Élaboration et validation d’une échelle des agents de stress dans les organisations

Cette recherche a pour but d'expliciter les mécanismes du stress et d'établir puis valider une échelle hiérarchique des différents agents de stress dans les organisations.The object of this research is to elaborate a model of organizational stress and to establish a hierarchical scale of various organizational stressors in addition to validating such a scale.Many researchers, amongst them Beehr, Walsh and Taber have established, the fact that stress related to task role such as role ambiguity and non participation has an effect on fatigue, tension and job dissatisfaction. However, up to now, no effort has been made to take stock of the many different organizational stressors. Therefore, an organizational stressors scale was built using the Delphi Technique. The scale was then tested amongst 148 managers in 10 different organizations.This research demonstrated that there exists a relationship between organizational stress and psychological stress manifestation such as aggressiveness, depression and concentration problems, as well as physiological stress manifestation such as insomnia, gastrointestinal and respiratory problems. This research has also proved that there is a relationship between high organizational stress scores and a high rate of use or abuse of pharmaceutical products such as stimulants

Youth Integration, Social Cohesion, and Social Capital: An Analysis of the General Social Survey on Time Use

Abstract not availabl

Demonstration of a Hybrid Space Architecture During RIMPAC 2020

The Micro-Satellite Military Utility (MSMU) Project Arrangement (PA) is an agreement under the Responsive Space Capabilities (RSC) Memorandum of Understanding (MOU) that involves the Departments and Ministries of Defence of Australia, Canada, Germany, Italy, the Netherlands, New Zealand, Norway, United Kingdom and United States. MSMU’s charter is to inform a space enterprise that provides military users with reliable access to a broad spectrum of information in an opportunistic environment. Research and Development teams from MSMU partner nations supported Exercise Rim of the Pacific (RIMPAC) 2020 which took place 17 to 31 August 2020 in the Hawaiian region. RIMPAC 2020 provided an opportunity to explore the military utility of a Hybrid Space Architecture (HSA) of satellites including traditional government and commercial satellites, as well as micro-satellites and nanosatellites, by leveraging contributions across the MSMU partner nations. The objective was to continue testing the hypothesis that an HSA, mostly composed of small satellites, can bring significant value to the operational theatre. The MSMU PA partner nations have leveraged several multi-national exercises, with the first being the Exercise RIMPAC 2018. Previous exercises enabled multinational technology advancements, interoperability testing, process refinement, and capability developments to make advancements towards MSMU’s goal to address the warfighter’s need for diverse ISR capabilities. The most recent accomplishment was a major integration effort across mission planning tools, space-based Intelligence, Surveillance and Reconnaissance (ISR) data providers, and exploitation tools. The MSMU team accessed ~256 space-based sensors (EO – Electro Optical, SAR – Synthetic Aperture Radar, AIS – Automatic Identification System) to collect maritime domain and ISR data over a harbor, airfields and open sea. Data was exploited via international channels in order to determine the success rate of capturing pertinent data to be later exploited and disseminated. This paper describes results from the experiment and offers insights into the HSA military utility

Upregulated IL-32 expression and reduced gut short chain fatty acid caproic acid in people living with HIV with subclinical atherosclerosis

Despite the success of antiretroviral therapy (ART), people living with HIV (PLWH) are still at higher risk for cardiovascular diseases (CVDs) that are mediated by chronic inflammation. Identification of novel inflammatory mediators with the inherent potential to be used as CVD biomarkers and also as therapeutic targets is critically needed for better risk stratification and disease management in PLWH. Here, we investigated the expression and potential role of the multi-isoform proinflammatory cytokine IL-32 in subclinical atherosclerosis in PLWH (n=49 with subclinical atherosclerosis and n=30 without) and HIV- controls (n=25 with subclinical atherosclerosis and n=24 without). While expression of all tested IL-32 isoforms (α, β, γ, D, ϵ, and θ) was significantly higher in peripheral blood from PLWH compared to HIV- controls, IL-32D and IL-32θ isoforms were further upregulated in HIV+ individuals with coronary artery atherosclerosis compared to their counterparts without. Upregulation of these two isoforms was associated with increased plasma levels of IL-18 and IL-1β and downregulation of the atheroprotective protein TRAIL, which together composed a unique atherosclerotic inflammatory signature specific for PLWH compared to HIV- controls. Logistic regression analysis demonstrated that modulation of these inflammatory variables was independent of age, smoking, and statin treatment. Furthermore, our in vitro functional data linked IL-32 to macrophage activation and production of IL-18 and downregulation of TRAIL, a mechanism previously shown to be associated with impaired cholesterol metabolism and atherosclerosis. Finally, increased expression of IL-32 isoforms in PLWH with subclinical atherosclerosis was associated with altered gut microbiome (increased pathogenic bacteria; Rothia and Eggerthella species) and lower abundance of the gut metabolite short-chain fatty acid (SCFA) caproic acid, measured in fecal samples from the study participants. Importantly, caproic acid diminished the production of IL-32, IL-18, and IL-1β in human PBMCs in response to bacterial LPS stimulation. In conclusion, our studies identified an HIV-specific atherosclerotic inflammatory signature including specific IL-32 isoforms, which is regulated by the SCFA caproic acid and that may lead to new potential therapies to prevent CVD in ART-treated PLWH

Genomic architecture and evolution of clear cell renal cell carcinomas defined by multiregion sequencing

Clear cell renal carcinomas (ccRCCs) can display intratumor heterogeneity (ITH). We applied multiregion exome sequencing (M-seq) to resolve the genetic architecture and evolutionary histories of ten ccRCCs. Ultra-deep sequencing identified ITH in all cases. We found that 73–75% of identified ccRCC driver aberrations were subclonal, confounding estimates of driver mutation prevalence. ITH increased with the number of biopsies analyzed, without evidence of saturation in most tumors. Chromosome 3p loss and VHL aberrations were the only ubiquitous events. The proportion of C>T transitions at CpG sites increased during tumor progression. M-seq permits the temporal resolution of ccRCC evolution and refines mutational signatures occurring during tumor development