121 research outputs found
Vesnarinone and glucocorticoids cooperatively induce G1 arrest and have an anti-tumour effect on human non-small cell lung carcinoma cells grown in nude mice
EAN consensus statement for management of patients with neurological diseases during the COVIDâ19 pandemic
Background and purpose
The recent SARSâCoVâ2 pandemic has posed multiple challenges to the practice of clinical neurology including recognition of emerging neurological complications and management of coexistent neurological diseases. In a fastâevolving pandemic, evidenceâbased studies are lacking in many areas. This paper presents European Academy of Neurology (EAN) expert consensus statements to guide neurologists caring for patients with COVIDâ19.
Methods
A refined Delphi methodology was applied. In round 1, statements were provided by EAN scientific panels (SPs). In round 2, these statements were circulated to SP members not involved in writing them, asking for agreement/disagreement. Items with agreement >70% were retained for round 3, in which SP coâchairs rated importance on a fiveâpoint Likert scale. Results were graded by importance and reported as consensus statements.
Results
In round one, 70 statements were provided by 23 SPs. In round two, 259/1061 SP member responses were received. Fiftyânine statements obtained >70% agreement and were retained. In round three, responses were received from 55 coâchairs of 29 SPs. Whilst general recommendations related to prevention of COVIDâ19 transmission had high levels of agreement and importance, opinion was more varied concerning statements related to therapy.
Conclusion
This is the first structured consensus statement on good clinical practice in patients with neurological disease during the COVIDâ19 pandemic that provides immediate guidance for neurologists. In this fastâevolving pandemic, a rapid response using refined Delphi methodology is possible, but guidance may be subject to change as further evidence emerges
A plea for equitable global access to COVIDâ19 diagnostics, vaccination and therapy: The NeuroCOVIDâ19 Task Force of the European Academy of Neurology
Coronavirus disease 2019 (COVIDâ19), a multiâorgan disease caused by severe acute respiratory syndrome coronavirus 2 (SARSâCoVâ2), continues to challenge health and care systems around the globe. The pandemic has disrupted acute neurology services and routine patient care and has impacted the clinical course in patients with chronic neurological disease. COVIDâ19 appears to have exposed inequalities of societies and healthcare systems and had a disproportionate impact on already vulnerable communities. The next challenge will be to set up initiatives to stop disparities in all aspects related to COVIDâ19. From the medical perspective, there is a need to consider inequalities in prevention, treatment and longâterm consequences. Some of the issues of direct relevance to neurologists are summarised. With this appraisal, the European Academy of Neurology NeuroCOVIDâ19 Task Force intends to raise awareness of the potential impact of COVIDâ19 on inequalities in healthcare and calls for action to prevent disparity at individual, national and supranational levels
Orme di italiani sul Karakorum : immagini e documenti dalla spedizione di Aimone di Savoia-Aosta, duca di Spoleto, in Karakorum (1927-1936)
Orme di Italiani sul Karakorum : Immagini e documenti dalla spedizione di Aimone di Savoia-Aosta, duca di Spoleto, in Karakorum (1927-1936)
Mostra collegata al Convegno internazionale di studi "Dall'Artico agli 8000. Ricerca scientifica, alpinismo, geografia e imperialismo in una prospettiva internazionale (1880-1964)". Milano, Universit\ue0 degli studi di Milano - Atrio dell'Aula Magn
Inversion of the spatiotemporal distribution of early postseismic slip within the rate-and-state framework using high-rate GNSS position time series
International audienceWhereas the spatial and temporal evolution of early postseismic slip (i.e., the first few hours) has been shown to be complex, we do not know well the mechanisms that control its behaviour. One pending question is to know whether or not the rate-and-state friction law is required to explain it, or if the rate-dependent friction law, traditionally used to explain afterslip observations on a day-to-month time scale, is sufficient. Based on 30-sec high-rate position time series that show the early postseismic surface displacements at 13 stations from 2.5 minutes to 3 days after the 2015 M8.3 Illapel, Chile, earthquake, we attempt to infer the frictional properties that control early postseismic slip on the fault. We invert simultaneously for the location and the amplitude of the slip patches, and for the frictional parameters that control their temporal behaviour. We use the elliptic slip patch inversion method (Vallée et Bouchon, 2004; Twardzik et al., 2012) that allows to reduce the number of unknown parameters and we solve, in particular, for the rate-and-state friction law parameters. The obtained frictional parameters are consistent with a velocity-strengthening behaviour. Our first results indicate that 1) the framework can explain the full time series, 2) the postseismic slip patches are located on the edge of the coseismic slip distribution, 3) the obtained stress drop parameter is consistent with that found for the coseismic rupture, and 4) the stiffness of the rate-and-state friction law is consistent with the size of the slip patches. We will also discuss the ability of compatible models to apply at longer postseismic timescales which would suggest a unique underlying physical process
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