771 research outputs found
Phenotypic Transition of the Collecting Duct Epithelium in Congenital Urinary Tract Obstruction
Epithelial-mesenchymal transition (EMT) has emerged in recent years as an important process in the development of organ fibrosis in many human diseases. Our previous experience in a nonhuman primate model of obstructive nephropathy suggested that EMT of collecting duct epithelium contributes to the development of interstitial fibrosis. In this study we demonstrate for the first time in humans that obstructed fetal collecting duct epithelium undergoes transition to mesenchymal phenotype, characterized by decreased expression of epithelial markers, de novo expression of mesenchymal markers with subsequent loss of cell-cell interaction, disruption of the basement membrane, and increased deposition of extracellular matrix into the expanded interstitium of the obstructed kidney. The results of this study therefore support the previous findings from animal studies and suggest that EMT of the collecting duct epithelium might contribute to the development of interstitial fibrosis in human fetal obstructive nephropathy
Current perceptions on climate change impacts and adaptation for arable crops in Europe
vokKAT. Yksikön huom.: KA
Amplitudes at Weak Coupling as Polytopes in AdS_5
We show that one-loop scalar box functions can be interpreted as volumes of
geodesic tetrahedra embedded in a copy of AdS_5 that has dual conformal
space-time as boundary. When the tetrahedron is space-like, it lies in a
totally geodesic hyperbolic three-space inside AdS_5, with its four vertices on
the boundary. It is a classical result that the volume of such a tetrahedron is
given by the Bloch-Wigner dilogarithm and this agrees with the standard physics
formulae for such box functions. The combinations of box functions that arise
in the n-particle one-loop MHV amplitude in N=4 super Yang-Mills correspond to
the volume of a three-dimensional polytope without boundary, all of whose
vertices are attached to a null polygon (which in other formulations is
interpreted as a Wilson loop) at infinity.Comment: 16 pages, 5 figure
Local Spacetime Physics from the Grassmannian
A duality has recently been conjectured between all leading singularities of
n-particle N^(k-2)MHV scattering amplitudes in N=4 SYM and the residues of a
contour integral with a natural measure over the Grassmannian G(k,n). In this
note we show that a simple contour deformation converts the sum of Grassmannian
residues associated with the BCFW expansion of NMHV tree amplitudes to the CSW
expansion of the same amplitude. We propose that for general k the same
deformation yields the (k-2) parameter Risager expansion. We establish this
equivalence for all MHV-bar amplitudes and show that the Risager degrees of
freedom are non-trivially determined by the GL(k-2) "gauge" degrees of freedom
in the Grassmannian. The Risager expansion is known to recursively construct
the CSW expansion for all tree amplitudes, and given that the CSW expansion
follows directly from the (super) Yang-Mills Lagrangian in light-cone gauge,
this contour deformation allows us to directly see the emergence of local
space-time physics from the Grassmannian.Comment: 22 pages, 13 figures; v2: minor updates, typos correcte
Unification of Residues and Grassmannian Dualities
The conjectured duality relating all-loop leading singularities of n-particle
N^(k-2)MHV scattering amplitudes in N=4 SYM to a simple contour integral over
the Grassmannian G(k,n) makes all the symmetries of the theory manifest. Every
residue is individually Yangian invariant, but does not have a local space-time
interpretation--only a special sum over residues gives physical amplitudes. In
this paper we show that the sum over residues giving tree amplitudes can be
unified into a single algebraic variety, which we explicitly construct for all
NMHV and N^2MHV amplitudes. Remarkably, this allows the contour integral to
have a "particle interpretation" in the Grassmannian, where higher-point
amplitudes can be constructed from lower-point ones by adding one particle at a
time, with soft limits manifest. We move on to show that the connected
prescription for tree amplitudes in Witten's twistor string theory also admits
a Grassmannian particle interpretation, where the integral over the
Grassmannian localizes over the Veronese map from G(2,n) to G(k,n). These
apparently very different theories are related by a natural deformation with a
parameter t that smoothly interpolates between them. For NMHV amplitudes, we
use a simple residue theorem to prove t-independence of the result, thus
establishing a novel kind of duality between these theories.Comment: 56 pages, 11 figures; v2: typos corrected, minor improvement
Generic multiloop methods and application to N=4 super-Yang-Mills
We review some recent additions to the tool-chest of techniques for finding
compact integrand representations of multiloop gauge-theory amplitudes -
including non-planar contributions - applicable for N=4 super-Yang-Mills in
four and higher dimensions, as well as for theories with less supersymmetry. We
discuss a general organization of amplitudes in terms of purely cubic graphs,
review the method of maximal cuts, as well as some special D-dimensional
recursive cuts, and conclude by describing the efficient organization of
amplitudes resulting from the conjectured duality between color and kinematic
structures on constituent graphs.Comment: 42 pages, 18 figures, invited review for a special issue of Journal
of Physics A devoted to "Scattering Amplitudes in Gauge Theories", v2 minor
corrections, v3 added reference
Study of in-medium meson properties in Ap, pA and AA collisions
We propose to investigate the in-medium properties of vector mesons
at the normal nuclear density in Ap(pA) collisions and at higher density in AA
collisions at the ITEP accelerator facility TWAC. Using of the inverse Ap
kinematics will permit us to study the meson production in a wide
momentum interval included the not yet explored range of small meson momenta
relative to the projectile nuclei where the mass modification effect in nuclear
matter is expected to be the strongest. Momentum dependence of the in-medium
meson width will be studied in the traditional pA kinematics. We
intend to use the electromagnetic calorimeter for reconstruction of the
meson invariant mass by detecting photons from the decay. The model calculations and simulations with
RQMD generator show feasibility of the proposed experiment. Available now
intensity of the ion beams provides a possibility to collect large statistics
and make decisive conclusion about the meson properties at density of
normal nuclei. At the second stage of the investigation the meson
properties will be studied in AA collisions at higher density. Interpretation
of these measurements will be based on the results obtained in Ap(pA)
interactions. Further investigation of the in-medium properties of light
unflavored and charmed mesons can be performed at ITEP and at GSI(FAIR) where
higher ion energies will be accessible in near future.Comment: 26 pages, 10 figures, 2 table
On the background in the reaction and mixed event simulation
In this paper we evaluate sources of background for the , with the detected through its decay channel, to
compare with the experiment carried out at ELSA. We find background from
followed by decay of a into two ,
recombining one and one , and from the reaction with subsequent decay of the into two photons. This
background accounts for the data at invariant masses beyond 700
MeV, but strength is missing at lower invariant masses which was attributed to
photon misidentification events, which we simulate to get a good reproduction
of the experimental background. Once this is done, we perform an event mixing
simulation to reproduce the calculated background and we find that the method
provides a good description of the background at low invariant
masses but fakes the background at high invariant masses, making background
events at low invariant masses, which are due to misidentification
events, responsible for the background at high invariant masses which is due to
the and reactions.Comment: 10 pages, 5 figure
Tree-Level Formalism
We review two novel techniques used to calculate tree-level scattering
amplitudes efficiently: MHV diagrams, and on-shell recursion relations. For the
MHV diagrams, we consider applications to tree-level amplitudes and focus in
particular on the N=4 supersymmetric formulation. We also briefly describe the
derivation of loop amplitudes using MHV diagrams. For the recursion relations,
after presenting their general proof, we discuss several applications to
massless theories with and without supersymmetry, to theories with massive
particles, and to graviton amplitudes in General Relativity. This article is an
invited review for a special issue of Journal of Physics A devoted to
"Scattering Amplitudes in Gauge Theories".Comment: 40 pages, 8 figures, invited review for a special issue of Journal of
Physics A devoted to "Scattering Amplitudes in Gauge Theories", R.
Roiban(ed), M. Spradlin(ed), A. Volovich(ed); v2: minor corrections,
references adde
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