Development of a jet pump-assisted arterial heat pipe

The development of a jet pump assisted arterial heat pipe is described. The concept utilizes a built-in capillary driven jet pump to remove vapor and gas from the artery and to prime it. The continuous pumping action also prevents depriming during operation of the heat pipe. The concept is applicable to fixed conductance and gas loaded variable conductance heat pipes. A theoretical model for the jet pump assisted arterial heat pipe is presented. The model was used to design a prototype for laboratory demonstration. The 1.2 m long heat pipe was designed to transport 500 watts and to prime at an adverse elevation of up to 1.3 cm. The test results were in good agreement with the theoretical predictions. The heat pipe carried as much as 540 watts and was able to prime up to 1.9 cm. Introduction of a considerable amount of noncondensible gas had no adverse effect on the priming capability

Design, development and testing of a cryogenic temperature heat pipe for the icicle system

An analytical model was formulated for a cryogenic heat pipe, and thermal and transport analyses were developed to predict the performance characteristics of various heat pipe designs. These analyses permitted optimization of various design parameters. A series of four breadboard heat pipes were fabricated and tested to provide inputs such as internal film coefficients, minimum capillary radii, and wick permeabilities which are required for the analyses. The results of instrumentation, charging, and testing of cryogenic heat pipes were applied to the prototype heat pipes. After a thorough design analysis of three potential heat pipe wicks (slab, artery, and axial groove), the first two were chosen for application to two prototype heat pipes. Detailed designs were made of the two heat pipes and the units were fabricated. Tests were conducted which verified the integrity and safety margin of the design to withstand the internal pressure at ambient temperature and fatigue of thermal cycling. During the acceptance testing in the vacuum chamber, no difficulty was experienced in priming the slab-wick heat pipe and it met the performance design requirements. The artery-wick heat pipe would not prime with nitrogen working fluid for any test conditions

Heterogeneity in Kv2 Channel Expression Shapes Action Potential Characteristics and Firing Patterns in CA1 versus CA2 Hippocampal Pyramidal Neurons.

The CA1 region of the hippocampus plays a critical role in spatial and contextual memory, and has well-established circuitry, function and plasticity. In contrast, the properties of the flanking CA2 pyramidal neurons (PNs), important for social memory, and lacking CA1-like plasticity, remain relatively understudied. In particular, little is known regarding the expression of voltage-gated K+ (Kv) channels and the contribution of these channels to the distinct properties of intrinsic excitability, action potential (AP) waveform, firing patterns and neurotransmission between CA1 and CA2 PNs. In the present study, we used multiplex fluorescence immunolabeling of mouse brain sections, and whole-cell recordings in acute mouse brain slices, to define the role of heterogeneous expression of Kv2 family Kv channels in CA1 versus CA2 pyramidal cell excitability. Our results show that the somatodendritic delayed rectifier Kv channel subunits Kv2.1, Kv2.2, and their auxiliary subunit AMIGO-1 have region-specific differences in expression in PNs, with the highest expression levels in CA1, a sharp decrease at the CA1-CA2 boundary, and significantly reduced levels in CA2 neurons. PNs in CA1 exhibit a robust contribution of Guangxitoxin-1E-sensitive Kv2-based delayed rectifier current to AP shape and after-hyperpolarization potential (AHP) relative to that seen in CA2 PNs. Our results indicate that robust Kv2 channel expression confers a distinct pattern of intrinsic excitability to CA1 PNs, potentially contributing to their different roles in hippocampal network function

Entanglement and Symmetry: A Case Study in Superselection Rules, Reference Frames, and Beyond

This paper concentrates on a particular example of a constraint imposed by superselection rules (SSRs): that which applies when the parties (Alice and Bob) cannot distinguish among certain quantum objects they have. This arises naturally in the context of ensemble quantum information processing such as in liquid NMR. We discuss how a SSR for the symmetric group can be applied, and show how the extractable entanglement can be calculated analytically in certain cases, with a maximum bipartite entanglement in an ensemble of N Bell-state pairs scaling as log(N) as N goes to infinity . We discuss the apparent disparity with the asymptotic (N >> 1) recovery of unconstrained entanglement for other sorts of superselection rules, and show that the disparity disappears when the correct notion of applying the symmetric group SSR to multiple copies is used. Next we discuss reference frames in the context of this SSR, showing the relation to the work of von Korff and Kempe [Phys. Rev. Lett. 93, 260502 (2004)]. The action of a reference frame can be regarded as the analog of activation in mixed-state entanglement. We also discuss the analog of distillation: there exist states such that one copy can act as an imperfect reference frame for another copy. Finally we present an example of a stronger operational constraint, that operations must be non-collective as well as symmetric. Even under this stronger constraint we nevertheless show that Bell-nonlocality (and hence entanglement) can be demonstrated for an ensemble of N Bell-state pairs no matter how large N is. This last work is a generalization of that of Mermin [Phys. Rev. D 22, 356 (1980)].Comment: 16 pages, 6 figures. v2 updated version published in Phys Rev

A new mechanism for exchange processes observed in the compounds [M(η-C_5H_5)_2(exo-η-RCH = CH_2)H], M = Nb and Ta

Dynamic n.m.r. studies of the exchange processes in the complexes [M(η-C_5H_5)(exo-η-RCH=CH_2)H], M = Nb, Ta, lead to the proposal of a new mechanism involving intermediates with agostic bonding

High-sensitivity force measurement using entangled probes

We show the possibility to improve the measurement sensitivity of a weak force by using two meters in an entangled state. This latter can be achieved by exploiting radiation pressure effects.Comment: ReVTeX file, 11 pages, 2 eps figure

Carbon Nanotube Electron Windmills: A Novel Design for Nanomotors

We propose a new drive mechanism for carbon nanotube (CNT) motors, based upon the torque generated by a flux of electrons passing through a chiral nanotube. The structure of interest comprises a double-walled CNT, formed from, for example, an achiral outer tube encompassing a chiral inner tube. Through a detailed analysis of electrons passing through such a "windmill", we find that the current due to a potential difference applied to the outer CNT generates sufficient torque to overcome the static and dynamic frictional forces that exists between the inner and outer walls, thereby causing the inner tube to rotate.Comment: 10 pages and 4 figure

A toolbox of nanobodies developed and validated for use as intrabodies and nanoscale immunolabels in mammalian brain neurons.

Nanobodies (nAbs) are small, minimal antibodies that have distinct attributes that make them uniquely suited for certain biomedical research, diagnostic and therapeutic applications. Prominent uses include as intracellular antibodies or intrabodies to bind and deliver cargo to specific proteins and/or subcellular sites within cells, and as nanoscale immunolabels for enhanced tissue penetration and improved spatial imaging resolution. Here, we report the generation and validation of nAbs against a set of proteins prominently expressed at specific subcellular sites in mammalian brain neurons. We describe a novel hierarchical validation pipeline to systematically evaluate nAbs isolated by phage display for effective and specific use as intrabodies and immunolabels in mammalian cells including brain neurons. These nAbs form part of a robust toolbox for targeting proteins with distinct and highly spatially-restricted subcellular localization in mammalian brain neurons, allowing for visualization and/or modulation of structure and function at those sites

Interventions to support recovery following an episode of delirium: A realist synthesis

This is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this recordOBJECTIVES: Persistent delirium is associated with poor outcomes in older adults but little is known about how to support longer-term recovery from delirium. The aim of this review was to identify and synthesise literature to understand mechanisms of recovery from delirium as a basis for designing an intervention that enables more effective recovery. METHODS: A systematic search of literature relevant to the research question was conducted in two phases. Phase one focused on studies evaluating the efficacy of interventions to support recovery from delirium, and stage two used a wider search strategy to identify other relevant literature including similar patient groups and wider methodologies. Synthesis of the literature followed realist principles. RESULTS: Phase one identified four relevant studies and stage two identified a further forty-six studies. Three interdependent recovery domains and four recovery facilitators were identified. Recovery domains were 1) support for physical recovery through structured exercise programmes; 2) support for cognitive recovery through reality orientation and cognitive stimulation; 3) support for emotional recovery through talking with skilled helpers. Recovery facilitators were 1) involvement and support of carers; 2) tailoring intervention to individual needs, preferences and abilities; 3) interpersonal connectivity and continuity in relationships and; 4) facilitating positive expressions of self. CONCLUSIONS: Multicomponent interventions with elements that address all recovery domains and facilitators may have the most promise. Future research should build on this review and explore patients', carers', and professionals' tacit theories about the persistence of delirium or recovery from delirium in order to inform an effective intervention

Continuous pumping and control of mesoscopic superposition state in a lossy QED cavity

Here we consider the continuous pumping of a dissipative QED cavity and derive the time-dependent density operator of the cavity field prepared initially as a superposition of mesoscopic coherent states. The control of the coherence of this superposition is analyzed considering the injection of a beam of two-level Rydberg atoms through the cavity. Our treatment is compared to other approaches.Comment: 15 pages, 6 PostScript figures, To appear in Phys. Rev.