cGMP and its clinical importance: Review [cGMP ve klinik önemi]

The evaluation of mechanisms of signal transduction pathways is crucial to the understanding of disease etiology and, in turn, the development of novel therapeutic strategies. 3-5-cyclic guanosine monophosphate (cGMP), an important secondary messenger, though yet to be explicitly detailed, is thought to be a molecule of significant importance in maintaining homeostasis. Guanylyl cyclases and cGMP-mediated signaling cascades play a central role in the regulation of diverse (patho-) physiological processes, including vascular smooth muscle motility, intestinal fluid and electrolyte homeostasis, as well as retinal photo-transduction. An understanding of the stages of the cGMP pathway and their relationships to individual disease processes may prove to be useful both diagnostically and therapeutically. Copyright © 2005 by Türkiye Klinikleri

Thermal characterization of chicken feather/PLA biocomposites

In this work, thermal properties of composites from chicken feather fiber (CFF) and polylactic acid (PLA) were investigated. CFF/PLA green composites were manufactured by extrusion and injection molding. Short and long fibers (3 and 20 mm) were used at different contents (2, 5 and 10 mass%). The effects of fiber concentration and fiber length on thermal properties of CFF/PLA composites were studied. Thermal properties of CFF/PLA composites were examined through differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and dynamic mechanical analysis (DMA). From the experiments, it was found that addition of CFF was effective to improve the thermal properties of PLA. The DSC results showed that heat flow increased with the increase in CFF content on the glass transition, on the crystallization temperature and on melting temperature. The TG results revealed that addition of CFF to PLA had positive effect on the thermal stability. In addition, the results of DMA experiments showed that the tan δ decreased with the increasing CFF content, indicating less damping and more elastic behavior in the composites. The results obtained from this study provide important information on the temperature-dependent properties of CFF/PLA and lead to new product development based on natural resources. © 2017, Akadémiai Kiadó, Budapest, Hungary

Preparation and mechanical characterization of chicken feather/PLA composites

Green composites, a bio-based polymer matrix is reinforced by natural fibers, are special class of bio-composites. Interest about green composites is continuously growing because they are environment-friendly. This study describes the preparation and mechanical characterization of green composites using polylactic acid (PLA) matrix including chicken feather fiber (CFF) as reinforcement. Extrusion and an injection molding process were used to prepare CFF/PLA composites at a controlled temperature range. CFF/PLA composites with fiber mass content of 2%, 5%, and 10% were manufactured. The effects of fiber concentration and fiber length on mechanical properties of CFF/PLA composites have been studied. Mechanical properties of composites were investigated by tensile, compression, bending, hardness, and Izod impact testing. The results of experiments indicated that Young's modulus, compressive strength, flexural modulus, and hardness of the PLA reinforced CFF composites are higher but tensile strength, elongation at break, bending strength and impact strength of them are lower than pure PLA. The results indicate that these types of composites can be used for various applications. POLYM. COMPOS., 38:837–845, 2017. © 2015 Society of Plastics Engineers. © 2015 Society of Plastics Engineer

Liquid-liquid equilibria of propionic acid - water - solvent (n-hexane, cyclohexane, cyclohexanol and cyclohexyl acetate) ternaries at 298.15 K

The experimental liquid-liquid equilibrium data on propionic acid-water-solvent ternary mixtures at a temperature of 298.15 K are presented. The solvents are n-hexane, cyclohexane, cyclohexanol and cyclohexyl acetate. The distribution coefficients and separation factors are reported. The tie line data are correlated using the methods of Othmer-Tobias and Hand. The experimental results are compared with the values predicted by the UNIFAC group-contribution method

Investigation of long-term ageing effect on the thermal properties of chicken feather fibre/poly(lactic acid) biocomposites

In this study, the effects of long-term natural atmospheric ageing on the thermal properties of chicken feather fibre reinforced poly(lactic acid) biocomposite materials having chicken feather fibre mass content of 2, 5, and 10% were investigated. Chicken feather fibres, which are bio-based reinforcement material, and poly(lactic acid), which is bio-based matrix material, are compounded with a twin-screw extruder and injection-moulded; hence, the biocomposite material is produced. The effect of long-term natural atmospheric ageing on the thermal stability, crystallization, and melting behaviour of the biocomposite materials were analysed by thermogravimetric, derivative thermogravimetry, differential thermal, and differential scanning calorimetry analyses. In addition, the fracture surface of the samples was examined in depth by scanning electron microscopy analysis. The experimental results show that the long-term natural ageing process decreases the thermal stability values of the biocomposite materials and increases the glass transition temperatures and degree of crystallinities. © 2020, The Polymer Society, Taipei

The effect of nifedipine tocolysis on Doppler indices of the uterine and umbilical Arteries

Purpose: The aim of this study was to evaluate the effect of oral nifedipine on Doppler indices of the uterine artery (UtA) and umbilical artery (UA) before and 24 hours, 48 hours, and 1 week after tocolytic treatment. Methods: This was a prospective, self-controlled, cohort study of 65 pregnant women undergoing nifedipine tocolysis. Doppler assessment of the UtA and UA was performed before treatment and 24 hours, 48 hours, and 1 week after the initial 4 doses of 10 mg of oral nifedipine, administered at 20-minute intervals. The maintenance dosage was 20 mg of oral nifedipine administered every 6 hours for 48 hours, for a total dose of 80 mg/day. Results: There was a decrease in the 24-hour values of the UA pulsatility index, resistance index (RI), systolic-diastolic (S:D) ratio, right UtA pulsatility index, RI, S:D ratio, and left UtA RI and S:D ratio with nifedipine therapy in comparison with the values recorded prior to nifedipine therapy. However, these differences were not statistically significant. There were no statistically significant differences between the data recorded prior to nifedipine administration and those obtained at 48 hours and 1 week after treatment. Conclusions: Oral nifedipine is a safe tocolytic agent with no long-term effect on fetomaternal circulation in pregnant women at risk of preterm delivery. © 2014 Wiley Periodicals, Inc

McMillan Barn at 500 East 5600 South

McMillan barn at their farm at 500 East 5600 South, built in 1933. An addition was added in 1969, and the 1969 tax assessor's form catagorizes the building as a meat plant. Is now demolished