Inflation Hedging Abilities of Residential Properties in Selected areas of Ibadan Metropolis, Nigeria

For long, investors perceived returns on real estate investments as a hedge against inflation; recently, while various empirical studies undertaken in some countries have produced varying results. In this study, the inflation hedging capacities of returns on residential property investments between the year 2002 and 2014 in selected areas in metropolitan Ibadan, Nigeria were empirically examined to ascertain the uncertain inflation hedging abilities in the areas. The study employed the Ordinary Least Squares regression model to regress the rates of returns of the considered residential property investments against actual, expected and unexpected inflation. The inflation hedging capacities of real estate investments were found to vary across geographical sub-markets and return components. Residential properties did not hedge against actual inflation in all the considered areas. However, with regards to expected inflation, the capital and total returns of residential properties in Akobo sub-market completely hedged; while for Bodija estate, it was the income and total returns that hedged against inflation completely and partially respectively. The study therefore recommends that in determining the real estate investments and the geographic locations to integrate in residential property portfolio, property investors should concentrate more in the mentioned geographical areas where residential property investments have shown to be hedging against inflation.Keywords: Ibadan, Inflation hedging capacity, Investments, Residential propertie

Shopping Mall Patronage: A Review of Predictive Factors

Given the increasing popularity of shopping malls globally, it is vital for would-be investors and their consultants (bankers, estate surveyors and valuers, among others) to examine the critical variables for the feasibility and viability of such an investment. Taking this into consideration, a systematic review of prior studies on shopping malls was conducted with the aim of highlighting the factors predicting patronage. To accomplish this aim, the researchers reviewed papers published within a ten-year period. According to the summary, research on shopping malls has gotten a lot of attention, especially in developing countries. The study also discovered that, in both developed and developing countries, income, location, accessibility, and price are the most important factors influencing mall patronage. In conclusion, shopping mall stakeholders should consider using the fifteen variables highlighted in this study as an investment guide

Design, Construction and Characterization of a Sliding- Plate- Evaporator Freezer (Spef)

This work embodied the design, construction and characterization of a sliding plate evaporator freezer, a modified version of the conventional freezer. The presence of a sliding plate evaporator reduces the freezing area, to increase the freezing rate and with a reduced freezing time. The freezer is intended to freeze agro and allied products in a record time. This is achieved by incorporating sliding plate evaporators to a conventional freezer to have two or more freezing sources, thereby, also giving the freezer with the option of a deferring freezing area to increase freezing rate. The results obtained are not exactly matched with the designed objectives because of construction flaws; and modifications can be made to improve the Coefficient of performance. The Coefficient of performance of the SPFE is obtained   to be 7.26. The SPEF is recommended for use in household and agro based industries for faster and effective freezing. Keyword: Freezer, Sliding Plate, Evaporator, and Refrigerator, Freezer chamber, Compressor power, Condenser power and Co-efficient of performance

Is backreaction really small within concordance cosmology?

Smoothing over structures in general relativity leads to a renormalisation of the background, and potentially many other effects which are poorly understood. Observables such as the distance-redshift relation when averaged on the sky do not necessarily yield the same smooth model which arises when performing spatial averages. These issues are thought to be of technical interest only in the standard model of cosmology, giving only tiny corrections. However, when we try to calculate observable quantities such as the all-sky average of the distance-redshift relation, we find that perturbation theory delivers divergent answers in the UV and corrections to the background of order unity. There are further problems. Second-order perturbations are the same size as first-order, and fourth-order at least the same as second, and possibly much larger, owing to the divergences. Much hinges on a coincidental balance of 2 numbers: the primordial power, and the ratio between the comoving Hubble scales at matter-radiation equality and today. Consequently, it is far from obvious that backreaction is irrelevant even in the concordance model, however natural it intuitively seems.Comment: 28 pages. Invited contribution to Classical and Quantum Gravity special issue "Inhomogeneous Cosmological Models and Averaging in Cosmology

Hepatic profile analyses of tipranavir in Phase II and III clinical trials

<p>Abstract</p> <p>Background</p> <p>The risk and course of serum transaminase elevations (TEs) and clinical hepatic serious adverse event (SAE) development in ritonavir-boosted tipranavir (TPV/r) 500/200 mg BID recipients, who also received additional combination antiretroviral treatment agents in clinical trials (TPV/r-based cART), was determined.</p> <p>Methods</p> <p>Aggregated transaminase and hepatic SAE data through 96 weeks of TPV/r-based cART from five Phase IIb/III trials were analyzed. Patients were categorized by the presence or absence of underlying liver disease (+LD or -LD). Kaplan-Meier (K-M) probability estimates for time-to-first US National Institutes of Health, Division of AIDS (DAIDS) Grade 3/4 TE and clinical hepatic SAE were determined and clinical actions/outcomes evaluated. Risk factors for DAIDS Grade 3/4 TE were identified through multivariate Cox regression statistical modeling.</p> <p>Results</p> <p>Grade 3/4 TEs occurred in 144/1299 (11.1%) patients; 123/144 (85%) of these were asymptomatic; 84% of these patients only temporarily interrupted treatment or continued, with transaminase levels returning to Grade ≤ 2. At 96 weeks of study treatment, the incidence of Grade 3/4 TEs was higher among the +LD (16.8%) than among the -LD (10.1%) patients. K-M analysis revealed an incremental risk for developing DAIDS Grade 3/4 TEs; risk was greatest through 24 weeks (6.1%), and decreasing thereafter (>24-48 weeks: 3.4%, >48 weeks-72 weeks: 2.0%, >72-96 weeks: 2.2%), and higher in +LD than -LD patients at each 24-week interval. Treatment with TPV/r, co-infection with hepatitis B and/or C, DAIDS grade >1 TE and CD4⁺> 200 cells/mm³at baseline were found to be independent risk factors for development of DAIDS Grade 3/4 TE; the hazard ratios (HR) were 2.8, 2.0, 2.1 and 1.5, respectively. Four of the 144 (2.7%) patients with Grade 3/4 TEs developed hepatic SAEs; overall, 14/1299 (1.1%) patients had hepatic SAEs including six with hepatic failure (0.5%). The K-M risk of developing hepatic SAEs through 96 weeks was 1.4%; highest risk was observed during the first 24 weeks and decreased thereafter; the risk was similar between +LD and -LD patients for the first 24 weeks (0.6% and 0.5%, respectively) and was higher for +LD patients, thereafter.</p> <p>Conclusion</p> <p>Through 96 weeks of TPV/r-based cART, DAIDS Grade 3/4 TEs and hepatic SAEs occurred in approximately 11% and 1% of TPV/r patients, respectively; most (84%) had no significant clinical implications and were managed without permanent treatment discontinuation. Among the 14 patients with hepatic SAE, 6 experienced hepatic failure (0.5%); these patients had profound immunosuppression and the rate appears higher among hepatitis co-infected patients. The overall probability of experiencing a hepatic SAE in this patient cohort was 1.4% through 96 weeks of treatment. Independent risk factors for DAIDS Grade 3/4 TEs include TPV/r treatment, co-infection with hepatitis B and/or C, DAIDS grade >1 TE and CD4⁺> 200 cells/mm³at baseline.</p> <p>Trial registration</p> <p>US-NIH Trial registration number: NCT00144170</p

The observed galaxy bispectrum from single-field inflation in the squeezed limit

Using the consistency relation in Fourier space, we derive the observed galaxy bispectrum from single- eld in ation in the squeezed limit, in which one of the three modes has a wavelength much longer than the other two. This provides a non-trivial check of the full computation of the bispectrum based on second-order cosmological perturbation theory in this limit. We show that gauge modes need to be carefully removed in the second-order cosmological perturbations in order to calculate the observed galaxy bispectrum in the squeezed limit. We then give an estimate of the e ective non- Gaussianity due to general-relativistic lightcone e ects that could mimic a primordial non-Gaussian signal

High-redshift post-reionization cosmology with 21cm intensity mapping

We investigate the possibility of performing cosmological studies in the redshift range 2.5<z<5 through suitable extensions of existing and upcoming radio-telescopes like CHIME, HIRAX and FAST. We use the Fisher matrix technique to forecast the bounds that those instruments can place on the growth rate, the BAO distance scale parameters, the sum of the neutrino masses and the number of relativistic degrees of freedom at decoupling, Neff. We point out that quantities that depend on the amplitude of the 21cm power spectrum, like f\u3c38, are completely degenerate with \u3a9HI and bHI, and propose several strategies to independently constrain them through cross-correlations with other probes. Assuming 5% priors on \u3a9HI and bHI, kmax=0.2 h Mpc-1 and the primary beam wedge, we find that a HIRAX extension can constrain, within bins of \u394 z=0.1: 1) the value of f\u3c38 at 4%, 2) the value of DA and H at 1%. In combination with data from Euclid-like galaxy surveys and CMB S4, the sum of the neutrino masses can be constrained with an error equal to 23 meV (1\u3c3), while Neff can be constrained within 0.02 (1\u3c3). We derive similar constraints for the extensions of the other instruments. We study in detail the dependence of our results on the instrument, amplitude of the HI bias, the foreground wedge coverage, the nonlinear scale used in the analysis, uncertainties in the theoretical modeling and the priors on bHI and \u3a9HI. We conclude that 21cm intensity mapping surveys operating in this redshift range can provide extremely competitive constraints on key cosmological parameters

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

Observational signatures of modified gravity on ultra-large scales

Extremely large surveys with future experiments like Euclid and the SKA will soon allow us to access perturbation modes close to the Hubble scale, with wavenumbers $k\sim {\mathcal{H}}.$ If a modified gravity (MG) theory is responsible for cosmic acceleration, then the Hubble scale is a natural regime for deviations from General Relativity (GR) to become manifest. However, the majority of studies to date have concentrated on the consequences of alternative gravity theories for the subhorizon, quasi-static regime. In this paper, we investigate how modifications to the gravitational field equations affect perturbations around the Hubble scale. We choose functional forms to represent the generic scale-dependent behavior of gravity theories that modify GR at long wavelengths, and study the resulting deviations of ultra-large-scale relativistic observables from their GR behavior. We find that these are small unless modifications to the field equations are drastic. The angular dependence and redshift evolution of the deviations is highly parameterization- and survey-dependent, however, and so they are possibly a rich source of MG phenomenology if they can be measured

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children &lt;18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p&lt;0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p&lt;0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p&lt;0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer