H2S biosynthesis and catabolism: new insights from molecular studies

Hydrogen sulfide (H2S) has profound biological effects within living organisms and is now increasingly being considered alongside other gaseous signalling molecules, such as nitric oxide (NO) and carbon monoxide (CO). Conventional use of pharmacological and molecular approaches has spawned a rapidly growing research field that has identified H2S as playing a functional role in cell-signalling and post-translational modifications. Recently, a number of laboratories have reported the use of siRNA methodologies and genetic mouse models to mimic the loss of function of genes involved in the biosynthesis and degradation of H2S within tissues. Studies utilising these systems are revealing new insights into the biology of H2S within the cardiovascular system, inflammatory disease, and in cell signalling. In light of this work, the current review will describe recent advances in H2S research made possible by the use of molecular approaches and genetic mouse models with perturbed capacities to generate or detoxify physiological levels of H2S gas within tissue

Resolution of inflammation: a new therapeutic frontier

Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success. However, insight into the pathways by which inflammation is resolved has highlighted novel opportunities to pharmacologically manipulate these processes — a strategy that might represent a complementary (and perhaps even superior) therapeutic approach. This Review discusses the state of the art in the biology of resolution of inflammation, highlighting the opportunities and challenges for translational research in this field

Acigol shallow-perennial playa-lake basin, SW Anatolia, Turkey

The late Cenozoic extensional deformation formed several NE-trending fluvio-lacustrine basins in SW Anatolia, filled by alluvial, fluvial and lacustrine deposits. Among them, the Acigol basin, is notable for its tectono-sedimentary development of a prominent shallow-perennial playa-lake setting. The basin initially subsided to receive coarse-clastic alluvial deposits, merging into fluvial systems and central shallow lakes. Subsequent basin deepening with significant sediment supply from surrounding basement horsts caused gradual shrinkage of the relatively small shallow lakes, due to renewed progradation of alluvial fans and they eventually dried out completely. The sedimentation pattern and palaeoenvironmental changes record a constant tectonic, sedimentation, climatic and lake chemistry interaction from the late Miocene onward, with close relation to the coeval adjacent basins. The modern Acigol Lake was formed by progressively inward narrowing and deepening caused by the activity of the basin bounding faults and eventually by newly generated synthetic and antithetic fault systems. The modern depression is a typical shallow-perennial playa-lake basin with active evaporation and dominant precipitation of sodium sulphates, Mg-Ca carbonates and clay minerals. In this study three deep bore-hole logs of the recent drilling completed in the modern Acigol lake plain were examined to document the mode of deposition and development of the basin. The bore-hole logs show that the Acigol basin was gradually transformed from a perennial deep lake into shallow perennial/ephemeral playa settings

Zinc(II) and cadmium(II) coordination polymers containing phenylenediacetate and 4,4′-azobis(pyridine) ligands: Syntheses, structures, dye adsorption properties and molecular dynamics simulations

Due to copyright restrictions, the access to the full text of this article is only available via subscription.Two new coordination polymers (CPs) – [Zn(µ4-ppda)(µ-abpy)0.5]n(1) and [Cd(μ3-opda)(µ-abpy)0.5(H2O)]n(2) (o/ppda = 1,2/1,4-phenylenediacetate, abpy = 4,4′-azobis(pyridine)) – have been synthesized by using Zn(II)/Cd(II) salts in the presence of o- and p-phenylenediacetic acid and abpy under hydrothermal conditions. Their structures have been characterized by FT-IR spectroscopy, elemental analysis, X-ray powder diffraction and single crystal X-ray diffraction techniques. The structural diversities were observed depending on anionic ligands and metal centers in the synthesized complexes. Complex 1 consists of a 2-fold interpenetrated 3D+3D→3D framework with pcu topology while complex 2 has a 2D structure with sql topology. The adsorption of methylene blue (MB) was studied to examine the potential of the title CPs for removal of dyes from aqueous solution. Molecular dynamics (MD) simulations were also performed to examine diffusion of MB in 1 and 2. Thermal and optical properties of two complexes were also discussed.Eskisehir Osmangazi Universites

Geochemical characterization of geothermal systems in western Anatolia (Turkey): implications for CO 2

Geological storage of CO2 is currently regarded as one of the major strategies to mitigate the increasing CO2 concentrations in the atmosphere due to anthropogenic emissions from large-scale point sources. Enhanced geothermal systems (EGS) are a novel concept in which CO2 is used as a working fluid to increase energy recovery, combined with its subsurface storage. In this study, the geothermal systems of western Anatolia are considered as potential sites for EGS, and the published hydrogeochemical data relevant to these systems are compiled and evaluated in terms of potential water/CO2/rock interaction processes. The evaluation is performed with geochemical approaches including speciation-solubility calculations, and inverse and dedolomitization modelling. The results lead to the recognition of two different groups with respect to the effective processes: carbonate precipitation, and carbonate precipitation plus dissolution. In high-enthalpy fields, carbonate precipitation seems to be the major mechanism, while others show the effects of both precipitation and dissolution; dedolomitization is also identified as a potential mechanism for one of the fields. These processes are examined with regard to CO2-fixation; carbonate precipitation may lead to mineral trapping while carbonate dissolution provides additional cations to the system to react with CO2. Being relevant to CO2 storage in geothermal fields, the conclusions from this study point to the importance of temperature control for CO2 stabilization, as high temperatures seem to promote mineral trapping. The success of a CO2-EGS project depends on complete geochemical characterization of reservoir processes with further kinetic modelling accompanying the thermodynamic modelling exemplified by this study. (c) 2017 Society of Chemical Industry and John Wiley & Sons, Ltd