Контрольні повноваження Рахункової палати у сфері дотримання бюджетного законодавства

Олексій У. О. Контрольні повноваження Рахункової палати у сфері дотримання бюджетного законодавства / У. О. Олексій // Правові та інституційні механізми забезпечення розвитку України в умовах європейської інтеграції : матеріали Міжнародної науково-практичної конференції (м. Одеса, 18 травня 2018 р.) У 2-х т. Т. 2 / відп. ред. Г.О. Ульянова. – Одеса : Видавничий дім «Гельветика», 2018. – С. 100-101

Deformation and Damage Accumulation in a Ceramic Composite under Dynamic Loading

Methods of computer modelling were used to investigate the processes of deformation and microdamage formation in ceramic composite materials under intense dynamic loading. It was shown that there was no damage caused by dynamic compression in the vicinity of phase borders of a nanostructured aluminum oxide matrix and reinforcing particles of tetragonal zirconium dioxide. Also, the local origination of microdamages occurs only in the zones close to micropores

Basic methodical grounds of teaching international students chinese field-specific terms in technical institutes of higher education (in the context of polymer production)

We look at the problem connected with methods of teaching Chinese field-specific terms to international students in technical institutes of higher education. The basis of our research is represented by Chinese scientists’ articles in the sphere of manufacturing polymer. Our research is focused on the solution of problems connected with teaching Chinese field-specific terms to international students in technical institutes of higher education. The task required analysis of teaching and studying issues of field-specific disciplines in Tomsk Polytechnic University, study of terminological processes in Chinese, description of how field-specific terms are adopted from foreign languages into Chinese. Studying the above listed aspects provided a basis for developing a classification of polymer production terms. The way the Chinese language borrows a terminological item is considered when dividing terminological elements into groups for further systematization. We structured our classification of terms and terminological combinations by taking into account the fundamentals of high-molecular composition chemistry for easier understanding of polymer production terminology by teachers and students of technical institutions of higher education

Estrategia de aula invertida con modalidad virtual. Estudio de caso en la formación de profesionales en ciencias naturales

A pocos días para el comienzo de las clases se presentó un fuerte cambio de contexto en el marco de la pandemia por SARS-CoV-2. Ante el crecimiento exponencial de contagios, el aislamiento social obligatorio fue una de las medidas principales adoptadas por los diferentes países del mundo. En esta realidad resultó inevitable retrasar o detener el dictado de clases en los distintos ámbitos académicos, especialmente de educación superior (Cayo-Rojas y Rosell, 2020). Como muchas instituciones educativas de Argentina, la UNC implementó el cursado completamente virtual de sus carreras. En la Facultad de Ciencias Agropecuarias, inmediatamente se comenzó a trabajar en la adaptación del dictado de todos los espacios curriculares hacia el Campus Académico.Como alternativa a las metodologías de enseñanza tradicionales surge el Aula Invertida como enfoque integral que fomenta el aprendizaje autónomo de los estudiantes, contando con acceso a los contenidos a través de entornos virtuales para luego aplicarlos en actividades diversas y participativas. En este trabajo se plantea valorar la implementación del modelo aula invertida para el dictado virtual del espacio curricular Fisicoquímica de la carrera Licenciatura en Agroalimentos de la Facultad de Ciencias Agropecuarias. Inicialmente, la asignatura fue planificada para llevarse a cabo mediante un enfoque de Aula Invertida, aprovechando los entornos virtuales desde un modelo de aprendizaje centrado en la construcción activa del conocimiento por parte de los estudiantes. Del total de alumnos matriculados, accedió a promoción directa de la asignatura el 62,3% y adquirió condición de alumno regular el 4,1%. Considerando que fue la primera vez que se dictó la materia, sin antecedentes de dictado presencial, se podría decir que los resultados fueron favorables ya que los alumnos demostraron en su gran mayoría una elevada adherencia a las actividades planteadas, a pesar de las vicisitudes presentadas por la dificultad de acceso a internet. Esta situación debe ser considerada al pensar la planificación de una asignatura desde la virtualidad.publishedVersionFil: Uliana, A. S. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias. Departamento de Fundamentación Biológica. Cátedra de Biología Celular; ArgentinaFil: Prieto, María Cecilia. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Prieto, María Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Bergesse, A. E. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Bergesse, A. E. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Camiletti, O. F. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina.Fil: Camiletti, O. F. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto Multidisciplinario de Biología Vegetal; Argentina.Fil: Mariani, E. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias. Departamento de Fundamentación Biológica. Cátedra de Química Orgánica; Argentina.Fil: Valentinuzzi, M. C. Universidad Nacional de Córdoba. Facultad de Ciencias Agropecuarias. Departamento de Ingeniería y Mecanización Rural. Cátedra de Física; Argentina

Tamoxifen Is Effective in the Treatment of Leishmania amazonensis Infections in Mice

Leishmaniasis is an antropozoonotic disease with a wide range of clinical manifestations. In humans, signs of disease vary from skin and mucosal ulcers to enlargement of internal organs such as the liver and spleen. The unicellular parasite Leishmania amazonensis is able to infect humans and cause localized or diffuse skin lesions. The treatment for this disease is difficult, as it requires prolonged and painful applications of toxic drugs that are poorly tolerated. Therefore, a key area in leishmaniasis research is the study of new therapeutic schemes and less toxic drugs. The present report is based on the investigation of tamoxifen's activity (a compound that has been in clinical use since the 1970s for the treatment of breast cancer) in the treatment of mice experimentally infected with L. amazonensis. We observed that infected mice treated with 20 mg/kg/day of tamoxifen for 15 days showed a significant clinical and parasitological response, with reduction in the size of lesions and ulcers and decreased numbers of parasites. These promising results pave the way for further testing of this drug as a new alternative in the chemotherapy of leishmaniasis

Association of novel monomethine cyanine dyes with bacteriophage MS2:A fluorescence study

Novel monomethine cyanine dyes Cl-YO, F-YO, Cl-YO-Et, Cl-YO-Bu, and YO-Pent were evaluated as agents to detect and characterise a small virus, the MS2 bacteriophage, using the dye and virus intrinsic fluorescence, kinetic and thermal properties, chemical denaturation, and molecular docking and quantum chemistry modelling. The examined compounds demonstrated enhanced fluorescence responses and high affinities (~1 μM−1) for the intact bacteriophage at physiological ionic strength. The linear Scatchard plots revealed the existence of one binding mode for most dyes. Strong evidence that the cyanines bind to the bacteriophage external surface were obtained, although the possibility of the dye penetration through the virus shell and subsequent complexation with the viral RNA was also tested. The main arguments in favour of the former were that i) the fluorescence of the MS2-bound fluorophores decreased under the influence of protein denaturants, urea and guanidine hydrochloride; ii) the fluorescence responses of the dyes to MS2 and bovine serum albumin were similar; and (iii) one order of magnitude higher sensitivity of the dyes to the yeast RNA was found. Simple docking studies suggested that one cyanine molecule is trapped in a cleft formed by three proteins composing the virus shell. Significant role of electrostatic forces in the stabilisation of the dye-MS2 complexes at low ionic strength (10 mM) was demonstrated, while the influence of steric, hydrophobic, and van-der-Waals interactions was expected to increase at physiological ionic strength. The spectral properties of the novel cyanine dyes compared to other fluorophores demonstrated higher sensitivity of the cyanines to MS2, rendering them promising agents for the investigation of the changes in the virus structure under the influence of heat (Cl-YO-Et, Cl-YO-Bu), denaturants (Cl-YO, F-YO), and ionic strength (all the compounds)

Population response during an Oceanic Anoxic Event: The case of Posidonotis (Bivalvia) from the Lower Jurassic of the Neuquén Basin, Argentina

Benthonic marine species show a wide range of biological reactions to seawater chemical changes through time, from subtle adjustments to extinction. The Early Toarcian Oceanic Anoxic Event (T-OAE) was recently recognized in the Neuquén Basin, Argentina, confirming its global scope. The event was identified chemostratigraphically on the basis of a relative increase in marine organic carbon and a characteristic negative carbonisotope excursion (δ13Corg) in bulk rock and fossil wood in the upper Pliensbachian-lower Toarcian interval in the Arroyo Lapa section (Neuquén). Simultaneously with collection of lithological samples, a high-resolution biostratigraphical survey was carried out, and the scarce benthonic fauna was collected in order to check the biotic response to changing marine geochemical conditions. We present here an analysis of size and abundance data from the T-OAE interval in the Neuquén Basin for the dominant bivalve species, the paper-clam Posidonotis cancellata (Leanza), and relate these data to geochemical proxies (%TOC and δ13Corg) obtained at the same locality. The abundance of P. cancellata increased when the rest of the benthos diminished, reaching a maximum at the onset level of the T-OAE, and then decreasing. Size-frequency distributions show a noteworthy lack of juvenile shells. Shell size shows a positive correlation with %TOC in the whole section, though over the T-OAE interval proper, it decreases below the level where the maximum %TOC value is attained and increases above it. Posidonotis cancellata shows features of opportunistic species, such as high tolerance to hypoxia, strong dominance in impoverished environments and a strong dependence on primary productivity, but at the same time had a reproductive strategy more similar to equilibrium species, with relatively low juvenile mortality rates. Several anatomical features suggest adaptation to permanently dysaerobic environments. The species disappeared just before the minimum negative carbon-isotope value was reached; and by the same time the genus became extinct worldwide