572 research outputs found

    Dynamics of viscous dissipative gravitational collapse: A full causal approach

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    The Misner and Sharp approach to the study of gravitational collapse is extended to the viscous dissipative case in, both, the streaming out and the diffusion approximations. The dynamical equation is then coupled to causal transport equations for the heat flux, the shear and the bulk viscosity, in the context of Israel--Stewart theory, without excluding the thermodynamics viscous/heat coupling coefficients. The result is compared with previous works where these later coefficients were neglected and viscosity variables were not assumed to satisfy causal transport equations. Prospective applications of this result to some astrophysical scenarios are discussed.Comment: 22 pages Latex. To appear in Int. J. Mod. Phys. D. Typos correcte

    Inverse problem for wave equation with sources and observations on disjoint sets

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    We consider an inverse problem for a hyperbolic partial differential equation on a compact Riemannian manifold. Assuming that Γ1\Gamma_1 and Γ2\Gamma_2 are two disjoint open subsets of the boundary of the manifold we define the restricted Dirichlet-to-Neumann operator ΛΓ1,Γ2\Lambda_{\Gamma_1,\Gamma_2}. This operator corresponds the boundary measurements when we have smooth sources supported on Γ1\Gamma_1 and the fields produced by these sources are observed on Γ2\Gamma_2. We show that when Γ1\Gamma_1 and Γ2\Gamma_2 are disjoint but their closures intersect at least at one point, then the restricted Dirichlet-to-Neumann operator ΛΓ1,Γ2\Lambda_{\Gamma_1,\Gamma_2} determines the Riemannian manifold and the metric on it up to an isometry. In the Euclidian space, the result yields that an anisotropic wave speed inside a compact body is determined, up to a natural coordinate transformations, by measurements on the boundary of the body even when wave sources are kept away from receivers. Moreover, we show that if we have three arbitrary non-empty open subsets Γ1,Γ2\Gamma_1,\Gamma_2, and Γ3\Gamma_3 of the boundary, then the restricted Dirichlet-to-Neumann operators ΛΓj,Γk\Lambda_{\Gamma_j,\Gamma_k} for 1j<k31\leq j<k\leq 3 determine the Riemannian manifold to an isometry. Similar result is proven also for the finite-time boundary measurements when the hyperbolic equation satisfies an exact controllability condition

    Some analytical models of radiating collapsing spheres

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    We present some analytical solutions to the Einstein equations, describing radiating collapsing spheres in the diffusion approximation. Solutions allow for modeling physical reasonable situations. The temperature is calculated for each solution, using a hyperbolic transport equation, which permits to exhibit the influence of relaxational effects on the dynamics of the system.Comment: 17 pages Late

    Pore-size dependence of the thermal conductivity of porous silicon : a phonon hydrodynamic approach

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    Phononhydrodynamics is used to analyze the influence of porosity and of pore size on reduction in thermal conductivity in porous silicon, with respect to crystalline silicon. The expressions predict that the thermal conductivity is lower for higher porosity and for smaller pore radius, as a consequence of phononballisticeffects. The theoretical results describe experimental data better than the assumption that they only depend on porosity

    Immunoproteasome Overexpression Underlies the Pathogenesis of Thyroid Oncocytes and Primary Hypothyroidism: Studies in Humans and Mice

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    BACKGROUND:Oncocytes of the thyroid gland (Hürthle cells) are found in tumors and autoimmune diseases. They have a unique appearance characterized by abundant granular eosinophilic cytoplasm and hyperchromatic nucleus. Their pathogenesis has remained, thus far, unknown. METHODOLOGY/PRINCIPAL FINDINGS:Using transgenic mice chronically expressing IFNgamma in thyroid gland, we showed changes in the thyroid follicular epithelium reminiscent of the human oncocyte. Transcriptome analysis comparing transgenic to wild type thyrocytes revealed increased levels of immunoproteasome subunits like LMP2 in transgenics, suggesting an important role of the immunoproteasome in oncocyte pathogenesis. Pharmacologic blockade of the proteasome, in fact, ameliorated the oncocytic phenotype. Genetic deletion of LMP2 subunit prevented the development of the oncocytic phenotype and primary hypothyroidism. LMP2 was also found expressed in oncocytes from patients with Hashimoto thyroiditis and Hürthle cell tumors. CONCLUSIONS/SIGNIFICANCE:In summary, we report that oncocytes are the result of an increased immunoproteasome expression secondary to a chronic inflammatory milieu, and suggest LMP2 as a novel therapeutic target for the treatment of oncocytic lesions and autoimmune hypothyroidism

    Organics in comet 67P – a first comparative analysis of mass spectra from ROSINA–DFMS, COSAC and Ptolemy

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    The ESA Rosetta spacecraft followed comet 67P at a close distance for more than 2 yr. In addition, it deployed the lander Philae on to the surface of the comet. The (surface) composition of the comet is of great interest to understand the origin and evolution of comets. By combining measurements made on the comet itself and in the coma, we probe the nature of this surface material and compare it to remote sensing observations. We compare data from the double focusing mass spectrometer (DFMS) of the ROSINA experiment on ESA's Rosetta mission and previously published data from the two mass spectrometers COSAC (COmetary Sampling And Composition) and Ptolemy on the lander. The mass spectra of all three instruments show very similar patterns of mainly CHO-bearing molecules that sublimate at temperatures of 275 K. The DFMS data also show a great variety of CH-, CHN-, CHS-, CHO2- and CHNO-bearing saturated and unsaturated species. Methyl isocyanate, propanal and glycol aldehyde suggested by the earlier analysis of the measured COSAC spectrum could not be confirmed. The presence of polyoxymethylene in the Ptolemy spectrum was found to be unlikely. However, the signature of the aromatic compound toluene was identified in DFMS and Ptolemy data. Comparison with remote sensing instruments confirms the complex nature of the organics on the surface of 67P, which is much more diverse than anticipated

    Lack of phenotypic and evolutionary cross-resistance against parasitoids and pathogens in Drosophila melanogaster

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    BackgroundWhen organisms are attacked by multiple natural enemies, the evolution of a resistance mechanism to one natural enemy will be influenced by the degree of cross-resistance to another natural enemy. Cross-resistance can be positive, when a resistance mechanism against one natural enemy also offers resistance to another; or negative, in the form of a trade-off, when an increase in resistance against one natural enemy results in a decrease in resistance against another. Using Drosophila melanogaster, an important model system for the evolution of invertebrate immunity, we test for the existence of cross-resistance against parasites and pathogens, at both a phenotypic and evolutionary level.MethodsWe used a field strain of D. melanogaster to test whether surviving parasitism by the parasitoid Asobara tabida has an effect on the resistance against Beauveria bassiana, an entomopathogenic fungus; and whether infection with the microsporidian Tubulinosema kingi has an effect on the resistance against A. tabida. We used lines selected for increased resistance to A. tabida to test whether increased parasitoid resistance has an effect on resistance against B. bassiana and T. kingi. We used lines selected for increased tolerance against B. bassiana to test whether increased fungal resistance has an effect on resistance against A. tabida.Results/ConclusionsWe found no positive cross-resistance or trade-offs in the resistance to parasites and pathogens. This is an important finding, given the use of D. melanogaster as a model system for the evolution of invertebrate immunity. The lack of any cross-resistance to parasites and pathogens, at both the phenotypic and the evolutionary level, suggests that evolution of resistance against one class of natural enemies is largely independent of evolution of resistance against the other

    Evolution of water production of 67P/Churyumov-Gerasimenko: An empirical model and a multi-instrument study

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    We examine the evolution of the water production of comet 67P/Churyumov–Gerasimenko during the Rosetta mission (2014 June–2016 May) based on in situ and remote sensing measurements made by Rosetta instruments, Earth-based telescopes and through the development of an empirical coma model. The derivation of the empirical model is described and the model is then applied to detrend spacecraft position effects from the Rosetta Orbiter Spectrometer for Ion and Neutral Analysis (ROSINA) data. The inter-comparison of the instrument data sets shows a high level of consistency and provides insights into the water and dust production. We examine different phases of the orbit, including the early mission (beyond 3.5 au) where the ROSINA water production does not show the expected increase with decreasing heliocentric distance. A second important phase is the period around the inbound equinox, where the peak water production makes a dramatic transition from northern to southern latitudes. During this transition, the water distribution is complex, but is driven by rotation and active areas in the north and south. Finally, we consider the perihelion period, where there may be evidence of time dependence in the water production rate. The peak water production, as measured by ROSINA, occurs 18–22 d after perihelion at 3.5 ± 0.5 × 1028 water molecules s-1. We show that the water production is highly correlated with ground-based dust measurements, possibly indicating that several dust parameters are constant during the observed period. Using estimates of the dust/gas ratio, we use our measured water production rate to calculate a uniform surface loss of 2–4 m during the current perihelion passage

    On the stability in phase-lag heat conduction with two temperatures

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    We investigate the well-posedness and the stability of the solutions for several Taylor approximations of the phase-lag two-temperature equations.We give conditions on the parameters which guarantee the existence and uniqueness of solutions as well as the stability and the instability of the solutions for each approximationPeer ReviewedPostprint (author's final draft
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