluorcarbon-alginate microparticles could be a promising system for the delivery of compounds, such as proteins, peptides, and small-molecule drugs in ultrasound-based therapies.The authors acknowledge Gulden Camci-Unal for her help with the confocal microscope analysis. A.R.C.D. acknowledges the Fulbright Commission for the visiting scholar granted. We also acknowledge the financial support from project "Novel smart and biomimetic materials for innovative regenerative medicine approaches (RL1 - ABMR - NORTE-01-0124-FEDER-000016)" cofinanced by the North Portugal Regional Operational Programme (ON.2 - O Novo Norte) under the National Strategic Reference Framework (NSRF) through the European Regional Development Fund (ERDF) and FEDER

Determining North Atlantic meridional transport variability from pressure on the western boundary: a model investigation.

In this paper we investigate the possibility of determining North Atlantic meridional transport variability using pressure on the western boundary, focusing on the 42degN latitude of the Halifax WAVE array. We start by reviewing the theoretical foundations of this approach. Next we present results from a model analysis, both statistical and dynamic, that demonstrate the feasibility of the approach. We consider how well we can quantify the meridional transport variability at 42degN given complete knowledge of bottom pressure across the basin, and to what degree this quantification is degraded by first ignoring the effect of intervening topography, and then by using only bottom pressure on the western boundary. We find that for periods of greater than one year we can recover more than 90% of the variability of the main overturning cell at 42degN using only the western boundary pressure, provided we remove the depth-average boundary pressure signal. This signal arises from a basin mode of bottom pressure variability, which has power at all timescales, but that does not in truth have a meridional transport signal associated with it, and from the geostrophic depth-independent compensation of the Ekman transport. An additional benefit of the removal of the depth-average pressure is that this high-frequency Ekman signal, which is essentially noise as far as monitoring the MOC for climatically important changes is concerned, is clearly separated from other modes

Dual functionality of conjugated polymer nanoparticles as an anticancer drug carrier and a fluorescent probe for cell imaging

Cataloged from PDF version of article.Multifunctional nanoparticles based on a green emitting, hydrophobic conjugated polymer, poly[(9,9-bis{propeny}fluorenyl-2,7-diyl)-co-(1,4- benzo-{2,1,3}-thiodiazole)] (PPFBT), that acts both as a fluorescent reporter and a matrix to accommodate an anti-cancer compound, camptothecin (CPT), were prepared, characterized and their potential as a fluorescent probe for cell imaging and as a drug delivery vehicle were evaluated via in vitro cell assays. The cell viability of human hepatocellular carcinoma cell line (Huh7) was investigated in the absence and presence of CPT with sulforhodamine B (SRB) and real-time cell electronic sensing (RT-CES) cytotoxicity assays