Settlement Of Oyster (Crassostrea-Virginica) Larvae - Effects Of Water-Flow And A Water-Soluble Chemical Cue

Although previous evidence indicates that larvae of benthic marine invertebrates can respond to waterborne cues in still water, the importance of waterborne cues in mediating natural settlement out of flowing water has been questioned. Here, we summarize the results of flume experiments demonstrating enhanced settlement of oyster larvae in small target wells (circles of 7-cm diam) with the release of a waterborne settlement cue compared to identical substrates without the cue. In concurrent still-water experiments, more oyster larvae settled in solutions of waterborne cue than in seawater controls. Velocity and electrochemical measurements of a conservative tracer verified that at low flow velocities (2 and 6 cm s(-1)) with U* value

Heretics and Party-Crashers: Al-Khāṭīb al-Baghdādī’s Kitāb al-Taṭfīl

This is the author accepted manuscript. The final version is available from Brill via the DOI in this record.Taṭfīl (party-crashing) stories, in addition to being humorous and entertaining, provided a space to explore a number of serious theological and ethical issues. Given their inherent concern with inclusion and exclusion (i.e., who should be admitted to the “party”), they are an especially appropriate vehicle for the exploration of ideas concerning the categorization and exclusion of “heretics,” enacted as part of various efforts to define and control orthodoxy. We will argue that some party-crashing stories presented a plea for more inclusiveness in religion, by subtly invoking the value systems of hospitality, and by emphasizing the impossibility of knowing who will be saved and who will be damned. In the analogy that these stories present, paradise is like a party and God is the host. As Julia Bray writes in her essay “The Physical World and the Writer’s Eye,” “Though medieval Arabic has a vast literature of ideas nakedly expressed as such, it is…highly characteristic of the culture that some of its guiding ideas are not expressed abstractly, but are explored through narrative, or through other forms of representation which are not overtly analytical. A problem raised in one discipline, such as Ḥadīth or theology, may, as we have seen, be debated outside the rules and conventions of that discipline.

Walking as a meaningful leisure occupation: the implications for occupational therapy

Introduction: In response to growing interest in leisure in occupational therapy and the importance of understanding how occupations maintain, enhance and promote health and wellbeing, a qualitative phenomenological study was conducted to explore the experiences of walking for leisure. Method: Six healthy student participants, identified as regular walkers, were interviewed using a semi-structured format. Data were analysed following interpretative phenomenological analysis methodology. Findings: Participants expressed how and why walking was meaningful to them; the four main themes were social connectedness, wellbeing, connection to nature and achievement from a challenge. Findings suggest that occupational therapists could use walking and leisure occupations in intervention, and that there is scope for an occupational therapy perspective in health promotion. Conclusion: Determining the subjective meaning of engaging in walking as a leisure occupation has implications for occupational science and health promotion in helping to explain why people do what they do

Insulin therapy and dietary adjustments to normalize glycaemia and prevent nocturnal hypoglycaemia after evening exercise in type 1 diabetes: a randomized controlled trial

Introduction Evening-time exercise is a frequent cause of severe hypoglycemia in type 1 diabetes, fear of which deters participation in regular exercise. Recommendations for normalizing glycemia around exercise consist of prandial adjustments to bolus insulin therapy and food composition, but this carries only short-lasting protection from hypoglycemia. Therefore, this study aimed to examine the impact of a combined basal-bolus insulin dose reduction and carbohydrate feeding strategy on glycemia and metabolic parameters following evening exercise in type 1 diabetes. Methods Ten male participants (glycated hemoglobin: 52.4±2.2 mmol/mol), treated with multiple daily injections, completed two randomized study-days, whereby administration of total daily basal insulin dose was unchanged (100%), or reduced by 20% (80%). Participants attended the laboratory at ∼08:00 h for a fasted blood sample, before returning in the evening. On arrival (∼17:00 h), participants consumed a carbohydrate meal and administered a 75% reduced rapid-acting insulin dose and 60 min later performed 45 min of treadmill running. At 60 min postexercise, participants consumed a low glycemic index (LGI) meal and administered a 50% reduced rapid-acting insulin dose, before returning home. At ∼23:00 h, participants consumed a LGI bedtime snack and returned to the laboratory the following morning (∼08:00 h) for a fasted blood sample. Venous blood samples were analyzed for glucose, glucoregulatory hormones, non-esterified fatty acids, β-hydroxybutyrate, interleukin 6, and tumor necrosis factor α. Interstitial glucose was monitored for 24 h pre-exercise and postexercise. Results Glycemia was similar until 6 h postexercise, with no hypoglycemic episodes. Beyond 6 h glucose levels fell during 100%, and nine participants experienced nocturnal hypoglycemia. Conversely, all participants during 80% were protected from nocturnal hypoglycemia, and remained protected for 24 h postexercise. All metabolic parameters were similar. Conclusions Reducing basal insulin dose with reduced prandial bolus insulin and LGI carbohydrate feeding provides protection from hypoglycemia during and for 24 h following evening exercise. This strategy is not associated with hyperglycemia, or adverse metabolic disturbances

Large-eddy simulation of buoyant plane plumes

In the present study a turbulent plane plume is examined by means of numerical simulations. Results are compared with experiments and results from integral models based on an entrainment assumption. The objective of this research is to determine wheter a large-eddy simulation can be applied in this case and what subgrid scale model performs best

The Star Formation in Radio Survey: Jansky Very Large Array 33 GHz Observations of Nearby Galaxy Nuclei and Extranuclear Star-Forming Regions

We present 33 GHz imaging for 112 pointings towards galaxy nuclei and extranuclear star-forming regions at $\approx$2" resolution using the Karl G. Jansky Very Large Array (VLA) as part of the Star Formation in Radio Survey. A comparison with 33 GHz Robert C. Byrd Green Bank Telescope single-dish observations indicates that the interferometric VLA observations recover $78\pm4$ of the total flux density over 25" regions ($\approx$ kpc-scales) among all fields. On these scales, the emission being resolved out is most likely diffuse non-thermal synchrotron emission. Consequently, on the $\approx30-300$ pc scales sampled by our VLA observations, the bulk of the 33 GHz emission is recovered and primarily powered by free-free emission from discrete HII regions, making it an excellent tracer of massive star formation. Of the 225 discrete regions used for aperture photometry, 162 are extranuclear (i.e., having galactocentric radii $r_{\rm G} \geq 250$ pc) and detected at $>3\sigma$ significance at 33 GHz and in H$\alpha$. Assuming a typical 33 GHz thermal fraction of 90 %, the ratio of optically-thin 33 GHz-to-uncorrected H$\alpha$ star formation rates indicate a median extinction value on $\approx30-300$ pc scales of $A_{\rm H\alpha} \approx 1.26\pm0.09$ mag with an associated median absolute deviation of 0.87 mag. We find that 10 % of these sources are "highly embedded" (i.e., $A_{\rm H\alpha}\gtrsim3.3$ mag), suggesting that on average HII regions remain embedded for $\lesssim1$ Myr. Finally, we find the median 33 GHz continuum-to-H$\alpha$ line flux ratio to be statistically larger within $r_{\rm G}<250$ pc relative the outer-disk regions by a factor of $1.82\pm0.39$, while the ratio of 33 GHz-to-24 $\mu$m flux densities are lower by a factor of $0.45\pm0.08$, which may suggest increased extinction in the central regions.E.J.M. acknowledges the hospitality of the Aspen Center for Physics, which is supported by National Science Foundation grant No. PHY-1066293. The National Radio Astronomy Observatory is a facility of the National Science Foundation operated under cooperative agreement by Associated Universities, Inc. This research made use of APLpy, an open-source plotting package for Python hosted at http://aplpy.github.com

The Cost of Annual versus Biannual Community-Directed Treatment of Onchocerciasis with Ivermectin: Ghana as a Case Study

BACKGROUND: It has been proposed that switching from annual to biannual (twice yearly) mass community-directed treatment with ivermectin (CDTI) might improve the chances of onchocerciasis elimination in some African foci. However, historically, relatively few communities have received biannual treatments in Africa, and there are no cost data associated with increasing ivermectin treatment frequency at a large scale. Collecting cost data is essential for conducting economic evaluations of control programmes. Some countries, such as Ghana, have adopted a biannual treatment strategy in selected districts. We undertook a study to estimate the costs associated with annual and biannual CDTI in Ghana. METHODOLOGY: The study was conducted in the Brong-Ahafo and Northern regions of Ghana. Data collection was organized at the national, regional, district, sub-district and community levels, and involved interviewing key personnel and scrutinizing national records. Data were collected in four districts; one in which treatment is delivered annually, two in which it is delivered biannually, and one where treatment takes place biannually in some communities and annually in others. Both financial and economic costs were collected from the health care provider's perspective. PRINCIPAL FINDINGS: The estimated cost of treating annually was US Dollars (USD) 0.45 per person including the value of time donated by the community drug distributors (which was estimated at USD 0.05 per person per treatment round). The cost of CDTI was approximately 50–60% higher in those districts where treatment was biannual than in those where it was annual. Large-scale mass biannual treatment was reported as being well received and considered sustainable. CONCLUSIONS/SIGNIFICANCE: This study provides rigorous evidence of the different costs associated with annual and biannual CDTI in Ghana which can be used to inform an economic evaluation of the debate on the optimal treatment frequency required to control (or eliminate) onchocerciasis in Africa

Tenascin C upregulates interleukin-6 expression in human cardiac myofibroblasts via toll-like receptor 4.

AIM: To investigate the effect of Tenascin C (TNC) on the expression of pro-inflammatory cytokines and matrix metalloproteinases in human cardiac myofibroblasts (CMF). METHODS: CMF were isolated and cultured from patients undergoing coronary artery bypass grafting. Cultured cells were treated with either TNC (0.1 μmol/L, 24 h) or a recombinant protein corresponding to different domains of the TNC protein; fibrinogen-like globe (FBG) and fibronectin type III-like repeats (TNIII 5-7) (both 1 μmol/L, 24 h). The expression of the pro-inflammatory cytokines; interleukin (IL)-6, IL-1β, TNFα and the matrix metalloproteinases; MMPs (MMP1, 2, 3, 9, 10, MT1-MMP) was assessed using real time RT-PCR and western blot analysis. RESULTS: TNC increased both IL-6 and MMP3 (P < 0.01) mRNA levels in cultured human CMF but had no significant effect on the other markers studied. The increase in IL-6 mRNA expression was mirrored by an increase in protein secretion as assessed by enzyme-linked immunosorbant assay (P < 0.01). Treating CMF with the recombinant protein FBG increased IL-6 mRNA and protein (P < 0.01) whereas the recombinant protein TNIII 5-7 had no effect. Neither FBG nor TNIII 5-7 had any significant effect on MMP3 expression. The expression of toll-like receptor 4 (TLR4) in human CMF was confirmed by real time RT-PCR, western blot and immunohistochemistry. Pre-incubation of cells with TLR4 neutralising antisera attenuated the effect of both TNC and FBG on IL-6 mRNA and protein expression. CONCLUSION: TNC up-regulates IL-6 expression in human CMF, an effect mediated through the FBG domain of TNC and via the TLR4 receptor