9 research outputs found
A compilation of worksheets for use in a systematic program of arithmetic instruction in grade one.
Thesis (M.A.)--Boston Universit
Building leaders for the UN Ocean Science Decade : a guide to supporting early career women researchers within academic marine research institutions
Diverse and inclusive marine research is paramount to addressing ocean sustainability challenges in the 21st century, as envisioned by the UN Decade of Ocean Science for Sustainable Development. Despite increasing efforts to diversify ocean science, women continue to face barriers at various stages of their career, which inhibits their progression to leadership within academic institutions. In this perspective, we draw on the collective experiences of thirty-four global women leaders, bolstered by a narrative review, to identify practical strategies and actions that will help empower early career women researchers to become the leaders of tomorrow. We propose five strategies: (i) create a more inclusive culture, (ii) ensure early and equitable career development opportunities for women ECRs, (iii) ensure equitable access to funding for women ECRs, (iv) offer mentoring opportunities and, (v) create flexible, family-friendly environments. Transformational, meaningful, and lasting change will only be achieved through commitment and collaborative action across various scales and by multiple stakeholders.Peer reviewe
Association between funding source, methodological quality and research outcomes in randomized controlled trials of synbiotics, probiotics and prebiotics added to infant formula: A Systematic Review
Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury.
Cortical spreading depolarizations (CSDs) are increasingly suspected to play an exacerbating role in a range of acute brain injuries, including stroke, possibly through their interactions with cortical blood flow. We use simultaneous wide-field imaging of neural activity and hemodynamics in Thy1-GCaMP6f mice to explore the neurovascular dynamics of CSDs during and following Rose Bengal-mediated photothrombosis. CSDs are observed in all mice as slow-moving waves of GCaMP fluorescence extending far beyond the photothrombotic area. Initial CSDs are accompanied by profound vasoconstriction and leave residual oligemia and ischemia in their wake. Later, CSDs evoke variable responses, from constriction to biphasic to vasodilation. However, CSD-evoked vasoconstriction is found to be more likely during rapid, high-amplitude CSDs in regions with stronger oligemia and ischemia, which, in turn, worsens after each repeated CSD. This feedback loop may explain the variable but potentially devastating effects of CSDs in the context of acute brain injury
Intratracheal Administration to the Lung Enhances Therapeutic Benefit of an MBP Peptide in the Treatment of Murine Experimental Autoimmune Encephalomyelitis
Breaking down barriers: The identification of actions to promote gender equality in interdisciplinary marine research institutions
Interdisciplinary research is paramount to addressing ocean sustainability challenges in the 21st century. However, women leaders have been underrepresented in interdisciplinary marine research, and there is little guidance on how to achieve the conditions that will lead to an increased proportion of women scientists in positions of leadership. Here, we conduct in-depth qualitative research to explore the main barriers and enablers to womenâs leadership in an academic interdisciplinary marine research context. We found that interdisciplinarity can present unique and additional barriers to women leaders (e.g., complexity and lack of value attributed to interdisciplinary research) and are exacerbated by existing gender-specific issues that women experience (e.g., isolation and underrepresentation and stereotyping). Together these barriers overlap forming the âglass obstacle courseââwhich is particularly challenging for women in minoritized groups. Here, we provide a list of concrete, ambitious, and actionable enablers that can promote and support womenâs leadership in academic interdisciplinary marine research
Building leaders for the UN Ocean Science Decade:a guide to supporting early career women researchers within academic marine research institutions
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Urinary metabolomic profiling to identify biomarkers of a flavonoid-rich and flavonoid-poor fruits and vegetables diet: the FLAVURS trial in adults: the FLAVURS trial
The present study aims to investigate the dose
dependent effects of consuming diets enriched in flavonoid-rich
and flavonoid-poor fruits and vegetables on the urine
metabolome of adults who had a C1.5 fold increased risk of
cardiovascular diseases. A single-blind, dose-dependent,
parallel randomized controlled dietary intervention was conducted
where volunteers (n = 126) were randomly assigned
to one of three diets: high flavonoid diet, low flavonoid diet or
habitual diet as a control for 18 weeks. High resolution LCâ
MS untargeted metabolomics with minimal sample cleanup
was performed using an Orbitrap mass spectrometer. Putative
biomarkers which characterize diets with high and low flavonoid
content were selected by state-of-the-art data analysis
strategies and identified by HR-MS and HR-MS/MS assays.
Discrimination between diets was observed by application of
two linear mixedmodels: one including a diet-time interaction
effect and the second containing only a time effect. Valerolactones,
phenolic acids and their derivatives were among
sixteen biomarkers related to the high flavonoid dietary
exposure. Four biomarkers related to the low flavonoid diet
belonged to the family of phenolic acids. For the first time
abscisic acid glucuronide was reported as a biomarker after a
dietary intake, however its origins have to be examined by
future hypothesis driven experiments using a more targeted
approach. This metabolomic analysis has identified a number
of dose dependent urinary biomarkers (i.e. proline betaine or
iberin-N-acetyl cysteine), which can be used in future observation
and intervention studies to assess flavonoids and nonflavonoid
phenolic intakes and compliance to fruit and
vegetable intervention