29 research outputs found
End-Stage Renal Disease After Renal Surgery in Patients with Normal Preoperative Kidney Function: Balancing Surgical Strategy and Individual Disorders at Baseline
Although nephron-sparing surgery (NSS) has demonstrated benefit in terms of renal function preservation, it is unclear whether NSS might also decrease the risk of end-stage renal disease (ESRD) relative to radical nephrectomy (RN). In the current paper, we aimed to report the rate and the predictors of ESRD after surgery, accounting for detailed individual baseline characteristics and comorbidities. A multi-institutional collaboration among five European tertiary care centers allowed study of 2027 patients with normal preoperative renal function and a clinically localized T1abN0M0 renal mass. Cox regression analyses were used to predict the risk of ESRD (defined as the onset of a postoperative estimated glomerular filtration rate <15 ml/min per 1.73 m2) after adjusting for the individual baseline risk of developing chronic kidney disease. Univariable ESRD rates at 5 and 10 yr of follow-up were virtually equivalent for patients who underwent NSS (1.5% and 2.5%, respectively) versus RN (1.9% and 2.7%, respectively; hazard ratio [HR]: 0.8; 95% confidence interval [CI], 0.4\ue2\u80\u931.6). However, diabetes, smoking, uncontrolled hypertension, and other comorbidities were consistently more frequent in the NSS group relative to their RN counterparts. After adjusting for detailed baseline individual characteristics, NSS was shown to have an independent protective effect relative to RN (HR: 0.4; 95% CI, 0.2\ue2\u80\u930.8; p = 0.02) at multivariable analyses. Patient summary After accounting for individual baseline characteristics, such as age, diabetes, uncontrolled hypertension, or other comorbidities, partial nephrectomy independently protects against end-stage renal disease and the consequent need for dialysis relative to radical nephrectomy
BCS and BEC p-wave pairing in Bose-Fermi gases
The pairing of fermionic atoms in a mixture of atomic fermion and boson gases
at zero temperature is investigated. The attractive interaction between
fermions, that can be induced by density fluctuations of the bosonic
background, can give rise to a superfluid phase in the Fermi component of the
mixture. The atoms of both species are assumed to be in only one internal
state, so that the pairing of fermions is effective only in odd-l channels. No
assumption about the value of the ratio between the Fermi velocity and the
sound velocity in the Bose gas is made in the derivation of the energy gap
equation. The gap equation is solved without any particular "ansatz" for the
pairing field or the effective interaction. The p-wave superfluidity is studied
in detail. By increasing the strength and/or decreasing the range of the
effective interaction a transition of the fermion pairing regime, from the
Bardeen-Cooper-Schrieffer state to a system of tightly bound couples can be
realized. These composite bosons behave as a weakly-interacting Bose-Einstein
condensate.Comment: 14 pages, 6 eps-figures. To be published in European Physical Journal