Making Prevention Work: Case Study Netherlands. Materials about Prevention Vol. 18 June 2020

As part of a larger project mapping preventive structures and policies for children, young people and families in 12 European countries, the Making Prevention Work study aims to provide a consistent base for developing preventive policies in Europe. It examines approaches across the EU that demonstrate success with local preventive work. The in-depth case study of the Netherlands presented in this publication is one of three published in the context of the Making Prevention Work study. Making Prevention Work draws on a concept of prevention that is framed in universalist and integrative terms. The concept is universalist in that it addresses all children and young people, even those not seen as being “at-risk.” It is integrative because prevention should be organized from a child’s point of view, not in terms of administrative responsibilities. As such, this concept targets the establishment of prevention chains that link different institutions over the life-course. Making Prevention Work includes summary factsheets of the preventive concepts, structures and practices mapped in 12 EU member states (Austria, Czech Republic, Denmark, England (UK), Finland, France, Germany, Ireland, Lithuania, the Netherlands, Spain and Sweden) as well as three case studies (Austria, France and the Netherlands) featuring data from interviews with experts and implementing actors

Making Prevention Work: Preventive structures and policies for children, youth and families: Comprehensive report. Materials about Prevention Vol. 15 June 2020.

This report maps preventive structures and policies for children, young people and families in 12 European countries. By examining what works in each of the countries surveyed, it aims to provide a foundation for the development of prevention policies across Europe. The report draws on a concept of prevention that is framed in universalist and integrative terms. The concept is universalist in that it addresses all children and young people, even those not seen as being “at-risk.” It is integrative because prevention should be organized from a child’s point of view, not in terms of administrative responsibilities. As such, this concept targets the establishment of prevention chains that link different institutions over the life-course. The report includes summary factsheets of the preventive concepts, structures and practices mapped in 12 EU member states (Austria, Czechia, Denmark, England (UK), Finland, France, Germany, Ireland, Lithuania, the Netherlands, Spain and Sweden). In addition, three in-depth case studies (Austria, France and the Netherlands) featuring data from interviews with experts and implementing actors are also presented

Photoelectron spectra of anionic sodium clusters from time-dependent density-functional theory in real-time

We calculate the excitation energies of small neutral sodium clusters in the framework of time-dependent density-functional theory. In the presented calculations, we extract these energies from the power spectra of the dipole and quadrupole signals that result from a real-time and real-space propagation. For comparison with measured photoelectron spectra, we use the ionic configurations of the corresponding single-charged anions. Our calculations clearly improve on earlier results for photoelectron spectra obtained from static Kohn-Sham eigenvalues

Neutralizing misinformation through inoculation:Exposing misleading argumentation techniques reduces their influence

Misinformation can undermine a well-functioning democracy. For example, public misconceptions about climate change can lead to lowered acceptance of the reality of climate change and lowered support for mitigation policies. This study experimentally explored the impact of misinformation about climate change and tested several pre-emptive interventions designed to reduce the influence of misinformation. We found that false-balance media coverage (giving contrarian views equal voice with climate scientists) lowered perceived consensus overall, although the effect was greater among free-market supporters. Likewise, misinformation that confuses people about the level of scientific agreement regarding anthropogenic global warming (AGW) had a polarizing effect, with free-market supporters reducing their acceptance of AGW and those with low free-market support increasing their acceptance of AGW. However, we found that inoculating messages that (1) explain the flawed argumentation technique used in the misinformation or that (2) highlight the scientific consensus on climate change were effective in neutralizing those adverse effects of misinformation. We recommend that climate communication messages should take into account ways in which scientific content can be distorted, and include preemptive inoculation messages

Großtagespflegestellen in Niedersachsen : Abschlussbericht des EFRE-Forschungsprojektes

Ein Forschungsteam unter Leitung von Prof. Dr. Romppel hat zwischen 1.8.2011 und 31.7.2014 die Betreuung von Kindern in der Großtagespflege untersucht. Mit der Neufassung des § 24 Abs. 2 SGB VIII zum 1. August 2013 besteht für alle Kinder ab dem 2. Lebensjahr ein Rechtsanspruch auf individuelle Förderung. Der erwarteten wachsenden Nachfrage nach Plätzen für Kinder unter 3 Jahren soll neben dem Krippenausbau auch mit einem Ausbau der Kindertagespflege, in Niedersachsen besonders auch der Großtagespflege, begegnet werden. Großtagespflegestellen sind rechtlich ein gleichwertiges Angebot zur Krippe. Die vorliegende Untersuchung in Niedersachsen geht zum einen der Frage nach, ob die Qualität der pädagogischen Arbeit in den Großtagespflegestellen diesem Anspruch genügen kann. Mit der TAS-R, einem Beobachtungs- und Bewertungsverfahren werden ausgewählte Großtagespflegestellen beurteilt und mit strukturierten Interviews zu ihrer Arbeit befragt. Zudem wird die telefonische und schriftliche Befragung aller Jugendämter Niedersachsens zur Organisation der Fachberatung sowie zur Struktur der finanziellen und fachlichen Unterstützung der Großtagespflegestellen vor Ort vorgestellt. Die Ergebnisse und Empfehlungen für die Verantwortlichen verweisen auf Handlungsbedarf

Pretubulysin derived probes as novel tools for monitoring the microtubule network via activity-based protein profiling and fluorescence microscopy

Microtubules (mt) are highly dynamic polymers composed of alpha- and beta-tubulin monomers that are present in all dividing and non-dividing cells. A broad variety of natural products exists that are known to interfere with the microtubule network, by either stabilizing or de-stabilizing these rope-like polymers. Among those tubulysins represent a new and potent class of cytostatic tetrapeptides originating from myxobacteria. Early studies suggested that tubulysins interact with the eukaryotic cytoskeleton by inhibition of tubulin polymerization with EC50 values in the picomolar range. Recently, pretubulysins have been described to retain the high tubulindegradation activity of their more complex tubulysin relatives and represent an easier synthetic target with an efficient synthesis already in place. Although tubulin has been suggested as the dedicated target of tubulysin a comprehensive molecular target analysis of pretubulysin in the context of the whole proteome has not been carried out so far. Here we utilize synthetic chemistry to develop two pretubulysin photoaffinity probes which were applied in cellular activity-based protein profiling and imaging studies in order to unravel and visualize dedicated targets. Our results clearly show a remarkable selectivity of pretubulysin for beta-tubulin which we independently confirmed by a mass-spectrometry based proteomic profiling platform as well as by tubulin antibody based co-staining on intact cells