The Construction of Sorkin Triangulations

Some time ago, Sorkin (1975) reported investigations of the time evolution and initial value problems in Regge calculus, for one triangulation each of the manifolds $R*S^3$ and $R^4$. Here we display the simple, local characteristic of those triangulations which underlies the structure found by Sorkin, and emphasise its general applicability, and therefore the general validity of Sorkin's conclusions. We also make some elementary observations on the resulting structure of the time evolution and initial value problems in Regge calculus, and add some comments and speculations.Comment: 5 pages (plus one figure not included, available from author on request), Plain Tex, no local preprint number (Only change: omitted "\magnification" command now replaced

Active Site Structures of CYP11A1 in the Presence of Its Physiological Substrates and Alterations upon Binding of Adrenodoxin

The rate-limiting step in the steroid synthesis pathway is catalyzed by CYP11A1 through three sequential reactions. The first two steps involve hydroxylations at positions 22 and 20, generating 20(R),22(R)-dihydroxycholesterol (20R,22R-DiOHCH), with the third stage leading to a C20–C22 bond cleavage, forming pregnenolone. This work provides detailed information about the active site structure of CYP11A1 in the resting state and substrate-bound ferric forms as well as the CO-ligated adducts. In addition, high-quality resonance Raman spectra are reported for the dioxygen complexes, providing new insight into the status of Fe–O–O fragments encountered during the enzymatic cycle. Results show that the three natural substrates of CYP11A1 have quite different effects on the active site structure, including variations of spin state populations, reorientations of heme peripheral groups, and, most importantly, substrate-mediated distortions of Fe–CO and Fe–O2 fragments, as revealed by telltale shifts of the observed vibrational modes. Specifically, the vibrational mode patterns observed for the Fe–O–O fragments with the first and third substrates are consistent with H-bonding interactions with the terminal oxygen, a structural feature that tends to promote O–O bond cleavage to form the Compound I intermediate. Furthermore, such spectral data are acquired for complexes with the natural redox partner, adrenodoxin (Adx), revealing protein–protein-induced active site structural perturbations. While this work shows that Adx has an only weak effect on ferric and ferrous CO states, it has a relatively stronger impact on the Fe–O–O fragments of the functionally relevant oxy complexes

Contemporary splinting practice in the UK for adults with neurological dysfunction: A cross-sectional survey

This article is made available through the Brunel Open Access Publishing Fund.Aim: To explore the contemporary splinting practice of UK occupational therapists and physiotherapists for adults with neurological dysfunction. Method: Cross-sectional online survey of members of the Association of Chartered Physiotherapists in Neurology and College of Occupational Therapists Specialist Section Neurological Practice. Results: Four hundred and twenty therapists completed the survey. Contracture management is the most common rationale for therapists splinting adults with neurological dysfunction. Other shared therapeutic goals of splinting include maintaining muscle and joint alignment, spasticity management, function, pain management and control of oedema. Considerable clinical uncertainty was uncovered in practice particularly around wearing regimens of splints. Most therapists have access to locally-derived splinting guidelines, which may contribute to this diversity of practice. Conclusions: This study provides a unique insight into aspects of contemporary splinting practice among UK therapists, who belong to a specialist neurological professional network and work in a number of different health-care settings with adults who have a neurological condition. Study findings show a wide variation in splinting practice, thereby indicating a potential need for national guidance to assist therapists in this area of clinical uncertainty. Further research is required to establish best practice parameters for splinting in neurological rehabilitation

A comparison of intramuscular diamorphine and intramuscular pethidine for labour analgesia: a two-centre randomised blinded controlled trial.

Intramuscular (i.m.) pethidine is used worldwide for labour analgesia and i.m. diamorphine usage has increased in the UK in the last 15 years. This trial aims to ascertain the relative efficacy and adverse effects of diamorphine and pethidine for labour pain

Unresolved taxonomy confounds invasive species identification: the Lysmata vittata Stimpson, 1860 (Decapoda: Caridea: Lysmatidae) species complex and recent introduction of Lysmata vittata sensu stricto in the western Atlantic

Peppermint shrimp resembling Lysmata vittata Stimpson, 1860, a species native to the Indo- West Pacific, were found in the lower Chesapeake Bay and adjacent coastal embayments in 2013, representing the first recorded introduction of this species in the northwestern Atlantic. Conflicting morphological descriptions, inconsistent morphological terminology, and limited molecular data (i.e., unresolved taxonomy), as well as the destruction of the type material of L. vittata, created uncertainty regarding proper identification. We provide the first phylogeny incorporating individuals from across the presumed native and introduced range of L. vittata. Morphological and phylogenetic analyses clearly indicate L. vittata represents a species complex of two widely divergent groups: 1) “Bruce Type” with a uniramous dorsal antennule that agrees with A.J. Bruce’s 1990 redescription of L. vittata, and 2) “Rauli Type” with a one-article accessory branch on the dorsal antennule that agrees most closely with the junior synonym L. rauli Laubenheimer & Rhyne, 2010. Given the taxonomic ambiguity surrounding L. vittata, we designate the individual used by A.J. Bruce to redescribe L. vittata and incorporated in our analyses as a neotype to fix the identity of this species. We therefore identify introduced North American and New Zealand populations as L. vittata sensu stricto and postulate that the native range spans temperate/subtropical East Asia. These data suggest that L. rauli is a valid species, which includes a possible undescribed sister species. We confirm the presence of L. californica Stimpson, 1866 in New Zealand, the first non-native record for this species. We also provide data suggesting L. dispar Hayashi, 2007 may be more widespread in the Indo-West Pacific than currently known and consider L. lipkei Okuno & Fiedler, 2010 to be a likely junior synonym

Radiotherapy students' perceptions of support provided by clinical supervisors

Aim: The aim of this study was to explore the experiences of radiotherapy students on clinical placement, specifically focussing on the provision of well-being support from clinical supervisors. Materials and methods: Twenty-five students from the University of the West of England and City University of London completed an online evaluation survey relating to their experiences of placement, involving Likert scales and open-ended questions. Results: The quantitative results were generally positive; however, the qualitative findings were mixed. Three themes emerged: (1) provision of information and advice; (2) an open, inclusive and supportive working environment; and (3) a lack of communication, understanding, and consistency. Findings: Students' experiences on placement differed greatly and appeared to relate to their specific interactions with different members of staff. It is suggested that additional training around providing well-being support to students may be of benefit to clinical supervisors

Extent of Suitable Habitats for Juvenile Striped Bass: Dynamics and Implications for Recruitment in Chesapeake Bay

The production of striped bass Morone saxatilis in Chesapeake Bay supports recreational and commercial fisheries along the Atlantic coast of the United States, but factors that contribute to high abundances of juvenile life stages are not fully understood. In this study, we characterized and quantified suitable and optimal habitat conditions in the Chesapeake Bay for two age groups of juvenile striped bass in discrete portions of the Bay: young-of-the-year (age-0) fish in shoreline and nearshore habitats, and resident sub-adults (age-1 to -4) in the mainstem and Bay-wide. We coupled information from 24 years of monthly fisheries surveys with hindcasts from a 3-D hydrodynamic model of the Bay and a numerical model of dissolved oxygen (DO) conditions. These models provided estimates of habitat conditions for 1996 to 2019 for 33 metrics of temperature, salinity, current speed, depth, DO, and physical features of habitats. Boosted regression trees were used to identify influential habitat covariates for each group, and those covariates were used to develop nonparametric habitat suitability models based on environmental conditions at the time and location of sampling. Habitat suitability indices (HSI), ranging from 0 (poor habitat) to 1 (high-quality habitat), were assigned to each grid in the 3-D model for each season in 1996 to 2019. We quantified suitable (HSI \u3e 0.5) and optimal (HSI \u3e 0.7) on a seasonal and annual basis, and across a range of environmental conditions (wet vs. dry years; warm vs. cool years). We also estimated the persistence of suitable habitats through time as the percent of years during which conditions were suitable at a given site; persistence allowed us to identify areas of the Bay and tidal tributaries that consistently supported suitable conditions for juvenile striped bass. Specific habitat conditions that defined suitable and optimal habitats for age-0 and age 1-4 striped bass varied across seasons and among years, reflecting changes in water quality conditions in Chesapeake Bay and changes in habitat use by striped bass during their first few years of life. Metrics of water quality, especially dissolved oxygen, were consistently identified as important covariates for juvenile striped bass; these conditions are of greater importance in determining habitat suitability than specific physical features especially for a highly mobile species and may be used to inform existing decision-support tools. In our study, we found no evidence that habitat use by striped bass in Chesapeake Bay was moderated by a strict threshold for any given covariate, and average to above-average abundances of striped bass were encountered in sub-suitable conditions; thus, habitat use resulted from a combination of abiotic, and likely biotic, conditions. Neither age group exhibited a statistically significant relationship between relative abundance and the extent of suitable habitats, however, for nearly all ages and seasons, relative abundance increased with greater extent of suitable habitats suggesting that detection of this relationship requires additional annual observations. A significant decrease in the extent of suitable habitat through time (1996 to present) was observed in spring and early summer, reflecting a change in suitable environmental conditions; with additional study years, declines in the relative abundance of age-0 and age 1-4 fish may be observed as suitability of habitats continues to decline. Given the high degree of interannual variability in abundance that is characteristic of estuarine-dependent species like striped bass, the availability and quantity of suitable and high-quality habitats at the scale of individual tributaries and Bay-wide may play an important role in production of this species

Seasonal and Annual Variation in the Extent of Suitable Habitats for Forage Fishes in Chesapeake Bay, 2000-2016

The sustained production of sufficient forage is critical to advancing ecosystem-based management in Chesapeake Bay. Yet factors that affect local abundances and habitat conditions necessary to support forage production remain largely unexplored. Here, we quantified suitable habitat in the Chesapeake Bay region for four key forage fishes: bay anchovy Anchoa mitchilli, juvenile spot Leiostomus xanthurus, juvenile weakfish Cynoscion regalis, and juvenile spotted hake Urophycis regia. We coupled information from 17 years of monthly fisheries surveys with hindcasts from a numerical model of dissolved oxygen (DO) conditions and a 3-D hydrodynamic model of the Bay that provided estimates of habitat conditions across 18 covariates of salinity, temperature, DO, depth, and current speed for the period 2000 to 2016. Sediment composition and distance to shore metrics were also considered. The hindcast covariates were subsampled at the times and locations of the fisheries surveys to provide dynamic habitat metrics that are not generally observed at the time of fish sampling (e.g., current velocity, salinity stratification). Hindcast covariates were also used to describe habitat conditions in areas of Chesapeake Bay that are not sampled routinely by fisheries-independent surveys such as the Potomac River and Mobjack Bay. Boosted regression trees were used to identify influential habitat covariates for each species, and these influential covariates were then used to construct habitat suitability models. Habitat suitability indices, which ranged between 0 (poor habitat) and 1 (superior habitat), were assigned to each location in the 3-D model grid for each season in 2000-2016. Based on the estimated habitat suitability index and using a GIS approach, we quantified suitable habitat (defined as habitats with a habitat suitability index \u3e 0.5) throughout the Chesapeake Bay and its tidal tributaries. Furthermore, we validated the modeling approach using out-of-sample observations from Mobjack Bay in 2010-2012. Suitable seasonal habitat extents for forage species exhibited strong seasonal and annual signals reflecting temporal heterogeneity in habitat conditions in Chesapeake Bay. Current speed, water depth, and either temperature or dissolved oxygen were identified as important covariates for the four forage species we examined, and distance to shore was important for three of the four species; thus, suitable habitat conditions resulted from a complex interplay between water quality and the physical properties of the habitat. In our study, two species exhibited a relationship between relative abundance and extent of suitable habitats – juvenile spot in summer and bay anchovy in winter; as such, estimates of the minimum habitat area required to produce a desired abundance (or biomass) of forage fish can be used to establish quantitative habitat targets or spatial thresholds that may serve as spatial reference points for management. In an ecosystem-based approach, important habitats may be targeted for protection (e.g., by limiting fishing activities that may incidentally capture or injure forage fishes) or restoration (e.g., by improving water quality conditions), thereby ensuring production of sufficient forage for predators. In addition, the consequences of aquatic habitat alterations, whether due to climate change or physical disturbances can be investigated using projections of environmental conditions and habitat suitability in the region, though these projections will introduce additional uncertainty

Discrete quantum gravity in the framework of Regge calculus formalism

An approach to the discrete quantum gravity based on the Regge calculus is discussed which was developed in a number of our papers. Regge calculus is general relativity for the subclass of general Riemannian manifolds called piecewise flat ones. Regge calculus deals with the discrete set of variables, triangulation lengths, and contains continuous general relativity as a particular limiting case when the lengths tend to zero. In our approach the quantum length expectations are nonzero and of the order of Plank scale $10^{-33}cm$. This means the discrete spacetime structure on these scales.Comment: LaTeX, 16 pages, to appear in JET