Development of value metrics for specific basketball contexts: a positional approach for the defensive rebound value

Over the past decade, NBA teams are making an increasing investment in the development and growth of data analytics to help each team's ultimate goal of winning the championship. This growth has been accompanied by improvements in data collection from the league's games, moving from superficial, manually annotated statistics - box scores - to much richer data that can provide much more information - the optical tracking data. This study aims to analyze a very specific facet of the game: defensive rebounding. This section of the game is one of the least information that can be collected manually. Using optical game tracking data from the 2020/2021 season, we will try to capture the contribution that players have in achieving the rebounding for the team. In this work, multiple metrics have been developed to explain different dimensions of the defensive rebounding process, in addition to different analyses of these metrics. This has allowed us to discover different player profiles in this phase of the game and team behaviors that were invisible to the eyes of traditional statistics

Implications of Gallium Solar Neutrino Data for the Resonant Spin-Flavor Precession Scenario

We consider the implications of the recent results of SAGE and GALLEX experiments for the solution of the solar neutrino problem in the framework of the resonant neutrino spin-flavor precession scenario. It is shown that this scenario is consistent with all the existing solar neutrino data including the gallium results. The quality of the fit of the data depends crucially on the magnetic field profile used which makes it possible to get information about the magnetic field in the solar interior. In particular, the magnetic field in the core of the sun must not be too strong ($<3 \times 10^6$ G). The detection rate in the gallium detectors turns out to be especially sensitive to the magnitude of $\Delta m^2$. Predictions for forthcoming solar-neutrino experiments are made.Comment: LaTeX, 16 pages, 5 figures (not included by available upon request by fax or ordinary mail

Unidad Didáctica de Estadística y Probabilidad mediante proyectos en 1.º de la ESO

Treball Final de Màster Universitari en Professor/a d'Educació Secundària Obligatòria i Batxillerat, Formació Professional i Ensenyaments d'Idiomes. Codi: SAP509. Curs: 2019/2020El Trabajo Fin de Máster se centra en el desarrollo de una Unidad Didáctica enmarcada en la asignatura de matemáticas (bloque de Estadística y Probabilidad) dirigida a 1.º ESO. Está basada en un proyecto que abarca una actividad centrada en la realización de una encuesta que haga uso de términos estadísticos (5 sesiones) y otra actividad situada en el contexto de juegos probabilísticos (5 sesiones). Todo ello con la motivación de ampliar, mejorar y ofrecer un material enfocado a una metodología innovadora, lúdica y orientado a cumplir una serie de objetivos de cumplimiento de contenidos y competencias. Mediante la referenciación a otros autores se refuerza la idoneidad de trabajar estadística y probabilidad mediante proyectos; los contenidos, competencias y metodologías que deben abarcar estos; la transversalidad y la atención a la diversidad previstas; y el aconsejable uso de recursos tecnológicos. A continuación, se exponen unidades didácticas llevadas a cabo por varios autores de renombre, así como sus conclusiones de poner en marcha dichas actividades. La Unidad Didáctica de Estadística y Probabilidad basada en proyectos en 1.º ESO trata de dar respuesta a: la contextualización demandada; los asuntos curriculares; los objetivos, contenidos y competencias; actividades temporalizadas en sesiones; metodología estructurada en el espacio y el tiempo; dificultades previstas y atención a la diversidad; materiales y recursos didácticos; evaluación; y construcción del conocimiento. De forma teórica e hipotética, la Unidad Didáctica se considera efectiva en cuanto a consecución de objetivos; buen enfoque de dificultad; correcta consideración de contenido, motivación, metodología, entretenimiento, esfuerzo y proceso de aprendizaje; y revisable en cuanto al tiempo invertido. En conclusión, los puntos fuertes de la actividad son aquellos relacionados con la significación y afianzamiento del aprendizaje, pues de forma lúdica se permite una mejor captación de ideas. A pesar de ello, los puntos débiles sería la no puesta en práctica en su totalidad y por ende la no valoración de resultados. Además, también cabe la posibilidad de incluirla en una programación didáctica enfocada a un curso académico completo

Mate-Tuber

En el presente trabajo se pretende ofrecer a los alumnos de 4.º de Educación Secundaria Obligatoria una forma innovadora y entretenida de aprender matemáticas. Para ello, se tiene en cuenta el contexto histórico actual en el que existen muchos vídeos y explicaciones en internet y el trabajo en grupo en el mundo laboral. Se plantea la adquisición de otras competencias transversales como las TIC y la colaboración en grupos, entrelazando el contenido del curso con la creación de vídeos explicativos para facilitar el aprendizaje

Synthesis of phenylalaninol-derived oxazolopyrrolidone lactams and evaluation as NMDA receptor antagonists

N-Methyl-D-aspartate (NMDA) receptor antagonists are known to rescue neuronal cell death caused by excessive activation of glutamate receptors. This phenomenon, known as excitotoxicity, is implicated in the pathogenesis of several neurodegenerative disorders including ischemia, Alzheimer's disease, Parkinson's disease, and Huntington's disease. Unfortunately, some NMDA receptor antagonists have shown discouraging results when tested in clinical trials. However, recent advances in the physiology and pharmacology of the NMDA receptor have kept interest alive in modulating NMDA receptors for therapeutic intervention. We present here the synthesis of a small library of phenylalaninol-derived oxazolopyrrolidone lactams and their evaluation as NMDA receptor antagonists. The compounds were easily synthesized in yields up to 92 %. In addition, one of the compounds has a 50 % inhibitory concentration (IC 50) of 62 μM and offers potential to develop more potent NMDA receptor antagonists

Disruption of cortical cell type composition and function underlies diabetes-associated cognitive decline

Cognitive decline; Cortex; MetabolismDeclivi cognitiu; Còrtex; MetabolismeDeterioro cognitivo; Corteza; MetabolismoAims/hypothesis Type 2 diabetes is associated with increased risk of cognitive decline although the pathogenic basis for this remains obscure. Deciphering diabetes-linked molecular mechanisms in cells of the cerebral cortex could uncover novel therapeutic targets. Methods Single-cell transcriptomic sequencing (scRNA-seq) was conducted on the cerebral cortex in a mouse model of type 2 diabetes (db/db mice) and in non-diabetic control mice in order to identify gene expression changes in distinct cell subpopulations and alterations in cell type composition. Immunohistochemistry and metabolic assessment were used to validate the findings from scRNA-seq and to investigate whether these cell-specific dysfunctions impact the neurovascular unit (NVU). Furthermore, the behavioural and cognitive alterations related to these dysfunctions in db/db mice were assessed via Morris water maze and novel object discrimination tests. Finally, results were validated in post-mortem sections and protein isolates from individuals with type 2 diabetes. Results Compared with non-diabetic control mice, the db/db mice demonstrated disrupted brain function as revealed by losses in episodic and spatial memory and this occurred concomitantly with dysfunctional NVU, neuronal circuitry and cerebral atrophy. scRNA-seq of db/db mouse cerebral cortex revealed cell population changes in neurons, glia and microglia linked to functional regulatory disruption including neuronal maturation and altered metabolism. These changes were validated through immunohistochemistry and protein expression analysis not just in the db/db mouse cerebral cortex but also in post-mortem sections and protein isolates from individuals with type 2 diabetes (74.3 ± 5.5 years) compared with non-diabetic control individuals (87.0 ± 8.5 years). Furthermore, metabolic and synaptic gene disruptions were evident in cortical NVU cell populations and associated with a decrease in vascular density. Conclusions/interpretation Taken together, our data reveal disruption in the cellular and molecular architecture of the cerebral cortex induced by diabetes, which can explain, at least in part, the basis for progressive cognitive decline in individuals with type 2 diabetes

Synthesis of phenylalaninol-derived oxazolopyrrolidone lactams and evaluation as NMDA receptor antagonists

N-Methyl-d-aspartate (NMDA) receptor antagonists are known to rescue neuronal cell death caused by excessive activation of glutamate receptors. This phenomenon, known as excitotoxicity, is implicated in the pathogenesis of several neurodegenerative disorders including ischemia, Alzheimer's disease, Parkinson's disease, and Huntington's disease. Unfortunately, some NMDA receptor antagonists have shown discouraging results when tested in clinical trials. However, recent advances in the physiology and pharmacology of the NMDA receptor have kept interest alive in modulating NMDA receptors for therapeutic intervention. We present here the synthesis of a small library of phenylalaninol-derived oxazolopyrrolidone lactams and their evaluation as NMDA receptor antagonists. The compounds were easily synthesized in yields up to 92 %. In addition, one of the compounds has a 50 % inhibitory concentration (IC (50)) of 62 mu M and offers potential to develop more potent NMDA receptor antagonists.Fundação para a Ciência e Tecnologia (Portugal) is acknowledged for financial support (PTDC/QUI-QUI/111664/2009; PEst-OE/SAU/UI4013/2011; REDE/1518/REM/2005). We also thank the Portuguese–Spanish Integrated Action (E-07/11 and AIB2010PT-00324) and the Spanish Ministerio de Ciencia e Innovación (MICINN) (CTQ2009-07021/BQU) for financial support

Disruption of cortical cell type composition and function underlies diabetes-associated cognitive decline

Aims/hypothesis Type 2 diabetes is associated with increased risk of cognitive decline although the pathogenic basis for this remains obscure. Deciphering diabetes-linked molecular mechanisms in cells of the cerebral cortex could uncover novel therapeutic targets. Methods Single-cell transcriptomic sequencing (scRNA-seq) was conducted on the cerebral cortex in a mouse model of type 2 diabetes (db/db mice) and in non-diabetic control mice in order to identify gene expression changes in distinct cell subpopulations and alterations in cell type composition. Immunohistochemistry and metabolic assessment were used to validate the fndings from scRNA-seq and to investigate whether these cell-specifc dysfunctions impact the neurovascular unit (NVU). Furthermore, the behavioural and cognitive alterations related to these dysfunctions in db/db mice were assessed via Morris water maze and novel object discrimination tests. Finally, results were validated in post-mortem sections and protein isolates from individuals with type 2 diabetes. Results Compared with non-diabetic control mice, the db/db mice demonstrated disrupted brain function as revealed by losses in episodic and spatial memory and this occurred concomitantly with dysfunctional NVU, neuronal circuitry and cerebral atrophy. scRNA-seq of db/db mouse cerebral cortex revealed cell population changes in neurons, glia and microglia linked to functional regulatory disruption including neuronal maturation and altered metabolism. These changes were validated through immunohistochemistry and protein expression analysis not just in the db/db mouse cerebral cortex but also in postmortem sections and protein isolates from individuals with type 2 diabetes (74.3 ± 5.5 years) compared with non-diabetic control individuals (87.0 ± 8.5 years). Furthermore, metabolic and synaptic gene disruptions were evident in cortical NVU cell populations and associated with a decrease in vascular density

Estimación de curvatura en curvas discretas

Treball final de Grau en Matemàtica Computacional. Codi: MT1030. Curs acadèmic 2017/2018El presente Trabajo Final de Grado abarca los aspectos más importantes de mi estancia en prácticas en Actualmed así como un análisis sobre las distintas posibles curvaturas en el ámbito de la Geometría Diferencial Discreta. En la empresa tuve como objetivos el lograr elaborar una herramienta de análisis en base a las imágenes médicas con las que se trataba allí. De esta forma se iría desarrollando mi estancia en prácticas, detallando los objetivos del proyecto as´ı como la metodología utilizada para lograr dichas metas. A continuación, en cuanto al tema para desarrollar en la memoria se ha escogido la Geometría Diferencial Discreta. Para ello se irán definiendo términos básicos de la geometría diferencial para posteriormente extrapolarlo al ámbito discreto. De esta forma se verá como cuando se pasa al entorno discreto, la materia se torna más compleja de entender y aplicar. Observaremos como la definición de curvatura en el entorno continuo es algo fácil e intuitivo de entender y formular mientras que en el discreto habrá que desarrollarlo con más cuidado

Propuesta de rehabilitación neuropsicológica en pacientes con afasia anómica tras un ictus

La afasia anómica es un trastorno del lenguaje que afecta a la capacidad de encontrar y recuperar palabras de manera adecuada, causando dificultades en la denominación y la expresión verbal. Esta condición es común en pacientes que han sufrido un ictus, enfermedad que representa la primera causa de discapacidad permanente en adultos mayores de 55 años. Esta condición neurológica aguda puede tener un impacto significativo en la comunicación y la calidad de vida de los individuos. En España no se han encontrado programas de intervención empíricamente validados para personas con este tipo de afasia. El objetivo de este trabajo es proponer una intervención terapéutica efectiva para pacientes con afasia anómica como consecuencia de un ictus. Se busca reestablecer las funciones cognitivas superiores mediante un programa de intervención centrado en las funciones dañadas. El programa está formado por 10 sesiones individuales y presenciales, donde se pretenden trabajar todos los objetivos específicos divididos en 6 bloques: atención, memoria, funciones ejecutivas, acceso al léxico y denominación, lenguaje comprensivo y lenguaje expresivo. Una vez finalizado el programa se espera en el paciente: una mejoría en los procesos cognitivos que le permitan un mejor uso del lenguaje con el fin de mejorar su calidad de vida y de comunicación.Anomic aphasia is a language disorder that affects the ability to find and retrieve words properly, causing difficulties in naming and verbal expression. This condition is common in patients who have suffered a stroke, a disease that represents the first cause of permanent disability in adults over 55 years of age. This acute neurological condition can have a significant impact on individuals' communication and quality of life. In Spain, no empirically validated intervention programs have been found for people with this type of aphasia. The objective of this work is to propose an effective therapeutic intervention for patients with anomic aphasia because of a stroke. The aim is to restore higher cognitive functions through an intervention program focused on damaged functions. The program is made up of 10 individual and face-to-face sessions, where the aim is to work on all the specific objectives divided into 6 blocks: attention, memory, executive functions, access to the lexicon and names, comprehensive language and expressive language. Once the program is finished, the following is expected in the patient: an improvement in cognitive processes that allow a better use of language in order to improve their quality of life and communication.Psicologí