Augmented Reality for Real-time Navigation Assistance to Wheelchair Users with Obstacles' Management

International audienceDespite a rapid technological evolution in the field of technical assistance for people with motor disabilities, their ability to move independently in a wheelchair is still limited. New information and communication technologies (NICT) such as augmented reality (AR) are a real opportunity to integrate people with disabilities into their everyday life and work. AR can afford real-time information about buildings and locations' accessibility through mobile applications that allow the user to have a clear view of the building details. By interacting with augmented environments that appear in the real world using a smart device, users with disabilities have more control of their environment. In this paper, we propose a decision support system using AR for motor disabled people navigation assistance. We describe a real-time wheelchair navigation system equipped with geological mapping that indicates access path to a desired location, the shortest route towards it and identifies obstacles to avoid. The prototyped wheelchair navigation system was developed for use within the University of Lille campus

How people talk when teaching a robot

We examine affective vocalizations provided by human teach-ers to robotic learners. In unscripted one-on-one interac-tions, participants provided vocal input to a robotic dinosaur as the robot selected toy buildings to knock down. We find that (1) people vary their vocal input depending on the learner’s performance history, (2) people do not wait until a robotic learner completes an action before they provide in-put and (3) people näıvely and spontaneously use intensely affective vocalizations. Our findings suggest modifications may be needed to traditional machine learning models to better fit observed human tendencies. Our observations of human behavior contradict the popular assumptions made by machine learning algorithms (in particular, reinforcement learning) that the reward function is stationary and path-independent for social learning interactions. We also propose an interaction taxonomy that describes three phases of a human-teacher’s vocalizations: direction, spoken before an action is taken; guidance, spoken as the learner communicates an intended action; and feedback, spo-ken in response to a completed action

“I Want That”: Human-in-the-Loop Control of a Wheelchair-Mounted Robotic Arm

Wheelchair-mounted robotic arms have been commercially available for a decade. In order to operate these robotic arms, a user must have a high level of cognitive function. Our research focuses on replacing a manufacturer-provided, menu-based interface with a vision-based system while adding autonomy to reduce the cognitive load. Instead of manual task decomposition and execution, the user explicitly designates the end goal, and the system autonomously retrieves the object. In this paper, we present the complete system which can autonomously retrieve a desired object from a shelf. We also present the results of a 15-week study in which 12 participants from our target population used our system, totaling 198 trials

Ly6cLo non-classical monocytes promote resolution of rhesus rotavirus-mediated perinatal hepatic infammation

Perinatal hepatic inflammation can have devastating consequences. Monocytes play an important role in the initiation and resolution of inflammation, and their diverse functions can be attributed to specific cellular subsets: pro-inflammatory or classical monocytes (Ly6c(Hi)) and pro-reparative or non-classical monocytes (Ly6c(Lo)). We hypothesized that inherent differences in Ly6c(Hi) classical monocytes and Ly6c(Lo) non-classical monocytes determine susceptibility to perinatal hepatic inflammation in late gestation fetuses and neonates. We found an anti-inflammatory transcriptional profile expressed by Ly6c(Lo) non-classical monocytes, and a physiologic abundance of these cells in the late gestation fetal liver. Unlike neonatal pups, late gestation fetuses proved to be resistant to rhesus rotavirus (RRV) mediated liver inflammation. Furthermore, neonatal pups were rendered resistant to RRV-mediated liver injury when Ly6c(Lo) non-classical monocytes were expanded. Pharmacologic inhibition of Ly6c(Lo) non-classical monocytes in this setting restored susceptibility to RRV-mediated disease. These data demonstrate that Ly6c(Lo) monocytes promote resolution of perinatal liver inflammation in the late gestation fetus, where there is a physiologic expansion of non-classical monocytes, and in the neonatal liver upon experimental expansion of these cells. Therapeutic strategies directed towards enhancing Ly6c(Lo) non-classical monocyte function may mitigate the detrimental effects of perinatal liver inflammation

Trust in AV: An Uncertainty Reduction Model of AV-Pedestrian Interactions

Autonomous vehicles (AVs) have the potential to improve road safety. Trust in AVs, especially among pedestrians, is vital to alleviate public skepticism. Yet much of the research has focused on trust between the AV and its driver/passengers. To address this shortcoming, we examined the interactions between AVs and pedestrians using uncertainty reduction theory (URT). We empirically verified this model with a user study in an immersive virtual reality environment (IVE). The study manipulated two factors: AV driving behavior (defensive, normal and aggressive) and the traffic situation (signalized and unsignalized). Results suggest that the impact of aggressive driving on trust in AVs depends on the type of crosswalk. At signalized crosswalks the AV’s driving behavior had little impact on trust, but at unsignalized crosswalks the AV’s driving behavior was a major determinant of trust. Our findings shed new insights on trust between AVs and pedestrians.Toyota Research InstitutePeer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140747/1/Trust-AV-Uncertainty.pdfDescription of Trust-AV-Uncertainty.pdf : Main Articl

Multifocal clonal evolution characterized using circulating tumour DNA in a case of metastatic breast cancer.

Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here we follow a patient with metastatic ER-positive and HER2-positive breast cancer receiving two lines of targeted therapy over 3 years. We characterize genomic architecture and infer clonal evolution in eight tumour biopsies and nine plasma samples collected over 1,193 days of clinical follow-up using exome and targeted amplicon sequencing. Mutation levels in the plasma samples reflect the clonal hierarchy inferred from sequencing of tumour biopsies. Serial changes in circulating levels of sub-clonal private mutations correlate with different treatment responses between metastatic sites. This comparison of biopsy and plasma samples in a single patient with metastatic breast cancer shows that circulating tumour DNA can allow real-time sampling of multifocal clonal evolution.We thank the Human Research Tissue Bank at Addenbrooke’s Hospital which is supported by the NIHR Cambridge Biomedical Research Centre. We acknowledge the support of Cancer Research UK, the University of Cambridge, National Institute for Health Research Cambridge Biomedical Research Centre and Cambridge Experimental Cancer Medicine Centre. Dr. Dawson was supported by an Australian National Breast Cancer Foundation and Victorian Cancer Agency Early Career Fellowship. Dr. Murtaza was supported by Science Foundation Arizona’s Bisgrove Scholars Early Tenure Track award.This is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/ncomms976

Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.

OBJECTIVE: The functional role of interleukin-22 (IL22) in chronic inflammation is controversial, and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22 in chronic colitis and probed mechanisms of IL22-mediated regulation of colonic epithelial cells. DESIGN: To investigate the functional role of IL22 in chronic colitis and how it regulates colonic epithelial cells, we employed a three-dimentional mini-gut epithelial organoid system, in vivo disease models and transcriptomic datasets in human IBD. RESULTS: As well as inducing transcriptional modules implicated in antimicrobial responses, IL22 also coordinated an endoplasmic reticulum (ER) stress response transcriptional programme in colonic epithelial cells. In the colon of patients with active colonic Crohn's disease (CD), there was enrichment of IL22-responsive transcriptional modules and ER stress response modules. Strikingly, in an IL22-dependent model of chronic colitis, targeting IL22 alleviated colonic epithelial ER stress and attenuated colitis. Pharmacological modulation of the ER stress response similarly impacted the severity of colitis. In patients with colonic CD, antibody blockade of IL12p40, which simultaneously blocks IL12 and IL23, the key upstream regulator of IL22 production, alleviated the colonic epithelial ER stress response. CONCLUSIONS: Our data challenge perceptions of IL22 as a predominantly beneficial cytokine in IBD and provide novel insights into the molecular mechanisms of IL22-mediated pathogenicity in chronic colitis. Targeting IL22-regulated pathways and alleviating colonic epithelial ER stress may represent promising therapeutic strategies in patients with colitis. TRIAL REGISTRATION NUMBER: NCT02749630

Erratum to: Methods for evaluating medical tests and biomarkers

[This corrects the article DOI: 10.1186/s41512-016-0001-y.]