5,948 research outputs found
Validation Methods Research for Fault-Tolerant Avionics and Control Systems Sub-Working Group Meeting. CARE 3 peer review
A computer aided reliability estimation procedure (CARE 3), developed to model the behavior of ultrareliable systems required by flight-critical avionics and control systems, is evaluated. The mathematical models, numerical method, and fault-tolerant architecture modeling requirements are examined, and the testing and characterization procedures are discussed. Recommendations aimed at enhancing CARE 3 are presented; in particular, the need for a better exposition of the method and the user interface is emphasized
The Nefarious Nexus of Noncoding RNAs in Cancer
The past decade has witnessed enormous progress, which has seen the noncoding RNAs (ncRNAs) turn from the so called dark matter RNA to critical functional molecules, influencing most physiological processes in development and disease contexts. Many ncRNAs interact with each other and are part of networks that influence the cell transcriptome and proteome and consequently the outcome of biological processes. The regulatory circuits controlled by ncRNAs have become increasingly more relevant in cancer. Further understanding of these complex network interactions and how ncRNAs are regulated, is paving the way for the identification of better therapeutic strategies in cancer
Validation Methods Research for Fault-Tolerant Avionics and Control Systems: Working Group Meeting, 2
The validation process comprises the activities required to insure the agreement of system realization with system specification. A preliminary validation methodology for fault tolerant systems documented. A general framework for a validation methodology is presented along with a set of specific tasks intended for the validation of two specimen system, SIFT and FTMP. Two major areas of research are identified. First, are those activities required to support the ongoing development of the validation process itself, and second, are those activities required to support the design, development, and understanding of fault tolerant systems
Competition between antiferromagnetism and superconductivity, electron-hole doping asymmetry and "Fermi Surface" topology in cuprates
We investigate the asymmetry between electron and hole doping in a 2D Mott
insulator, and the resulting competition between antiferromagnetism (AF) and
d-wave superconductivity (SC), using variational Monte Carlo for projected wave
functions. We find that key features of the T = 0 phase diagram, such as
critical doping for SC-AF coexistence and the maximum value of the SC order
parameter, are determined by a single parameter which characterises the
topology of the "Fermi surface" at half filling defined by the bare
tight-binding parameters. Our results give insight into why AF wins for
electron doping, while SC is dominant on the hole doped side. We also suggest
using band structure engineering to control the parameter for enhancing SC.Comment: 4 pages, 4 figure
Storm-time changes of geomagnetic field at MAGSAT altitudes (325-550 Km) and their comparison with changes at ground locations
The values of H, X, Y, Z at MAGSAT altitudes were first expressed as residuals delta H, delta X, delta Y, delta Z after subtracting the model HMD, XMD, YMD, ZMC. The storm-time variations of H showed that delta H (Dusk) was larger (negative) than delta H (Dawn) and occurred earlier, indicating a sort of hysteresis effect. Effects at MAGSAT altitudes were roughly the same (10% accuracy) as at ground, indicating that these effects were mostly of magnetospheric origin. The delta Y component also showed large storm-time changes. The latitudinal distribution of storm-time delta H showed north-south asymmetries varying in nature as the storm progressed. It seems that the central plane of the storm-time magnetospheric ring current undergoes latitudinal meanderings during the course of the storm
Assessment of Iron Overload in Homozygous and Heterozygous Beta Thalassemic Children below 5 Years of Age
Background: Thalassemia is a genetic disease having
3-7% carrier rate in Indians. It is transfusion dependent
anemia having high risk of iron overloading. A clinical
symptom of iron overload becomes detectable in
second decade causing progressive liver, heart and
endocrine glands damage. There is a need to assess
iron overload in thalassemics below 5 years of age to
protect them from complications at later age of life.
Aims and objectives: Present study was undertaken to
estimate serum iron status and evaluate serum
transferrin saturation in both homozygous & heterozygous
form of thalassemia as an index of iron overload
among children of one to five years of age.
Materials and Methods: Clinically diagnosed thirty
cases of β thalassemia major & thirty cases of β
thalassemia minor having severe anemia, hepatospleenomegaly
and between 1 year to 5 years of age
were included in study group and same age matched
healthy controls were included in the study. RBC
indices and HbA, HbA2 and HbF were estimated along
with serum iron & serum Total Iron Binding Capacity
(TIBC) and serum transferrin levels. Results: Significant
difference was observed in hemoglobin levels
between control and both beta thalassemia groups.
Mean Corpuscular Volume (MCV) and Mean Corpuscular
Hemoglobin (MCH) values were reduced.
Hemoglobin electrophoresis showed the elevated
levels of HbF and HbA2 in both beta thalassemia
groups. Among serum iron parameters, serum iron,
TIBC and transferrin saturation were elevated whereas
serum transferrin levels were low in thalassemia major
in children below 5 years of age. Conclusion: Although
clinical symptoms of iron overload have been absent in thalassemic children below five years of age, biochemical
iron overloading has started at much lower age
which is of great concern
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