Turbulence and Cavitation Suppression by Quaternary Ammonium Salt Additives

We identify the physical mechanism through which newly developed quaternary ammonium salt (QAS) deposit control additives (DCAs) affect the rheological properties of cavitating turbulent flows, resulting in an increase in the volumetric efficiency of clean injectors fuelled with diesel or biodiesel fuels. Quaternary ammonium surfactants with appropriate counterions can be very effective in reducing the turbulent drag in aqueous solutions, however, less is known about the effect of such surfactants in oil-based solvents or in cavitating flow conditions. Small-angle neutron scattering (SANS) investigations show that in traditional DCA fuel compositions only reverse spherical micelles form, whereas reverse cylindrical micelles are detected by blending the fuel with the QAS additive. Moreover, experiments utilising X-ray micro computed tomography (micro-CT) in nozzle replicas, quantify that in cavitation regions the liquid fraction is increased in the presence of the QAS additive. Furthermore, high-flux X-ray phase contrast imaging (XPCI) measurements identify a flow stabilization effect in the region of vortex cavitation by the QAS additive. The effect of the formation of cylindrical micelles is reproduced with computational fluid dynamics (CFD) simulations by including viscoelastic characteristics for the flow. It is demonstrated that viscoelasticity can reduce turbulence and suppress cavitation, and subsequently increase the injector’s volumetric efficiency

High-Affinity Small Molecule Inhibitors of T Cell Costimulation: Compounds for Immunotherapy

SummaryCostimulatory molecules are important regulators of T cell activation and thus favored targets for therapeutic manipulation of immune responses. One of the key costimulatory receptors is CD80, which binds the T cell ligands, CD28, and CTLA-4. We describe a set of small compounds that bind with high specificity and low nanomolar affinity to CD80. The compounds have relatively slow off-rates and block both CD28 and CTLA-4 binding, implying that they occlude the shared ligand binding site. The compounds inhibit proinflammatory cytokine release in T cell assays with submicromolar potency, and as such, they represent promising leads for the development of novel therapeutics for immune-mediated inflammatory disease. Our results also suggest that other predominantly β proteins, such as those that dominate the cell surface, may also be accessible as potentially therapeutic targets

The Role of Compensatory Beliefs in Rationalizing Environmentally Detrimental Behaviors

Compensatory green beliefs (CGBs) reflect the idea that a pro-environmental behavior (e.g., recycling) can off-set the negative effects of an environmentally detrimental behavior (e.g., driving). It is thought that CGBs might help explain why people act in ways that appear to contradict their pro-environmental intentions, and inconsistently engage in pro-environmental behaviors. The present study sought to investigate the nature and use of CGBs. A series of interviews suggested that participants endorsed CGBs to: (a) reduce feelings of guilt with respect to (the assumed or actual) negative environmental impact of their actions, and (b) to defend their green credentials in social situations. Participants also justified detrimental behaviors on the basis of higher loyalties (e.g., family’s needs), or the perceived difficulty of performing more pro-environmental actions. In addition to shedding light on how, when, and why people might hold and use CGBs, the research also provides new insight into how CGBs should be assessed

Scoping the future law and social justice - listening & hearing from the frontline: final report

'Scoping the Future Law and Social Justice – Listening & Hearing from the Frontline' ran for eight months from November 2021 until June 2022. The project aimed to identify research priorities for the AHRC in the area of law and social justice, a broad field of study with diverse points of focus. It explores the role that the law and legal institutions play in addressing contemporary social challenges such as those associated with gender, the COVID-19 pandemic, modern slavery, hate crime, inequality, the digital revolution, capitalism, and climate change to achieve a more just society, particularly around meeting the needs and safeguarding the rights of excluded, vulnerable and marginalised communities. In considering the subthemes identified by the AHRC (governance, citizenship & representation, transitional justice, and cultures of exclusion), we note that many of the current debates in these fields are underpinned by the notion of accountability. The project was designed around four workstreams (WS), which were designed to align with the AHRC and broader UKRI priorities. An interdisciplinary team at Nottingham Trent University undertook a comprehensive theoretical and empirical inquiry, informed by participatory action research, to formulate thematic and format-based recommendations for the AHRC. The research was co-designed with our research partners whom we refer to as ‘trusted intermediaries’ (TIs). Feedback and guidance were received from the Advisory Group (AG), represented by members of academia and the public whose work is broadly related to social justice issues. Six meetings with the AG, either collectively or individually were held, and their feedback has been indispensable for sharpening our project design and reflecting on progress. The team adopted a mixed-methods approach, combining a literature (scoping) review as well as qualitative data collection and analysis. Through different stages of the project, we have developed three templates to enable consistent collation of data across the research team. The first template sought to elicit the gaps in the existing literature. The second reflected on the data collected through individual interviews or focus groups. The third triangulated the literature, transcripts from interviews, and transcript and field notes analysis against five benchmarks which had been identified at the beginning of the project in consultation with our TIs. Overall, we conducted 29 partners and TI semi-structured interviews, and six interviews and three focus groups with service-users. Analysis of this data led to findings and team discussions. A first draft of the report was presented at a Roundtable for feedback from TIs and the government officials present. High quality research in the field of social justice, broadly defined, in the area of social justice is complex and multi-layered. This report recommends that future research in the field priorities stakeholder engagement that enables ongoing and respectful participatory research models involving the active co-design and collaboration of research partners. This should ensure that the nature of challenges in the field are properly understood, rather than based on assumptions contained in much of the established literature that may be outdated or may not be evidenced through the lived experiences of beneficiaries. While the research was commissioned by the AHRC, there are clear overlaps with the remit of the ESRC. Causes of social injustice (as the data and access to justice literature reflect) are complex and multi-layered, and key issues often intersect, compound, and are often structural in nature. Accordingly, academic ‘silos’ can be unhelpful in seeking to provide impactful and effective solutions to social injustice. This project has revealed fundamental inequities in policy and administrative settings that exacerbate exclusion. This report recommends that future research should prioritise interdisciplinary and participatory approaches which adopt shared language which cuts across disciplinary boundaries and is accessible to frontline service providers and end-users. While the research team for this project drew from expertise across different fields of law, politics and social psychology, we appreciate that future cross-disciplinary research might usefully draw upon the wider range of subject areas falling within the AHRC’s remit, including (but not limited to) to history, archaeology, anthropology, philosophy, languages, literature and the creative arts. This conclusion is based on our finding that creative pursuits can potentially play a useful role in reducing community isolation, build confidence, improve public trust and civic participation. The importance of interdisciplinary and cross-/multidisciplinary practise is also an area emerging as a way to improve responsiveness. This was noted by the REF2021 panel to be a point of strength and vibrancy in the current research landscape. The research findings also highlight the importance of using non-technical and accessible language and non- judgemental ways of working in order to gain buy-in from frontline service-providers, including groups who represent the interests of socially excluded communities. Such an approach would help to combat research fatigue and the sense of ‘being used but not included’ which had been flagged by a number of our TIs in relation to their involvement previous academic research projects. It is well established that austerity and competition for limited resources has had a major impact upon this sector. The sense of exhaustion and distrust should be acknowledged in in formulating future research strategies. While our own approach to this project can be characterised as iterative, reflective and responsive so as to enable a sense of ‘buy-in’ among our TIs, this has clearly not been the case in many previous research exercises. The allocation of future research funding should bear in mind the importance of co-design and collaboration to ensure that such funding represents value for money and that the nature of any findings are practical, relevant and evidence-based. These recommendations are in line with the REF panel’s observation that ‘the strongest submissions included Impact at all Points of the Research strategy and provided support, training and resources to develop External partnerships and relationships,’ further noting the ‘importance of outward focussing research with the outside organisation as ‘of vital importance to social progress and development. Our recommendations for the AHRC focus is on the general characteristics of the support needed, specific recommendations for next steps, aims, type, scale, timelines, justification of support needed as well as partners and their roles. 1. The AHRC would benefit from funding mid to long term “Engagement Research”: with local communities, NGOs (including Foodbanks, Legal Advice Centres, Domestic Abuse services with modest additional resources so as not to deflect from service delivery on the front line), local government, policy makers, corporations, legal practitioners etc. We have identified four themes for Engagement Research (trust, accountability, vulnerability, citizen’s rights) and 10 topics. 2. The AHRC should fund Fellowships that utilise opportunities to work on internship/externship models to partner with third sector agencies so that on-the ground practical realities can shape and support empirical, comparative, theoretical and doctrinal research to address current global and domestic challenges. These areas of study are key to address particular challenges for which researchers may find it difficult to secure funding from other sources due to the nature of their discipline and research. These fellowships may follow three different routes: AHRC Scholarship Fellowships, AHRC Interdisciplinary Fellowships, and AHRC Engagement Fellowships. We have identified six themes to engage with for AHRC. 3. AHRC should fund an independently evaluated pilot Digital Hub for police, which serves an important role in supplementing community policing by building and retaining useful shared information. Project design is in line with equality, diversity, and inclusion (EDI) criteria – which were taken into consideration not only with respect to how we have formed our team and distributed the tasks, but also how we recruited and drew on the expertise of partners and participants within the project

Evidence-Based Mental Health Programs in Schools: Barriers and Facilitators of Successful Implementation

Although schools can improve children’s access to mental health services, not all school-based providers are able to successfully deliver evidence-based practices. Indeed, even when school clinicians are trained in evidence-based practices (EBP), the training does not necessarily result in the implementation of those practices. This study explores factors that influence implementation of a particular EBP, Cognitive Behavioral Intervention for Trauma in Schools (CBITS). Semi-structured telephone interviews with 35 site administrators and clinicians from across the United States were conducted 6–18 months after receiving CBITS training to discuss implementation experiences. The implementation experiences of participants differed, but all reported similar barriers to implementation. Sites that successfully overcame such barriers differed from their unsuccessful counterparts by having greater organizational structure for delivering school services, a social network of other clinicians implementing CBITS, and administrative support for implementation. This study suggests that EBP implementation can be facilitated by having the necessary support from school leadership and peers

Chemical diversity in a metal-organic framework revealed by fluorescence lifetime imaging

The presence and variation of chemical functionality and defects in crystalline materials, such as metal–organic frameworks (MOFs), have tremendous impact on their properties. Finding a means of identifying and characterizing this chemical diversity is an important ongoing challenge. This task is complicated by the characteristic problem of bulk measurements only giving a statistical average over an entire sample, leaving uncharacterized any diversity that might exist between crystallites or even within individual crystals. Here we show that by using fluorescence imaging and lifetime analysis, both the spatial arrangement of functionalities and the level of defects within a multivariable MOF crystal can be determined for the bulk as well as for the individual constituent crystals. We apply these methods to UiO-67, to study the incorporation of functional groups and their consequences on the structural features. We believe that the potential of the techniques presented here in uncovering chemical diversity in what is generally assumed to be homogeneous systems can provide a new level of understanding of materials properties

The effect of maltreatment type on adolescent executive functioning and inner speech

There are indications that different types of maltreatment can lead to different cognitive and behavioural outcomes. This study investigated whether maltreatment type was related to executive functioning (EF) abilities and the use of inner speech. Forty maltreated adolescents and a comparison group of 40 non-maltreated typically developing (TD) adolescents completed a battery of tasks designed to assess both their EF abilities and their vulnerability to disruptions to inner speech. They also completed an IQ test. MANCOVA and ANCOVA analyses were carried out to examine potential effects of maltreatment type (abuse alone; neglect alone; abuse/neglect combined and no maltreatment) on EF and use of inner speech. Maltreatment type was related to EF abilities. In particular, abuse only and abuse/neglect combined had a greater negative impact on EF than neglect only. However, the neglect alone group were more vulnerable to disruptions to inner speech than the other two maltreatment groups, suggesting that they may be more reliant on the use of inner speech. These findings provide new insights into the differential impact of maltreatment type on EF and the use of inner speech in adolescence, and could be used to improve the educational outcomes of these vulnerable young people

Big-Data Science in Porous Materials: Materials Genomics and Machine Learning

By combining metal nodes with organic linkers we can potentially synthesize millions of possible metal organic frameworks (MOFs). At present, we have libraries of over ten thousand synthesized materials and millions of in-silico predicted materials. The fact that we have so many materials opens many exciting avenues to tailor make a material that is optimal for a given application. However, from an experimental and computational point of view we simply have too many materials to screen using brute-force techniques. In this review, we show that having so many materials allows us to use big-data methods as a powerful technique to study these materials and to discover complex correlations. The first part of the review gives an introduction to the principles of big-data science. We emphasize the importance of data collection, methods to augment small data sets, how to select appropriate training sets. An important part of this review are the different approaches that are used to represent these materials in feature space. The review also includes a general overview of the different ML techniques, but as most applications in porous materials use supervised ML our review is focused on the different approaches for supervised ML. In particular, we review the different method to optimize the ML process and how to quantify the performance of the different methods. In the second part, we review how the different approaches of ML have been applied to porous materials. In particular, we discuss applications in the field of gas storage and separation, the stability of these materials, their electronic properties, and their synthesis. The range of topics illustrates the large variety of topics that can be studied with big-data science. Given the increasing interest of the scientific community in ML, we expect this list to rapidly expand in the coming years.Comment: Editorial changes (typos fixed, minor adjustments to figures

PAUSED for thought? Using verbal protocol analysis to understand the situational and temporal cues in the decision-making of residential burglars

Using verbal protocol analysis (VPA) alongside semi-structured interviews, this research aimed to explicate the situational dynamics that inform the decision-making and target selection of residential burglars. Focusing on the VPA method, novel to criminological research, the paper considers the contribution of this empirical approach for studying the decision-making of offenders in situ. The findings reveal a series of cues, encapsulated in the ‘PAUSED’ model, that are drawn upon by residential burglars to assess the suitability of a target; determining whether it is profitable, accessible, uninterruptible, surveillable, escapable and/or dishonourable. The PAUSED model is unpacked to articulate a collection of visual stimuli that serve to disrupt and suspend the otherwise rapid flow of target appraisal. Discussion of the strengths and limitations of the VPA method, and how it can compliment other approaches to understanding the decision-making of residential burglars, is provided

Stepwise Maturation of Lytic Granules during Differentiation and Activation of Human CD8+ T Lymphocytes

During differentiation, cytotoxic T lymphocytes (CTL) acquire their killing potential through the biogenesis and maturation of lytic granules that are secreted upon target cell recognition. How lytic granule load in lytic molecules evolves during CTL differentiation and which subsets of lytic granules are secreted following activation remains to be investigated. We set up a flow cytometry approach to analyze single lytic granules isolated from primary human CTL according to their size and molecular content. During CTL in vitro differentiation, a relatively homogeneous population of lytic granules appeared through the progressive loading of Granzyme B, Perforin and Granzyme A within LAMP1+ lysosomes. PMA/ionomycin-induced lytic granule exocytosis was preceded by a rapid association of the docking molecule Rab27a to approximately half of the lytic granules. Activated CTL were found to limit exocytosis by sparing lytic granules including some associated to Rab27a. Our study provides a quantification of key steps of lytic granule biogenesis and highlights the potential of flow cytometry to study organelle composition and dynamics